YJR074W / MOG1

Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR074W / MOG1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.20|P-value:2.56E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.35|P-value:7.28E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.40|P-value:1.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.32|P-value:1.59E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.34|P-value:6.25E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.36|P-value:5.88E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.40|P-value:1.01E-7 ID:SGTC_159|Compound:3970-0959|FD-Score:5.16|P-value:3.40E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:8.98|P-value:3.25E-18 ID:SGTC_214|Compound:4373-3496|FD-Score:5.23|P-value:2.39E-7 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.35|P-value:6.17E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.09|P-value:3.98E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.44|P-value:9.54E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.46|P-value:4.24E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.05|P-value:4.71E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.37|P-value:5.68E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.85|P-value:1.26E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.06|P-value:4.63E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.25|P-value:8.62E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.32|P-value:6.69E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.42|P-value:1.03E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.67|P-value:2.42E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.45|P-value:9.16E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.26|P-value:8.12E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.87|P-value:9.38E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.54|P-value:3.83E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:13.90|P-value:9.35E-41 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.65|P-value:3.73E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.80|P-value:1.25E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.90|P-value:8.57E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.44|P-value:9.65E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.63|P-value:2.28E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.56|P-value:2.95E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.83|P-value:1.09E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.21|P-value:1.60E-15 ID:SGTC_1801|Compound:st050089|FD-Score:4.12|P-value:3.54E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.55|P-value:3.09E-4 ID:SGTC_1854|Compound:st056233|FD-Score:7.01|P-value:8.07E-12 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.84|P-value:1.08E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-4.00|P-value:7.29E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-3.73|P-value:1.98E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.03|P-value:5.21E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.86|P-value:9.88E-5 ID:SGTC_2089|Compound:5281248|FD-Score:5.14|P-value:3.82E-7 ID:SGTC_2110|Compound:5483698|FD-Score:3.45|P-value:4.37E-4 ID:SGTC_2141|Compound:5621638|FD-Score:5.41|P-value:9.86E-8 ID:SGTC_2145|Compound:5634607|FD-Score:3.72|P-value:1.64E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.26|P-value:8.34E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.51|P-value:3.51E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.25|P-value:8.46E-4 ID:SGTC_2290|Compound:7904846|FD-Score:5.37|P-value:1.17E-7 ID:SGTC_2322|Compound:7413319|FD-Score:5.37|P-value:1.19E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.07|P-value:4.35E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.81|P-value:2.92E-11 ID:SGTC_2701|Compound:st077767|FD-Score:3.48|P-value:3.94E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.78|P-value:1.33E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.98|P-value:4.31E-9 ID:SGTC_2940|Compound:9060638|FD-Score:3.96|P-value:6.84E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.72|P-value:1.68E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.92|P-value:7.96E-5 ID:SGTC_3091|Compound:9116372|FD-Score:4.93|P-value:1.04E-6 ID:SGTC_3200|Compound:9114385|FD-Score:8.13|P-value:2.94E-15 ID:SGTC_3207|Compound:9114163|FD-Score:-3.26|P-value:9.86E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.18|P-value:4.07E-7 ID:SGTC_3326|Compound:9140064|FD-Score:-3.35|P-value:7.48E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:4.20|P-value:2.56E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.35|P-value:7.28E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.40|P-value:1.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.32|P-value:1.59E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.34|P-value:6.25E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.36|P-value:5.88E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.40|P-value:1.01E-7 ID:SGTC_159|Compound:3970-0959|FD-Score:5.16|P-value:3.40E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:8.98|P-value:3.25E-18 ID:SGTC_214|Compound:4373-3496|FD-Score:5.23|P-value:2.39E-7 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.35|P-value:6.17E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.09|P-value:3.98E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.44|P-value:9.54E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.46|P-value:4.24E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.05|P-value:4.71E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.37|P-value:5.68E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.85|P-value:1.26E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.06|P-value:4.63E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.25|P-value:8.62E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.32|P-value:6.69E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.42|P-value:1.03E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.67|P-value:2.42E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.45|P-value:9.16E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.26|P-value:8.12E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.87|P-value:9.38E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.54|P-value:3.83E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:13.90|P-value:9.35E-41 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.65|P-value:3.73E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.80|P-value:1.25E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.90|P-value:8.57E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.44|P-value:9.65E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.63|P-value:2.28E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.56|P-value:2.95E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.83|P-value:1.09E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.21|P-value:1.60E-15 ID:SGTC_1801|Compound:st050089|FD-Score:4.12|P-value:3.54E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.55|P-value:3.09E-4 ID:SGTC_1854|Compound:st056233|FD-Score:7.01|P-value:8.07E-12 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.84|P-value:1.08E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-4.00|P-value:7.29E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-3.73|P-value:1.98E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.03|P-value:5.21E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.86|P-value:9.88E-5 ID:SGTC_2089|Compound:5281248|FD-Score:5.14|P-value:3.82E-7 ID:SGTC_2110|Compound:5483698|FD-Score:3.45|P-value:4.37E-4 ID:SGTC_2141|Compound:5621638|FD-Score:5.41|P-value:9.86E-8 ID:SGTC_2145|Compound:5634607|FD-Score:3.72|P-value:1.64E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.26|P-value:8.34E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.51|P-value:3.51E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.25|P-value:8.46E-4 ID:SGTC_2290|Compound:7904846|FD-Score:5.37|P-value:1.17E-7 ID:SGTC_2322|Compound:7413319|FD-Score:5.37|P-value:1.19E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.07|P-value:4.35E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.81|P-value:2.92E-11 ID:SGTC_2701|Compound:st077767|FD-Score:3.48|P-value:3.94E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.78|P-value:1.33E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.98|P-value:4.31E-9 ID:SGTC_2940|Compound:9060638|FD-Score:3.96|P-value:6.84E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.72|P-value:1.68E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.92|P-value:7.96E-5 ID:SGTC_3091|Compound:9116372|FD-Score:4.93|P-value:1.04E-6 ID:SGTC_3200|Compound:9114385|FD-Score:8.13|P-value:2.94E-15 ID:SGTC_3207|Compound:9114163|FD-Score:-3.26|P-value:9.86E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.18|P-value:4.07E-7 ID:SGTC_3326|Compound:9140064|FD-Score:-3.35|P-value:7.48E-4

Top fitness defect scores for YJR074W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1287 0971-0001 13.90 34.6 µM 9.35E-41 sphingolipid biosynthesis & PDR1 6 4.03E-44
2 SGTC_168 3970-0862 8.98 530.5 µM 3.25E-18 14 1.35E-19
3 SGTC_1687 st020778 8.21 55.4 µM 1.60E-15 67 1.14E-16
4 SGTC_3200 9114385 8.13 49.5 µM 2.94E-15 2 2.21E-16
5 SGTC_1854 st056233 7.01 32.9 µM 8.07E-12 amide catabolism 2 1.19E-12
6 SGTC_2651 1327-0036 6.81 5.0 µM 2.92E-11 50 4.81E-12
7 SGTC_2858 9025781 5.98 9.0 µM 4.31E-9 sphingolipid biosynthesis & PDR1 46 1.09E-9
8 SGTC_2141 5621638 5.41 7.7 µM 9.86E-8 tubulin folding & SWR complex 15 3.23E-8
9 SGTC_150 3970-0969 5.40 77.2 µM 1.01E-7 29 3.32E-8
10 SGTC_2290 7904846 5.37 200.0 µM 1.17E-7 6 3.89E-8
11 SGTC_2322 7413319 5.37 38.2 µM 1.19E-7 ERAD & cell cycle 79 3.95E-8
12 SGTC_214 4373-3496 5.23 70.0 µM 2.39E-7 23 8.42E-8
13 SGTC_159 3970-0959 5.16 50.0 µM 3.40E-7 35 1.23E-7
14 SGTC_2089 5281248 5.14 129.7 µM 3.82E-7 superoxide 8 1.40E-7
15 SGTC_3091 9116372 4.93 49.5 µM 1.04E-6 5 4.13E-7
16 SGTC_1288 0973-0013 4.65 65.5 µM 3.73E-6 9 1.65E-6
17 SGTC_588 3970-1144 4.45 52.9 µM 9.16E-6 19 4.35E-6
18 SGTC_241 5hr heat shock (37°C) + cantharidin 4.44 155.4 µM 9.54E-6 cell wall signaling 60 4.55E-6
19 SGTC_1547 harmine 4.44 94.2 µM 9.65E-6 ergosterol biosynthesis 30 4.60E-6
20 SGTC_528 3492-0019 4.42 172.0 µM 1.03E-5 calcium & mitochondrial duress 187 4.93E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.298 6.18E-70 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.295 4.49E-68 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.290 3.64E-66 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.279 8.45E-61 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.259 1.23E-52 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.255 4.51E-51 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.228 1.22E-40 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.215 1.65E-36 YNL235C_d YNL235C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
0.212 2.11E-35 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.210 7.23E-35 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.210 1.20E-34 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.200 2.26E-31 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.193 1.57E-29 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.180 9.31E-26 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.173 6.87E-24 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase