YJR072C / NPA3

Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR072C / NPA3

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-2.95|P-value:2.89E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.11|P-value:4.48E-13 ID:SGTC_165|Compound:k038-0023|FD-Score:3.29|P-value:5.55E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.01|P-value:2.01E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.83|P-value:4.85E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-2.76|P-value:6.47E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.78|P-value:5.44E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.15|P-value:1.21E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.55|P-value:1.67E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.97|P-value:1.53E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:-2.88|P-value:3.91E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.53|P-value:1.94E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.05|P-value:1.89E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.57|P-value:1.36E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:2.82|P-value:4.56E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.40|P-value:3.30E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:2.81|P-value:4.72E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.27|P-value:6.87E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.77|P-value:5.56E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.70|P-value:1.12E-11 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.80|P-value:4.97E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.87|P-value:3.06E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.24|P-value:7.79E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:2.76|P-value:5.91E-4 ID:SGTC_1611|Compound:st001856|FD-Score:2.71|P-value:7.06E-4 ID:SGTC_1678|Compound:st019265|FD-Score:2.95|P-value:2.64E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.04|P-value:1.78E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-2.80|P-value:5.38E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.72|P-value:6.91E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.36|P-value:3.90E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.63|P-value:9.99E-6 ID:SGTC_1971|Compound:st069429|FD-Score:3.05|P-value:1.68E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-2.89|P-value:3.69E-4 ID:SGTC_1987|Compound:st072290|FD-Score:2.94|P-value:2.75E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.70|P-value:7.48E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-3.21|P-value:8.88E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.54|P-value:1.60E-5 ID:SGTC_2269|Compound:7935389|FD-Score:2.69|P-value:7.74E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.24|P-value:7.80E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.71|P-value:7.80E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:2.91|P-value:3.15E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.57|P-value:1.38E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.00|P-value:2.11E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-4.08|P-value:9.44E-7 ID:SGTC_2834|Compound:9001755|FD-Score:2.91|P-value:3.07E-4 ID:SGTC_2922|Compound:7999257|FD-Score:2.88|P-value:3.55E-4 ID:SGTC_2949|Compound:9072542|FD-Score:5.65|P-value:1.67E-11 ID:SGTC_2951|Compound:9072950|FD-Score:-3.41|P-value:3.50E-5 ID:SGTC_3125|Compound:9127534|FD-Score:4.25|P-value:2.97E-7 ID:SGTC_3132|Compound:9126706|FD-Score:4.08|P-value:8.17E-7 ID:SGTC_3135|Compound:9127742|FD-Score:-2.77|P-value:6.10E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.04|P-value:1.95E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.95|P-value:2.89E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.11|P-value:4.48E-13 ID:SGTC_165|Compound:k038-0023|FD-Score:3.29|P-value:5.55E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.01|P-value:2.01E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.83|P-value:4.85E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-2.76|P-value:6.47E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.78|P-value:5.44E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.15|P-value:1.21E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.55|P-value:1.67E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.97|P-value:1.53E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:-2.88|P-value:3.91E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.53|P-value:1.94E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.05|P-value:1.89E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.57|P-value:1.36E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:2.82|P-value:4.56E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.40|P-value:3.30E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:2.81|P-value:4.72E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.27|P-value:6.87E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.77|P-value:5.56E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.70|P-value:1.12E-11 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.80|P-value:4.97E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.87|P-value:3.06E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.24|P-value:7.79E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:2.76|P-value:5.91E-4 ID:SGTC_1611|Compound:st001856|FD-Score:2.71|P-value:7.06E-4 ID:SGTC_1678|Compound:st019265|FD-Score:2.95|P-value:2.64E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.04|P-value:1.78E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-2.80|P-value:5.38E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.72|P-value:6.91E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.36|P-value:3.90E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.63|P-value:9.99E-6 ID:SGTC_1971|Compound:st069429|FD-Score:3.05|P-value:1.68E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-2.89|P-value:3.69E-4 ID:SGTC_1987|Compound:st072290|FD-Score:2.94|P-value:2.75E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.70|P-value:7.48E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-3.21|P-value:8.88E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.54|P-value:1.60E-5 ID:SGTC_2269|Compound:7935389|FD-Score:2.69|P-value:7.74E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.24|P-value:7.80E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.71|P-value:7.80E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:2.91|P-value:3.15E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.57|P-value:1.38E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.00|P-value:2.11E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-4.08|P-value:9.44E-7 ID:SGTC_2834|Compound:9001755|FD-Score:2.91|P-value:3.07E-4 ID:SGTC_2922|Compound:7999257|FD-Score:2.88|P-value:3.55E-4 ID:SGTC_2949|Compound:9072542|FD-Score:5.65|P-value:1.67E-11 ID:SGTC_2951|Compound:9072950|FD-Score:-3.41|P-value:3.50E-5 ID:SGTC_3125|Compound:9127534|FD-Score:4.25|P-value:2.97E-7 ID:SGTC_3132|Compound:9126706|FD-Score:4.08|P-value:8.17E-7 ID:SGTC_3135|Compound:9127742|FD-Score:-2.77|P-value:6.10E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.04|P-value:1.95E-4

Top fitness defect scores for YJR072C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1204 4049-0315 5.70 18.3 µM 1.12E-11 4 5.96E-9 1.13
2 SGTC_2949 9072542 5.65 2.2 µM 1.67E-11 TSC3-RPN4 3 7.97E-9 0.75
3 SGTC_3125 9127534 4.25 49.5 µM 2.97E-7 1 1.06E-5 0.30
4 SGTC_3132 9126706 4.08 49.5 µM 8.17E-7 9 2.22E-5 0.60
5 SGTC_533 1222-0222 3.97 6.7 µM 1.53E-6 PDR1 13 3.54E-5 0.12
6 SGTC_1970 st070122 3.63 35.8 µM 9.99E-6 TSC3-RPN4 11 1.41E-4 0.15
7 SGTC_820 1582-0060 3.57 59.9 µM 1.36E-5 13 1.78E-4 0.12
8 SGTC_2657 nystatin 3.57 74.4 µM 1.38E-5 9 1.79E-4 0.20
9 SGTC_2233 sulbentine 3.54 40.4 µM 1.60E-5 42 2.00E-4 0.04
10 SGTC_972 1319-0219 3.40 195.0 µM 3.30E-5 10 3.42E-4 0.06
11 SGTC_1969 st069479 3.36 40.1 µM 3.90E-5 5 3.87E-4 0.12
12 SGTC_165 k038-0023 3.29 64.4 µM 5.55E-5 ubiquinone biosynthesis & proteasome 29 5.02E-4 0.03
13 SGTC_1971 st069429 3.05 63.5 µM 1.68E-4 60S ribosome export 8 0.00114 0.03
14 SGTC_1728 st035614 3.04 33.8 µM 1.78E-4 16 0.00119 0.16
15 SGTC_175 3793-3120 3.01 23.7 µM 2.01E-4 15 0.00130 0.01
16 SGTC_2790 5423970 3.00 71.4 µM 2.11E-4 endomembrane recycling 31 0.00135 0.07
17 SGTC_1678 st019265 2.95 80.2 µM 2.64E-4 60S ribosome export 17 0.00160 0.11
18 SGTC_1987 st072290 2.94 61.9 µM 2.75E-4 14 0.00165 0.11
19 SGTC_2834 9001755 2.91 58.4 µM 3.07E-4 14 0.00179 0.03
20 SGTC_2598 perillyl alcohol 2.91 100.0 µM 3.15E-4 24 0.00182 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 3.54E-37 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.209 1.58E-34 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.187 8.10E-28 YGR140W CBF2 het Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
0.183 1.00E-26 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.182 2.95E-26 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.181 4.00E-26 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.173 5.62E-24 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.168 1.36E-22 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.165 6.61E-22 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.153 5.14E-19 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.149 5.08E-18 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.148 5.24E-18 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.146 1.76E-17 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.145 3.09E-17 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.141 2.09E-16 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication