YJR102C / VPS25

Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR102C / VPS25

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-7.22|P-value:1.67E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:7.90|P-value:7.45E-10 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.73|P-value:1.47E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.68|P-value:1.74E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.09|P-value:8.71E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:7.35|P-value:9.29E-9 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:9.80|P-value:3.13E-14 ID:SGTC_117|Compound:lucigenin|FD-Score:8.90|P-value:4.81E-12 ID:SGTC_123|Compound:0083-0120|FD-Score:6.35|P-value:5.89E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:4.57|P-value:2.33E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.01|P-value:6.26E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.84|P-value:1.07E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.38|P-value:4.00E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:8.83|P-value:7.09E-12 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.90|P-value:3.21E-23 ID:SGTC_227|Compound:fluconazole|FD-Score:11.70|P-value:1.45E-19 ID:SGTC_232|Compound:clozapine|FD-Score:7.38|P-value:8.09E-9 ID:SGTC_288|Compound:1315-0019|FD-Score:4.10|P-value:8.54E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:5.39|P-value:1.86E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:12.20|P-value:3.99E-21 ID:SGTC_304|Compound:1310-0298|FD-Score:-6.26|P-value:8.27E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:-5.23|P-value:3.16E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.59|P-value:9.20E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:4.36|P-value:4.18E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.35|P-value:5.75E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:4.31|P-value:4.81E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.72|P-value:1.54E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.17|P-value:6.95E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.28|P-value:5.27E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.41|P-value:4.55E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:11.60|P-value:2.39E-19 ID:SGTC_528|Compound:3492-0019|FD-Score:7.32|P-value:1.03E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:4.82|P-value:1.11E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.16|P-value:7.27E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.77|P-value:1.36E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.08|P-value:8.97E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:8.32|P-value:9.50E-11 ID:SGTC_608|Compound:k048-0125|FD-Score:4.45|P-value:3.24E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.99|P-value:2.25E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:12.90|P-value:3.83E-23 ID:SGTC_674|Compound:0498-0004|FD-Score:5.88|P-value:3.33E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:5.27|P-value:2.75E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:10.80|P-value:9.34E-17 ID:SGTC_768|Compound:0384-0033|FD-Score:8.69|P-value:1.43E-11 ID:SGTC_769|Compound:0302-0231|FD-Score:-6.61|P-value:2.17E-7 ID:SGTC_772|Compound:k072-0172|FD-Score:-4.75|P-value:1.38E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.78|P-value:1.26E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:5.36|P-value:2.02E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:5.25|P-value:2.94E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:5.02|P-value:6.10E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:5.89|P-value:3.22E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:10.90|P-value:3.60E-17 ID:SGTC_900|Compound:1112-0045|FD-Score:4.84|P-value:1.04E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.33|P-value:4.62E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.68|P-value:1.70E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:5.30|P-value:2.43E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:7.82|P-value:1.06E-9 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.23|P-value:1.54E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.07|P-value:9.24E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:7.27|P-value:1.28E-8 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.84|P-value:8.29E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:32.00|P-value:5.23E-133 ID:SGTC_1130|Compound:3454-2858|FD-Score:14.60|P-value:2.18E-29 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.84|P-value:1.04E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.22|P-value:1.62E-8 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.56|P-value:2.41E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.44|P-value:3.37E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.94|P-value:7.84E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:-4.04|P-value:9.91E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.70|P-value:1.59E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.42|P-value:3.55E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.25|P-value:1.42E-8 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.73|P-value:1.44E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:21.60|P-value:9.63E-62 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-6.17|P-value:1.17E-6 ID:SGTC_1635|Compound:st007035|FD-Score:7.09|P-value:2.90E-8 ID:SGTC_1672|Compound:st016598|FD-Score:9.16|P-value:1.16E-12 ID:SGTC_1687|Compound:st020778|FD-Score:13.80|P-value:1.63E-26 ID:SGTC_1716|Compound:st033144|FD-Score:-4.09|P-value:8.69E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.24|P-value:5.84E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-4.39|P-value:3.88E-4 ID:SGTC_1750|Compound:st081859|FD-Score:15.50|P-value:9.96E-33 ID:SGTC_1754|Compound:st042065|FD-Score:9.99|P-value:1.00E-14 ID:SGTC_1760|Compound:st045453|FD-Score:11.50|P-value:8.48E-19 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.46|P-value:1.47E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.96|P-value:7.38E-5 ID:SGTC_1801|Compound:st050089|FD-Score:4.92|P-value:8.18E-5 ID:SGTC_1803|Compound:st050068|FD-Score:8.18|P-value:1.85E-10 ID:SGTC_1818|Compound:st052136|FD-Score:4.09|P-value:8.65E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.09|P-value:1.55E-6 ID:SGTC_1884|Compound:5633444|FD-Score:11.00|P-value:2.23E-17 ID:SGTC_1939|Compound:st074455|FD-Score:-4.65|P-value:1.88E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.10|P-value:8.49E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.86|P-value:1.00E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.63|P-value:2.01E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.20|P-value:1.02E-6 ID:SGTC_2006|Compound:4011487|FD-Score:4.45|P-value:3.31E-4 ID:SGTC_2016|Compound:5121758|FD-Score:12.00|P-value:2.36E-20 ID:SGTC_2028|Compound:5153890|FD-Score:4.78|P-value:1.27E-4 ID:SGTC_2124|Compound:5246320|FD-Score:4.39|P-value:3.82E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.60|P-value:2.15E-4 ID:SGTC_2141|Compound:5621638|FD-Score:4.36|P-value:4.17E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.65|P-value:7.53E-6 ID:SGTC_2210|Compound:7115885|FD-Score:5.37|P-value:1.98E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.22|P-value:6.09E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.03|P-value:5.93E-5 ID:SGTC_2300|Compound:7976697|FD-Score:4.45|P-value:3.26E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.12|P-value:1.38E-6 ID:SGTC_2366|Compound:9070441|FD-Score:-4.13|P-value:7.93E-4 ID:SGTC_2389|Compound:9091542|FD-Score:4.67|P-value:1.74E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.49|P-value:2.89E-4 ID:SGTC_2452|Compound:5863136|FD-Score:5.02|P-value:6.08E-5 ID:SGTC_2485|Compound:5633444|FD-Score:6.79|P-value:9.93E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.39|P-value:7.61E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.80|P-value:7.26E-34 ID:SGTC_2586|Compound:curcumin|FD-Score:5.73|P-value:5.71E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:11.00|P-value:1.39E-17 ID:SGTC_2647|Compound:atorvastatin|FD-Score:5.61|P-value:8.57E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:7.84|P-value:9.91E-10 ID:SGTC_2661|Compound:dactinomycin|FD-Score:5.14|P-value:4.14E-5 ID:SGTC_2671|Compound:danthron|FD-Score:5.12|P-value:4.37E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.66|P-value:7.35E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:12.30|P-value:2.25E-21 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:12.70|P-value:1.13E-22 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.85|P-value:3.70E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.99|P-value:4.76E-10 ID:SGTC_2756|Compound:carbadox|FD-Score:5.12|P-value:4.37E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.86|P-value:3.59E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:7.34|P-value:9.70E-9 ID:SGTC_2784|Compound:7567673|FD-Score:5.19|P-value:3.50E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.80|P-value:4.51E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-4.96|P-value:7.40E-5 ID:SGTC_2810|Compound:7959871|FD-Score:4.11|P-value:8.25E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.68|P-value:1.70E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-6.03|P-value:2.01E-6 ID:SGTC_2912|Compound:7964298|FD-Score:6.17|P-value:1.15E-6 ID:SGTC_2925|Compound:9010536|FD-Score:4.57|P-value:2.30E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-4.34|P-value:4.49E-4 ID:SGTC_2930|Compound:9013230|FD-Score:6.94|P-value:5.47E-8 ID:SGTC_2949|Compound:9072542|FD-Score:4.15|P-value:7.48E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.20|P-value:6.49E-4 ID:SGTC_2991|Compound:9074669|FD-Score:6.19|P-value:1.08E-6 ID:SGTC_3037|Compound:9091026|FD-Score:9.49|P-value:1.91E-13 ID:SGTC_3062|Compound:9077494|FD-Score:4.43|P-value:3.44E-4 ID:SGTC_3110|Compound:9122132|FD-Score:8.71|P-value:1.27E-11 ID:SGTC_3123|Compound:9126162|FD-Score:-5.42|P-value:1.66E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.61|P-value:8.75E-6 ID:SGTC_3152|Compound:9099253|FD-Score:8.91|P-value:4.45E-12 ID:SGTC_3247|Compound:9135149|FD-Score:-4.60|P-value:2.16E-4 ID:SGTC_3296|Compound:9122258|FD-Score:8.19|P-value:1.77E-10 ID:SGTC_3330|Compound:9141424|FD-Score:-6.26|P-value:8.39E-7 ID:SGTC_3335|Compound:9143315|FD-Score:-5.00|P-value:6.47E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-7.22|P-value:1.67E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:7.90|P-value:7.45E-10 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.73|P-value:1.47E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.68|P-value:1.74E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.09|P-value:8.71E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:7.35|P-value:9.29E-9 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:9.80|P-value:3.13E-14 ID:SGTC_117|Compound:lucigenin|FD-Score:8.90|P-value:4.81E-12 ID:SGTC_123|Compound:0083-0120|FD-Score:6.35|P-value:5.89E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:4.57|P-value:2.33E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.01|P-value:6.26E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.84|P-value:1.07E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.38|P-value:4.00E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:8.83|P-value:7.09E-12 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.90|P-value:3.21E-23 ID:SGTC_227|Compound:fluconazole|FD-Score:11.70|P-value:1.45E-19 ID:SGTC_232|Compound:clozapine|FD-Score:7.38|P-value:8.09E-9 ID:SGTC_288|Compound:1315-0019|FD-Score:4.10|P-value:8.54E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:5.39|P-value:1.86E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:12.20|P-value:3.99E-21 ID:SGTC_304|Compound:1310-0298|FD-Score:-6.26|P-value:8.27E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:-5.23|P-value:3.16E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.59|P-value:9.20E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:4.36|P-value:4.18E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.35|P-value:5.75E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:4.31|P-value:4.81E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.72|P-value:1.54E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.17|P-value:6.95E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.28|P-value:5.27E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.41|P-value:4.55E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:11.60|P-value:2.39E-19 ID:SGTC_528|Compound:3492-0019|FD-Score:7.32|P-value:1.03E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:4.82|P-value:1.11E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.16|P-value:7.27E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.77|P-value:1.36E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.08|P-value:8.97E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:8.32|P-value:9.50E-11 ID:SGTC_608|Compound:k048-0125|FD-Score:4.45|P-value:3.24E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.99|P-value:2.25E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:12.90|P-value:3.83E-23 ID:SGTC_674|Compound:0498-0004|FD-Score:5.88|P-value:3.33E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:5.27|P-value:2.75E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:10.80|P-value:9.34E-17 ID:SGTC_768|Compound:0384-0033|FD-Score:8.69|P-value:1.43E-11 ID:SGTC_769|Compound:0302-0231|FD-Score:-6.61|P-value:2.17E-7 ID:SGTC_772|Compound:k072-0172|FD-Score:-4.75|P-value:1.38E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.78|P-value:1.26E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:5.36|P-value:2.02E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:5.25|P-value:2.94E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:5.02|P-value:6.10E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:5.89|P-value:3.22E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:10.90|P-value:3.60E-17 ID:SGTC_900|Compound:1112-0045|FD-Score:4.84|P-value:1.04E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.33|P-value:4.62E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.68|P-value:1.70E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:5.30|P-value:2.43E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:7.82|P-value:1.06E-9 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.23|P-value:1.54E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.07|P-value:9.24E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:7.27|P-value:1.28E-8 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.84|P-value:8.29E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:32.00|P-value:5.23E-133 ID:SGTC_1130|Compound:3454-2858|FD-Score:14.60|P-value:2.18E-29 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.84|P-value:1.04E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.22|P-value:1.62E-8 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.56|P-value:2.41E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.44|P-value:3.37E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.94|P-value:7.84E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:-4.04|P-value:9.91E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.70|P-value:1.59E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.42|P-value:3.55E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.25|P-value:1.42E-8 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.73|P-value:1.44E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:21.60|P-value:9.63E-62 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-6.17|P-value:1.17E-6 ID:SGTC_1635|Compound:st007035|FD-Score:7.09|P-value:2.90E-8 ID:SGTC_1672|Compound:st016598|FD-Score:9.16|P-value:1.16E-12 ID:SGTC_1687|Compound:st020778|FD-Score:13.80|P-value:1.63E-26 ID:SGTC_1716|Compound:st033144|FD-Score:-4.09|P-value:8.69E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.24|P-value:5.84E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-4.39|P-value:3.88E-4 ID:SGTC_1750|Compound:st081859|FD-Score:15.50|P-value:9.96E-33 ID:SGTC_1754|Compound:st042065|FD-Score:9.99|P-value:1.00E-14 ID:SGTC_1760|Compound:st045453|FD-Score:11.50|P-value:8.48E-19 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.46|P-value:1.47E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.96|P-value:7.38E-5 ID:SGTC_1801|Compound:st050089|FD-Score:4.92|P-value:8.18E-5 ID:SGTC_1803|Compound:st050068|FD-Score:8.18|P-value:1.85E-10 ID:SGTC_1818|Compound:st052136|FD-Score:4.09|P-value:8.65E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.09|P-value:1.55E-6 ID:SGTC_1884|Compound:5633444|FD-Score:11.00|P-value:2.23E-17 ID:SGTC_1939|Compound:st074455|FD-Score:-4.65|P-value:1.88E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.10|P-value:8.49E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.86|P-value:1.00E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.63|P-value:2.01E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.20|P-value:1.02E-6 ID:SGTC_2006|Compound:4011487|FD-Score:4.45|P-value:3.31E-4 ID:SGTC_2016|Compound:5121758|FD-Score:12.00|P-value:2.36E-20 ID:SGTC_2028|Compound:5153890|FD-Score:4.78|P-value:1.27E-4 ID:SGTC_2124|Compound:5246320|FD-Score:4.39|P-value:3.82E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.60|P-value:2.15E-4 ID:SGTC_2141|Compound:5621638|FD-Score:4.36|P-value:4.17E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.65|P-value:7.53E-6 ID:SGTC_2210|Compound:7115885|FD-Score:5.37|P-value:1.98E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.22|P-value:6.09E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.03|P-value:5.93E-5 ID:SGTC_2300|Compound:7976697|FD-Score:4.45|P-value:3.26E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.12|P-value:1.38E-6 ID:SGTC_2366|Compound:9070441|FD-Score:-4.13|P-value:7.93E-4 ID:SGTC_2389|Compound:9091542|FD-Score:4.67|P-value:1.74E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.49|P-value:2.89E-4 ID:SGTC_2452|Compound:5863136|FD-Score:5.02|P-value:6.08E-5 ID:SGTC_2485|Compound:5633444|FD-Score:6.79|P-value:9.93E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.39|P-value:7.61E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.80|P-value:7.26E-34 ID:SGTC_2586|Compound:curcumin|FD-Score:5.73|P-value:5.71E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:11.00|P-value:1.39E-17 ID:SGTC_2647|Compound:atorvastatin|FD-Score:5.61|P-value:8.57E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:7.84|P-value:9.91E-10 ID:SGTC_2661|Compound:dactinomycin|FD-Score:5.14|P-value:4.14E-5 ID:SGTC_2671|Compound:danthron|FD-Score:5.12|P-value:4.37E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.66|P-value:7.35E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:12.30|P-value:2.25E-21 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:12.70|P-value:1.13E-22 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.85|P-value:3.70E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.99|P-value:4.76E-10 ID:SGTC_2756|Compound:carbadox|FD-Score:5.12|P-value:4.37E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.86|P-value:3.59E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:7.34|P-value:9.70E-9 ID:SGTC_2784|Compound:7567673|FD-Score:5.19|P-value:3.50E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.80|P-value:4.51E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-4.96|P-value:7.40E-5 ID:SGTC_2810|Compound:7959871|FD-Score:4.11|P-value:8.25E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.68|P-value:1.70E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-6.03|P-value:2.01E-6 ID:SGTC_2912|Compound:7964298|FD-Score:6.17|P-value:1.15E-6 ID:SGTC_2925|Compound:9010536|FD-Score:4.57|P-value:2.30E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-4.34|P-value:4.49E-4 ID:SGTC_2930|Compound:9013230|FD-Score:6.94|P-value:5.47E-8 ID:SGTC_2949|Compound:9072542|FD-Score:4.15|P-value:7.48E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.20|P-value:6.49E-4 ID:SGTC_2991|Compound:9074669|FD-Score:6.19|P-value:1.08E-6 ID:SGTC_3037|Compound:9091026|FD-Score:9.49|P-value:1.91E-13 ID:SGTC_3062|Compound:9077494|FD-Score:4.43|P-value:3.44E-4 ID:SGTC_3110|Compound:9122132|FD-Score:8.71|P-value:1.27E-11 ID:SGTC_3123|Compound:9126162|FD-Score:-5.42|P-value:1.66E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.61|P-value:8.75E-6 ID:SGTC_3152|Compound:9099253|FD-Score:8.91|P-value:4.45E-12 ID:SGTC_3247|Compound:9135149|FD-Score:-4.60|P-value:2.16E-4 ID:SGTC_3296|Compound:9122258|FD-Score:8.19|P-value:1.77E-10 ID:SGTC_3330|Compound:9141424|FD-Score:-6.26|P-value:8.39E-7 ID:SGTC_3335|Compound:9143315|FD-Score:-5.00|P-value:6.47E-5

Top fitness defect scores for YJR102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1083 didemethylchlorpromazine sulfoxide 32.00 707.4 nM 5.23E-133 redox potentiating 1 2.20E-225
2 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 21.60 54.9 µM 9.63E-62 redox potentiating 1 7.62E-104
3 SGTC_2582 agaric acid 15.80 100.0 µM 7.26E-34 redox potentiating 8 2.37E-56
4 SGTC_1750 st081859 15.50 2.4 µM 9.96E-33 endomembrane recycling 20 2.05E-54
5 SGTC_1130 3454-2858 14.60 15.9 µM 2.18E-29 NEO1 7 9.90E-49
6 SGTC_1687 st020778 13.80 55.4 µM 1.63E-26 25 7.67E-44
7 SGTC_221 trifluoperazine 12.90 10.3 µM 3.21E-23 NEO1-PIK1 32 3.06E-38
8 SGTC_670 4204-0025 12.90 119.0 µM 3.83E-23 copper-dependent oxidative stress 1 4.13E-38
9 SGTC_2697 mebhydrolin 12.70 72.4 µM 1.13E-22 NEO1 11 2.59E-37
10 SGTC_2688 kanamycin b 12.30 96.7 µM 2.25E-21 calcium & mitochondrial duress 9 4.21E-35
11 SGTC_301 4119-0100 12.20 24.5 µM 3.99E-21 NEO1 8 1.11E-34
12 SGTC_2016 5121758 12.00 140.0 µM 2.36E-20 redox potentiating 1 2.27E-33
13 SGTC_227 fluconazole 11.70 33.5 µM 1.45E-19 azole & statin 11 4.97E-32
14 SGTC_525 k781-2675 11.60 26.7 µM 2.39E-19 redox potentiating 4 1.17E-31
15 SGTC_1760 st045453 11.50 10.4 µM 8.48E-19 NEO1-PIK1 22 9.99E-31
16 SGTC_2619 obliquin 11.00 87.9 µM 1.39E-17 cell wall 17 1.15E-28
17 SGTC_1884 5633444 11.00 25.0 µM 2.23E-17 redox potentiating 9 2.57E-28
18 SGTC_888 0916-0002 10.90 7.0 µM 3.60E-17 NEO1 7 5.79E-28
19 SGTC_748 0136-0228 10.80 77.9 µM 9.34E-17 redox potentiating 9 2.92E-27
20 SGTC_1754 st042065 9.99 16.1 µM 1.00E-14 NEO1-PIK1 26 8.13E-24

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.638 0 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.615 0 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.589 7.31E-312 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.585 2.33E-307 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.527 1.62E-239 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.506 6.47E-217 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.471 2.57E-184 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.418 3.61E-142 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.395 1.55E-125 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.395 4.77E-125 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.390 6.58E-122 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.372 2.44E-110 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.371 5.66E-110 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.365 4.01E-106 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.361 7.81E-104 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance