YJR077C / MIR1

Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR077C / MIR1

Click on Significant Values for Screen Details ID:SGTC_113|Compound:0099-0221|FD-Score:-3.35|P-value:4.20E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.60|P-value:1.41E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:16.20|P-value:4.78E-60 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.47|P-value:2.73E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.52|P-value:2.65E-11 ID:SGTC_787|Compound:4152-0075|FD-Score:3.55|P-value:1.70E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.54|P-value:2.07E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.39|P-value:4.87E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.98|P-value:2.95E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.07|P-value:9.66E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.63|P-value:1.24E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.79|P-value:6.74E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.19|P-value:6.35E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.33|P-value:3.82E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.74|P-value:7.96E-5 ID:SGTC_1843|Compound:st055809|FD-Score:7.67|P-value:6.06E-15 ID:SGTC_1871|Compound:st057448|FD-Score:3.40|P-value:2.97E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.28|P-value:4.65E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.62|P-value:1.57E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.34|P-value:4.38E-4 ID:SGTC_2088|Compound:5278280|FD-Score:5.23|P-value:7.05E-8 ID:SGTC_2170|Compound:morpholine|FD-Score:3.20|P-value:6.07E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.26|P-value:8.73E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.06|P-value:9.95E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.17|P-value:1.33E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.20|P-value:6.21E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.00|P-value:2.40E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.48|P-value:3.13E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.15|P-value:1.45E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.55|P-value:1.68E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.06|P-value:9.86E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-4.10|P-value:2.14E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.02|P-value:3.13E-5 ID:SGTC_3264|Compound:9137442|FD-Score:4.07|P-value:2.08E-5 ID:SGTC_3269|Compound:9137823|FD-Score:-3.25|P-value:6.08E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.15|P-value:8.53E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.17|P-value:6.90E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.35|P-value:4.20E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.60|P-value:1.41E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:16.20|P-value:4.78E-60 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.47|P-value:2.73E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.52|P-value:2.65E-11 ID:SGTC_787|Compound:4152-0075|FD-Score:3.55|P-value:1.70E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.54|P-value:2.07E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.39|P-value:4.87E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.98|P-value:2.95E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.07|P-value:9.66E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.63|P-value:1.24E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.79|P-value:6.74E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.19|P-value:6.35E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.33|P-value:3.82E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.74|P-value:7.96E-5 ID:SGTC_1843|Compound:st055809|FD-Score:7.67|P-value:6.06E-15 ID:SGTC_1871|Compound:st057448|FD-Score:3.40|P-value:2.97E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.28|P-value:4.65E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.62|P-value:1.57E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.34|P-value:4.38E-4 ID:SGTC_2088|Compound:5278280|FD-Score:5.23|P-value:7.05E-8 ID:SGTC_2170|Compound:morpholine|FD-Score:3.20|P-value:6.07E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.26|P-value:8.73E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.06|P-value:9.95E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.17|P-value:1.33E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.20|P-value:6.21E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.00|P-value:2.40E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.48|P-value:3.13E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.15|P-value:1.45E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.55|P-value:1.68E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.06|P-value:9.86E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-4.10|P-value:2.14E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.02|P-value:3.13E-5 ID:SGTC_3264|Compound:9137442|FD-Score:4.07|P-value:2.08E-5 ID:SGTC_3269|Compound:9137823|FD-Score:-3.25|P-value:6.08E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.15|P-value:8.53E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.17|P-value:6.90E-4

Top fitness defect scores for YJR077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 16.20 5.3 µM 4.78E-60 85 1.35E-59
2 SGTC_1843 st055809 7.67 45.5 µM 6.06E-15 1 8.41E-15
3 SGTC_386 1509-0011 6.52 3.1 µM 2.65E-11 85 3.45E-11
4 SGTC_2088 5278280 5.23 127.4 µM 7.05E-8 8 8.57E-8
5 SGTC_2682 pyrogallin 5.00 40.0 µM 2.40E-7 copper-dependent oxidative stress 12 2.89E-7
6 SGTC_2774 tamoxifen 4.48 10.9 µM 3.13E-6 9 3.68E-6
7 SGTC_1184 1269-1718 4.39 139.0 µM 4.87E-6 19 5.69E-6
8 SGTC_2264 7948757 4.26 110.8 µM 8.73E-6 9 1.01E-5
9 SGTC_2566 crystal violet carbinol 4.17 226.0 nM 1.33E-5 36 1.54E-5
10 SGTC_2791 5663188 4.15 71.4 µM 1.45E-5 RPP1 & pyrimidine depletion 17 1.68E-5
11 SGTC_3264 9137442 4.07 49.5 µM 2.08E-5 13 2.40E-5
12 SGTC_1268 0828-0275 3.98 2.5 µM 2.95E-5 19 3.39E-5
13 SGTC_1311 1190-0148 3.79 100.0 µM 6.74E-5 azole & statin 30 7.68E-5
14 SGTC_1826 st055655 3.74 41.6 µM 7.96E-5 ERG2 47 9.04E-5
15 SGTC_1299 1079-1439 3.63 3.7 µM 1.24E-4 TSC3-RPN4 16 1.40E-4
16 SGTC_177 1327-0068 3.60 8.4 µM 1.41E-4 57 1.60E-4
17 SGTC_3099 9120367 3.55 49.5 µM 1.68E-4 25 1.90E-4
18 SGTC_787 4152-0075 3.55 138.0 µM 1.70E-4 35 1.92E-4
19 SGTC_1871 st057448 3.40 67.3 µM 2.97E-4 45 3.33E-4
20 SGTC_1734 st037168 3.33 69.4 µM 3.82E-4 49 4.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.488 1.83E-200 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.479 2.39E-192 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.478 2.99E-191 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.455 9.82E-171 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.454 4.33E-170 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.446 6.16E-164 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.442 7.61E-161 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.435 4.66E-155 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.433 5.00E-153 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.419 1.14E-142 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.417 1.78E-141 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.416 1.61E-140 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.414 3.39E-139 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.413 3.14E-138 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.402 1.53E-130 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER