YJR067C / YAE1

Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR067C / YAE1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.23|P-value:9.97E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.55|P-value:2.92E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.80|P-value:1.37E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.99|P-value:6.71E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.27|P-value:8.77E-4 ID:SGTC_512|Compound:prima-1|FD-Score:-3.31|P-value:6.69E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.75|P-value:1.67E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.16|P-value:3.38E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.63|P-value:2.57E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.74|P-value:1.73E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-4.08|P-value:3.78E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-3.34|P-value:5.98E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.33|P-value:6.23E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-4.11|P-value:3.34E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.28|P-value:8.64E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.67|P-value:2.26E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.38|P-value:5.15E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.25|P-value:8.04E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:6.80|P-value:3.29E-11 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.36|P-value:1.49E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.77|P-value:1.53E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-6.49|P-value:1.72E-10 ID:SGTC_2781|Compound:5567276|FD-Score:3.74|P-value:1.70E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.42|P-value:5.29E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.29|P-value:7.08E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-5.34|P-value:1.18E-7 ID:SGTC_2946|Compound:9065502|FD-Score:-4.14|P-value:2.95E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.56|P-value:2.77E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.51|P-value:3.27E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-3.68|P-value:1.81E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.64|P-value:4.41E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:3.23|P-value:9.97E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.55|P-value:2.92E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.80|P-value:1.37E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.99|P-value:6.71E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.27|P-value:8.77E-4 ID:SGTC_512|Compound:prima-1|FD-Score:-3.31|P-value:6.69E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.75|P-value:1.67E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.16|P-value:3.38E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.63|P-value:2.57E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.74|P-value:1.73E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-4.08|P-value:3.78E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-3.34|P-value:5.98E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.33|P-value:6.23E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-4.11|P-value:3.34E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.28|P-value:8.64E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.67|P-value:2.26E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.38|P-value:5.15E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.25|P-value:8.04E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:6.80|P-value:3.29E-11 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.36|P-value:1.49E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.77|P-value:1.53E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-6.49|P-value:1.72E-10 ID:SGTC_2781|Compound:5567276|FD-Score:3.74|P-value:1.70E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.42|P-value:5.29E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.29|P-value:7.08E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-5.34|P-value:1.18E-7 ID:SGTC_2946|Compound:9065502|FD-Score:-4.14|P-value:2.95E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.56|P-value:2.77E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.51|P-value:3.27E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-3.68|P-value:1.81E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.64|P-value:4.41E-6

Top fitness defect scores for YJR067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2528 xanthyletin 6.80 44.8 µM 3.29E-11 2 5.15E-12 1.99
2 SGTC_3209 9113616 4.64 49.5 µM 4.41E-6 2 1.77E-6 0.62
3 SGTC_2529 gangaleoidin 4.36 93.6 µM 1.49E-5 3 6.56E-6 0.96
4 SGTC_1130 3454-2858 4.16 15.9 µM 3.38E-5 NEO1 9 1.59E-5 0.00
5 SGTC_397 arbidol 3.99 50.0 µM 6.71E-5 cell wall 6 3.33E-5 0.19
6 SGTC_369 0957-0393 3.80 4.5 µM 1.37E-4 cell wall signaling 11 7.19E-5 0.09
7 SGTC_2535 4',4'-dimethoxydalbergione 3.77 51.2 µM 1.53E-4 DNA damage response 1 8.12E-5 0.23
8 SGTC_752 1896-0090 3.75 130.0 µM 1.67E-4 TSC3-RPN4 7 8.89E-5 0.02
9 SGTC_2781 5567276 3.74 71.4 µM 1.70E-4 11 9.11E-5 0.01
10 SGTC_1578 josamycin 3.74 24.2 µM 1.73E-4 8 9.26E-5 0.43
11 SGTC_2112 5488546 3.67 200.0 µM 2.26E-4 TSC3-RPN4 8 1.24E-4 0.09
12 SGTC_1373 2887-0003 3.63 58.5 µM 2.57E-4 Golgi 13 1.42E-4 0.01
13 SGTC_2787 5284540 3.42 71.4 µM 5.29E-4 13 3.09E-4 0.08
14 SGTC_2090 5301565 3.28 104.5 µM 8.64E-4 TSC3-RPN4 15 5.25E-4 0.10
15 SGTC_428 3448-4153 3.27 16.5 µM 8.77E-4 TSC3-RPN4 16 5.34E-4 0.05
16 SGTC_18 0111-0177 3.23 500.0 nM 9.97E-4 8 6.13E-4 0.00
17 SGTC_2762 leflunomide 3.13 42.1 µM 0.00140 13 8.85E-4 0.10
18 SGTC_1377 2944-0135 3.10 198.0 µM 0.00154 calcium & mitochondrial duress 17 9.78E-4 0.07
19 SGTC_90 0870-0863 3.09 4.6 µM 0.00159 14 0.00101 0.04
20 SGTC_7 0192-1582 3.04 4.2 µM 0.00184 15 0.00119 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 5.38E-14 YPR140W TAZ1 hom Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome
0.129 8.44E-14 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.121 1.85E-12 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.121 1.79E-12 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.116 1.91E-11 YBL097W BRN1 het Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
0.103 2.42E-9 YNL188W KAR1 het Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
0.102 2.80E-9 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.102 2.88E-9 YNR020C ATP23 hom Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p
0.100 6.12E-9 YPR170C_d YPR170C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
0.095 3.68E-8 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.094 4.23E-8 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.090 1.60E-7 YNR063W_p YNR063W_p hom Putative zinc-cluster protein of unknown function
0.087 4.51E-7 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.086 5.88E-7 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.085 7.21E-7 YBR296C-A_p YBR296C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching