YJR070C / LIA1

Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR070C / LIA1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.34|P-value:6.35E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.77|P-value:1.33E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.23|P-value:8.86E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.99|P-value:5.96E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.88|P-value:8.92E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.25|P-value:8.54E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:6.12|P-value:1.76E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.52|P-value:4.98E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.38|P-value:1.14E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.45|P-value:4.32E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.26|P-value:8.20E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:6.41|P-value:3.02E-10 ID:SGTC_872|Compound:0588-0139|FD-Score:4.01|P-value:5.35E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:-5.20|P-value:2.54E-7 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.85|P-value:9.93E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.51|P-value:3.48E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.59|P-value:2.60E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.24|P-value:8.73E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.81|P-value:1.19E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.36|P-value:5.88E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.58|P-value:2.72E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.85|P-value:1.01E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.11|P-value:4.06E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.35|P-value:1.23E-7 ID:SGTC_1657|Compound:st012939|FD-Score:-3.22|P-value:9.26E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.35|P-value:6.05E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:6.76|P-value:3.46E-11 ID:SGTC_1689|Compound:st020265|FD-Score:5.16|P-value:3.13E-7 ID:SGTC_1755|Compound:st041960|FD-Score:5.15|P-value:3.29E-7 ID:SGTC_1818|Compound:st052136|FD-Score:-4.18|P-value:2.65E-5 ID:SGTC_1974|Compound:st069448|FD-Score:4.98|P-value:7.68E-7 ID:SGTC_2077|Compound:5212015|FD-Score:3.43|P-value:4.63E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.51|P-value:3.59E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.76|P-value:1.39E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.75|P-value:1.47E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.32|P-value:6.77E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-4.04|P-value:4.72E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-5.32|P-value:1.38E-7 ID:SGTC_2282|Compound:7944268|FD-Score:-4.04|P-value:4.69E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-3.93|P-value:7.43E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-3.62|P-value:2.36E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.46|P-value:4.08E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.89|P-value:1.19E-6 ID:SGTC_2375|Compound:9072683|FD-Score:7.61|P-value:9.94E-14 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.94|P-value:7.06E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.49|P-value:7.38E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.79|P-value:2.77E-11 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.49|P-value:7.19E-6 ID:SGTC_2591|Compound:skatole|FD-Score:5.66|P-value:2.39E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.65|P-value:3.58E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.21|P-value:2.44E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.16|P-value:2.95E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.83|P-value:1.09E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.15|P-value:3.10E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.93|P-value:7.26E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.85|P-value:9.99E-5 ID:SGTC_2906|Compound:7926292|FD-Score:4.70|P-value:2.91E-6 ID:SGTC_2940|Compound:9060638|FD-Score:4.50|P-value:6.95E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.39|P-value:5.34E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.53|P-value:3.28E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.35|P-value:6.06E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.33|P-value:6.55E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.21|P-value:9.86E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.34|P-value:6.35E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.77|P-value:1.33E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.23|P-value:8.86E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.99|P-value:5.96E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.88|P-value:8.92E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.25|P-value:8.54E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:6.12|P-value:1.76E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.52|P-value:4.98E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.38|P-value:1.14E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.45|P-value:4.32E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.26|P-value:8.20E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:6.41|P-value:3.02E-10 ID:SGTC_872|Compound:0588-0139|FD-Score:4.01|P-value:5.35E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:-5.20|P-value:2.54E-7 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.85|P-value:9.93E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.51|P-value:3.48E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.59|P-value:2.60E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.24|P-value:8.73E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.81|P-value:1.19E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.36|P-value:5.88E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.58|P-value:2.72E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.85|P-value:1.01E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.11|P-value:4.06E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.35|P-value:1.23E-7 ID:SGTC_1657|Compound:st012939|FD-Score:-3.22|P-value:9.26E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.35|P-value:6.05E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:6.76|P-value:3.46E-11 ID:SGTC_1689|Compound:st020265|FD-Score:5.16|P-value:3.13E-7 ID:SGTC_1755|Compound:st041960|FD-Score:5.15|P-value:3.29E-7 ID:SGTC_1818|Compound:st052136|FD-Score:-4.18|P-value:2.65E-5 ID:SGTC_1974|Compound:st069448|FD-Score:4.98|P-value:7.68E-7 ID:SGTC_2077|Compound:5212015|FD-Score:3.43|P-value:4.63E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.51|P-value:3.59E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.76|P-value:1.39E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.75|P-value:1.47E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.32|P-value:6.77E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-4.04|P-value:4.72E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-5.32|P-value:1.38E-7 ID:SGTC_2282|Compound:7944268|FD-Score:-4.04|P-value:4.69E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-3.93|P-value:7.43E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-3.62|P-value:2.36E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.46|P-value:4.08E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.89|P-value:1.19E-6 ID:SGTC_2375|Compound:9072683|FD-Score:7.61|P-value:9.94E-14 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.94|P-value:7.06E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.49|P-value:7.38E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.79|P-value:2.77E-11 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.49|P-value:7.19E-6 ID:SGTC_2591|Compound:skatole|FD-Score:5.66|P-value:2.39E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.65|P-value:3.58E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.21|P-value:2.44E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.16|P-value:2.95E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.83|P-value:1.09E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.15|P-value:3.10E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.93|P-value:7.26E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.85|P-value:9.99E-5 ID:SGTC_2906|Compound:7926292|FD-Score:4.70|P-value:2.91E-6 ID:SGTC_2940|Compound:9060638|FD-Score:4.50|P-value:6.95E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.39|P-value:5.34E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.53|P-value:3.28E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.35|P-value:6.06E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.33|P-value:6.55E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.21|P-value:9.86E-4

Top fitness defect scores for YJR070C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2375 9072683 7.61 200.0 µM 9.94E-14 mitochondrial processes 1 1.33E-14
2 SGTC_1681 tripelennamine 6.76 100.0 µM 3.46E-11 2 7.04E-12
3 SGTC_638 3970-0837 6.41 4.1 µM 3.02E-10 12 7.17E-11
4 SGTC_365 0121-0052 6.12 13.6 µM 1.76E-9 mitochondrial response to ROS 14 4.74E-10
5 SGTC_2591 skatole 5.66 100.0 µM 2.39E-8 6 7.73E-9
6 SGTC_451 chloral hydrate 5.52 100.0 µM 4.98E-8 18 1.70E-8
7 SGTC_1574 spiramycin 5.35 23.7 µM 1.23E-7 8 4.45E-8
8 SGTC_1689 st020265 5.16 53.5 µM 3.13E-7 7 1.22E-7
9 SGTC_1755 st041960 5.15 45.2 µM 3.29E-7 11 1.28E-7
10 SGTC_1528 arabinosylhypoxanthine 5.11 74.6 µM 4.06E-7 9 1.61E-7
11 SGTC_1974 st069448 4.98 26.9 µM 7.68E-7 10 3.18E-7
12 SGTC_2348 9022543 4.89 33.4 µM 1.19E-6 mitochondrial processes 14 5.08E-7
13 SGTC_2906 7926292 4.70 26.4 µM 2.91E-6 11 1.32E-6
14 SGTC_2612 dictamnine 4.65 15.5 µM 3.58E-6 RNA pol III & RNase P/MRP 28 1.65E-6
15 SGTC_2940 9060638 4.50 45.9 µM 6.95E-6 amide catabolism 12 3.35E-6
16 SGTC_2573 2',4'-dihydroxychalcone 4.49 15.0 µM 7.38E-6 31 3.58E-6
17 SGTC_2630 antimycin a 4.21 100.0 µM 2.44E-5 mitochondrial processes 32 1.28E-5
18 SGTC_2690 usnic acid 4.16 100.0 µM 2.95E-5 25 1.58E-5
19 SGTC_2756 carbadox 4.15 75.1 µM 3.10E-5 50 1.66E-5
20 SGTC_872 0588-0139 4.01 234.0 µM 5.35E-5 33 2.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.25E-13 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.117 1.07E-11 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.110 1.51E-10 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.108 3.64E-10 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.103 2.16E-9 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.090 1.80E-7 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.084 9.99E-7 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.084 1.16E-6 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.083 1.59E-6 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.081 2.52E-6 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.079 4.49E-6 YJL100W LSB6 hom Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
0.078 6.50E-6 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.077 7.83E-6 YML108W YML108W hom Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
0.076 1.01E-5 YNL025C SSN8 hom Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
0.076 1.03E-5 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene