YJR061W_p

Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR061W / YJR061W

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.67|P-value:1.16E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.64|P-value:7.38E-9 ID:SGTC_37|Compound:0566-0070|FD-Score:3.73|P-value:9.12E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.72|P-value:7.96E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.82|P-value:5.27E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.17|P-value:7.36E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.78|P-value:7.47E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.86|P-value:5.47E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.10|P-value:9.54E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.88|P-value:4.87E-7 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.51|P-value:2.14E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.82|P-value:6.44E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.74|P-value:8.84E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.28|P-value:5.12E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.34|P-value:4.13E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.50|P-value:2.24E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.34|P-value:4.05E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.14|P-value:8.18E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.44|P-value:2.43E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.10|P-value:9.51E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.34|P-value:6.61E-6 ID:SGTC_2284|Compound:7945075|FD-Score:3.30|P-value:4.66E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.07|P-value:9.09E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.41|P-value:2.68E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.80|P-value:6.88E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.52|P-value:2.86E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.06|P-value:1.86E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.26|P-value:7.87E-6 ID:SGTC_2856|Compound:9022925|FD-Score:-4.67|P-value:1.10E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-5.59|P-value:7.52E-9 ID:SGTC_2892|Compound:9047358|FD-Score:4.24|P-value:1.04E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.13|P-value:8.51E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.51|P-value:2.21E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.25|P-value:4.78E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.41|P-value:3.19E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.67|P-value:1.16E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.64|P-value:7.38E-9 ID:SGTC_37|Compound:0566-0070|FD-Score:3.73|P-value:9.12E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.72|P-value:7.96E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.82|P-value:5.27E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.17|P-value:7.36E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.78|P-value:7.47E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.86|P-value:5.47E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.10|P-value:9.54E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.88|P-value:4.87E-7 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.51|P-value:2.14E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.82|P-value:6.44E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.74|P-value:8.84E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.28|P-value:5.12E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.34|P-value:4.13E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.50|P-value:2.24E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.34|P-value:4.05E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.14|P-value:8.18E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.44|P-value:2.43E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.10|P-value:9.51E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.34|P-value:6.61E-6 ID:SGTC_2284|Compound:7945075|FD-Score:3.30|P-value:4.66E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.07|P-value:9.09E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.41|P-value:2.68E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.80|P-value:6.88E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.52|P-value:2.86E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.06|P-value:1.86E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.26|P-value:7.87E-6 ID:SGTC_2856|Compound:9022925|FD-Score:-4.67|P-value:1.10E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-5.59|P-value:7.52E-9 ID:SGTC_2892|Compound:9047358|FD-Score:4.24|P-value:1.04E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.13|P-value:8.51E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.51|P-value:2.21E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.25|P-value:4.78E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.41|P-value:3.19E-4

Top fitness defect scores for YJR061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_36 0335-0881 5.64 14.2 µM 7.38E-9 ubiquinone biosynthesis & proteasome 72 8.63E-9
2 SGTC_2751 anetholtrithion 5.06 17.2 µM 1.86E-7 11 2.09E-7
3 SGTC_1234 0326-0494 4.88 15.5 µM 4.87E-7 5 5.40E-7
4 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.52 100.0 µM 2.86E-6 6 3.10E-6
5 SGTC_2001 4023502 4.34 57.7 µM 6.61E-6 mitochondrial processes 9 7.10E-6
6 SGTC_2892 9047358 4.24 58.4 µM 1.04E-5 6 1.11E-5
7 SGTC_962 1254-0300 3.86 21.5 µM 5.47E-5 25 5.73E-5
8 SGTC_1503 4585-0012 3.82 61.3 µM 6.44E-5 18 6.74E-5
9 SGTC_2419 paclitaxel 3.80 166.5 µM 6.88E-5 46 7.19E-5
10 SGTC_909 3448-9333 3.78 149.0 µM 7.47E-5 20 7.80E-5
11 SGTC_1512 0259-0544 3.74 12.2 µM 8.84E-5 20 9.21E-5
12 SGTC_37 0566-0070 3.73 1.6 µM 9.12E-5 36 9.51E-5
13 SGTC_20 0481-0013 3.67 4.9 µM 1.16E-4 32 1.21E-4
14 SGTC_999 4022-0066 3.60 22.7 µM 1.52E-4 Golgi 59 1.58E-4
15 SGTC_966 1300-0360 3.58 30.2 µM 1.64E-4 heme requiring 36 1.70E-4
16 SGTC_1452 4194-0072 3.51 190.0 µM 2.14E-4 23 2.21E-4
17 SGTC_3006 9075424 3.51 71.4 µM 2.21E-4 19 2.28E-4
18 SGTC_1741 st038134 3.50 10.2 µM 2.24E-4 42 2.31E-4
19 SGTC_1927 st060202 3.44 13.8 µM 2.83E-4 34 2.91E-4
20 SGTC_3233 9132340 3.41 49.5 µM 3.19E-4 38 3.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.41E-19 YHR138C YHR138C hom Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress
0.150 3.23E-18 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.132 1.59E-14 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.132 1.68E-14 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.129 5.83E-14 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.128 1.05E-13 YER048W-A ISD11 het Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis
0.128 1.14E-13 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.128 1.17E-13 YGL018C JAC1 het Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
0.124 5.34E-13 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.123 8.26E-13 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.120 2.79E-12 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.120 2.92E-12 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.119 4.96E-12 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.118 7.62E-12 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.113 6.50E-11 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes