YJR105W / ADO1

Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR105W / ADO1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:4.58|P-value:3.10E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:6.33|P-value:1.14E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:4.20|P-value:8.61E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:4.75|P-value:1.95E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:4.16|P-value:9.53E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.39|P-value:5.30E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:8.03|P-value:9.72E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.39|P-value:5.08E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:6.83|P-value:1.71E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.80|P-value:4.56E-19 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:13.50|P-value:4.19E-24 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.89|P-value:1.31E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.43|P-value:4.73E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.14|P-value:6.19E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:6.05|P-value:3.05E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.65|P-value:2.50E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.87|P-value:1.37E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.28|P-value:4.08E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.82|P-value:2.38E-9 ID:SGTC_408|Compound:cantharidin|FD-Score:6.56|P-value:4.85E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:8.35|P-value:2.25E-10 ID:SGTC_439|Compound:amiodarone|FD-Score:4.32|P-value:6.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.99|P-value:8.60E-12 ID:SGTC_679|Compound:0422-0091|FD-Score:5.64|P-value:1.26E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:4.63|P-value:2.74E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:4.16|P-value:9.37E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.21|P-value:8.46E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.29|P-value:1.32E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:5.26|P-value:4.33E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.29|P-value:6.82E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.89|P-value:1.31E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:5.26|P-value:4.21E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:10.10|P-value:2.30E-14 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.26|P-value:7.42E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.79|P-value:7.54E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:8.65|P-value:4.99E-11 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.56|P-value:3.29E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.62|P-value:1.37E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.22|P-value:8.07E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-4.72|P-value:2.04E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:-4.96|P-value:1.02E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.71|P-value:2.20E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.41|P-value:5.00E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.28|P-value:7.05E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:5.01|P-value:9.25E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.68|P-value:2.36E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.89|P-value:1.31E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.32|P-value:6.07E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-4.52|P-value:3.52E-4 ID:SGTC_1750|Compound:st081859|FD-Score:15.40|P-value:8.00E-31 ID:SGTC_1862|Compound:st057513|FD-Score:4.44|P-value:4.55E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.65|P-value:2.57E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.71|P-value:2.19E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.71|P-value:2.19E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.37|P-value:5.49E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.72|P-value:2.14E-4 ID:SGTC_2211|Compound:7117706|FD-Score:6.28|P-value:1.35E-6 ID:SGTC_2245|Compound:6637752|FD-Score:7.55|P-value:8.45E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.65|P-value:2.84E-13 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.44|P-value:2.41E-5 ID:SGTC_2335|Compound:9018011|FD-Score:6.24|P-value:1.59E-6 ID:SGTC_2370|Compound:9071495|FD-Score:11.00|P-value:1.18E-16 ID:SGTC_2402|Compound:5553605|FD-Score:4.26|P-value:7.30E-4 ID:SGTC_2403|Compound:6032726|FD-Score:5.79|P-value:7.65E-6 ID:SGTC_2411|Compound:st077133|FD-Score:7.89|P-value:1.89E-9 ID:SGTC_2429|Compound:5902844|FD-Score:8.30|P-value:2.75E-10 ID:SGTC_2489|Compound:cantharidin|FD-Score:6.87|P-value:1.43E-7 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.77|P-value:1.84E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:8.05|P-value:9.12E-10 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.14|P-value:9.96E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.64|P-value:2.64E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.13|P-value:9.83E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:10.10|P-value:2.62E-14 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.26|P-value:7.33E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.26|P-value:7.38E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.87|P-value:1.38E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.19|P-value:8.46E-4 ID:SGTC_2948|Compound:9070189|FD-Score:5.07|P-value:7.59E-5 ID:SGTC_3047|Compound:9092122|FD-Score:4.97|P-value:1.02E-4 ID:SGTC_3053|Compound:9095903|FD-Score:4.78|P-value:1.81E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.96|P-value:1.07E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.28|P-value:6.92E-4 ID:SGTC_3101|Compound:9120531|FD-Score:5.39|P-value:2.80E-5 ID:SGTC_3103|Compound:9120822|FD-Score:5.58|P-value:1.54E-5 ID:SGTC_3126|Compound:9127922|FD-Score:6.59|P-value:4.29E-7 ID:SGTC_3212|Compound:9128307|FD-Score:4.21|P-value:8.36E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-4.97|P-value:9.90E-5 ID:SGTC_3245|Compound:9134821|FD-Score:5.01|P-value:9.18E-5 ID:SGTC_3308|Compound:9128332|FD-Score:7.09|P-value:5.93E-8 ID:SGTC_25|Compound:0118-0223|FD-Score:4.58|P-value:3.10E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:6.33|P-value:1.14E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:4.20|P-value:8.61E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:4.75|P-value:1.95E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:4.16|P-value:9.53E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.39|P-value:5.30E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:8.03|P-value:9.72E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.39|P-value:5.08E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:6.83|P-value:1.71E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.80|P-value:4.56E-19 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:13.50|P-value:4.19E-24 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.89|P-value:1.31E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.43|P-value:4.73E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.14|P-value:6.19E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:6.05|P-value:3.05E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.65|P-value:2.50E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.87|P-value:1.37E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.28|P-value:4.08E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.82|P-value:2.38E-9 ID:SGTC_408|Compound:cantharidin|FD-Score:6.56|P-value:4.85E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:8.35|P-value:2.25E-10 ID:SGTC_439|Compound:amiodarone|FD-Score:4.32|P-value:6.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.99|P-value:8.60E-12 ID:SGTC_679|Compound:0422-0091|FD-Score:5.64|P-value:1.26E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:4.63|P-value:2.74E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:4.16|P-value:9.37E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.21|P-value:8.46E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.29|P-value:1.32E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:5.26|P-value:4.33E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.29|P-value:6.82E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.89|P-value:1.31E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:5.26|P-value:4.21E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:10.10|P-value:2.30E-14 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.26|P-value:7.42E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.79|P-value:7.54E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:8.65|P-value:4.99E-11 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.56|P-value:3.29E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.62|P-value:1.37E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.22|P-value:8.07E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-4.72|P-value:2.04E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:-4.96|P-value:1.02E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.71|P-value:2.20E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.41|P-value:5.00E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.28|P-value:7.05E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:5.01|P-value:9.25E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.68|P-value:2.36E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.89|P-value:1.31E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.32|P-value:6.07E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-4.52|P-value:3.52E-4 ID:SGTC_1750|Compound:st081859|FD-Score:15.40|P-value:8.00E-31 ID:SGTC_1862|Compound:st057513|FD-Score:4.44|P-value:4.55E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.65|P-value:2.57E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.71|P-value:2.19E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.71|P-value:2.19E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.37|P-value:5.49E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.72|P-value:2.14E-4 ID:SGTC_2211|Compound:7117706|FD-Score:6.28|P-value:1.35E-6 ID:SGTC_2245|Compound:6637752|FD-Score:7.55|P-value:8.45E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.65|P-value:2.84E-13 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.44|P-value:2.41E-5 ID:SGTC_2335|Compound:9018011|FD-Score:6.24|P-value:1.59E-6 ID:SGTC_2370|Compound:9071495|FD-Score:11.00|P-value:1.18E-16 ID:SGTC_2402|Compound:5553605|FD-Score:4.26|P-value:7.30E-4 ID:SGTC_2403|Compound:6032726|FD-Score:5.79|P-value:7.65E-6 ID:SGTC_2411|Compound:st077133|FD-Score:7.89|P-value:1.89E-9 ID:SGTC_2429|Compound:5902844|FD-Score:8.30|P-value:2.75E-10 ID:SGTC_2489|Compound:cantharidin|FD-Score:6.87|P-value:1.43E-7 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.77|P-value:1.84E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:8.05|P-value:9.12E-10 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.14|P-value:9.96E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.64|P-value:2.64E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.13|P-value:9.83E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:10.10|P-value:2.62E-14 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.26|P-value:7.33E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.26|P-value:7.38E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.87|P-value:1.38E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.19|P-value:8.46E-4 ID:SGTC_2948|Compound:9070189|FD-Score:5.07|P-value:7.59E-5 ID:SGTC_3047|Compound:9092122|FD-Score:4.97|P-value:1.02E-4 ID:SGTC_3053|Compound:9095903|FD-Score:4.78|P-value:1.81E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.96|P-value:1.07E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.28|P-value:6.92E-4 ID:SGTC_3101|Compound:9120531|FD-Score:5.39|P-value:2.80E-5 ID:SGTC_3103|Compound:9120822|FD-Score:5.58|P-value:1.54E-5 ID:SGTC_3126|Compound:9127922|FD-Score:6.59|P-value:4.29E-7 ID:SGTC_3212|Compound:9128307|FD-Score:4.21|P-value:8.36E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-4.97|P-value:9.90E-5 ID:SGTC_3245|Compound:9134821|FD-Score:5.01|P-value:9.18E-5 ID:SGTC_3308|Compound:9128332|FD-Score:7.09|P-value:5.93E-8

Top fitness defect scores for YJR105W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 15.40 2.4 µM 8.00E-31 endomembrane recycling 21 1.45E-53
2 SGTC_241 5hr heat shock (37°C) + cantharidin 13.50 155.4 µM 4.19E-24 cell wall signaling 7 1.38E-41
3 SGTC_221 trifluoperazine 11.80 10.3 µM 4.56E-19 NEO1-PIK1 39 1.28E-32
4 SGTC_2370 9071495 11.00 200.0 µM 1.18E-16 mitochondrial processes 2 2.49E-28
5 SGTC_1130 3454-2858 10.10 15.9 µM 2.30E-14 NEO1 15 2.96E-24
6 SGTC_2725 haloperidol 10.10 53.2 µM 2.62E-14 plasma membrane duress 12 3.71E-24
7 SGTC_2249 haloperidol 9.65 116.4 µM 2.84E-13 ergosterol depletion effects on membrane 16 2.56E-22
8 SGTC_1235 benzylparaben 8.65 21.5 µM 4.99E-11 1 2.46E-18
9 SGTC_422 cantharidin 8.35 155.0 µM 2.25E-10 cell wall signaling 8 3.53E-17
10 SGTC_2429 5902844 8.30 64.4 µM 2.75E-10 3 5.05E-17
11 SGTC_2565 isoliquiritigenin 8.05 100.0 µM 9.12E-10 3 4.23E-16
12 SGTC_207 4185-0010 8.03 4.5 µM 9.72E-10 endomembrane recycling 25 4.73E-16
13 SGTC_2411 st077133 7.89 39.9 µM 1.89E-9 RNA pol III & RNase P/MRP 4 1.54E-15
14 SGTC_2245 6637752 7.55 200.0 µM 8.45E-9 3 2.17E-14
15 SGTC_3308 9128332 7.09 17.6 µM 5.93E-8 plasma membrane duress 32 6.78E-13
16 SGTC_2489 cantharidin 6.87 73.4 µM 1.43E-7 cell wall signaling 4 3.20E-12
17 SGTC_218 alverine citrate 6.83 93.8 µM 1.71E-7 fatty acid desaturase (OLE1) 8 4.37E-12
18 SGTC_3126 9127922 6.59 49.5 µM 4.29E-7 fatty acid desaturase (OLE1) 15 2.23E-11
19 SGTC_408 cantharidin 6.56 100.0 µM 4.85E-7 cell wall signaling 7 2.76E-11
20 SGTC_66 0109-0187 6.33 42.4 µM 1.14E-6 10 1.24E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.323 4.67E-82 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.316 2.31E-78 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.315 4.55E-78 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.289 2.13E-65 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.284 6.09E-63 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.272 1.23E-57 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.268 4.37E-56 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.268 8.44E-56 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.259 1.64E-52 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.249 1.88E-48 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.248 3.43E-48 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.247 1.01E-47 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.246 2.47E-47 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.240 6.21E-45 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.235 3.13E-43 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data