YJR059W / PTK2

Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR059W / PTK2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.69|P-value:6.56E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.48|P-value:5.78E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:4.05|P-value:4.64E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-4.98|P-value:2.38E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:4.80|P-value:4.31E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.10|P-value:4.10E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.64|P-value:7.43E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.81|P-value:9.18E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.65|P-value:2.70E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:12.30|P-value:4.67E-24 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.82|P-value:9.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.33|P-value:1.03E-9 ID:SGTC_465|Compound:cgp-37157|FD-Score:6.95|P-value:6.57E-9 ID:SGTC_470|Compound:aa-861|FD-Score:10.60|P-value:2.47E-18 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.87|P-value:3.37E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.46|P-value:3.98E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:4.95|P-value:2.61E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:4.69|P-value:6.32E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:6.16|P-value:2.40E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:6.70|P-value:2.20E-8 ID:SGTC_687|Compound:k029-0044|FD-Score:6.53|P-value:4.70E-8 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.77|P-value:1.26E-6 ID:SGTC_786|Compound:4544-0069|FD-Score:9.14|P-value:3.93E-14 ID:SGTC_863|Compound:0466-0191|FD-Score:3.78|P-value:9.98E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.09|P-value:4.17E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.09|P-value:1.58E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:10.70|P-value:9.54E-19 ID:SGTC_994|Compound:3910-0338|FD-Score:3.85|P-value:8.23E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.95|P-value:6.33E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.81|P-value:9.16E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.94|P-value:6.33E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.54|P-value:2.98E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-5.45|P-value:4.26E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.17|P-value:3.27E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-4.29|P-value:2.32E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.41|P-value:1.58E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-5.21|P-value:1.04E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-4.43|P-value:1.47E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.83|P-value:3.92E-5 ID:SGTC_1769|Compound:st044406|FD-Score:4.16|P-value:3.30E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.06|P-value:4.55E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.83|P-value:8.79E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.90|P-value:7.14E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:7.63|P-value:2.20E-10 ID:SGTC_1870|Compound:st057514|FD-Score:4.46|P-value:1.35E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:8.81|P-value:2.94E-13 ID:SGTC_1915|Compound:st067105|FD-Score:-4.06|P-value:4.67E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.88|P-value:3.33E-5 ID:SGTC_1970|Compound:st070122|FD-Score:7.09|P-value:3.41E-9 ID:SGTC_2077|Compound:5212015|FD-Score:6.75|P-value:1.70E-8 ID:SGTC_2082|Compound:5219693|FD-Score:4.00|P-value:5.39E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.88|P-value:3.33E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.26|P-value:2.47E-4 ID:SGTC_2192|Compound:5915882|FD-Score:5.89|P-value:7.45E-7 ID:SGTC_2239|Compound:6685329|FD-Score:5.79|P-value:1.11E-6 ID:SGTC_2248|Compound:tofa|FD-Score:16.00|P-value:1.46E-39 ID:SGTC_2306|Compound:7482397|FD-Score:-3.91|P-value:7.02E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.12|P-value:3.81E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.85|P-value:8.37E-4 ID:SGTC_2416|Compound:tofa|FD-Score:10.40|P-value:1.27E-17 ID:SGTC_2461|Compound:5755302|FD-Score:4.46|P-value:1.34E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.93|P-value:6.62E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.04|P-value:4.81E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.98|P-value:5.09E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.52|P-value:3.17E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-5.21|P-value:1.04E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.62|P-value:8.09E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.98|P-value:5.81E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.90|P-value:2.90E-26 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.97|P-value:5.89E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:6.01|P-value:4.46E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:7.02|P-value:4.81E-9 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.00|P-value:3.78E-23 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.07|P-value:1.70E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.86|P-value:7.89E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.62|P-value:7.98E-5 ID:SGTC_3303|Compound:9125618|FD-Score:4.87|P-value:3.43E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.36|P-value:1.80E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.17|P-value:3.23E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.69|P-value:6.56E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.48|P-value:5.78E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:4.05|P-value:4.64E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-4.98|P-value:2.38E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:4.80|P-value:4.31E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.10|P-value:4.10E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.64|P-value:7.43E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.81|P-value:9.18E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.65|P-value:2.70E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:12.30|P-value:4.67E-24 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.82|P-value:9.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.33|P-value:1.03E-9 ID:SGTC_465|Compound:cgp-37157|FD-Score:6.95|P-value:6.57E-9 ID:SGTC_470|Compound:aa-861|FD-Score:10.60|P-value:2.47E-18 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.87|P-value:3.37E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.46|P-value:3.98E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:4.95|P-value:2.61E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:4.69|P-value:6.32E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:6.16|P-value:2.40E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:6.70|P-value:2.20E-8 ID:SGTC_687|Compound:k029-0044|FD-Score:6.53|P-value:4.70E-8 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.77|P-value:1.26E-6 ID:SGTC_786|Compound:4544-0069|FD-Score:9.14|P-value:3.93E-14 ID:SGTC_863|Compound:0466-0191|FD-Score:3.78|P-value:9.98E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.09|P-value:4.17E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.09|P-value:1.58E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:10.70|P-value:9.54E-19 ID:SGTC_994|Compound:3910-0338|FD-Score:3.85|P-value:8.23E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.95|P-value:6.33E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.81|P-value:9.16E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.94|P-value:6.33E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.54|P-value:2.98E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-5.45|P-value:4.26E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.17|P-value:3.27E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-4.29|P-value:2.32E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.41|P-value:1.58E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-5.21|P-value:1.04E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-4.43|P-value:1.47E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.83|P-value:3.92E-5 ID:SGTC_1769|Compound:st044406|FD-Score:4.16|P-value:3.30E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.06|P-value:4.55E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.83|P-value:8.79E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.90|P-value:7.14E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:7.63|P-value:2.20E-10 ID:SGTC_1870|Compound:st057514|FD-Score:4.46|P-value:1.35E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:8.81|P-value:2.94E-13 ID:SGTC_1915|Compound:st067105|FD-Score:-4.06|P-value:4.67E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.88|P-value:3.33E-5 ID:SGTC_1970|Compound:st070122|FD-Score:7.09|P-value:3.41E-9 ID:SGTC_2077|Compound:5212015|FD-Score:6.75|P-value:1.70E-8 ID:SGTC_2082|Compound:5219693|FD-Score:4.00|P-value:5.39E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.88|P-value:3.33E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.26|P-value:2.47E-4 ID:SGTC_2192|Compound:5915882|FD-Score:5.89|P-value:7.45E-7 ID:SGTC_2239|Compound:6685329|FD-Score:5.79|P-value:1.11E-6 ID:SGTC_2248|Compound:tofa|FD-Score:16.00|P-value:1.46E-39 ID:SGTC_2306|Compound:7482397|FD-Score:-3.91|P-value:7.02E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.12|P-value:3.81E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.85|P-value:8.37E-4 ID:SGTC_2416|Compound:tofa|FD-Score:10.40|P-value:1.27E-17 ID:SGTC_2461|Compound:5755302|FD-Score:4.46|P-value:1.34E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.93|P-value:6.62E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.04|P-value:4.81E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.98|P-value:5.09E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.52|P-value:3.17E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-5.21|P-value:1.04E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.62|P-value:8.09E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.98|P-value:5.81E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.90|P-value:2.90E-26 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.97|P-value:5.89E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:6.01|P-value:4.46E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:7.02|P-value:4.81E-9 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.00|P-value:3.78E-23 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.07|P-value:1.70E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.86|P-value:7.89E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.62|P-value:7.98E-5 ID:SGTC_3303|Compound:9125618|FD-Score:4.87|P-value:3.43E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.36|P-value:1.80E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.17|P-value:3.23E-4

Top fitness defect scores for YJR059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2248 tofa 16.00 1.1 µM 1.46E-39 sphingolipid biosynthesis & PDR1 4 3.21E-58
2 SGTC_2582 agaric acid 12.90 100.0 µM 2.90E-26 redox potentiating 30 2.41E-38
3 SGTC_266 formosanin C 12.30 406.0 nM 4.67E-24 sphingolipid biosynthesis & PDR1 11 4.76E-35
4 SGTC_2651 1327-0036 12.00 5.0 µM 3.78E-23 15 1.08E-33
5 SGTC_955 1216-0110 10.70 33.0 µM 9.54E-19 sphingolipid biosynthesis & PDR1 14 4.01E-27
6 SGTC_470 aa-861 10.60 153.0 µM 2.47E-18 sphingolipid biosynthesis & PDR1 9 1.66E-26
7 SGTC_2416 tofa 10.40 880.0 nM 1.27E-17 sphingolipid biosynthesis & PDR1 10 1.90E-25
8 SGTC_786 4544-0069 9.14 423.0 µM 3.93E-14 1 3.04E-20
9 SGTC_1872 amphotericin b 8.81 148.0 nM 2.94E-13 RNA pol III & RNase P/MRP 4 6.09E-19
10 SGTC_1789 tunicamycin 7.63 25.0 nM 2.20E-10 unfolded protein response 9 1.15E-14
11 SGTC_453 enantio-paf c16 7.33 10.0 µM 1.03E-9 21 1.14E-13
12 SGTC_1970 st070122 7.09 35.8 µM 3.41E-9 TSC3-RPN4 3 6.70E-13
13 SGTC_2645 abamectin 7.02 100.0 µM 4.81E-9 heme requiring 3 1.12E-12
14 SGTC_2581 avocatin a 6.98 64.0 µM 5.81E-9 sphingolipid biosynthesis & PDR1 11 1.48E-12
15 SGTC_465 cgp-37157 6.95 41.0 µM 6.57E-9 2 1.78E-12
16 SGTC_2077 5212015 6.75 200.0 µM 1.70E-8 18 7.26E-12
17 SGTC_683 panaxydol 6.70 45.0 µM 2.20E-8 sphingolipid biosynthesis & PDR1 12 1.06E-11
18 SGTC_255 tunicamycin 6.65 200.5 nM 2.70E-8 unfolded protein response 24 1.44E-11
19 SGTC_687 k029-0044 6.53 34.9 µM 4.70E-8 PDR1 2 3.29E-11
20 SGTC_58 0957-0393 6.48 9.0 µM 5.78E-8 cell wall 183 4.47E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 1.68E-60 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.269 1.05E-56 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.259 1.00E-52 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.256 3.49E-51 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.238 1.77E-44 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.233 9.86E-43 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.218 1.50E-37 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.217 4.76E-37 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.209 2.49E-34 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.204 7.15E-33 YDL173W PAR32 hom Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.198 3.98E-31 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.197 1.19E-30 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.195 4.78E-30 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.192 4.43E-29 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.191 4.60E-29 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress