HIPHOP chemogenomics database
YJR065C / ARP3 
Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YJR065C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.217 | 3.45E-37 | YKL013C | ARC19 | het | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
| 0.172 | 1.39E-23 | YNR035C | ARC35 | het | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |
| 0.134 | 5.88E-15 | YJL159W | HSP150 | hom | O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication |
| 0.130 | 4.35E-14 | YGR078C | PAC10 | hom | Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding |
| 0.107 | 4.35E-10 | YJL174W | KRE9 | het | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects |
| 0.101 | 4.78E-9 | YHR030C | SLT2 | hom | Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway |
| 0.097 | 1.89E-8 | YPL002C | SNF8 | hom | Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression |
| 0.097 | 1.93E-8 | YLR119W | SRN2 | hom | Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus |
| 0.096 | 3.04E-8 | YBL100W-C_p | YBL100W-C_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.095 | 3.16E-8 | YLR200W | YKE2 | hom | Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin |
| 0.094 | 5.73E-8 | YFL025C | BST1 | hom | GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules |
| 0.093 | 5.91E-8 | YDL203C | ACK1 | hom | Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria |
| 0.093 | 6.50E-8 | YOR294W | RRS1 | het | Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice |
| 0.093 | 7.01E-8 | YPR173C | VPS4 | hom | AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism |
| 0.092 | 9.81E-8 | YNL084C | END3 | hom | EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p |