YJR068W / RFC2

Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR068W / RFC2

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-3.22|P-value:1.25E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.40|P-value:2.78E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.69|P-value:1.38E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:2.74|P-value:8.30E-4 ID:SGTC_499|Compound:genistein|FD-Score:4.29|P-value:4.44E-7 ID:SGTC_508|Compound:roscovitine|FD-Score:3.19|P-value:1.29E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.48|P-value:3.31E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:2.76|P-value:7.77E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.26|P-value:9.35E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.11|P-value:2.02E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.03|P-value:2.23E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:-4.32|P-value:4.57E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:2.91|P-value:4.25E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.62|P-value:1.70E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-2.90|P-value:4.94E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.79|P-value:7.61E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.17|P-value:1.41E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.04|P-value:2.46E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.94|P-value:3.67E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.73|P-value:8.48E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.12|P-value:1.99E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.15|P-value:1.71E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-2.97|P-value:3.74E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.25|P-value:9.87E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.92|P-value:3.94E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.36|P-value:5.71E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.04|P-value:2.71E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-2.89|P-value:5.14E-4 ID:SGTC_1625|Compound:st003711|FD-Score:2.74|P-value:8.33E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-2.82|P-value:6.78E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.99|P-value:6.69E-9 ID:SGTC_1784|Compound:st039334|FD-Score:2.87|P-value:5.02E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.72|P-value:9.06E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.09|P-value:1.94E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.33|P-value:6.62E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.54|P-value:2.48E-5 ID:SGTC_2007|Compound:4011539|FD-Score:-3.30|P-value:8.73E-5 ID:SGTC_2008|Compound:4012253|FD-Score:2.81|P-value:6.16E-4 ID:SGTC_2055|Compound:5235184|FD-Score:2.85|P-value:5.34E-4 ID:SGTC_2270|Compound:7924575|FD-Score:2.92|P-value:4.05E-4 ID:SGTC_2271|Compound:7849410|FD-Score:2.88|P-value:4.66E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.47|P-value:3.45E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.43|P-value:4.14E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.98|P-value:2.49E-6 ID:SGTC_2320|Compound:7373003|FD-Score:-2.82|P-value:6.84E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.92|P-value:3.42E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.26|P-value:1.07E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-4.08|P-value:1.75E-6 ID:SGTC_2427|Compound:5545055|FD-Score:6.09|P-value:1.60E-12 ID:SGTC_2429|Compound:5902844|FD-Score:5.03|P-value:4.21E-9 ID:SGTC_2436|Compound:5633522|FD-Score:6.61|P-value:2.03E-14 ID:SGTC_2458|Compound:5808907|FD-Score:3.19|P-value:1.25E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.13|P-value:1.90E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.83|P-value:6.55E-4 ID:SGTC_3125|Compound:9127534|FD-Score:2.87|P-value:4.94E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.90|P-value:4.63E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.81|P-value:7.44E-6 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.22|P-value:1.25E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.40|P-value:2.78E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.69|P-value:1.38E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:2.74|P-value:8.30E-4 ID:SGTC_499|Compound:genistein|FD-Score:4.29|P-value:4.44E-7 ID:SGTC_508|Compound:roscovitine|FD-Score:3.19|P-value:1.29E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.48|P-value:3.31E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:2.76|P-value:7.77E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.26|P-value:9.35E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.11|P-value:2.02E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.03|P-value:2.23E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:-4.32|P-value:4.57E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:2.91|P-value:4.25E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.62|P-value:1.70E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-2.90|P-value:4.94E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.79|P-value:7.61E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.17|P-value:1.41E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.04|P-value:2.46E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.94|P-value:3.67E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.73|P-value:8.48E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.12|P-value:1.99E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.15|P-value:1.71E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-2.97|P-value:3.74E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.25|P-value:9.87E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.92|P-value:3.94E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.36|P-value:5.71E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.04|P-value:2.71E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-2.89|P-value:5.14E-4 ID:SGTC_1625|Compound:st003711|FD-Score:2.74|P-value:8.33E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-2.82|P-value:6.78E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.99|P-value:6.69E-9 ID:SGTC_1784|Compound:st039334|FD-Score:2.87|P-value:5.02E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.72|P-value:9.06E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.09|P-value:1.94E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.33|P-value:6.62E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.54|P-value:2.48E-5 ID:SGTC_2007|Compound:4011539|FD-Score:-3.30|P-value:8.73E-5 ID:SGTC_2008|Compound:4012253|FD-Score:2.81|P-value:6.16E-4 ID:SGTC_2055|Compound:5235184|FD-Score:2.85|P-value:5.34E-4 ID:SGTC_2270|Compound:7924575|FD-Score:2.92|P-value:4.05E-4 ID:SGTC_2271|Compound:7849410|FD-Score:2.88|P-value:4.66E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.47|P-value:3.45E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.43|P-value:4.14E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.98|P-value:2.49E-6 ID:SGTC_2320|Compound:7373003|FD-Score:-2.82|P-value:6.84E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.92|P-value:3.42E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.26|P-value:1.07E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-4.08|P-value:1.75E-6 ID:SGTC_2427|Compound:5545055|FD-Score:6.09|P-value:1.60E-12 ID:SGTC_2429|Compound:5902844|FD-Score:5.03|P-value:4.21E-9 ID:SGTC_2436|Compound:5633522|FD-Score:6.61|P-value:2.03E-14 ID:SGTC_2458|Compound:5808907|FD-Score:3.19|P-value:1.25E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.13|P-value:1.90E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.83|P-value:6.55E-4 ID:SGTC_3125|Compound:9127534|FD-Score:2.87|P-value:4.94E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.90|P-value:4.63E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.81|P-value:7.44E-6

Top fitness defect scores for YJR068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2436 5633522 6.61 8.1 µM 2.03E-14 2 1.99E-11 1.43
2 SGTC_2427 5545055 6.09 42.8 µM 1.60E-12 1 5.70E-10 0.76
3 SGTC_2429 5902844 5.03 64.4 µM 4.21E-9 5 2.46E-7 0.64
4 SGTC_499 genistein 4.29 192.0 µM 4.44E-7 1 8.96E-6 0.57
5 SGTC_2279 7948423 3.98 32.9 µM 2.49E-6 7 3.39E-5 0.21
6 SGTC_2421 5690543 3.92 90.7 µM 3.42E-6 2 4.34E-5 0.28
7 SGTC_823 0417-1665 3.62 178.0 µM 1.70E-5 5 1.50E-4 0.04
8 SGTC_2002 4023503 3.54 131.0 µM 2.48E-5 mitochondrial processes 14 2.01E-4 0.03
9 SGTC_597 k018-0003 3.48 82.8 µM 3.31E-5 RNA pol III & RNase P/MRP 6 2.52E-4 0.05
10 SGTC_2272 7805186 3.47 180.0 µM 3.45E-5 cell wall signaling 6 2.60E-4 0.07
11 SGTC_2273 7815444 3.43 169.1 µM 4.14E-5 5 2.99E-4 0.08
12 SGTC_1418 3966-3099 3.36 2.4 µM 5.71E-5 5 3.84E-4 0.08
13 SGTC_2001 4023502 3.33 57.7 µM 6.62E-5 mitochondrial processes 11 4.31E-4 0.19
14 SGTC_774 k060-0086 3.26 136.0 µM 9.35E-5 11 5.63E-4 0.10
15 SGTC_1212 0520-0165 3.25 585.0 µM 9.87E-5 11 5.87E-4 0.01
16 SGTC_2458 5808907 3.19 16.4 µM 1.25E-4 12 7.04E-4 0.15
17 SGTC_508 roscovitine 3.19 141.0 µM 1.29E-4 3 7.21E-4 0.23
18 SGTC_922 1866-0035 3.17 480.0 µM 1.41E-4 excess fatty acid 20 7.75E-4 0.01
19 SGTC_1996 st072960 3.09 66.8 µM 1.94E-4 8 9.92E-4 0.09
20 SGTC_930 2810-3379 3.04 265.0 µM 2.46E-4 14 0.00120 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 2.59E-17 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.117 1.01E-11 YGL228W SHE10 hom Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
0.114 3.42E-11 YJR008W MHO1 hom Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility
0.110 1.70E-10 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.103 2.50E-9 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.46E-9 YPR048W TAH18 het Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance
0.102 3.73E-9 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.101 4.16E-9 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.099 8.35E-9 YGR027C RPS25A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication
0.097 1.99E-8 YKL121W_p DGR2_p hom Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
0.092 9.06E-8 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
0.092 9.73E-8 YLR145W RMP1 het Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
0.091 1.37E-7 YDR308C SRB7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
0.087 4.39E-7 YBR047W_p FMP23_p hom Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.085 7.17E-7 YBR034C HMT1 hom Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.