YJR057W / CDC8

Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR057W / CDC8

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:3.16|P-value:3.83E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.51|P-value:9.37E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:4.69|P-value:2.98E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:4.47|P-value:9.49E-7 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:2.94|P-value:8.75E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.01|P-value:6.75E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.07|P-value:7.28E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:3.34|P-value:1.91E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.38|P-value:1.53E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:-2.94|P-value:8.03E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.62|P-value:3.65E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:3.58|P-value:6.88E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.65|P-value:5.10E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.27|P-value:2.52E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.49|P-value:1.01E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.14|P-value:3.71E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.28|P-value:2.39E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.05|P-value:5.87E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:4.07|P-value:7.40E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.85|P-value:1.77E-5 ID:SGTC_1526|Compound:st051518|FD-Score:3.28|P-value:2.37E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.10|P-value:4.93E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-3.50|P-value:8.64E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-6.22|P-value:1.33E-11 ID:SGTC_1739|Compound:st037196|FD-Score:3.37|P-value:1.65E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.63|P-value:1.93E-16 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.08|P-value:5.93E-6 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.36|P-value:1.56E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.54|P-value:8.35E-5 ID:SGTC_1900|Compound:st060200|FD-Score:-4.57|P-value:4.75E-7 ID:SGTC_1904|Compound:st060225|FD-Score:-3.33|P-value:1.71E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.83|P-value:2.00E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.49|P-value:1.03E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.07|P-value:4.93E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.40|P-value:1.32E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.03|P-value:6.35E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.24|P-value:2.85E-4 ID:SGTC_2274|Compound:7947094|FD-Score:5.13|P-value:2.22E-8 ID:SGTC_2276|Compound:7947513|FD-Score:3.25|P-value:2.71E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.36|P-value:1.77E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.35|P-value:1.79E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.28|P-value:2.46E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.78|P-value:2.86E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.03|P-value:5.57E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.70|P-value:4.00E-5 ID:SGTC_2693|Compound:st077581|FD-Score:5.92|P-value:1.33E-10 ID:SGTC_3044|Compound:9093193|FD-Score:-2.96|P-value:7.26E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.04|P-value:5.36E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.15|P-value:3.52E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.16|P-value:3.83E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.51|P-value:9.37E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:4.69|P-value:2.98E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:4.47|P-value:9.49E-7 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:2.94|P-value:8.75E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.01|P-value:6.75E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.07|P-value:7.28E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:3.34|P-value:1.91E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.38|P-value:1.53E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:-2.94|P-value:8.03E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.62|P-value:3.65E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:3.58|P-value:6.88E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.65|P-value:5.10E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.27|P-value:2.52E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.49|P-value:1.01E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.14|P-value:3.71E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.28|P-value:2.39E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.05|P-value:5.87E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:4.07|P-value:7.40E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.85|P-value:1.77E-5 ID:SGTC_1526|Compound:st051518|FD-Score:3.28|P-value:2.37E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.10|P-value:4.93E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-3.50|P-value:8.64E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-6.22|P-value:1.33E-11 ID:SGTC_1739|Compound:st037196|FD-Score:3.37|P-value:1.65E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.63|P-value:1.93E-16 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.08|P-value:5.93E-6 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.36|P-value:1.56E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.54|P-value:8.35E-5 ID:SGTC_1900|Compound:st060200|FD-Score:-4.57|P-value:4.75E-7 ID:SGTC_1904|Compound:st060225|FD-Score:-3.33|P-value:1.71E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.83|P-value:2.00E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.49|P-value:1.03E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.07|P-value:4.93E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.40|P-value:1.32E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.03|P-value:6.35E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.24|P-value:2.85E-4 ID:SGTC_2274|Compound:7947094|FD-Score:5.13|P-value:2.22E-8 ID:SGTC_2276|Compound:7947513|FD-Score:3.25|P-value:2.71E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.36|P-value:1.77E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.35|P-value:1.79E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.28|P-value:2.46E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.78|P-value:2.86E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.03|P-value:5.57E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.70|P-value:4.00E-5 ID:SGTC_2693|Compound:st077581|FD-Score:5.92|P-value:1.33E-10 ID:SGTC_3044|Compound:9093193|FD-Score:-2.96|P-value:7.26E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.04|P-value:5.36E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.15|P-value:3.52E-4

Top fitness defect scores for YJR057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1742 st038235 7.63 28.9 µM 1.93E-16 mitochondrial stress 2 1.16E-14 1.38
2 SGTC_2693 st077581 5.92 40.7 µM 1.33E-10 1 1.57E-9 0.93
3 SGTC_2274 7947094 5.13 46.1 µM 2.22E-8 2 1.42E-7 0.34
4 SGTC_165 k038-0023 4.69 64.4 µM 2.98E-7 ubiquinone biosynthesis & proteasome 16 1.40E-6 0.03
5 SGTC_216 k038-0035 4.47 28.4 µM 9.49E-7 ubiquinone biosynthesis & proteasome 12 3.88E-6 0.39
6 SGTC_691 1548-0686 4.38 185.0 µM 1.53E-6 8 5.91E-6 0.08
7 SGTC_572 0960-0087 4.07 17.7 µM 7.28E-6 11 2.34E-5 0.18
8 SGTC_1462 k081-0014 4.07 26.5 µM 7.40E-6 3 2.38E-5 0.78
9 SGTC_2591 skatole 3.78 100.0 µM 2.86E-5 5 7.85E-5 0.13
10 SGTC_2690 usnic acid 3.70 100.0 µM 4.00E-5 7 1.06E-4 0.05
11 SGTC_956 1185-0240 3.65 191.0 µM 5.10E-5 3 1.31E-4 0.16
12 SGTC_794 k038-0031 3.58 316.0 µM 6.88E-5 ubiquinone biosynthesis & proteasome 25 1.71E-4 0.13
13 SGTC_1891 st059073 3.54 26.2 µM 8.35E-5 TSC3-RPN4 8 2.03E-4 0.02
14 SGTC_142 0335-0849 3.51 62.7 µM 9.37E-5 ubiquinone biosynthesis & proteasome 24 2.24E-4 0.02
15 SGTC_1186 1319-0216 3.49 26.0 µM 1.01E-4 4 2.39E-4 0.06
16 SGTC_2064 5220758 3.49 200.0 µM 1.03E-4 14 2.45E-4 0.19
17 SGTC_1739 st037196 3.37 92.5 µM 1.65E-4 5 3.71E-4 0.04
18 SGTC_2428 5615643 3.36 7.8 µM 1.77E-4 11 3.94E-4 0.00
19 SGTC_2457 5731572 3.35 11.7 µM 1.79E-4 5 3.98E-4 0.04
20 SGTC_582 0987-0078 3.34 156.0 µM 1.91E-4 calcium & mitochondrial duress 13 4.22E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.05E-17 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.139 5.28E-16 YKR027W BCH2 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication
0.136 2.24E-15 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.134 6.26E-15 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.129 6.24E-14 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.123 9.30E-13 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.119 5.40E-12 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 4.31E-11 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.111 1.01E-10 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.108 3.18E-10 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.108 3.68E-10 YFR032C_p RRT5_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation
0.104 1.33E-9 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 1.84E-9 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.103 1.95E-9 YPL164C MLH3 hom Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
0.100 7.48E-9 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p