YJR064W / CCT5

Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR064W / CCT5

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:6.57|P-value:1.12E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-4.15|P-value:4.63E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.57|P-value:1.61E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.50|P-value:1.98E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.18|P-value:5.15E-4 ID:SGTC_229|Compound:benomyl|FD-Score:8.19|P-value:5.29E-11 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.98|P-value:7.61E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-4.11|P-value:5.28E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-4.06|P-value:5.98E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:-4.67|P-value:9.93E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:-5.13|P-value:2.23E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.36|P-value:2.56E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.12|P-value:5.04E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.80|P-value:7.91E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:6.05|P-value:9.31E-7 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.01|P-value:8.23E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.50|P-value:2.00E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-4.36|P-value:2.57E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.87|P-value:9.99E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.46|P-value:2.29E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:10.30|P-value:1.71E-16 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.87|P-value:6.46E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-4.33|P-value:2.75E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.52|P-value:5.55E-6 ID:SGTC_1812|Compound:st052057|FD-Score:7.60|P-value:1.02E-9 ID:SGTC_1829|Compound:berberine|FD-Score:-4.50|P-value:1.68E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:16.40|P-value:1.32E-38 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.05|P-value:2.86E-5 ID:SGTC_1908|Compound:st060353|FD-Score:4.19|P-value:4.98E-4 ID:SGTC_2089|Compound:5281248|FD-Score:6.86|P-value:3.25E-8 ID:SGTC_2111|Compound:5486399|FD-Score:-4.17|P-value:4.39E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.01|P-value:8.26E-4 ID:SGTC_2174|Compound:5790901|FD-Score:5.62|P-value:4.89E-6 ID:SGTC_2274|Compound:7947094|FD-Score:3.95|P-value:9.53E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-4.61|P-value:1.19E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-4.52|P-value:1.57E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.02|P-value:7.94E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.37|P-value:2.93E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.94|P-value:9.77E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.96|P-value:1.34E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.51|P-value:1.97E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.73|P-value:9.94E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.32|P-value:3.46E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.00|P-value:7.10E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.06|P-value:7.06E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.97|P-value:7.74E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.08|P-value:2.60E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.44|P-value:2.02E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.27|P-value:3.95E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.96|P-value:4.78E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-4.12|P-value:5.14E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-5.12|P-value:2.31E-5 ID:SGTC_3144|Compound:9087057|FD-Score:4.02|P-value:7.85E-4 ID:SGTC_3145|Compound:9085516|FD-Score:6.33|P-value:3.13E-7 ID:SGTC_3208|Compound:9114115|FD-Score:4.03|P-value:7.63E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.59|P-value:4.28E-6 ID:SGTC_3238|Compound:9133470|FD-Score:4.82|P-value:7.42E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:6.57|P-value:1.12E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-4.15|P-value:4.63E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.57|P-value:1.61E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.50|P-value:1.98E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.18|P-value:5.15E-4 ID:SGTC_229|Compound:benomyl|FD-Score:8.19|P-value:5.29E-11 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.98|P-value:7.61E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-4.11|P-value:5.28E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-4.06|P-value:5.98E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:-4.67|P-value:9.93E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:-5.13|P-value:2.23E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.36|P-value:2.56E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.12|P-value:5.04E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.80|P-value:7.91E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:6.05|P-value:9.31E-7 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.01|P-value:8.23E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.50|P-value:2.00E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-4.36|P-value:2.57E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.87|P-value:9.99E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.46|P-value:2.29E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:10.30|P-value:1.71E-16 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.87|P-value:6.46E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-4.33|P-value:2.75E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.52|P-value:5.55E-6 ID:SGTC_1812|Compound:st052057|FD-Score:7.60|P-value:1.02E-9 ID:SGTC_1829|Compound:berberine|FD-Score:-4.50|P-value:1.68E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:16.40|P-value:1.32E-38 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.05|P-value:2.86E-5 ID:SGTC_1908|Compound:st060353|FD-Score:4.19|P-value:4.98E-4 ID:SGTC_2089|Compound:5281248|FD-Score:6.86|P-value:3.25E-8 ID:SGTC_2111|Compound:5486399|FD-Score:-4.17|P-value:4.39E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.01|P-value:8.26E-4 ID:SGTC_2174|Compound:5790901|FD-Score:5.62|P-value:4.89E-6 ID:SGTC_2274|Compound:7947094|FD-Score:3.95|P-value:9.53E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-4.61|P-value:1.19E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-4.52|P-value:1.57E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.02|P-value:7.94E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.37|P-value:2.93E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.94|P-value:9.77E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.96|P-value:1.34E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.51|P-value:1.97E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.73|P-value:9.94E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.32|P-value:3.46E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.00|P-value:7.10E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.06|P-value:7.06E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.97|P-value:7.74E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.08|P-value:2.60E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.44|P-value:2.02E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.27|P-value:3.95E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.96|P-value:4.78E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-4.12|P-value:5.14E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-5.12|P-value:2.31E-5 ID:SGTC_3144|Compound:9087057|FD-Score:4.02|P-value:7.85E-4 ID:SGTC_3145|Compound:9085516|FD-Score:6.33|P-value:3.13E-7 ID:SGTC_3208|Compound:9114115|FD-Score:4.03|P-value:7.63E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.59|P-value:4.28E-6 ID:SGTC_3238|Compound:9133470|FD-Score:4.82|P-value:7.42E-5

Top fitness defect scores for YJR064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1875 nocodazole 16.40 6.0 µM 1.32E-38 tubulin folding & SWR complex 5 1.39E-60 2.66
2 SGTC_1357 1503-1303 10.30 39.5 µM 1.71E-16 1 2.46E-25 5.11
3 SGTC_229 benomyl 8.19 22.9 µM 5.29E-11 tubulin folding & SWR complex 5 1.32E-16 0.68
4 SGTC_1812 st052057 7.60 4.3 µM 1.02E-9 calcium & mitochondrial duress 2 1.44E-14 1.68
5 SGTC_2089 5281248 6.86 129.7 µM 3.25E-8 superoxide 1 3.51E-12 1.17
6 SGTC_67 0335-0847 6.57 266.0 µM 1.12E-7 ubiquinone biosynthesis & proteasome 7 2.49E-11 0.11
7 SGTC_3145 9085516 6.33 49.5 µM 3.13E-7 fatty acid desaturase (OLE1) 4 1.27E-10 0.82
8 SGTC_1042 0350-0096 6.05 82.0 µM 9.31E-7 TSC3-RPN4 1 7.11E-10 0.85
9 SGTC_2405 ticlatone 5.96 3.5 µM 1.34E-6 6 1.26E-9 0.04
10 SGTC_2174 5790901 5.62 200.0 µM 4.89E-6 tubulin folding & SWR complex 5 9.76E-9 0.35
11 SGTC_3091 9116372 4.96 49.5 µM 4.78E-5 7 3.55E-7 0.42
12 SGTC_1461 k072-0203 4.87 53.8 µM 6.46E-5 3 5.71E-7 0.11
13 SGTC_3238 9133470 4.82 49.5 µM 7.42E-5 1 7.10E-7 0.43
14 SGTC_923 1900-2434 4.80 73.3 µM 7.91E-5 RNA processing & uracil transport 6 7.84E-7 0.01
15 SGTC_2576 guaiol 4.73 23.1 µM 9.94E-5 5 1.12E-6 0.08
16 SGTC_115 0527-0192 4.57 112.0 µM 1.61E-4 14 2.40E-6 0.01
17 SGTC_2565 isoliquiritigenin 4.51 100.0 µM 1.97E-4 6 3.28E-6 0.05
18 SGTC_143 4032-1194 4.50 15.7 µM 1.98E-4 11 3.32E-6 0.20
19 SGTC_1247 0448-0043 4.50 5.8 µM 2.00E-4 ERG2 6 3.37E-6 0.07
20 SGTC_1354 1498-1681 4.46 81.0 µM 2.29E-4 4 4.16E-6 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.356 1.67E-100 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.333 7.11E-88 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.327 1.78E-84 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.313 3.22E-77 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.307 4.43E-74 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.303 4.05E-72 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.270 3.04E-57 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.253 3.72E-50 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.230 1.47E-41 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.213 1.10E-35 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.200 1.33E-31 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.184 5.49E-27 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.182 2.22E-26 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.179 1.78E-25 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.176 1.15E-24 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes