YJR104C / SOD1

Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR104C / SOD1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-5.28|P-value:1.46E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:10.60|P-value:8.22E-13 ID:SGTC_55|Compound:0767-0285|FD-Score:6.90|P-value:2.22E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:6.64|P-value:5.03E-6 ID:SGTC_106|Compound:0092-0003|FD-Score:9.53|P-value:9.98E-11 ID:SGTC_115|Compound:0527-0192|FD-Score:-5.28|P-value:1.48E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:8.05|P-value:4.05E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:11.20|P-value:4.24E-14 ID:SGTC_141|Compound:0443-0274|FD-Score:11.50|P-value:6.48E-15 ID:SGTC_148|Compound:3253-0744|FD-Score:8.14|P-value:2.92E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:8.00|P-value:4.95E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:9.39|P-value:1.85E-10 ID:SGTC_162|Compound:k030-0015|FD-Score:4.87|P-value:6.38E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:7.34|P-value:5.09E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:7.03|P-value:1.47E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.52|P-value:1.28E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.93|P-value:5.61E-4 ID:SGTC_394|Compound:menadione|FD-Score:6.36|P-value:1.20E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-5.40|P-value:1.05E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:6.70|P-value:4.25E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:7.13|P-value:1.04E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.74|P-value:3.67E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:5.85|P-value:5.26E-5 ID:SGTC_458|Compound:nppb|FD-Score:6.22|P-value:1.81E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.80|P-value:7.62E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.09|P-value:3.79E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:6.37|P-value:1.18E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.59|P-value:7.91E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.89|P-value:4.72E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:5.62|P-value:9.72E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:5.37|P-value:1.87E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.92|P-value:2.06E-6 ID:SGTC_858|Compound:0438-0351|FD-Score:4.97|P-value:5.05E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:5.75|P-value:6.87E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:6.34|P-value:1.27E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:10.20|P-value:5.04E-12 ID:SGTC_1001|Compound:4048-4355|FD-Score:6.48|P-value:8.34E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:6.43|P-value:9.74E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:9.53|P-value:9.91E-11 ID:SGTC_1081|Compound:sertraline|FD-Score:4.84|P-value:6.93E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.21|P-value:1.88E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:5.74|P-value:7.08E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.92|P-value:4.33E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:6.53|P-value:7.22E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.06|P-value:2.56E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.45|P-value:1.52E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.01|P-value:2.87E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.99|P-value:4.82E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.96|P-value:5.12E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:7.33|P-value:5.27E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-4.89|P-value:3.95E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:6.35|P-value:1.25E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:5.14|P-value:3.36E-4 ID:SGTC_1629|Compound:st005085|FD-Score:6.65|P-value:4.93E-6 ID:SGTC_1634|Compound:st006576|FD-Score:5.66|P-value:8.78E-5 ID:SGTC_1635|Compound:st007035|FD-Score:10.40|P-value:2.11E-12 ID:SGTC_1643|Compound:st009866|FD-Score:6.39|P-value:1.10E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:7.36|P-value:4.75E-7 ID:SGTC_1763|Compound:st044482|FD-Score:5.00|P-value:4.69E-4 ID:SGTC_1891|Compound:st059073|FD-Score:6.21|P-value:1.88E-5 ID:SGTC_1972|Compound:st070201|FD-Score:5.47|P-value:1.45E-4 ID:SGTC_2054|Compound:5233173|FD-Score:5.25|P-value:2.57E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.78|P-value:7.97E-4 ID:SGTC_2080|Compound:5212524|FD-Score:8.71|P-value:3.12E-9 ID:SGTC_2090|Compound:5301565|FD-Score:4.72|P-value:8.97E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:5.79|P-value:6.16E-5 ID:SGTC_2171|Compound:5739187|FD-Score:8.62|P-value:4.46E-9 ID:SGTC_2196|Compound:6573537|FD-Score:6.37|P-value:1.15E-5 ID:SGTC_2253|Compound:7938677|FD-Score:-4.82|P-value:4.60E-4 ID:SGTC_2259|Compound:7964009|FD-Score:12.30|P-value:1.07E-16 ID:SGTC_2266|Compound:7929956|FD-Score:7.70|P-value:1.48E-7 ID:SGTC_2269|Compound:7935389|FD-Score:4.69|P-value:9.69E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.60|P-value:7.74E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.71|P-value:9.23E-4 ID:SGTC_2284|Compound:7945075|FD-Score:5.31|P-value:2.19E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.78|P-value:6.38E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-5.36|P-value:1.17E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.95|P-value:5.37E-4 ID:SGTC_2398|Compound:5228213|FD-Score:7.81|P-value:9.96E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.12|P-value:3.12E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:8.85|P-value:1.76E-9 ID:SGTC_2430|Compound:5571206|FD-Score:7.25|P-value:6.98E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:14.60|P-value:7.44E-23 ID:SGTC_2526|Compound:patulin|FD-Score:5.84|P-value:5.38E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:6.05|P-value:3.01E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-7.12|P-value:5.72E-7 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.68|P-value:9.85E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:17.80|P-value:5.37E-33 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:12.40|P-value:4.22E-17 ID:SGTC_2671|Compound:danthron|FD-Score:8.86|P-value:1.73E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.87|P-value:4.14E-4 ID:SGTC_2681|Compound:menadione|FD-Score:9.05|P-value:7.76E-10 ID:SGTC_2682|Compound:pyrogallin|FD-Score:6.61|P-value:5.57E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.04|P-value:3.06E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.43|P-value:3.78E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:6.52|P-value:7.27E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:9.14|P-value:5.45E-10 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.59|P-value:1.05E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.71|P-value:9.31E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.12|P-value:3.55E-4 ID:SGTC_2966|Compound:9084041|FD-Score:5.58|P-value:1.07E-4 ID:SGTC_2967|Compound:9089538|FD-Score:8.34|P-value:1.36E-8 ID:SGTC_3062|Compound:9077494|FD-Score:6.90|P-value:2.26E-6 ID:SGTC_3114|Compound:9122766|FD-Score:5.43|P-value:1.61E-4 ID:SGTC_3119|Compound:9125183|FD-Score:6.42|P-value:9.89E-6 ID:SGTC_3166|Compound:9102297|FD-Score:5.78|P-value:6.26E-5 ID:SGTC_3190|Compound:9110366|FD-Score:5.56|P-value:1.15E-4 ID:SGTC_3197|Compound:9113331|FD-Score:5.58|P-value:1.09E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.28|P-value:1.46E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:10.60|P-value:8.22E-13 ID:SGTC_55|Compound:0767-0285|FD-Score:6.90|P-value:2.22E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:6.64|P-value:5.03E-6 ID:SGTC_106|Compound:0092-0003|FD-Score:9.53|P-value:9.98E-11 ID:SGTC_115|Compound:0527-0192|FD-Score:-5.28|P-value:1.48E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:8.05|P-value:4.05E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:11.20|P-value:4.24E-14 ID:SGTC_141|Compound:0443-0274|FD-Score:11.50|P-value:6.48E-15 ID:SGTC_148|Compound:3253-0744|FD-Score:8.14|P-value:2.92E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:8.00|P-value:4.95E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:9.39|P-value:1.85E-10 ID:SGTC_162|Compound:k030-0015|FD-Score:4.87|P-value:6.38E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:7.34|P-value:5.09E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:7.03|P-value:1.47E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.52|P-value:1.28E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.93|P-value:5.61E-4 ID:SGTC_394|Compound:menadione|FD-Score:6.36|P-value:1.20E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-5.40|P-value:1.05E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:6.70|P-value:4.25E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:7.13|P-value:1.04E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.74|P-value:3.67E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:5.85|P-value:5.26E-5 ID:SGTC_458|Compound:nppb|FD-Score:6.22|P-value:1.81E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.80|P-value:7.62E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.09|P-value:3.79E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:6.37|P-value:1.18E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.59|P-value:7.91E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.89|P-value:4.72E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:5.62|P-value:9.72E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:5.37|P-value:1.87E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.92|P-value:2.06E-6 ID:SGTC_858|Compound:0438-0351|FD-Score:4.97|P-value:5.05E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:5.75|P-value:6.87E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:6.34|P-value:1.27E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:10.20|P-value:5.04E-12 ID:SGTC_1001|Compound:4048-4355|FD-Score:6.48|P-value:8.34E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:6.43|P-value:9.74E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:9.53|P-value:9.91E-11 ID:SGTC_1081|Compound:sertraline|FD-Score:4.84|P-value:6.93E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.21|P-value:1.88E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:5.74|P-value:7.08E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.92|P-value:4.33E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:6.53|P-value:7.22E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.06|P-value:2.56E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.45|P-value:1.52E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.01|P-value:2.87E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.99|P-value:4.82E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.96|P-value:5.12E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:7.33|P-value:5.27E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-4.89|P-value:3.95E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:6.35|P-value:1.25E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:5.14|P-value:3.36E-4 ID:SGTC_1629|Compound:st005085|FD-Score:6.65|P-value:4.93E-6 ID:SGTC_1634|Compound:st006576|FD-Score:5.66|P-value:8.78E-5 ID:SGTC_1635|Compound:st007035|FD-Score:10.40|P-value:2.11E-12 ID:SGTC_1643|Compound:st009866|FD-Score:6.39|P-value:1.10E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:7.36|P-value:4.75E-7 ID:SGTC_1763|Compound:st044482|FD-Score:5.00|P-value:4.69E-4 ID:SGTC_1891|Compound:st059073|FD-Score:6.21|P-value:1.88E-5 ID:SGTC_1972|Compound:st070201|FD-Score:5.47|P-value:1.45E-4 ID:SGTC_2054|Compound:5233173|FD-Score:5.25|P-value:2.57E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.78|P-value:7.97E-4 ID:SGTC_2080|Compound:5212524|FD-Score:8.71|P-value:3.12E-9 ID:SGTC_2090|Compound:5301565|FD-Score:4.72|P-value:8.97E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:5.79|P-value:6.16E-5 ID:SGTC_2171|Compound:5739187|FD-Score:8.62|P-value:4.46E-9 ID:SGTC_2196|Compound:6573537|FD-Score:6.37|P-value:1.15E-5 ID:SGTC_2253|Compound:7938677|FD-Score:-4.82|P-value:4.60E-4 ID:SGTC_2259|Compound:7964009|FD-Score:12.30|P-value:1.07E-16 ID:SGTC_2266|Compound:7929956|FD-Score:7.70|P-value:1.48E-7 ID:SGTC_2269|Compound:7935389|FD-Score:4.69|P-value:9.69E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.60|P-value:7.74E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.71|P-value:9.23E-4 ID:SGTC_2284|Compound:7945075|FD-Score:5.31|P-value:2.19E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.78|P-value:6.38E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-5.36|P-value:1.17E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.95|P-value:5.37E-4 ID:SGTC_2398|Compound:5228213|FD-Score:7.81|P-value:9.96E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.12|P-value:3.12E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:8.85|P-value:1.76E-9 ID:SGTC_2430|Compound:5571206|FD-Score:7.25|P-value:6.98E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:14.60|P-value:7.44E-23 ID:SGTC_2526|Compound:patulin|FD-Score:5.84|P-value:5.38E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:6.05|P-value:3.01E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-7.12|P-value:5.72E-7 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.68|P-value:9.85E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:17.80|P-value:5.37E-33 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:12.40|P-value:4.22E-17 ID:SGTC_2671|Compound:danthron|FD-Score:8.86|P-value:1.73E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.87|P-value:4.14E-4 ID:SGTC_2681|Compound:menadione|FD-Score:9.05|P-value:7.76E-10 ID:SGTC_2682|Compound:pyrogallin|FD-Score:6.61|P-value:5.57E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.04|P-value:3.06E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.43|P-value:3.78E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:6.52|P-value:7.27E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:9.14|P-value:5.45E-10 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.59|P-value:1.05E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.71|P-value:9.31E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.12|P-value:3.55E-4 ID:SGTC_2966|Compound:9084041|FD-Score:5.58|P-value:1.07E-4 ID:SGTC_2967|Compound:9089538|FD-Score:8.34|P-value:1.36E-8 ID:SGTC_3062|Compound:9077494|FD-Score:6.90|P-value:2.26E-6 ID:SGTC_3114|Compound:9122766|FD-Score:5.43|P-value:1.61E-4 ID:SGTC_3119|Compound:9125183|FD-Score:6.42|P-value:9.89E-6 ID:SGTC_3166|Compound:9102297|FD-Score:5.78|P-value:6.26E-5 ID:SGTC_3190|Compound:9110366|FD-Score:5.56|P-value:1.15E-4 ID:SGTC_3197|Compound:9113331|FD-Score:5.58|P-value:1.09E-4

Top fitness defect scores for YJR104C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2575 plumbagin 17.80 510.0 nM 5.37E-33 superoxide 2 7.48E-71
2 SGTC_2507 purpurin 14.60 79.7 µM 7.44E-23 copper-dependent oxidative stress 3 1.65E-48
3 SGTC_2617 dihydrotanshinone i 12.40 20.8 µM 4.22E-17 copper-dependent oxidative stress 2 7.66E-36
4 SGTC_2259 7964009 12.30 200.0 µM 1.07E-16 superoxide 2 5.89E-35
5 SGTC_141 0443-0274 11.50 32.3 µM 6.48E-15 mitochondrial response to ROS 3 4.94E-31
6 SGTC_134 0269-0018 11.20 6.9 µM 4.24E-14 33 3.07E-29
7 SGTC_46 0329-0187a 10.60 2.2 µM 8.22E-13 6 2.08E-26
8 SGTC_1635 st007035 10.40 42.4 µM 2.11E-12 71 1.65E-25
9 SGTC_1000 4048-0884 10.20 8.7 µM 5.04E-12 copper-dependent oxidative stress 1 1.11E-24
10 SGTC_1058 3448-5425 9.53 97.3 µM 9.91E-11 4 7.72E-22
11 SGTC_106 0092-0003 9.53 11.6 µM 9.98E-11 copper-dependent oxidative stress 2 7.84E-22
12 SGTC_156 3474-0145 9.39 5.6 µM 1.85E-10 endomembrane recycling 7 3.02E-21
13 SGTC_2751 anetholtrithion 9.14 17.2 µM 5.45E-10 2 3.25E-20
14 SGTC_2681 menadione 9.05 3.2 µM 7.76E-10 superoxide 7 7.05E-20
15 SGTC_2671 danthron 8.86 100.0 µM 1.73E-9 DNA damage response 4 4.11E-19
16 SGTC_2408 sulbentine 8.85 18.4 µM 1.76E-9 9 4.26E-19
17 SGTC_2080 5212524 8.71 12.4 µM 3.12E-9 copper-dependent oxidative stress 2 1.49E-18
18 SGTC_2171 5739187 8.62 198.1 µM 4.46E-9 copper-dependent oxidative stress 3 3.26E-18
19 SGTC_2967 9089538 8.34 49.9 µM 1.36E-8 3 3.73E-17
20 SGTC_148 3253-0744 8.14 288.0 µM 2.92E-8 3 2.00E-16

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Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.509 6.05E-220 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.339 1.21E-90 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.266 1.59E-55 YPR124W CTR1 hom High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
0.263 5.69E-54 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.261 3.26E-53 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.227 1.71E-40 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.227 1.46E-40 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.199 2.37E-31 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.199 2.88E-31 YOR209C NPT1 hom Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
0.182 2.08E-26 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.181 4.39E-26 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.180 9.04E-26 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.152 8.41E-19 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.139 5.42E-16 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.138 1.10E-15 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis