YJR063W / RPA12

RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR063W / RPA12

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.96|P-value:1.73E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.12|P-value:2.89E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:4.79|P-value:6.99E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:6.46|P-value:2.25E-9 ID:SGTC_71|Compound:0417-1750|FD-Score:3.65|P-value:4.88E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.95|P-value:1.34E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.91|P-value:2.01E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.87|P-value:2.30E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.39|P-value:5.09E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.51|P-value:5.80E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.55|P-value:6.72E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.50|P-value:7.76E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.86|P-value:2.44E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.90|P-value:2.09E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.29|P-value:3.48E-9 ID:SGTC_301|Compound:4119-0100|FD-Score:5.88|P-value:4.66E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.58|P-value:7.07E-10 ID:SGTC_337|Compound:1315-0038|FD-Score:6.07|P-value:1.78E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.50|P-value:6.01E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.01|P-value:1.42E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.13|P-value:9.36E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.78|P-value:5.07E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:6.01|P-value:2.50E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:3.59|P-value:5.87E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.63|P-value:1.62E-7 ID:SGTC_638|Compound:3970-0837|FD-Score:4.11|P-value:9.86E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:6.42|P-value:2.79E-9 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.15|P-value:6.32E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.62|P-value:4.05E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.98|P-value:1.59E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.82|P-value:2.77E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:6.63|P-value:8.72E-10 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.43|P-value:9.67E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.26|P-value:5.87E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.28|P-value:5.37E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.99|P-value:3.00E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.26|P-value:5.69E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.95|P-value:1.76E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:6.61|P-value:9.57E-10 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.37|P-value:8.95E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.08|P-value:1.13E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.50|P-value:2.30E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.83|P-value:2.71E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.41|P-value:3.30E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.00|P-value:1.49E-4 ID:SGTC_1685|Compound:st024049|FD-Score:6.58|P-value:1.16E-9 ID:SGTC_1699|Compound:st031318|FD-Score:8.48|P-value:6.22E-15 ID:SGTC_1706|Compound:st031321|FD-Score:5.57|P-value:2.12E-7 ID:SGTC_1711|Compound:st032263|FD-Score:4.52|P-value:2.15E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.70|P-value:7.30E-6 ID:SGTC_1726|Compound:st035556|FD-Score:6.42|P-value:2.83E-9 ID:SGTC_1754|Compound:st042065|FD-Score:5.49|P-value:3.17E-7 ID:SGTC_1757|Compound:st041620|FD-Score:-4.48|P-value:1.75E-5 ID:SGTC_1760|Compound:st045453|FD-Score:9.34|P-value:9.82E-18 ID:SGTC_1781|Compound:st038725|FD-Score:12.90|P-value:3.08E-32 ID:SGTC_1786|Compound:berberine|FD-Score:-3.86|P-value:1.81E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.75|P-value:2.64E-4 ID:SGTC_1797|Compound:st048695|FD-Score:6.32|P-value:4.88E-9 ID:SGTC_1798|Compound:st045719|FD-Score:5.12|P-value:1.71E-6 ID:SGTC_1826|Compound:st055655|FD-Score:3.81|P-value:2.86E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.63|P-value:1.37E-5 ID:SGTC_1991|Compound:st073000|FD-Score:5.57|P-value:2.19E-7 ID:SGTC_2003|Compound:4023581|FD-Score:7.61|P-value:2.30E-12 ID:SGTC_2006|Compound:4011487|FD-Score:-8.11|P-value:4.71E-14 ID:SGTC_2172|Compound:5754775|FD-Score:3.48|P-value:8.48E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.50|P-value:2.27E-5 ID:SGTC_2254|Compound:7938975|FD-Score:4.81|P-value:6.51E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.30|P-value:5.01E-5 ID:SGTC_2277|Compound:7947813|FD-Score:6.58|P-value:1.13E-9 ID:SGTC_2332|Compound:7982454|FD-Score:4.64|P-value:1.34E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.24|P-value:6.12E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.54|P-value:6.84E-4 ID:SGTC_2461|Compound:5755302|FD-Score:7.51|P-value:4.22E-12 ID:SGTC_2483|Compound:5729050|FD-Score:3.47|P-value:8.72E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.47|P-value:8.58E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.08|P-value:1.13E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.11|P-value:7.24E-5 ID:SGTC_2681|Compound:menadione|FD-Score:3.77|P-value:3.23E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.22|P-value:6.63E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.48|P-value:6.34E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.45|P-value:3.79E-12 ID:SGTC_2921|Compound:7974240|FD-Score:6.79|P-value:3.35E-10 ID:SGTC_3044|Compound:9093193|FD-Score:4.57|P-value:1.73E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:7.61|P-value:2.33E-12 ID:SGTC_3063|Compound:1327-0034|FD-Score:7.68|P-value:1.44E-12 ID:SGTC_3080|Compound:9117754|FD-Score:3.81|P-value:2.82E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.79|P-value:2.29E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.13|P-value:9.37E-5 ID:SGTC_3224|Compound:9130643|FD-Score:3.60|P-value:5.78E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.93|P-value:1.92E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.96|P-value:1.73E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.12|P-value:2.89E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:4.79|P-value:6.99E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:6.46|P-value:2.25E-9 ID:SGTC_71|Compound:0417-1750|FD-Score:3.65|P-value:4.88E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.95|P-value:1.34E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.91|P-value:2.01E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.87|P-value:2.30E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.39|P-value:5.09E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.51|P-value:5.80E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.55|P-value:6.72E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.50|P-value:7.76E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.86|P-value:2.44E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.90|P-value:2.09E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.29|P-value:3.48E-9 ID:SGTC_301|Compound:4119-0100|FD-Score:5.88|P-value:4.66E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.58|P-value:7.07E-10 ID:SGTC_337|Compound:1315-0038|FD-Score:6.07|P-value:1.78E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.50|P-value:6.01E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.01|P-value:1.42E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.13|P-value:9.36E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.78|P-value:5.07E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:6.01|P-value:2.50E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:3.59|P-value:5.87E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.63|P-value:1.62E-7 ID:SGTC_638|Compound:3970-0837|FD-Score:4.11|P-value:9.86E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:6.42|P-value:2.79E-9 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.15|P-value:6.32E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.62|P-value:4.05E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.98|P-value:1.59E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.82|P-value:2.77E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:6.63|P-value:8.72E-10 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.43|P-value:9.67E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.26|P-value:5.87E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.28|P-value:5.37E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.99|P-value:3.00E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.26|P-value:5.69E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.95|P-value:1.76E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:6.61|P-value:9.57E-10 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.37|P-value:8.95E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.08|P-value:1.13E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.50|P-value:2.30E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.83|P-value:2.71E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.41|P-value:3.30E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.00|P-value:1.49E-4 ID:SGTC_1685|Compound:st024049|FD-Score:6.58|P-value:1.16E-9 ID:SGTC_1699|Compound:st031318|FD-Score:8.48|P-value:6.22E-15 ID:SGTC_1706|Compound:st031321|FD-Score:5.57|P-value:2.12E-7 ID:SGTC_1711|Compound:st032263|FD-Score:4.52|P-value:2.15E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.70|P-value:7.30E-6 ID:SGTC_1726|Compound:st035556|FD-Score:6.42|P-value:2.83E-9 ID:SGTC_1754|Compound:st042065|FD-Score:5.49|P-value:3.17E-7 ID:SGTC_1757|Compound:st041620|FD-Score:-4.48|P-value:1.75E-5 ID:SGTC_1760|Compound:st045453|FD-Score:9.34|P-value:9.82E-18 ID:SGTC_1781|Compound:st038725|FD-Score:12.90|P-value:3.08E-32 ID:SGTC_1786|Compound:berberine|FD-Score:-3.86|P-value:1.81E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.75|P-value:2.64E-4 ID:SGTC_1797|Compound:st048695|FD-Score:6.32|P-value:4.88E-9 ID:SGTC_1798|Compound:st045719|FD-Score:5.12|P-value:1.71E-6 ID:SGTC_1826|Compound:st055655|FD-Score:3.81|P-value:2.86E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.63|P-value:1.37E-5 ID:SGTC_1991|Compound:st073000|FD-Score:5.57|P-value:2.19E-7 ID:SGTC_2003|Compound:4023581|FD-Score:7.61|P-value:2.30E-12 ID:SGTC_2006|Compound:4011487|FD-Score:-8.11|P-value:4.71E-14 ID:SGTC_2172|Compound:5754775|FD-Score:3.48|P-value:8.48E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.50|P-value:2.27E-5 ID:SGTC_2254|Compound:7938975|FD-Score:4.81|P-value:6.51E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.30|P-value:5.01E-5 ID:SGTC_2277|Compound:7947813|FD-Score:6.58|P-value:1.13E-9 ID:SGTC_2332|Compound:7982454|FD-Score:4.64|P-value:1.34E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.24|P-value:6.12E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.54|P-value:6.84E-4 ID:SGTC_2461|Compound:5755302|FD-Score:7.51|P-value:4.22E-12 ID:SGTC_2483|Compound:5729050|FD-Score:3.47|P-value:8.72E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.47|P-value:8.58E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.08|P-value:1.13E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.11|P-value:7.24E-5 ID:SGTC_2681|Compound:menadione|FD-Score:3.77|P-value:3.23E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.22|P-value:6.63E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.48|P-value:6.34E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.45|P-value:3.79E-12 ID:SGTC_2921|Compound:7974240|FD-Score:6.79|P-value:3.35E-10 ID:SGTC_3044|Compound:9093193|FD-Score:4.57|P-value:1.73E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:7.61|P-value:2.33E-12 ID:SGTC_3063|Compound:1327-0034|FD-Score:7.68|P-value:1.44E-12 ID:SGTC_3080|Compound:9117754|FD-Score:3.81|P-value:2.82E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.79|P-value:2.29E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.13|P-value:9.37E-5 ID:SGTC_3224|Compound:9130643|FD-Score:3.60|P-value:5.78E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.93|P-value:1.92E-4

Top fitness defect scores for YJR063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1781 st038725 12.90 66.3 µM 3.08E-32 NEO1 10 2.03E-38
2 SGTC_1760 st045453 9.34 10.4 µM 9.82E-18 NEO1-PIK1 38 5.02E-21
3 SGTC_1699 st031318 8.48 29.1 µM 6.22E-15 7 1.15E-17
4 SGTC_3063 1327-0034 7.68 4.0 µM 1.44E-12 14 7.89E-15
5 SGTC_2003 4023581 7.61 200.0 µM 2.30E-12 cell wall signaling 9 1.38E-14
6 SGTC_3059 1327-0034 7.61 3.0 µM 2.33E-12 20 1.40E-14
7 SGTC_2461 5755302 7.51 26.1 µM 4.22E-12 5 2.86E-14
8 SGTC_2921 7974240 6.79 10.7 µM 3.35E-10 11 5.42E-12
9 SGTC_974 1326-0144 6.63 138.0 µM 8.72E-10 ERG2 8 1.71E-11
10 SGTC_1279 0874-0590 6.61 65.2 µM 9.57E-10 4 1.91E-11
11 SGTC_2277 7947813 6.58 106.9 µM 1.13E-9 RSC complex & mRNA processing 4 2.33E-11
12 SGTC_1685 st024049 6.58 53.1 µM 1.16E-9 TSC3-RPN4 3 2.40E-11
13 SGTC_64 000l-0018 6.46 272.1 µM 2.25E-9 ubiquinone biosynthesis & proteasome 70 5.33E-11
14 SGTC_639 0833-0042 6.42 114.0 µM 2.79E-9 8 6.89E-11
15 SGTC_1726 st035556 6.42 14.6 µM 2.83E-9 10 7.00E-11
16 SGTC_1797 st048695 6.32 56.8 µM 4.88E-9 NEO1 36 1.35E-10
17 SGTC_337 1315-0038 6.07 354.0 µM 1.78E-8 amide catabolism 10 6.34E-10
18 SGTC_513 4245-1575 6.01 41.7 µM 2.50E-8 unfolded protein response 45 9.55E-10
19 SGTC_301 4119-0100 5.88 24.5 µM 4.66E-8 NEO1 41 2.02E-9
20 SGTC_562 3772-2733 5.63 112.0 µM 1.62E-7 ERG2 37 9.00E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 1.78E-60 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.261 2.20E-53 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.259 1.62E-52 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.248 2.52E-48 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.246 2.35E-47 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.246 2.47E-47 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.243 2.18E-46 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.238 2.15E-44 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP
0.219 8.71E-38 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.219 1.33E-37 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.218 3.08E-37 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.213 1.00E-35 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.208 5.32E-34 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.205 4.67E-33 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.199 2.05E-31 YER107C GLE2 hom RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1