YJR090C / GRR1

F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR090C / GRR1

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:-5.07|P-value:8.98E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.38|P-value:6.69E-4 ID:SGTC_442|Compound:cape|FD-Score:4.48|P-value:2.04E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.34|P-value:3.60E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:-4.55|P-value:8.60E-6 ID:SGTC_606|Compound:k015-0008|FD-Score:4.25|P-value:5.05E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.53|P-value:1.66E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:4.08|P-value:9.43E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.40|P-value:9.81E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.22|P-value:5.53E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:4.45|P-value:2.32E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.28|P-value:9.28E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.92|P-value:1.72E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.42|P-value:5.96E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.45|P-value:8.42E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.71|P-value:3.49E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.44|P-value:2.39E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:3.72|P-value:3.36E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.29|P-value:4.24E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.07|P-value:9.72E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:5.69|P-value:8.53E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.51|P-value:6.89E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.97|P-value:1.45E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.34|P-value:3.56E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.78|P-value:2.76E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.53|P-value:1.63E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.57|P-value:1.40E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:-4.97|P-value:1.39E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:-4.52|P-value:1.00E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.93|P-value:9.89E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.80|P-value:1.60E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-4.77|P-value:3.40E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.44|P-value:5.61E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-3.77|P-value:1.82E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-4.72|P-value:4.33E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:-4.02|P-value:7.09E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.64|P-value:5.98E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-4.90|P-value:1.90E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.62|P-value:4.75E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.74|P-value:7.07E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.95|P-value:2.76E-6 ID:SGTC_1467|Compound:k284-1082|FD-Score:5.87|P-value:3.38E-8 ID:SGTC_1496|Compound:4469-0713|FD-Score:5.55|P-value:1.71E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:3.39|P-value:0.00100 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.92|P-value:1.68E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-3.51|P-value:4.34E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.48|P-value:7.48E-4 ID:SGTC_1824|Compound:st053723|FD-Score:5.68|P-value:9.02E-8 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.61|P-value:4.91E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.93|P-value:1.62E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:5.11|P-value:1.34E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-3.61|P-value:3.12E-4 ID:SGTC_1985|Compound:st071382|FD-Score:4.81|P-value:5.16E-6 ID:SGTC_2056|Compound:5235370|FD-Score:3.78|P-value:2.82E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.50|P-value:7.09E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.49|P-value:7.38E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.56|P-value:5.87E-4 ID:SGTC_2272|Compound:7805186|FD-Score:4.56|P-value:1.49E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-4.84|P-value:2.52E-6 ID:SGTC_2310|Compound:7668677|FD-Score:6.26|P-value:4.23E-9 ID:SGTC_2428|Compound:5615643|FD-Score:3.49|P-value:7.39E-4 ID:SGTC_2445|Compound:5742597|FD-Score:5.11|P-value:1.40E-6 ID:SGTC_2450|Compound:5739737|FD-Score:3.65|P-value:4.28E-4 ID:SGTC_2452|Compound:5863136|FD-Score:5.80|P-value:4.94E-8 ID:SGTC_2460|Compound:5552655|FD-Score:4.09|P-value:9.22E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.39|P-value:6.45E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.81|P-value:2.51E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.86|P-value:2.11E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.21|P-value:3.48E-5 ID:SGTC_2819|Compound:7996655|FD-Score:5.36|P-value:4.29E-7 ID:SGTC_2825|Compound:7998094|FD-Score:5.60|P-value:1.35E-7 ID:SGTC_2834|Compound:9001755|FD-Score:5.35|P-value:4.53E-7 ID:SGTC_2924|Compound:9010168|FD-Score:4.75|P-value:6.62E-6 ID:SGTC_2926|Compound:9010726|FD-Score:4.14|P-value:7.59E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-3.78|P-value:1.73E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.70|P-value:3.60E-4 ID:SGTC_2954|Compound:9074818|FD-Score:5.70|P-value:8.19E-8 ID:SGTC_2966|Compound:9084041|FD-Score:4.74|P-value:6.91E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.77|P-value:6.22E-6 ID:SGTC_3101|Compound:9120531|FD-Score:3.95|P-value:1.51E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.60|P-value:5.13E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.42|P-value:8.99E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.73|P-value:3.31E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.68|P-value:3.93E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.61|P-value:4.92E-4 ID:SGTC_3289|Compound:9119912|FD-Score:6.30|P-value:3.34E-9 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.07|P-value:8.98E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.38|P-value:6.69E-4 ID:SGTC_442|Compound:cape|FD-Score:4.48|P-value:2.04E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.34|P-value:3.60E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:-4.55|P-value:8.60E-6 ID:SGTC_606|Compound:k015-0008|FD-Score:4.25|P-value:5.05E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.53|P-value:1.66E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:4.08|P-value:9.43E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.40|P-value:9.81E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.22|P-value:5.53E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:4.45|P-value:2.32E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.28|P-value:9.28E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.92|P-value:1.72E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.42|P-value:5.96E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.45|P-value:8.42E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.71|P-value:3.49E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.44|P-value:2.39E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:3.72|P-value:3.36E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.29|P-value:4.24E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.07|P-value:9.72E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:5.69|P-value:8.53E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.51|P-value:6.89E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.97|P-value:1.45E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.34|P-value:3.56E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.78|P-value:2.76E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.53|P-value:1.63E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.57|P-value:1.40E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:-4.97|P-value:1.39E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:-4.52|P-value:1.00E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.93|P-value:9.89E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.80|P-value:1.60E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-4.77|P-value:3.40E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.44|P-value:5.61E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-3.77|P-value:1.82E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-4.72|P-value:4.33E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:-4.02|P-value:7.09E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.64|P-value:5.98E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-4.90|P-value:1.90E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.62|P-value:4.75E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.74|P-value:7.07E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.95|P-value:2.76E-6 ID:SGTC_1467|Compound:k284-1082|FD-Score:5.87|P-value:3.38E-8 ID:SGTC_1496|Compound:4469-0713|FD-Score:5.55|P-value:1.71E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:3.39|P-value:0.00100 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.92|P-value:1.68E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-3.51|P-value:4.34E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.48|P-value:7.48E-4 ID:SGTC_1824|Compound:st053723|FD-Score:5.68|P-value:9.02E-8 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.61|P-value:4.91E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.93|P-value:1.62E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:5.11|P-value:1.34E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-3.61|P-value:3.12E-4 ID:SGTC_1985|Compound:st071382|FD-Score:4.81|P-value:5.16E-6 ID:SGTC_2056|Compound:5235370|FD-Score:3.78|P-value:2.82E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.50|P-value:7.09E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.49|P-value:7.38E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.56|P-value:5.87E-4 ID:SGTC_2272|Compound:7805186|FD-Score:4.56|P-value:1.49E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-4.84|P-value:2.52E-6 ID:SGTC_2310|Compound:7668677|FD-Score:6.26|P-value:4.23E-9 ID:SGTC_2428|Compound:5615643|FD-Score:3.49|P-value:7.39E-4 ID:SGTC_2445|Compound:5742597|FD-Score:5.11|P-value:1.40E-6 ID:SGTC_2450|Compound:5739737|FD-Score:3.65|P-value:4.28E-4 ID:SGTC_2452|Compound:5863136|FD-Score:5.80|P-value:4.94E-8 ID:SGTC_2460|Compound:5552655|FD-Score:4.09|P-value:9.22E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.39|P-value:6.45E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.81|P-value:2.51E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.86|P-value:2.11E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.21|P-value:3.48E-5 ID:SGTC_2819|Compound:7996655|FD-Score:5.36|P-value:4.29E-7 ID:SGTC_2825|Compound:7998094|FD-Score:5.60|P-value:1.35E-7 ID:SGTC_2834|Compound:9001755|FD-Score:5.35|P-value:4.53E-7 ID:SGTC_2924|Compound:9010168|FD-Score:4.75|P-value:6.62E-6 ID:SGTC_2926|Compound:9010726|FD-Score:4.14|P-value:7.59E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-3.78|P-value:1.73E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.70|P-value:3.60E-4 ID:SGTC_2954|Compound:9074818|FD-Score:5.70|P-value:8.19E-8 ID:SGTC_2966|Compound:9084041|FD-Score:4.74|P-value:6.91E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.77|P-value:6.22E-6 ID:SGTC_3101|Compound:9120531|FD-Score:3.95|P-value:1.51E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.60|P-value:5.13E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.42|P-value:8.99E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.73|P-value:3.31E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.68|P-value:3.93E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.61|P-value:4.92E-4 ID:SGTC_3289|Compound:9119912|FD-Score:6.30|P-value:3.34E-9

Top fitness defect scores for YJR090C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3289 9119912 6.30 71.4 µM 3.34E-9 2 1.46E-10
2 SGTC_2310 7668677 6.26 200.0 µM 4.23E-9 4 1.92E-10
3 SGTC_1467 k284-1082 5.87 293.0 µM 3.38E-8 3 2.16E-9
4 SGTC_2452 5863136 5.80 48.4 µM 4.94E-8 5 3.35E-9
5 SGTC_2954 9074818 5.70 52.7 µM 8.19E-8 12 6.05E-9
6 SGTC_1056 3448-1962 5.69 115.0 µM 8.53E-8 amide catabolism 6 6.33E-9
7 SGTC_1824 st053723 5.68 68.6 µM 9.02E-8 11 6.76E-9
8 SGTC_2825 7998094 5.60 58.4 µM 1.35E-7 fatty acid desaturase (OLE1) 11 1.08E-8
9 SGTC_1496 4469-0713 5.55 57.4 µM 1.71E-7 9 1.43E-8
10 SGTC_2819 7996655 5.36 46.4 µM 4.29E-7 6 4.16E-8
11 SGTC_2834 9001755 5.35 58.4 µM 4.53E-7 12 4.43E-8
12 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 5.11 70.1 µM 1.34E-6 5 1.57E-7
13 SGTC_2445 5742597 5.11 35.6 µM 1.40E-6 18 1.65E-7
14 SGTC_1465 k213-0056 4.95 144.0 µM 2.76E-6 DNA intercalators 9 3.63E-7
15 SGTC_1985 st071382 4.81 65.5 µM 5.16E-6 8 7.54E-7
16 SGTC_2970 9090938 4.77 41.9 µM 6.22E-6 RNA processing & uracil transport 15 9.36E-7
17 SGTC_2924 9010168 4.75 62.8 µM 6.62E-6 cell wall signaling 22 1.01E-6
18 SGTC_2966 9084041 4.74 48.0 µM 6.91E-6 17 1.06E-6
19 SGTC_1457 k015-0032 4.74 57.3 µM 7.07E-6 19 1.09E-6
20 SGTC_1154 4088-0362 4.57 150.0 µM 1.40E-5 9 2.42E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.31E-7 YLR240W VPS34 hom Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.088 3.89E-7 YNR023W SNF12 hom 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive
0.087 4.51E-7 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.080 3.07E-6 YBR252W DUT1 het deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
0.076 1.13E-5 YDR463W STP1 hom Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication
0.074 1.90E-5 YBR069C TAT1 hom Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress
0.070 4.64E-5 YPR129W SCD6 hom Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress
0.065 1.63E-4 YDR074W TPS2 hom Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress
0.062 3.09E-4 YHR192W LNP1 hom Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS
0.061 3.82E-4 YER044C ERG28 hom Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
0.060 5.06E-4 YIL114C POR2 hom Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication
0.060 5.32E-4 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.059 6.59E-4 YAR023C_p YAR023C_p hom Putative integral membrane protein, member of DUP240 gene family
0.059 6.77E-4 YGR262C BUD32 hom Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
0.058 8.04E-4 YEL029C BUD16 hom Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)