YJR084W

Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR084W / YJR084W

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.67|P-value:1.29E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.37|P-value:1.08E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:2.82|P-value:9.12E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.45|P-value:6.88E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.30|P-value:1.48E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-4.40|P-value:6.78E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:4.01|P-value:4.71E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:5.39|P-value:1.36E-9 ID:SGTC_628|Compound:1636-0253|FD-Score:4.45|P-value:4.63E-7 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.62|P-value:3.55E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.36|P-value:1.05E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.11|P-value:3.31E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.62|P-value:3.24E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:2.98|P-value:5.01E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.86|P-value:1.15E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.67|P-value:2.89E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.94|P-value:5.78E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.37|P-value:1.10E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:2.96|P-value:5.36E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.70|P-value:2.21E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.93|P-value:6.04E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-2.91|P-value:7.21E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.49|P-value:3.58E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.18|P-value:1.98E-6 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.84|P-value:8.63E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:2.84|P-value:8.38E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.15|P-value:2.50E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.96|P-value:6.93E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.16|P-value:2.24E-6 ID:SGTC_2108|Compound:5365811|FD-Score:2.85|P-value:8.27E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.20|P-value:2.05E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.62|P-value:3.24E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-3.31|P-value:1.43E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.75|P-value:1.78E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.34|P-value:1.15E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.48|P-value:6.69E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.57|P-value:4.49E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.72|P-value:1.41E-10 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.42|P-value:7.81E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.59|P-value:4.21E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.09|P-value:3.57E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.98|P-value:5.51E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.38|P-value:9.98E-13 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.46|P-value:7.51E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-2.85|P-value:8.98E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.00|P-value:5.07E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.21|P-value:1.73E-6 ID:SGTC_2958|Compound:9077254|FD-Score:4.06|P-value:3.74E-6 ID:SGTC_2960|Compound:9079389|FD-Score:3.60|P-value:3.55E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.47|P-value:6.49E-5 ID:SGTC_3027|Compound:9089541|FD-Score:4.46|P-value:4.19E-7 ID:SGTC_3213|Compound:9129884|FD-Score:-3.55|P-value:5.01E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.63|P-value:3.45E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-4.36|P-value:8.74E-7 ID:SGTC_3355|Compound:9151058|FD-Score:-2.99|P-value:5.35E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.67|P-value:1.29E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.37|P-value:1.08E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:2.82|P-value:9.12E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.45|P-value:6.88E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.30|P-value:1.48E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-4.40|P-value:6.78E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:4.01|P-value:4.71E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:5.39|P-value:1.36E-9 ID:SGTC_628|Compound:1636-0253|FD-Score:4.45|P-value:4.63E-7 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.62|P-value:3.55E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.36|P-value:1.05E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.11|P-value:3.31E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.62|P-value:3.24E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:2.98|P-value:5.01E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.86|P-value:1.15E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.67|P-value:2.89E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.94|P-value:5.78E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.37|P-value:1.10E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:2.96|P-value:5.36E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.70|P-value:2.21E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.93|P-value:6.04E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-2.91|P-value:7.21E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.49|P-value:3.58E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.18|P-value:1.98E-6 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.84|P-value:8.63E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:2.84|P-value:8.38E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.15|P-value:2.50E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.96|P-value:6.93E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.16|P-value:2.24E-6 ID:SGTC_2108|Compound:5365811|FD-Score:2.85|P-value:8.27E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.20|P-value:2.05E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.62|P-value:3.24E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-3.31|P-value:1.43E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.75|P-value:1.78E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.34|P-value:1.15E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.48|P-value:6.69E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.57|P-value:4.49E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.72|P-value:1.41E-10 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.42|P-value:7.81E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.59|P-value:4.21E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.09|P-value:3.57E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.98|P-value:5.51E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.38|P-value:9.98E-13 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.46|P-value:7.51E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-2.85|P-value:8.98E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.00|P-value:5.07E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.21|P-value:1.73E-6 ID:SGTC_2958|Compound:9077254|FD-Score:4.06|P-value:3.74E-6 ID:SGTC_2960|Compound:9079389|FD-Score:3.60|P-value:3.55E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.47|P-value:6.49E-5 ID:SGTC_3027|Compound:9089541|FD-Score:4.46|P-value:4.19E-7 ID:SGTC_3213|Compound:9129884|FD-Score:-3.55|P-value:5.01E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.63|P-value:3.45E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-4.36|P-value:8.74E-7 ID:SGTC_3355|Compound:9151058|FD-Score:-2.99|P-value:5.35E-4

Top fitness defect scores for YJR084W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 6.38 100.0 µM 9.98E-13 9 8.81E-11
2 SGTC_2409 alverine citrate 5.72 64.0 µM 1.41E-10 25 5.29E-9
3 SGTC_623 k072-0108 5.39 16.9 µM 1.36E-9 heme biosynthesis & mitochondrial translocase 2 3.46E-8
4 SGTC_39 0986-0283 4.67 58.4 µM 1.29E-7 calcium & mitochondrial duress 16 1.51E-6
5 SGTC_1378 2093-0007 4.49 380.0 nM 3.58E-7 9 3.52E-6
6 SGTC_3027 9089541 4.46 49.5 µM 4.19E-7 fatty acid desaturase (OLE1) 13 4.01E-6
7 SGTC_628 1636-0253 4.45 16.0 µM 4.63E-7 sphingolipid biosynthesis & PDR1 25 4.36E-6
8 SGTC_2832 7992762 4.21 52.0 µM 1.73E-6 21 1.30E-5
9 SGTC_1528 arabinosylhypoxanthine 4.18 74.6 µM 1.98E-6 16 1.46E-5
10 SGTC_1875 nocodazole 4.16 6.0 µM 2.24E-6 tubulin folding & SWR complex 45 1.61E-5
11 SGTC_2958 9077254 4.06 16.7 µM 3.74E-6 29 2.47E-5
12 SGTC_620 0109-0052 4.01 432.0 µM 4.71E-6 17 2.99E-5
13 SGTC_2309 7664088 3.75 163.9 µM 1.78E-5 42 9.01E-5
14 SGTC_1231 0242-0792 3.70 125.0 µM 2.21E-5 25 1.08E-4
15 SGTC_2181 6316240 3.62 54.3 µM 3.24E-5 29 1.48E-4
16 SGTC_761 k216-0224 3.62 480.0 µM 3.24E-5 31 1.49E-4
17 SGTC_2960 9079389 3.60 6.0 µM 3.55E-5 42 1.60E-4
18 SGTC_2981 9013952 3.47 39.0 µM 6.49E-5 61 2.64E-4
19 SGTC_531 3788-1495 3.45 174.0 µM 6.88E-5 unfolded protein response 33 2.78E-4
20 SGTC_2410 aloe-emodin-8-o-glycoside 3.42 46.3 µM 7.81E-5 mitochondrial processes 54 3.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.27E-17 YDR119W_p VBA4_p hom Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
0.131 3.25E-14 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.119 3.98E-12 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.105 1.11E-9 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.092 1.07E-7 YDR356W SPC110 het Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
0.090 1.62E-7 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.087 3.99E-7 YOL027C MDM38 hom Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
0.087 4.69E-7 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.080 3.41E-6 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.080 3.47E-6 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.080 3.58E-6 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.079 4.53E-6 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.078 5.99E-6 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.077 7.64E-6 YCL029C BIK1 hom Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
0.077 8.82E-6 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication