YJR096W

Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR096W / YJR096W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.53|P-value:6.88E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:4.23|P-value:3.33E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:3.09|P-value:5.03E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.18|P-value:2.77E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.93|P-value:7.26E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:4.03|P-value:8.97E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.12|P-value:3.56E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.06|P-value:5.78E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.14|P-value:4.17E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:2.95|P-value:8.56E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.02|P-value:6.76E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.94|P-value:1.33E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.22|P-value:3.05E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.13|P-value:4.43E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:2.94|P-value:8.82E-4 ID:SGTC_1795|Compound:st049545|FD-Score:5.09|P-value:2.72E-8 ID:SGTC_1804|Compound:st050076|FD-Score:3.36|P-value:1.79E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.49|P-value:7.78E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.26|P-value:2.81E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.55|P-value:7.80E-5 ID:SGTC_2171|Compound:5739187|FD-Score:-2.94|P-value:7.19E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.27|P-value:1.95E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.24|P-value:2.84E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-3.51|P-value:7.19E-5 ID:SGTC_2217|Compound:6934799|FD-Score:3.22|P-value:3.08E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.96|P-value:8.32E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.41|P-value:1.42E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.05|P-value:4.69E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.04|P-value:4.88E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.59|P-value:6.71E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.41|P-value:1.41E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.02|P-value:5.16E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.00|P-value:7.11E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.85|P-value:1.14E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.99|P-value:1.07E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-9.11|P-value:4.64E-23 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.12|P-value:4.60E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.14|P-value:4.29E-4 ID:SGTC_2925|Compound:9010536|FD-Score:2.94|P-value:8.84E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.01|P-value:6.88E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.53|P-value:6.88E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:4.23|P-value:3.33E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:3.09|P-value:5.03E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.18|P-value:2.77E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.93|P-value:7.26E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:4.03|P-value:8.97E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.12|P-value:3.56E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.06|P-value:5.78E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.14|P-value:4.17E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:2.95|P-value:8.56E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.02|P-value:6.76E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.94|P-value:1.33E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.22|P-value:3.05E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.13|P-value:4.43E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:2.94|P-value:8.82E-4 ID:SGTC_1795|Compound:st049545|FD-Score:5.09|P-value:2.72E-8 ID:SGTC_1804|Compound:st050076|FD-Score:3.36|P-value:1.79E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.49|P-value:7.78E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.26|P-value:2.81E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.55|P-value:7.80E-5 ID:SGTC_2171|Compound:5739187|FD-Score:-2.94|P-value:7.19E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.27|P-value:1.95E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.24|P-value:2.84E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-3.51|P-value:7.19E-5 ID:SGTC_2217|Compound:6934799|FD-Score:3.22|P-value:3.08E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.96|P-value:8.32E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.41|P-value:1.42E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.05|P-value:4.69E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.04|P-value:4.88E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.59|P-value:6.71E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.41|P-value:1.41E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.02|P-value:5.16E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.00|P-value:7.11E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.85|P-value:1.14E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.99|P-value:1.07E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-9.11|P-value:4.64E-23 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.12|P-value:4.60E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.14|P-value:4.29E-4 ID:SGTC_2925|Compound:9010536|FD-Score:2.94|P-value:8.84E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.01|P-value:6.88E-4

Top fitness defect scores for YJR096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1795 st049545 5.09 62.3 µM 2.72E-8 TSC3-RPN4 6 1.75E-7
2 SGTC_652 0437-0092 4.93 114.0 µM 7.26E-8 2 4.13E-7
3 SGTC_2753 fluvastatin 4.85 17.1 µM 1.14E-7 azole & statin 16 6.12E-7
4 SGTC_58 0957-0393 4.53 9.0 µM 6.88E-7 cell wall 325 2.97E-6
5 SGTC_2057 5236571 4.26 38.3 µM 2.81E-6 RPP1 & pyrimidine depletion 24 1.02E-5
6 SGTC_68 0986-0284 4.23 82.8 µM 3.33E-6 57 1.19E-5
7 SGTC_818 4072-2707 4.03 53.5 µM 8.97E-6 12 2.83E-5
8 SGTC_2757 clomiphene 3.99 4.2 µM 1.07E-5 fatty acid desaturase (OLE1) 39 3.32E-5
9 SGTC_1401 3807-4679 3.94 7.6 µM 1.33E-5 tubulin folding & SWR complex 18 4.00E-5
10 SGTC_2537 larixol 3.59 68.9 µM 6.71E-5 35 1.66E-4
11 SGTC_2110 5483698 3.55 200.0 µM 7.80E-5 TSC3-RPN4 34 1.90E-4
12 SGTC_2563 tomatine 3.41 8.5 µM 1.41E-4 77 3.20E-4
13 SGTC_2408 sulbentine 3.41 18.4 µM 1.42E-4 66 3.23E-4
14 SGTC_1804 st050076 3.36 49.1 µM 1.79E-4 38 3.96E-4
15 SGTC_350 k064-0020 3.26 19.8 µM 2.67E-4 heme requiring 49 5.63E-4
16 SGTC_2182 6325192 3.24 200.0 µM 2.84E-4 Golgi 32 5.95E-4
17 SGTC_1470 k295-0292 3.22 231.0 µM 3.05E-4 37 6.33E-4
18 SGTC_2217 6934799 3.22 96.1 µM 3.08E-4 TSC3-RPN4 15 6.40E-4
19 SGTC_988 1497-1057 3.14 103.0 µM 4.17E-4 32 8.34E-4
20 SGTC_2804 7954240 3.14 19.5 µM 4.29E-4 70 8.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.30E-30 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.149 5.09E-18 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.142 1.31E-16 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.138 1.21E-15 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.133 1.14E-14 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.130 4.65E-14 YBR208C DUR1,2 hom Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
0.126 2.50E-13 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.125 3.45E-13 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.124 6.77E-13 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.121 2.07E-12 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
0.120 3.16E-12 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.118 5.82E-12 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.114 2.98E-11 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.110 1.96E-10 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.110 1.97E-10 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate