YJR079W_p

Putative protein of unknown function; mutation results in impaired mitochondrial respiration

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR079W / YJR079W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.37|P-value:6.23E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:5.19|P-value:2.94E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.47|P-value:4.38E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.27|P-value:8.56E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:6.85|P-value:1.94E-11 ID:SGTC_562|Compound:3772-2733|FD-Score:-5.83|P-value:6.32E-9 ID:SGTC_633|Compound:0437-0093|FD-Score:3.32|P-value:7.37E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.39|P-value:5.89E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.38|P-value:4.59E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.67|P-value:1.57E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.25|P-value:9.12E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.57|P-value:3.10E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.77|P-value:1.47E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.52|P-value:3.65E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.42|P-value:3.94E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.33|P-value:1.58E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.38|P-value:5.96E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.33|P-value:5.49E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.68|P-value:1.56E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.25|P-value:2.22E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.47|P-value:4.40E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.92|P-value:8.54E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.48|P-value:4.24E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.85|P-value:1.12E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.47|P-value:4.34E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-4.00|P-value:4.41E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.28|P-value:6.50E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.43|P-value:3.77E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.44|P-value:4.87E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.76|P-value:1.53E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-4.44|P-value:7.01E-6 ID:SGTC_2807|Compound:7945238|FD-Score:-3.21|P-value:8.20E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-4.26|P-value:1.54E-5 ID:SGTC_2899|Compound:9053889|FD-Score:-3.38|P-value:4.50E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.53|P-value:3.56E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.37|P-value:6.23E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:5.19|P-value:2.94E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.47|P-value:4.38E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.27|P-value:8.56E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:6.85|P-value:1.94E-11 ID:SGTC_562|Compound:3772-2733|FD-Score:-5.83|P-value:6.32E-9 ID:SGTC_633|Compound:0437-0093|FD-Score:3.32|P-value:7.37E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.39|P-value:5.89E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.38|P-value:4.59E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.67|P-value:1.57E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.25|P-value:9.12E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.57|P-value:3.10E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.77|P-value:1.47E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.52|P-value:3.65E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.42|P-value:3.94E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.33|P-value:1.58E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.38|P-value:5.96E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.33|P-value:5.49E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.68|P-value:1.56E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.25|P-value:2.22E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.47|P-value:4.40E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.92|P-value:8.54E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.48|P-value:4.24E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.85|P-value:1.12E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.47|P-value:4.34E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-4.00|P-value:4.41E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.28|P-value:6.50E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.43|P-value:3.77E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.44|P-value:4.87E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.76|P-value:1.53E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-4.44|P-value:7.01E-6 ID:SGTC_2807|Compound:7945238|FD-Score:-3.21|P-value:8.20E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-4.26|P-value:1.54E-5 ID:SGTC_2899|Compound:9053889|FD-Score:-3.38|P-value:4.50E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.53|P-value:3.56E-4

Top fitness defect scores for YJR079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_556 4058-0063 6.85 51.5 µM 1.94E-11 4 3.58E-12
2 SGTC_347 4534-1311 5.19 26.2 µM 2.94E-7 RPP1 & pyrimidine depletion 4 1.05E-7
3 SGTC_1259 0671-0132 4.33 43.0 µM 1.58E-5 17 7.39E-6
4 SGTC_1872 amphotericin b 4.25 148.0 nM 2.22E-5 RNA pol III & RNase P/MRP 22 1.07E-5
5 SGTC_1986 st071812 3.92 45.0 µM 8.54E-5 8 4.50E-5
6 SGTC_2002 4023503 3.85 131.0 µM 1.12E-4 mitochondrial processes 35 6.01E-5
7 SGTC_1072 oxiconazole 3.77 14.9 nM 1.47E-4 ergosterol depletion effects on membrane 57 8.06E-5
8 SGTC_2666 tannic acid 3.76 100.0 µM 1.53E-4 iron homeostasis 45 8.42E-5
9 SGTC_1002 4049-0206 3.57 172.0 µM 3.10E-4 49 1.79E-4
10 SGTC_3304 9125678 3.53 46.1 µM 3.56E-4 70 2.07E-4
11 SGTC_1076 itraconazole 3.52 331.0 nM 3.65E-4 49 2.13E-4
12 SGTC_2000 st075254 3.48 36.4 µM 4.24E-4 19 2.50E-4
13 SGTC_2004 4023728 3.47 41.9 µM 4.34E-4 42 2.56E-4
14 SGTC_420 mitomycin C 3.47 81.9 mM 4.38E-4 27 2.59E-4
15 SGTC_1874 staurosporine 3.47 7.6 µM 4.40E-4 cell wall signaling 44 2.60E-4
16 SGTC_2607 solasodine 3.44 47.4 µM 4.87E-4 81 2.90E-4
17 SGTC_825 1988-2224 3.39 89.6 µM 5.89E-4 cell wall signaling 53 3.55E-4
18 SGTC_1651 st011928 3.38 86.1 µM 5.96E-4 RSC complex & mRNA processing 27 3.60E-4
19 SGTC_8 0354-0001 3.37 70.0 µM 6.23E-4 112 3.77E-4
20 SGTC_633 0437-0093 3.32 97.7 µM 7.37E-4 DNA intercalators 31 4.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 2.15E-8 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.097 2.19E-8 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.092 8.86E-8 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.090 2.12E-7 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.089 2.37E-7 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
0.089 2.60E-7 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.089 2.71E-7 YFL030W AGX1 hom Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
0.083 1.38E-6 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.082 2.03E-6 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.081 2.67E-6 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.081 2.76E-6 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.079 4.47E-6 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 5.33E-6 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.078 5.52E-6 YKL031W_d YKL031W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
0.078 5.93E-6 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog