YJR093C / FIP1

Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR093C / FIP1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:5.22|P-value:3.46E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:10.50|P-value:5.06E-20 ID:SGTC_131|Compound:0141-0277|FD-Score:-5.15|P-value:3.36E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:4.63|P-value:3.40E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.68|P-value:7.84E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.20|P-value:1.19E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.61|P-value:9.72E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.70|P-value:2.58E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:4.02|P-value:2.73E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.86|P-value:3.54E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.78|P-value:1.88E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.68|P-value:4.77E-7 ID:SGTC_539|Compound:4859-0462|FD-Score:4.89|P-value:1.25E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.93|P-value:3.60E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.63|P-value:9.11E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.61|P-value:2.77E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.91|P-value:3.90E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.29|P-value:1.12E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:12.60|P-value:6.26E-28 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.78|P-value:5.86E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:5.36|P-value:1.93E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.78|P-value:5.80E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.67|P-value:7.96E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.46|P-value:6.26E-5 ID:SGTC_1723|Compound:st034307|FD-Score:4.02|P-value:2.70E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-4.11|P-value:1.58E-4 ID:SGTC_1745|Compound:st081495|FD-Score:10.10|P-value:1.18E-18 ID:SGTC_1754|Compound:st042065|FD-Score:3.94|P-value:3.52E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.76|P-value:2.06E-5 ID:SGTC_1818|Compound:st052136|FD-Score:5.12|P-value:5.10E-6 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.98|P-value:3.08E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.51|P-value:5.12E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.86|P-value:4.54E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.60|P-value:9.81E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.89|P-value:1.85E-7 ID:SGTC_2143|Compound:5623677|FD-Score:-3.55|P-value:9.17E-4 ID:SGTC_2160|Compound:5660466|FD-Score:5.60|P-value:6.85E-7 ID:SGTC_2257|Compound:7960413|FD-Score:8.00|P-value:2.40E-12 ID:SGTC_2263|Compound:7948595|FD-Score:-4.99|P-value:6.49E-6 ID:SGTC_2267|Compound:7931562|FD-Score:7.66|P-value:1.81E-11 ID:SGTC_2277|Compound:7947813|FD-Score:-3.93|P-value:2.91E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.75|P-value:6.39E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.99|P-value:2.39E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.93|P-value:3.66E-4 ID:SGTC_2714|Compound:st079313|FD-Score:7.89|P-value:4.59E-12 ID:SGTC_2717|Compound:st081029|FD-Score:-3.63|P-value:7.33E-4 ID:SGTC_2990|Compound:9074105|FD-Score:6.73|P-value:3.06E-9 ID:SGTC_2999|Compound:9069765|FD-Score:-4.49|P-value:4.22E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.69|P-value:7.63E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.22|P-value:3.46E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:10.50|P-value:5.06E-20 ID:SGTC_131|Compound:0141-0277|FD-Score:-5.15|P-value:3.36E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:4.63|P-value:3.40E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.68|P-value:7.84E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.20|P-value:1.19E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.61|P-value:9.72E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.70|P-value:2.58E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:4.02|P-value:2.73E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.86|P-value:3.54E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.78|P-value:1.88E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.68|P-value:4.77E-7 ID:SGTC_539|Compound:4859-0462|FD-Score:4.89|P-value:1.25E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.93|P-value:3.60E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.63|P-value:9.11E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.61|P-value:2.77E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.91|P-value:3.90E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.29|P-value:1.12E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:12.60|P-value:6.26E-28 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.78|P-value:5.86E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:5.36|P-value:1.93E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.78|P-value:5.80E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.67|P-value:7.96E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.46|P-value:6.26E-5 ID:SGTC_1723|Compound:st034307|FD-Score:4.02|P-value:2.70E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-4.11|P-value:1.58E-4 ID:SGTC_1745|Compound:st081495|FD-Score:10.10|P-value:1.18E-18 ID:SGTC_1754|Compound:st042065|FD-Score:3.94|P-value:3.52E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.76|P-value:2.06E-5 ID:SGTC_1818|Compound:st052136|FD-Score:5.12|P-value:5.10E-6 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.98|P-value:3.08E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.51|P-value:5.12E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.86|P-value:4.54E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.60|P-value:9.81E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.89|P-value:1.85E-7 ID:SGTC_2143|Compound:5623677|FD-Score:-3.55|P-value:9.17E-4 ID:SGTC_2160|Compound:5660466|FD-Score:5.60|P-value:6.85E-7 ID:SGTC_2257|Compound:7960413|FD-Score:8.00|P-value:2.40E-12 ID:SGTC_2263|Compound:7948595|FD-Score:-4.99|P-value:6.49E-6 ID:SGTC_2267|Compound:7931562|FD-Score:7.66|P-value:1.81E-11 ID:SGTC_2277|Compound:7947813|FD-Score:-3.93|P-value:2.91E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.75|P-value:6.39E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.99|P-value:2.39E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.93|P-value:3.66E-4 ID:SGTC_2714|Compound:st079313|FD-Score:7.89|P-value:4.59E-12 ID:SGTC_2717|Compound:st081029|FD-Score:-3.63|P-value:7.33E-4 ID:SGTC_2990|Compound:9074105|FD-Score:6.73|P-value:3.06E-9 ID:SGTC_2999|Compound:9069765|FD-Score:-4.49|P-value:4.22E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.69|P-value:7.63E-4

Top fitness defect scores for YJR093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1083 didemethylchlorpromazine sulfoxide 12.60 707.4 nM 6.26E-28 redox potentiating 6 1.28E-36 2.69
2 SGTC_69 0096-0274 10.50 206.7 µM 5.06E-20 mitochondrial processes 3 4.07E-26 0.39
3 SGTC_1745 st081495 10.10 74.0 µM 1.18E-18 RNA processing & uracil transport 3 2.67E-24 1.12
4 SGTC_2257 7960413 8.00 200.0 µM 2.40E-12 NEO1-PIK1 5 6.31E-16 0.42
5 SGTC_2714 st079313 7.89 56.9 µM 4.59E-12 1 1.49E-15 3.10
6 SGTC_2267 7931562 7.66 200.0 µM 1.81E-11 1 9.19E-15 2.91
7 SGTC_2990 9074105 6.73 71.4 µM 3.06E-9 3 8.25E-12 1.58
8 SGTC_2036 5160441 5.89 105.0 µM 1.85E-7 NEO1 12 1.90E-9 0.07
9 SGTC_528 3492-0019 5.68 172.0 µM 4.77E-7 calcium & mitochondrial duress 11 6.62E-9 0.16
10 SGTC_2160 5660466 5.60 132.9 µM 6.85E-7 60S ribosome export 5 1.07E-8 0.15
11 SGTC_1409 3909-8004 5.36 61.9 µM 1.93E-6 1 4.21E-8 1.24
12 SGTC_54 0159-0055 5.22 9.0 µM 3.46E-6 ERG2 5 9.10E-8 0.71
13 SGTC_1818 st052136 5.12 56.3 µM 5.10E-6 NEO1-PIK1 10 1.52E-7 0.33
14 SGTC_539 4859-0462 4.89 2.5 µM 1.25E-5 RNA pol III & RNase P/MRP 13 4.99E-7 0.12
15 SGTC_424 splitomicin 4.78 100.0 mM 1.88E-5 1 8.56E-7 0.50
16 SGTC_1800 st050079 4.76 29.1 µM 2.06E-5 NEO1-PIK1 15 9.61E-7 0.09
17 SGTC_354 2783-3500 4.70 4.9 µM 2.58E-5 cell wall 21 1.30E-6 0.02
18 SGTC_133 0724-0033 4.63 378.9 µM 3.40E-5 7 1.87E-6 0.48
19 SGTC_1934 st074720 4.51 32.6 µM 5.12E-5 6 3.21E-6 0.28
20 SGTC_1712 st032288 4.46 53.4 µM 6.26E-5 calcium & mitochondrial duress 31 4.18E-6 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 1.15E-57 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.247 7.08E-48 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.161 7.25E-21 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.160 9.31E-21 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.158 3.58E-20 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.152 7.28E-19 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.137 1.91E-15 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.134 6.34E-15 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.134 6.73E-15 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.132 1.35E-14 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.132 1.96E-14 YMR061W RNA14 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.128 8.96E-14 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
0.127 1.66E-13 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.126 2.89E-13 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.122 1.46E-12 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data