YJR065C / ARP3

Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR065C / ARP3

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-4.35|P-value:7.81E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.77|P-value:1.11E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:-4.11|P-value:2.23E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.70|P-value:1.15E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.34|P-value:6.01E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.27|P-value:7.65E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.26|P-value:1.16E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:5.79|P-value:8.50E-9 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.28|P-value:5.47E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.48|P-value:3.77E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.61|P-value:3.66E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:7.89|P-value:6.31E-15 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.70|P-value:2.38E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.91|P-value:4.20E-9 ID:SGTC_1012|Compound:4112-3522|FD-Score:6.69|P-value:3.41E-11 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.85|P-value:1.19E-11 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.14|P-value:2.94E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.14|P-value:2.97E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.52|P-value:2.32E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.78|P-value:8.33E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.32|P-value:1.34E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.64|P-value:2.07E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.56|P-value:2.77E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.22|P-value:6.67E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.42|P-value:3.22E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.44|P-value:4.30E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.11|P-value:3.26E-5 ID:SGTC_1594|Compound:piperine|FD-Score:4.20|P-value:2.26E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.17|P-value:2.49E-7 ID:SGTC_1643|Compound:st009866|FD-Score:7.21|P-value:9.79E-13 ID:SGTC_1651|Compound:st011928|FD-Score:4.54|P-value:5.01E-6 ID:SGTC_1714|Compound:st033236|FD-Score:5.59|P-value:2.58E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.54|P-value:2.99E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.24|P-value:8.46E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.42|P-value:4.68E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.80|P-value:1.50E-6 ID:SGTC_2307|Compound:7538926|FD-Score:3.82|P-value:1.05E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.68|P-value:1.81E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.85|P-value:9.21E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.25|P-value:8.39E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.85|P-value:9.35E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.19|P-value:7.31E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.24|P-value:6.24E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.23|P-value:1.80E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.89|P-value:5.41E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.25|P-value:8.15E-4 ID:SGTC_2935|Compound:9038016|FD-Score:10.50|P-value:4.45E-25 ID:SGTC_3284|Compound:9108171|FD-Score:3.33|P-value:6.27E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.79|P-value:1.20E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.35|P-value:7.81E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.77|P-value:1.11E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:-4.11|P-value:2.23E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.70|P-value:1.15E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.34|P-value:6.01E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.27|P-value:7.65E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.26|P-value:1.16E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:5.79|P-value:8.50E-9 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.28|P-value:5.47E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.48|P-value:3.77E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.61|P-value:3.66E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:7.89|P-value:6.31E-15 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.70|P-value:2.38E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.91|P-value:4.20E-9 ID:SGTC_1012|Compound:4112-3522|FD-Score:6.69|P-value:3.41E-11 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.85|P-value:1.19E-11 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.14|P-value:2.94E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.14|P-value:2.97E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.52|P-value:2.32E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.78|P-value:8.33E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.32|P-value:1.34E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.64|P-value:2.07E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.56|P-value:2.77E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.22|P-value:6.67E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.42|P-value:3.22E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.44|P-value:4.30E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.11|P-value:3.26E-5 ID:SGTC_1594|Compound:piperine|FD-Score:4.20|P-value:2.26E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.17|P-value:2.49E-7 ID:SGTC_1643|Compound:st009866|FD-Score:7.21|P-value:9.79E-13 ID:SGTC_1651|Compound:st011928|FD-Score:4.54|P-value:5.01E-6 ID:SGTC_1714|Compound:st033236|FD-Score:5.59|P-value:2.58E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.54|P-value:2.99E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.24|P-value:8.46E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.42|P-value:4.68E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.80|P-value:1.50E-6 ID:SGTC_2307|Compound:7538926|FD-Score:3.82|P-value:1.05E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.68|P-value:1.81E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.85|P-value:9.21E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.25|P-value:8.39E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.85|P-value:9.35E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.19|P-value:7.31E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.24|P-value:6.24E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.23|P-value:1.80E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.89|P-value:5.41E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.25|P-value:8.15E-4 ID:SGTC_2935|Compound:9038016|FD-Score:10.50|P-value:4.45E-25 ID:SGTC_3284|Compound:9108171|FD-Score:3.33|P-value:6.27E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.79|P-value:1.20E-4

Top fitness defect scores for YJR065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2935 9038016 10.50 30.0 µM 4.45E-25 1 3.95E-26 3.36
2 SGTC_748 0136-0228 7.89 77.9 µM 6.31E-15 redox potentiating 4 1.45E-15 2.34
3 SGTC_1643 st009866 7.21 20.2 µM 9.79E-13 7 2.78E-13 0.30
4 SGTC_1015 4130-4525 6.85 82.0 µM 1.19E-11 60S ribosome export 2 3.76E-12 0.17
5 SGTC_1012 4112-3522 6.69 18.0 µM 3.41E-11 1 1.12E-11 1.62
6 SGTC_1010 4112-3296 5.91 15.2 µM 4.20E-9 2 1.70E-9 0.62
7 SGTC_367 0335-0881 5.79 7.1 µM 8.50E-9 ubiquinone biosynthesis & proteasome 8 3.55E-9 0.08
8 SGTC_1714 st033236 5.59 13.6 µM 2.58E-8 2 1.13E-8 0.74
9 SGTC_2619 obliquin 5.23 87.9 µM 1.80E-7 cell wall 22 8.57E-8 0.08
10 SGTC_1599 8-chlro-1-tetrahydronorharmanone 5.17 90.6 µM 2.49E-7 4 1.20E-7 0.12
11 SGTC_2286 7945697 4.80 125.0 µM 1.50E-6 5 7.86E-7 0.11
12 SGTC_1008 4106-0037 4.70 6.0 µM 2.38E-6 PDR1 2 1.27E-6 0.10
13 SGTC_663 1486-0733 4.61 13.9 µM 3.66E-6 cell wall signaling 4 1.99E-6 0.05
14 SGTC_1651 st011928 4.54 86.1 µM 5.01E-6 RSC complex & mRNA processing 7 2.77E-6 0.31
15 SGTC_1482 3346-2049 4.35 8.5 µM 1.19E-5 5 6.83E-6 0.05
16 SGTC_1369 1866-0067 4.32 208.0 µM 1.34E-5 RPP1 & pyrimidine depletion 7 7.72E-6 0.02
17 SGTC_1594 piperine 4.20 70.1 µM 2.26E-5 1 1.34E-5 0.46
18 SGTC_1029 k015-0030 4.14 64.7 µM 2.94E-5 5 1.76E-5 0.13
19 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 4.14 15.5 µM 2.97E-5 3 1.77E-5 0.63
20 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 4.11 54.9 µM 3.26E-5 redox potentiating 5 1.96E-5 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 3.45E-37 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.172 1.39E-23 YNR035C ARC35 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
0.134 5.88E-15 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.130 4.35E-14 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.107 4.35E-10 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.101 4.78E-9 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.097 1.89E-8 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.097 1.93E-8 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.096 3.04E-8 YBL100W-C_p YBL100W-C_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.095 3.16E-8 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.094 5.73E-8 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.093 5.91E-8 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.093 6.50E-8 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.093 7.01E-8 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.092 9.81E-8 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p