YJR058C / APS2

Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR058C / APS2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:2.62|P-value:9.32E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.38|P-value:1.32E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.86|P-value:2.76E-12 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.39|P-value:1.31E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.71|P-value:7.46E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.65|P-value:9.83E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.00|P-value:1.80E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:2.89|P-value:2.91E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.76|P-value:6.05E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.36|P-value:3.36E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:2.60|P-value:9.96E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.57|P-value:1.11E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.30|P-value:1.68E-7 ID:SGTC_1037|Compound:k284-1091|FD-Score:-2.67|P-value:8.97E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.88|P-value:3.09E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-2.73|P-value:6.90E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:2.77|P-value:5.05E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.44|P-value:2.26E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.52|P-value:4.29E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.61|P-value:3.00E-8 ID:SGTC_1634|Compound:st006576|FD-Score:3.14|P-value:9.78E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.07|P-value:1.60E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.70|P-value:5.55E-6 ID:SGTC_1976|Compound:st070609|FD-Score:2.83|P-value:3.85E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-2.93|P-value:3.05E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.26|P-value:5.42E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-4.21|P-value:3.94E-7 ID:SGTC_2295|Compound:7971645|FD-Score:2.87|P-value:3.19E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-2.80|P-value:5.12E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.44|P-value:2.21E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.84|P-value:3.76E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:5.25|P-value:2.48E-10 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.67|P-value:6.70E-6 ID:SGTC_2493|Compound:resveratrol|FD-Score:4.44|P-value:7.19E-8 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.84|P-value:2.62E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.83|P-value:5.15E-9 ID:SGTC_2694|Compound:st077685|FD-Score:-6.93|P-value:1.89E-16 ID:SGTC_2788|Compound:5282734|FD-Score:4.30|P-value:1.76E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:2.62|P-value:9.32E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.38|P-value:1.32E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.86|P-value:2.76E-12 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.39|P-value:1.31E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.71|P-value:7.46E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.65|P-value:9.83E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.00|P-value:1.80E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:2.89|P-value:2.91E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.76|P-value:6.05E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.36|P-value:3.36E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:2.60|P-value:9.96E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.57|P-value:1.11E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.30|P-value:1.68E-7 ID:SGTC_1037|Compound:k284-1091|FD-Score:-2.67|P-value:8.97E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.88|P-value:3.09E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-2.73|P-value:6.90E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:2.77|P-value:5.05E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.44|P-value:2.26E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.52|P-value:4.29E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.61|P-value:3.00E-8 ID:SGTC_1634|Compound:st006576|FD-Score:3.14|P-value:9.78E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.07|P-value:1.60E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.70|P-value:5.55E-6 ID:SGTC_1976|Compound:st070609|FD-Score:2.83|P-value:3.85E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-2.93|P-value:3.05E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.26|P-value:5.42E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-4.21|P-value:3.94E-7 ID:SGTC_2295|Compound:7971645|FD-Score:2.87|P-value:3.19E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-2.80|P-value:5.12E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.44|P-value:2.21E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.84|P-value:3.76E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:5.25|P-value:2.48E-10 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.67|P-value:6.70E-6 ID:SGTC_2493|Compound:resveratrol|FD-Score:4.44|P-value:7.19E-8 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.84|P-value:2.62E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.83|P-value:5.15E-9 ID:SGTC_2694|Compound:st077685|FD-Score:-6.93|P-value:1.89E-16 ID:SGTC_2788|Compound:5282734|FD-Score:4.30|P-value:1.76E-7

Top fitness defect scores for YJR058C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2491 paeonol 5.25 100.0 µM 2.48E-10 2 7.57E-8
2 SGTC_2591 skatole 4.83 100.0 µM 5.15E-9 13 6.77E-7
3 SGTC_2493 resveratrol 4.44 26.1 µM 7.19E-8 3 4.56E-6
4 SGTC_1034 k072-0165 4.30 12.7 µM 1.68E-7 Golgi 13 8.41E-6
5 SGTC_2788 5282734 4.30 71.4 µM 1.76E-7 30 8.70E-6
6 SGTC_2497 7-hydroxyflavone 3.84 100.0 µM 2.62E-6 21 6.17E-5
7 SGTC_1784 st039334 3.70 36.3 µM 5.55E-6 25 1.06E-4
8 SGTC_2492 derrusnin 3.67 100.0 µM 6.70E-6 9 1.22E-4
9 SGTC_1031 k035-0009 3.57 16.0 µM 1.11E-5 42 1.76E-4
10 SGTC_2399 5884133 3.44 200.0 µM 2.21E-5 cell wall signaling 96 2.90E-4
11 SGTC_1380 2291-0730 3.44 164.0 µM 2.26E-5 45 2.95E-4
12 SGTC_798 1287-0182 3.36 476.0 µM 3.36E-5 47 3.94E-4
13 SGTC_1998 st075797 3.26 76.8 µM 5.42E-5 mitochondrial response to ROS 39 5.58E-4
14 SGTC_1634 st006576 3.14 41.0 µM 9.78E-5 TSC3-RPN4 49 8.57E-4
15 SGTC_245 methotrexate 3.00 289.6 µM 1.80E-4 87 0.00134
16 SGTC_663 1486-0733 2.89 13.9 µM 2.91E-4 cell wall signaling 108 0.00190
17 SGTC_1059 3448-6867 2.88 171.0 µM 3.09E-4 53 0.00198
18 SGTC_2295 7971645 2.87 200.0 µM 3.19E-4 72 0.00203
19 SGTC_2490 carminic acid 2.84 95.4 µM 3.76E-4 35 0.00229
20 SGTC_1976 st070609 2.83 63.5 µM 3.85E-4 51 0.00233

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 1.59E-77 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.281 6.23E-62 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.265 5.02E-55 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.253 3.68E-50 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.242 8.10E-46 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.231 7.28E-42 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.225 2.11E-39 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.220 4.25E-38 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.213 1.50E-35 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.210 1.08E-34 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.204 6.61E-33 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.202 3.37E-32 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.202 4.18E-32 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.194 1.11E-29 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.192 3.15E-29 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family