YJR075W / HOC1

Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR075W / HOC1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.16|P-value:3.77E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.54|P-value:5.90E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.17|P-value:4.40E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:4.94|P-value:6.73E-8 ID:SGTC_214|Compound:4373-3496|FD-Score:4.97|P-value:5.78E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.03|P-value:5.98E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.61|P-value:5.97E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.86|P-value:1.09E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:4.14|P-value:5.00E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.04|P-value:5.89E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.29|P-value:2.31E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.22|P-value:3.05E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.45|P-value:1.06E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:2.93|P-value:8.91E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.85|P-value:2.06E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.60|P-value:6.29E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.00|P-value:7.07E-4 ID:SGTC_2007|Compound:4011539|FD-Score:8.55|P-value:3.47E-20 ID:SGTC_2009|Compound:4012297|FD-Score:9.48|P-value:2.39E-24 ID:SGTC_2011|Compound:4012611|FD-Score:3.86|P-value:1.89E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.81|P-value:2.38E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.04|P-value:6.06E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.28|P-value:2.51E-6 ID:SGTC_2081|Compound:5214970|FD-Score:3.04|P-value:5.97E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.61|P-value:5.82E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.79|P-value:2.72E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.70|P-value:3.81E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.14|P-value:3.81E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.23|P-value:2.88E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.23|P-value:2.92E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-2.95|P-value:7.96E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.91|P-value:1.51E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.03|P-value:5.98E-4 ID:SGTC_2884|Compound:9058502|FD-Score:2.99|P-value:7.18E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.98|P-value:1.10E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-4.37|P-value:1.49E-6 ID:SGTC_3020|Compound:9089140|FD-Score:3.06|P-value:5.46E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.13|P-value:4.29E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-3.03|P-value:5.95E-4 ID:SGTC_3037|Compound:9091026|FD-Score:10.30|P-value:2.37E-28 ID:SGTC_3142|Compound:9086498|FD-Score:3.06|P-value:5.55E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.64|P-value:3.67E-7 ID:SGTC_3153|Compound:9100258|FD-Score:4.17|P-value:4.27E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.24|P-value:2.75E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.36|P-value:1.69E-6 ID:SGTC_3211|Compound:9128781|FD-Score:3.27|P-value:2.42E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.12|P-value:4.12E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.09|P-value:4.97E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.54|P-value:8.08E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.69|P-value:2.90E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:3.16|P-value:3.77E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.54|P-value:5.90E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.17|P-value:4.40E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:4.94|P-value:6.73E-8 ID:SGTC_214|Compound:4373-3496|FD-Score:4.97|P-value:5.78E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.03|P-value:5.98E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.61|P-value:5.97E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.86|P-value:1.09E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:4.14|P-value:5.00E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.04|P-value:5.89E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.29|P-value:2.31E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.22|P-value:3.05E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.45|P-value:1.06E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:2.93|P-value:8.91E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.85|P-value:2.06E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.60|P-value:6.29E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.00|P-value:7.07E-4 ID:SGTC_2007|Compound:4011539|FD-Score:8.55|P-value:3.47E-20 ID:SGTC_2009|Compound:4012297|FD-Score:9.48|P-value:2.39E-24 ID:SGTC_2011|Compound:4012611|FD-Score:3.86|P-value:1.89E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.81|P-value:2.38E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.04|P-value:6.06E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.28|P-value:2.51E-6 ID:SGTC_2081|Compound:5214970|FD-Score:3.04|P-value:5.97E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.61|P-value:5.82E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.79|P-value:2.72E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.70|P-value:3.81E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.14|P-value:3.81E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.23|P-value:2.88E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.23|P-value:2.92E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-2.95|P-value:7.96E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.91|P-value:1.51E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.03|P-value:5.98E-4 ID:SGTC_2884|Compound:9058502|FD-Score:2.99|P-value:7.18E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.98|P-value:1.10E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-4.37|P-value:1.49E-6 ID:SGTC_3020|Compound:9089140|FD-Score:3.06|P-value:5.46E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.13|P-value:4.29E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-3.03|P-value:5.95E-4 ID:SGTC_3037|Compound:9091026|FD-Score:10.30|P-value:2.37E-28 ID:SGTC_3142|Compound:9086498|FD-Score:3.06|P-value:5.55E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.64|P-value:3.67E-7 ID:SGTC_3153|Compound:9100258|FD-Score:4.17|P-value:4.27E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.24|P-value:2.75E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.36|P-value:1.69E-6 ID:SGTC_3211|Compound:9128781|FD-Score:3.27|P-value:2.42E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.12|P-value:4.12E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.09|P-value:4.97E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.54|P-value:8.08E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.69|P-value:2.90E-7

Top fitness defect scores for YJR075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3037 9091026 10.30 49.5 µM 2.37E-28 NEO1-PIK1 4 4.03E-25
2 SGTC_2009 4012297 9.48 12.1 µM 2.39E-24 cell wall signaling 9 1.32E-21
3 SGTC_2007 4011539 8.55 71.8 µM 3.47E-20 cell wall signaling 16 5.99E-18
4 SGTC_214 4373-3496 4.97 70.0 µM 5.78E-8 30 3.36E-7
5 SGTC_212 3807-4682 4.94 38.8 µM 6.73E-8 tubulin folding & SWR complex 38 3.84E-7
6 SGTC_625 k213-0058 4.86 121.0 µM 1.09E-7 translation 61 5.89E-7
7 SGTC_3308 9128332 4.69 17.6 µM 2.90E-7 plasma membrane duress 54 1.39E-6
8 SGTC_3152 9099253 4.64 49.5 µM 3.67E-7 NEO1-PIK1 94 1.71E-6
9 SGTC_914 3820-6779 4.45 408.0 µM 1.06E-6 13 4.35E-6
10 SGTC_3188 9110789 4.36 49.5 µM 1.69E-6 iron homeostasis 14 6.61E-6
11 SGTC_2057 5236571 4.28 38.3 µM 2.51E-6 RPP1 & pyrimidine depletion 22 9.33E-6
12 SGTC_3153 9100258 4.17 49.5 µM 4.27E-6 14 1.49E-5
13 SGTC_146 3448-8650 4.17 53.1 µM 4.40E-6 NEO1-PIK1 124 1.53E-5
14 SGTC_663 1486-0733 4.14 13.9 µM 5.00E-6 cell wall signaling 45 1.72E-5
15 SGTC_2896 9052656 3.98 71.4 µM 1.10E-5 endomembrane recycling 112 3.45E-5
16 SGTC_2848 9016370 3.91 26.0 µM 1.51E-5 25 4.55E-5
17 SGTC_2011 4012611 3.86 177.0 µM 1.89E-5 mitochondrial processes 35 5.56E-5
18 SGTC_1568 digitonin 3.85 820.0 nM 2.06E-5 sphingolipid biosynthesis & PDR1 36 5.98E-5
19 SGTC_2055 5235184 3.81 200.0 µM 2.38E-5 ERG2 39 6.82E-5
20 SGTC_2399 5884133 3.79 200.0 µM 2.72E-5 cell wall signaling 79 7.67E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.263 4.96E-54 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.253 2.74E-50 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.249 8.85E-49 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.234 5.29E-43 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.221 2.23E-38 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.203 1.24E-32 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.197 1.49E-30 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.196 2.84E-30 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.194 7.77E-30 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.192 2.62E-29 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.192 3.18E-29 YEL036C ANP1 hom Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
0.190 1.24E-28 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.189 2.28E-28 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.187 1.13E-27 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.183 1.21E-26 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p