YJR073C / OPI3

Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR073C / OPI3

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:6.93|P-value:9.20E-9 ID:SGTC_23|Compound:0213-0011|FD-Score:4.75|P-value:5.64E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:10.10|P-value:1.23E-16 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.46|P-value:5.07E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:9.52|P-value:5.60E-15 ID:SGTC_61|Compound:0978-8327|FD-Score:5.34|P-value:7.35E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:-5.92|P-value:8.67E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.47|P-value:1.42E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.45|P-value:1.48E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.89|P-value:3.60E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.48|P-value:4.26E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:4.19|P-value:3.36E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:9.22|P-value:3.85E-14 ID:SGTC_159|Compound:3970-0959|FD-Score:6.59|P-value:4.47E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:5.17|P-value:1.34E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:5.97|P-value:6.22E-7 ID:SGTC_188|Compound:3229-0966|FD-Score:4.92|P-value:3.26E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.01|P-value:5.56E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:5.38|P-value:6.36E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.45|P-value:8.10E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:6.70|P-value:2.71E-8 ID:SGTC_300|Compound:r073-0011|FD-Score:7.01|P-value:6.27E-9 ID:SGTC_315|Compound:k915-0449|FD-Score:5.96|P-value:6.50E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.78|P-value:5.67E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.82|P-value:9.53E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.90|P-value:3.42E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:4.46|P-value:1.46E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.75|P-value:6.19E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:10.30|P-value:2.85E-17 ID:SGTC_447|Compound:ml7|FD-Score:4.29|P-value:2.46E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.16|P-value:1.37E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.85|P-value:1.03E-6 ID:SGTC_470|Compound:aa-861|FD-Score:4.25|P-value:2.77E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.07|P-value:4.70E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.86|P-value:8.48E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:9.10|P-value:7.84E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:4.99|P-value:2.51E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:5.96|P-value:6.58E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:5.96|P-value:6.45E-7 ID:SGTC_666|Compound:0272-0154|FD-Score:5.23|P-value:1.10E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:11.30|P-value:3.13E-20 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.16|P-value:1.39E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:4.03|P-value:5.34E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-4.37|P-value:2.10E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.33|P-value:2.20E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:5.40|P-value:5.86E-6 ID:SGTC_738|Compound:1315-0003|FD-Score:4.13|P-value:4.00E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:10.00|P-value:2.37E-16 ID:SGTC_790|Compound:1575-0012|FD-Score:6.71|P-value:2.60E-8 ID:SGTC_792|Compound:4534-1957|FD-Score:3.90|P-value:7.56E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:8.70|P-value:8.67E-13 ID:SGTC_795|Compound:0685-0265|FD-Score:-6.05|P-value:5.08E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:5.16|P-value:1.41E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:6.05|P-value:4.56E-7 ID:SGTC_810|Compound:3825-7150|FD-Score:-4.87|P-value:4.27E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:5.84|P-value:1.04E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:4.11|P-value:4.23E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.50|P-value:1.29E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:7.63|P-value:2.97E-10 ID:SGTC_964|Compound:1287-0107|FD-Score:4.55|P-value:1.11E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.94|P-value:6.80E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.91|P-value:7.43E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:5.18|P-value:1.31E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:7.45|P-value:7.39E-10 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.67|P-value:7.52E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:7.17|P-value:3.00E-9 ID:SGTC_1090|Compound:efavirenz|FD-Score:5.31|P-value:7.95E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.43|P-value:1.58E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:7.32|P-value:1.44E-9 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.59|P-value:2.81E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.33|P-value:2.34E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:6.25|P-value:1.95E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.84|P-value:9.09E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.40|P-value:5.75E-6 ID:SGTC_1696|Compound:st025591|FD-Score:7.52|P-value:5.21E-10 ID:SGTC_1699|Compound:st031318|FD-Score:4.60|P-value:9.32E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.90|P-value:3.40E-5 ID:SGTC_1773|Compound:st048542|FD-Score:5.50|P-value:4.06E-6 ID:SGTC_1775|Compound:st081588|FD-Score:-4.89|P-value:3.94E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.53|P-value:3.63E-6 ID:SGTC_1831|Compound:st055328|FD-Score:4.70|P-value:6.84E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-4.54|P-value:1.26E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.83|P-value:9.89E-4 ID:SGTC_1953|Compound:st076800|FD-Score:6.60|P-value:4.26E-8 ID:SGTC_1954|Compound:st077032|FD-Score:4.05|P-value:4.94E-4 ID:SGTC_2055|Compound:5235184|FD-Score:6.00|P-value:5.57E-7 ID:SGTC_2077|Compound:5212015|FD-Score:4.59|P-value:9.73E-5 ID:SGTC_2085|Compound:5307070|FD-Score:7.90|P-value:7.17E-11 ID:SGTC_2089|Compound:5281248|FD-Score:10.40|P-value:1.91E-17 ID:SGTC_2095|Compound:5432005|FD-Score:-4.66|P-value:8.40E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-3.89|P-value:8.57E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.88|P-value:8.15E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.89|P-value:7.88E-4 ID:SGTC_2241|Compound:6772625|FD-Score:9.24|P-value:3.24E-14 ID:SGTC_2268|Compound:7933382|FD-Score:-5.48|P-value:4.88E-6 ID:SGTC_2271|Compound:7849410|FD-Score:5.28|P-value:8.94E-6 ID:SGTC_2289|Compound:7946404|FD-Score:7.68|P-value:2.32E-10 ID:SGTC_2376|Compound:9072922|FD-Score:4.39|P-value:1.82E-4 ID:SGTC_2430|Compound:5571206|FD-Score:6.12|P-value:3.36E-7 ID:SGTC_2434|Compound:5670830|FD-Score:4.44|P-value:1.56E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.82|P-value:9.53E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.76|P-value:5.57E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.32|P-value:2.26E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:8.64|P-value:1.21E-12 ID:SGTC_2659|Compound:sanguinarine|FD-Score:7.04|P-value:5.47E-9 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.82|P-value:9.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.91|P-value:7.43E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:10.00|P-value:1.82E-16 ID:SGTC_2743|Compound:auranofin|FD-Score:11.90|P-value:2.43E-22 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.89|P-value:7.91E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.59|P-value:9.64E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.92|P-value:7.20E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-5.08|P-value:2.05E-5 ID:SGTC_3018|Compound:9082602|FD-Score:5.19|P-value:1.24E-5 ID:SGTC_3037|Compound:9091026|FD-Score:7.96|P-value:5.33E-11 ID:SGTC_3212|Compound:9128307|FD-Score:-3.83|P-value:9.87E-4 ID:SGTC_3303|Compound:9125618|FD-Score:5.87|P-value:9.33E-7 ID:SGTC_15|Compound:0266-0086|FD-Score:6.93|P-value:9.20E-9 ID:SGTC_23|Compound:0213-0011|FD-Score:4.75|P-value:5.64E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:10.10|P-value:1.23E-16 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.46|P-value:5.07E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:9.52|P-value:5.60E-15 ID:SGTC_61|Compound:0978-8327|FD-Score:5.34|P-value:7.35E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:-5.92|P-value:8.67E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.47|P-value:1.42E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.45|P-value:1.48E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.89|P-value:3.60E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.48|P-value:4.26E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:4.19|P-value:3.36E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:9.22|P-value:3.85E-14 ID:SGTC_159|Compound:3970-0959|FD-Score:6.59|P-value:4.47E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:5.17|P-value:1.34E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:5.97|P-value:6.22E-7 ID:SGTC_188|Compound:3229-0966|FD-Score:4.92|P-value:3.26E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.01|P-value:5.56E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:5.38|P-value:6.36E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.45|P-value:8.10E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:6.70|P-value:2.71E-8 ID:SGTC_300|Compound:r073-0011|FD-Score:7.01|P-value:6.27E-9 ID:SGTC_315|Compound:k915-0449|FD-Score:5.96|P-value:6.50E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.78|P-value:5.67E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.82|P-value:9.53E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.90|P-value:3.42E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:4.46|P-value:1.46E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.75|P-value:6.19E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:10.30|P-value:2.85E-17 ID:SGTC_447|Compound:ml7|FD-Score:4.29|P-value:2.46E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.16|P-value:1.37E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.85|P-value:1.03E-6 ID:SGTC_470|Compound:aa-861|FD-Score:4.25|P-value:2.77E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.07|P-value:4.70E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.86|P-value:8.48E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:9.10|P-value:7.84E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:4.99|P-value:2.51E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:5.96|P-value:6.58E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:5.96|P-value:6.45E-7 ID:SGTC_666|Compound:0272-0154|FD-Score:5.23|P-value:1.10E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:11.30|P-value:3.13E-20 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.16|P-value:1.39E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:4.03|P-value:5.34E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-4.37|P-value:2.10E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.33|P-value:2.20E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:5.40|P-value:5.86E-6 ID:SGTC_738|Compound:1315-0003|FD-Score:4.13|P-value:4.00E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:10.00|P-value:2.37E-16 ID:SGTC_790|Compound:1575-0012|FD-Score:6.71|P-value:2.60E-8 ID:SGTC_792|Compound:4534-1957|FD-Score:3.90|P-value:7.56E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:8.70|P-value:8.67E-13 ID:SGTC_795|Compound:0685-0265|FD-Score:-6.05|P-value:5.08E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:5.16|P-value:1.41E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:6.05|P-value:4.56E-7 ID:SGTC_810|Compound:3825-7150|FD-Score:-4.87|P-value:4.27E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:5.84|P-value:1.04E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:4.11|P-value:4.23E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.50|P-value:1.29E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:7.63|P-value:2.97E-10 ID:SGTC_964|Compound:1287-0107|FD-Score:4.55|P-value:1.11E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.94|P-value:6.80E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.91|P-value:7.43E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:5.18|P-value:1.31E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:7.45|P-value:7.39E-10 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.67|P-value:7.52E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:7.17|P-value:3.00E-9 ID:SGTC_1090|Compound:efavirenz|FD-Score:5.31|P-value:7.95E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.43|P-value:1.58E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:7.32|P-value:1.44E-9 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.59|P-value:2.81E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.33|P-value:2.34E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:6.25|P-value:1.95E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.84|P-value:9.09E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.40|P-value:5.75E-6 ID:SGTC_1696|Compound:st025591|FD-Score:7.52|P-value:5.21E-10 ID:SGTC_1699|Compound:st031318|FD-Score:4.60|P-value:9.32E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.90|P-value:3.40E-5 ID:SGTC_1773|Compound:st048542|FD-Score:5.50|P-value:4.06E-6 ID:SGTC_1775|Compound:st081588|FD-Score:-4.89|P-value:3.94E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.53|P-value:3.63E-6 ID:SGTC_1831|Compound:st055328|FD-Score:4.70|P-value:6.84E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-4.54|P-value:1.26E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.83|P-value:9.89E-4 ID:SGTC_1953|Compound:st076800|FD-Score:6.60|P-value:4.26E-8 ID:SGTC_1954|Compound:st077032|FD-Score:4.05|P-value:4.94E-4 ID:SGTC_2055|Compound:5235184|FD-Score:6.00|P-value:5.57E-7 ID:SGTC_2077|Compound:5212015|FD-Score:4.59|P-value:9.73E-5 ID:SGTC_2085|Compound:5307070|FD-Score:7.90|P-value:7.17E-11 ID:SGTC_2089|Compound:5281248|FD-Score:10.40|P-value:1.91E-17 ID:SGTC_2095|Compound:5432005|FD-Score:-4.66|P-value:8.40E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-3.89|P-value:8.57E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.88|P-value:8.15E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.89|P-value:7.88E-4 ID:SGTC_2241|Compound:6772625|FD-Score:9.24|P-value:3.24E-14 ID:SGTC_2268|Compound:7933382|FD-Score:-5.48|P-value:4.88E-6 ID:SGTC_2271|Compound:7849410|FD-Score:5.28|P-value:8.94E-6 ID:SGTC_2289|Compound:7946404|FD-Score:7.68|P-value:2.32E-10 ID:SGTC_2376|Compound:9072922|FD-Score:4.39|P-value:1.82E-4 ID:SGTC_2430|Compound:5571206|FD-Score:6.12|P-value:3.36E-7 ID:SGTC_2434|Compound:5670830|FD-Score:4.44|P-value:1.56E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.82|P-value:9.53E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.76|P-value:5.57E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.32|P-value:2.26E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:8.64|P-value:1.21E-12 ID:SGTC_2659|Compound:sanguinarine|FD-Score:7.04|P-value:5.47E-9 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.82|P-value:9.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.91|P-value:7.43E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:10.00|P-value:1.82E-16 ID:SGTC_2743|Compound:auranofin|FD-Score:11.90|P-value:2.43E-22 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.89|P-value:7.91E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.59|P-value:9.64E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.92|P-value:7.20E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-5.08|P-value:2.05E-5 ID:SGTC_3018|Compound:9082602|FD-Score:5.19|P-value:1.24E-5 ID:SGTC_3037|Compound:9091026|FD-Score:7.96|P-value:5.33E-11 ID:SGTC_3212|Compound:9128307|FD-Score:-3.83|P-value:9.87E-4 ID:SGTC_3303|Compound:9125618|FD-Score:5.87|P-value:9.33E-7

Top fitness defect scores for YJR073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2743 auranofin 11.90 4.3 µM 2.43E-22 RPP1 & pyrimidine depletion 1 5.69E-33
2 SGTC_669 0108-0021 11.30 26.2 µM 3.13E-20 fatty acid desaturase (OLE1) 3 9.06E-30
3 SGTC_2089 5281248 10.40 129.7 µM 1.91E-17 superoxide 2 1.52E-25
4 SGTC_439 amiodarone 10.30 34.4 µM 2.85E-17 NEO1-PIK1 14 2.78E-25
5 SGTC_55 0767-0285 10.10 6.6 µM 1.23E-16 3 2.54E-24
6 SGTC_2736 butenafine 10.00 14.7 µM 1.82E-16 1 4.62E-24
7 SGTC_781 4335-2806 10.00 94.4 µM 2.37E-16 3 6.90E-24
8 SGTC_59 0330-0160 9.52 1.3 µM 5.60E-15 10 8.30E-22
9 SGTC_2241 6772625 9.24 37.8 µM 3.24E-14 3 1.18E-20
10 SGTC_146 3448-8650 9.22 53.1 µM 3.85E-14 NEO1-PIK1 21 1.54E-20
11 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 9.10 150.0 µM 7.84E-14 Golgi 5 4.51E-20
12 SGTC_794 k038-0031 8.70 316.0 µM 8.67E-13 ubiquinone biosynthesis & proteasome 24 1.71E-18
13 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 8.64 70.0 µM 1.21E-12 redox potentiating 14 2.85E-18
14 SGTC_3037 9091026 7.96 49.5 µM 5.33E-11 NEO1-PIK1 14 8.65E-16
15 SGTC_2085 5307070 7.90 144.1 µM 7.17E-11 superoxide 2 1.36E-15
16 SGTC_2289 7946404 7.68 165.1 µM 2.32E-10 18 7.99E-15
17 SGTC_879 0831-1030 7.63 162.0 µM 2.97E-10 8 1.16E-14
18 SGTC_1696 st025591 7.52 34.8 µM 5.21E-10 SWF1 & branched chain AA biosynthesis 6 2.71E-14
19 SGTC_1067 clotrimazole 7.45 1.4 µM 7.39E-10 azole & statin 4 4.58E-14
20 SGTC_1173 0443-0020 7.32 122.0 µM 1.44E-9 TSC3-RPN4 6 1.25E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.02E-28 YNL216W RAP1 het Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
0.162 4.48E-21 YJR118C ILM1 hom Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
0.156 1.25E-19 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.154 3.67E-19 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.152 9.90E-19 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.142 1.78E-16 YNL231C PDR16 hom Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress
0.141 3.07E-16 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.140 5.08E-16 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.135 4.04E-15 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.134 5.91E-15 YEL031W SPF1 hom P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
0.131 3.39E-14 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.128 8.54E-14 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.127 1.68E-13 YGR229C SMI1 hom Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
0.127 1.74E-13 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.126 2.34E-13 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress