HIPHOP chemogenomics database
YJR105W / ADO1 
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YJR105W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.323 | 4.67E-82 | YFL034W_p | YFL034W_p | hom | Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk |
| 0.316 | 2.31E-78 | YKL135C | APL2 | hom | Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress |
| 0.315 | 4.55E-78 | YHL019C | APM2 | hom | Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport |
| 0.289 | 2.13E-65 | YDL226C | GCS1 | hom | ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p |
| 0.284 | 6.09E-63 | YLR170C | APS1 | hom | Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex |
| 0.272 | 1.23E-57 | YPR029C | APL4 | hom | Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport |
| 0.268 | 4.37E-56 | YJL204C | RCY1 | hom | F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth |
| 0.268 | 8.44E-56 | YJL207C | LAA1 | hom | AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene |
| 0.259 | 1.64E-52 | YLR169W_d | YLR169W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.249 | 1.88E-48 | YER031C | YPT31 | hom | Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication |
| 0.248 | 3.43E-48 | YML037C_p | YML037C_p | hom | Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene |
| 0.247 | 1.01E-47 | YMR071C | TVP18 | hom | Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments |
| 0.246 | 2.47E-47 | YOR039W | CKB2 | hom | Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase |
| 0.240 | 6.21E-45 | YGL019W | CKB1 | hom | Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases |
| 0.235 | 3.13E-43 | YLR171W_d | YLR171W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |