YJR095W / SFC1

Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR095W / SFC1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.33|P-value:2.94E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.21|P-value:4.58E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-4.03|P-value:1.84E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.00|P-value:9.80E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.32|P-value:3.47E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.89|P-value:2.32E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.11|P-value:6.78E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.16|P-value:5.51E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.73|P-value:6.74E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:3.63|P-value:8.98E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.79|P-value:5.24E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.53|P-value:1.34E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.30|P-value:3.73E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.08|P-value:7.44E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.15|P-value:9.56E-6 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.21|P-value:5.08E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-5.26|P-value:3.55E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.07|P-value:2.14E-10 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.36|P-value:2.65E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.35|P-value:3.64E-6 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.44|P-value:2.41E-6 ID:SGTC_1703|Compound:st026983|FD-Score:3.12|P-value:6.38E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.89|P-value:3.03E-5 ID:SGTC_1714|Compound:st033236|FD-Score:5.32|P-value:2.21E-8 ID:SGTC_1731|Compound:st035964|FD-Score:-3.38|P-value:2.75E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.80|P-value:5.01E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.04|P-value:8.59E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.34|P-value:3.16E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.21|P-value:4.68E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-5.44|P-value:1.30E-8 ID:SGTC_2181|Compound:6316240|FD-Score:3.22|P-value:4.47E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.17|P-value:5.30E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.75|P-value:5.60E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.29|P-value:3.43E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.69|P-value:7.15E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-4.54|P-value:1.70E-6 ID:SGTC_2341|Compound:7987486|FD-Score:-3.77|P-value:5.85E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-4.05|P-value:1.70E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-4.85|P-value:3.41E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.33|P-value:3.28E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.31|P-value:2.24E-8 ID:SGTC_2696|Compound:st077691|FD-Score:4.21|P-value:7.30E-6 ID:SGTC_2890|Compound:9046729|FD-Score:-3.07|P-value:8.56E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.10|P-value:7.75E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.53|P-value:1.53E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.35|P-value:3.12E-4 ID:SGTC_3124|Compound:9127567|FD-Score:4.57|P-value:1.23E-6 ID:SGTC_3210|Compound:9128157|FD-Score:-4.16|P-value:1.03E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-4.02|P-value:1.92E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.68|P-value:7.49E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.30|P-value:3.66E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.06|P-value:7.88E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.57|P-value:1.30E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.74|P-value:5.89E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.70|P-value:6.80E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-3.68|P-value:8.33E-5 ID:SGTC_3310|Compound:9130229|FD-Score:-7.10|P-value:1.71E-13 ID:SGTC_36|Compound:0335-0881|FD-Score:3.33|P-value:2.94E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.21|P-value:4.58E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-4.03|P-value:1.84E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.00|P-value:9.80E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.32|P-value:3.47E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.89|P-value:2.32E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.11|P-value:6.78E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.16|P-value:5.51E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.73|P-value:6.74E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:3.63|P-value:8.98E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.79|P-value:5.24E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.53|P-value:1.34E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.30|P-value:3.73E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.08|P-value:7.44E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.15|P-value:9.56E-6 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.21|P-value:5.08E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-5.26|P-value:3.55E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.07|P-value:2.14E-10 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.36|P-value:2.65E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.35|P-value:3.64E-6 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.44|P-value:2.41E-6 ID:SGTC_1703|Compound:st026983|FD-Score:3.12|P-value:6.38E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.89|P-value:3.03E-5 ID:SGTC_1714|Compound:st033236|FD-Score:5.32|P-value:2.21E-8 ID:SGTC_1731|Compound:st035964|FD-Score:-3.38|P-value:2.75E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.80|P-value:5.01E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.04|P-value:8.59E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.34|P-value:3.16E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.21|P-value:4.68E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-5.44|P-value:1.30E-8 ID:SGTC_2181|Compound:6316240|FD-Score:3.22|P-value:4.47E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.17|P-value:5.30E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.75|P-value:5.60E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.29|P-value:3.43E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.69|P-value:7.15E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-4.54|P-value:1.70E-6 ID:SGTC_2341|Compound:7987486|FD-Score:-3.77|P-value:5.85E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-4.05|P-value:1.70E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-4.85|P-value:3.41E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.33|P-value:3.28E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.31|P-value:2.24E-8 ID:SGTC_2696|Compound:st077691|FD-Score:4.21|P-value:7.30E-6 ID:SGTC_2890|Compound:9046729|FD-Score:-3.07|P-value:8.56E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.10|P-value:7.75E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.53|P-value:1.53E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.35|P-value:3.12E-4 ID:SGTC_3124|Compound:9127567|FD-Score:4.57|P-value:1.23E-6 ID:SGTC_3210|Compound:9128157|FD-Score:-4.16|P-value:1.03E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-4.02|P-value:1.92E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.68|P-value:7.49E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.30|P-value:3.66E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.06|P-value:7.88E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.57|P-value:1.30E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.74|P-value:5.89E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.70|P-value:6.80E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-3.68|P-value:8.33E-5 ID:SGTC_3310|Compound:9130229|FD-Score:-7.10|P-value:1.71E-13

Top fitness defect scores for YJR095W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1134 3477-0009 6.07 42.5 µM 2.14E-10 8 6.58E-10
2 SGTC_1714 st033236 5.32 13.6 µM 2.21E-8 7 5.33E-8
3 SGTC_2689 tacrolimus 5.31 100.0 µM 2.24E-8 16 5.39E-8
4 SGTC_158 k038-0087 4.89 26.4 µM 2.32E-7 ubiquinone biosynthesis & proteasome 91 4.95E-7
5 SGTC_3124 9127567 4.57 49.5 µM 1.23E-6 DNA damage response 11 2.41E-6
6 SGTC_1444 4112-3581 4.44 28.0 µM 2.41E-6 3 4.53E-6
7 SGTC_1413 3910-0535 4.35 34.4 µM 3.64E-6 6 6.71E-6
8 SGTC_2696 st077691 4.21 74.3 µM 7.30E-6 23 1.30E-5
9 SGTC_1083 didemethylchlorpromazine sulfoxide 4.15 707.4 nM 9.56E-6 redox potentiating 67 1.67E-5
10 SGTC_1708 st033234 3.89 31.8 µM 3.03E-5 18 4.99E-5
11 SGTC_2281 7943571 3.75 200.0 µM 5.60E-5 14 8.93E-5
12 SGTC_3302 9125395 3.74 16.4 µM 5.89E-5 14 9.38E-5
13 SGTC_3305 9127027 3.70 53.8 µM 6.80E-5 21 1.07E-4
14 SGTC_2287 7945887 3.69 168.8 µM 7.15E-5 11 1.13E-4
15 SGTC_3222 9128301 3.68 49.5 µM 7.49E-5 60S ribosome export 32 1.18E-4
16 SGTC_829 1635-0120 3.63 117.0 µM 8.98E-5 DNA damage response 52 1.40E-4
17 SGTC_909 3448-9333 3.53 149.0 µM 1.34E-4 29 2.05E-4
18 SGTC_1302 1159-0335 3.36 255.0 µM 2.65E-4 29 3.90E-4
19 SGTC_36 0335-0881 3.33 14.2 µM 2.94E-4 ubiquinone biosynthesis & proteasome 153 4.31E-4
20 SGTC_2282 7944268 3.29 200.0 µM 3.43E-4 RPP1 & pyrimidine depletion 65 4.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.38E-16 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.134 7.44E-15 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.130 4.33E-14 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.124 5.83E-13 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.121 2.16E-12 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.115 2.83E-11 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.113 6.28E-11 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.112 9.38E-11 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.32E-10 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.108 3.71E-10 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.106 8.40E-10 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.101 5.14E-9 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.100 6.38E-9 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.099 9.03E-9 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.099 1.06E-8 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W