YJR088C / EMC2

Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR088C / EMC2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:13.60|P-value:6.04E-54 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.26|P-value:9.98E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:7.91|P-value:1.29E-19 ID:SGTC_146|Compound:3448-8650|FD-Score:4.73|P-value:4.06E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:3.22|P-value:1.30E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.33|P-value:4.52E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:-2.83|P-value:6.29E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:6.21|P-value:9.06E-13 ID:SGTC_188|Compound:3229-0966|FD-Score:4.54|P-value:1.31E-7 ID:SGTC_192|Compound:3455-0609|FD-Score:3.20|P-value:1.42E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:5.94|P-value:7.43E-12 ID:SGTC_294|Compound:k038-0071|FD-Score:3.07|P-value:2.52E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.53|P-value:3.06E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.73|P-value:1.17E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:2.83|P-value:6.75E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:5.70|P-value:4.82E-11 ID:SGTC_352|Compound:k048-0007|FD-Score:7.08|P-value:4.49E-16 ID:SGTC_417|Compound:st075190|FD-Score:2.81|P-value:7.28E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.83|P-value:6.55E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:9.69|P-value:1.79E-28 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.56|P-value:1.06E-7 ID:SGTC_543|Compound:3844-1095|FD-Score:3.42|P-value:5.21E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.03|P-value:2.93E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:14.20|P-value:9.02E-59 ID:SGTC_658|Compound:3253-0951|FD-Score:3.33|P-value:8.10E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:3.29|P-value:9.38E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.13|P-value:1.92E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:2.75|P-value:9.12E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:6.02|P-value:3.96E-12 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.93|P-value:4.12E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.68|P-value:1.38E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-2.73|P-value:9.13E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.15|P-value:1.74E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.69|P-value:1.43E-5 ID:SGTC_1750|Compound:st081859|FD-Score:15.30|P-value:1.31E-67 ID:SGTC_1754|Compound:st042065|FD-Score:2.94|P-value:4.33E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-2.89|P-value:4.84E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.37|P-value:6.07E-5 ID:SGTC_1917|Compound:st066507|FD-Score:2.87|P-value:5.61E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.77|P-value:9.62E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-2.75|P-value:8.49E-4 ID:SGTC_2089|Compound:5281248|FD-Score:2.94|P-value:4.27E-4 ID:SGTC_2198|Compound:6589944|FD-Score:2.88|P-value:5.56E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.67|P-value:5.75E-8 ID:SGTC_2264|Compound:7948757|FD-Score:-3.29|P-value:9.02E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-2.92|P-value:4.30E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-2.95|P-value:3.84E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.05|P-value:2.70E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.99|P-value:3.55E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.87|P-value:5.78E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.95|P-value:9.34E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:2.83|P-value:6.76E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.35|P-value:7.17E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.27|P-value:9.65E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.28|P-value:5.43E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.23|P-value:1.25E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.63|P-value:1.80E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.88|P-value:5.25E-6 ID:SGTC_2858|Compound:9025781|FD-Score:2.81|P-value:7.33E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.90|P-value:4.74E-6 ID:SGTC_2918|Compound:7977171|FD-Score:2.89|P-value:5.27E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.34|P-value:7.64E-5 ID:SGTC_3010|Compound:9080089|FD-Score:2.80|P-value:7.54E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.54|P-value:2.80E-5 ID:SGTC_3084|Compound:9116877|FD-Score:2.81|P-value:7.16E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-2.94|P-value:4.06E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.01|P-value:2.74E-6 ID:SGTC_3257|Compound:9139206|FD-Score:3.00|P-value:3.28E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:13.60|P-value:6.04E-54 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.26|P-value:9.98E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:7.91|P-value:1.29E-19 ID:SGTC_146|Compound:3448-8650|FD-Score:4.73|P-value:4.06E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:3.22|P-value:1.30E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.33|P-value:4.52E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:-2.83|P-value:6.29E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:6.21|P-value:9.06E-13 ID:SGTC_188|Compound:3229-0966|FD-Score:4.54|P-value:1.31E-7 ID:SGTC_192|Compound:3455-0609|FD-Score:3.20|P-value:1.42E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:5.94|P-value:7.43E-12 ID:SGTC_294|Compound:k038-0071|FD-Score:3.07|P-value:2.52E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.53|P-value:3.06E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.73|P-value:1.17E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:2.83|P-value:6.75E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:5.70|P-value:4.82E-11 ID:SGTC_352|Compound:k048-0007|FD-Score:7.08|P-value:4.49E-16 ID:SGTC_417|Compound:st075190|FD-Score:2.81|P-value:7.28E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.83|P-value:6.55E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:9.69|P-value:1.79E-28 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.56|P-value:1.06E-7 ID:SGTC_543|Compound:3844-1095|FD-Score:3.42|P-value:5.21E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.03|P-value:2.93E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:14.20|P-value:9.02E-59 ID:SGTC_658|Compound:3253-0951|FD-Score:3.33|P-value:8.10E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:3.29|P-value:9.38E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.13|P-value:1.92E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:2.75|P-value:9.12E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:6.02|P-value:3.96E-12 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.93|P-value:4.12E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.68|P-value:1.38E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-2.73|P-value:9.13E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.15|P-value:1.74E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.69|P-value:1.43E-5 ID:SGTC_1750|Compound:st081859|FD-Score:15.30|P-value:1.31E-67 ID:SGTC_1754|Compound:st042065|FD-Score:2.94|P-value:4.33E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-2.89|P-value:4.84E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.37|P-value:6.07E-5 ID:SGTC_1917|Compound:st066507|FD-Score:2.87|P-value:5.61E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.77|P-value:9.62E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-2.75|P-value:8.49E-4 ID:SGTC_2089|Compound:5281248|FD-Score:2.94|P-value:4.27E-4 ID:SGTC_2198|Compound:6589944|FD-Score:2.88|P-value:5.56E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.67|P-value:5.75E-8 ID:SGTC_2264|Compound:7948757|FD-Score:-3.29|P-value:9.02E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-2.92|P-value:4.30E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-2.95|P-value:3.84E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.05|P-value:2.70E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.99|P-value:3.55E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.87|P-value:5.78E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.95|P-value:9.34E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:2.83|P-value:6.76E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.35|P-value:7.17E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.27|P-value:9.65E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.28|P-value:5.43E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.23|P-value:1.25E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.63|P-value:1.80E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.88|P-value:5.25E-6 ID:SGTC_2858|Compound:9025781|FD-Score:2.81|P-value:7.33E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.90|P-value:4.74E-6 ID:SGTC_2918|Compound:7977171|FD-Score:2.89|P-value:5.27E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.34|P-value:7.64E-5 ID:SGTC_3010|Compound:9080089|FD-Score:2.80|P-value:7.54E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.54|P-value:2.80E-5 ID:SGTC_3084|Compound:9116877|FD-Score:2.81|P-value:7.16E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-2.94|P-value:4.06E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.01|P-value:2.74E-6 ID:SGTC_3257|Compound:9139206|FD-Score:3.00|P-value:3.28E-4

Top fitness defect scores for YJR088C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 15.30 2.4 µM 1.31E-67 endomembrane recycling 22 7.65E-53
2 SGTC_562 3772-2733 14.20 112.0 µM 9.02E-59 ERG2 2 5.40E-46
3 SGTC_43 0570-0105 13.60 72.5 µM 6.04E-54 ERG2 4 2.97E-42
4 SGTC_528 3492-0019 9.69 172.0 µM 1.79E-28 calcium & mitochondrial duress 41 1.68E-22
5 SGTC_143 4032-1194 7.91 15.7 µM 1.29E-19 10 1.27E-15
6 SGTC_352 k048-0007 7.08 5.1 µM 4.49E-16 ERAD & cell cycle 21 7.22E-13
7 SGTC_176 1486-1328 6.21 72.8 µM 9.06E-13 18 2.69E-10
8 SGTC_1173 0443-0020 6.02 122.0 µM 3.96E-12 TSC3-RPN4 8 8.49E-10
9 SGTC_196 k015-0023 5.94 18.1 µM 7.43E-12 PDR1 5 1.39E-9
10 SGTC_349 k015-0014 5.70 24.0 µM 4.82E-11 4 5.96E-9
11 SGTC_2415 st077333 4.95 57.7 µM 9.34E-9 19 3.63E-7
12 SGTC_146 3448-8650 4.73 53.1 µM 4.06E-8 NEO1-PIK1 99 1.14E-6
13 SGTC_2249 haloperidol 4.67 116.4 µM 5.75E-8 ergosterol depletion effects on membrane 76 1.50E-6
14 SGTC_188 3229-0966 4.54 278.5 µM 1.31E-7 18 2.86E-6
15 SGTC_152 4469-0003 4.33 551.2 µM 4.52E-7 16 7.54E-6
16 SGTC_3237 9133362 4.01 49.5 µM 2.74E-6 33 3.09E-5
17 SGTC_2896 9052656 3.90 71.4 µM 4.74E-6 endomembrane recycling 118 4.75E-5
18 SGTC_2765 myclobutanil 3.88 7.7 µM 5.25E-6 azole & statin 49 5.14E-5
19 SGTC_2402 5553605 3.87 200.0 µM 5.78E-6 31 5.55E-5
20 SGTC_2021 4019055 3.77 173.0 µM 9.62E-6 endomembrane recycling 133 8.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.447 2.48E-164 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.408 6.57E-135 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.346 5.14E-95 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.345 1.07E-94 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.320 1.31E-80 YCL045C EMC1 hom Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.316 1.12E-78 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.288 7.44E-65 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.285 1.25E-63 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.275 2.83E-59 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.274 1.15E-58 YPR153W YPR153W hom Putative protein of unknown function
0.269 1.28E-56 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.246 2.52E-47 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.244 1.59E-46 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.241 1.85E-45 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.239 1.32E-44 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)