YJR109C / CPA2

Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR109C / CPA2

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.77|P-value:2.09E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.99|P-value:5.96E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.21|P-value:5.94E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:4.11|P-value:3.34E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:4.80|P-value:7.25E-8 ID:SGTC_194|Compound:1486-1323|FD-Score:3.00|P-value:4.90E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.22|P-value:2.04E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.98|P-value:5.38E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-2.86|P-value:9.68E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:2.95|P-value:5.93E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.38|P-value:1.04E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.15|P-value:3.15E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.02|P-value:4.64E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.94|P-value:6.27E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.82|P-value:1.65E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.26|P-value:1.97E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.29|P-value:1.31E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.93|P-value:8.11E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.51|P-value:5.93E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.67|P-value:2.83E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.00|P-value:5.56E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.21|P-value:2.47E-4 ID:SGTC_1618|Compound:st003135|FD-Score:2.90|P-value:7.34E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.02|P-value:4.56E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.95|P-value:5.97E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-2.86|P-value:9.65E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.91|P-value:1.08E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-3.93|P-value:9.72E-6 ID:SGTC_1991|Compound:st073000|FD-Score:-2.90|P-value:8.29E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.07|P-value:3.71E-4 ID:SGTC_2101|Compound:5377231|FD-Score:4.15|P-value:2.68E-6 ID:SGTC_2243|Compound:6634756|FD-Score:3.11|P-value:3.23E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.42|P-value:8.68E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.16|P-value:2.99E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.25|P-value:1.86E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-5.96|P-value:4.24E-11 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.78|P-value:1.99E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-5.02|P-value:2.39E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.26|P-value:2.00E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.60|P-value:4.51E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.67|P-value:3.28E-5 ID:SGTC_2822|Compound:7994718|FD-Score:-2.96|P-value:6.56E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-2.91|P-value:7.81E-4 ID:SGTC_3024|Compound:9090631|FD-Score:3.56|P-value:4.72E-5 ID:SGTC_3268|Compound:9137683|FD-Score:-3.10|P-value:3.87E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.81|P-value:1.69E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.08|P-value:3.60E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.77|P-value:2.09E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.99|P-value:5.96E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.21|P-value:5.94E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:4.11|P-value:3.34E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:4.80|P-value:7.25E-8 ID:SGTC_194|Compound:1486-1323|FD-Score:3.00|P-value:4.90E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.22|P-value:2.04E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.98|P-value:5.38E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-2.86|P-value:9.68E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:2.95|P-value:5.93E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.38|P-value:1.04E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.15|P-value:3.15E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.02|P-value:4.64E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.94|P-value:6.27E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.82|P-value:1.65E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.26|P-value:1.97E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.29|P-value:1.31E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.93|P-value:8.11E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.51|P-value:5.93E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.67|P-value:2.83E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.00|P-value:5.56E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.21|P-value:2.47E-4 ID:SGTC_1618|Compound:st003135|FD-Score:2.90|P-value:7.34E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.02|P-value:4.56E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.95|P-value:5.97E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-2.86|P-value:9.65E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.91|P-value:1.08E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-3.93|P-value:9.72E-6 ID:SGTC_1991|Compound:st073000|FD-Score:-2.90|P-value:8.29E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.07|P-value:3.71E-4 ID:SGTC_2101|Compound:5377231|FD-Score:4.15|P-value:2.68E-6 ID:SGTC_2243|Compound:6634756|FD-Score:3.11|P-value:3.23E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.42|P-value:8.68E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.16|P-value:2.99E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.25|P-value:1.86E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-5.96|P-value:4.24E-11 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.78|P-value:1.99E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-5.02|P-value:2.39E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.26|P-value:2.00E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.60|P-value:4.51E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.67|P-value:3.28E-5 ID:SGTC_2822|Compound:7994718|FD-Score:-2.96|P-value:6.56E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-2.91|P-value:7.81E-4 ID:SGTC_3024|Compound:9090631|FD-Score:3.56|P-value:4.72E-5 ID:SGTC_3268|Compound:9137683|FD-Score:-3.10|P-value:3.87E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.81|P-value:1.69E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.08|P-value:3.60E-4

Top fitness defect scores for YJR109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_54 0159-0055 5.21 9.0 µM 5.94E-9 ERG2 27 9.66E-8
2 SGTC_180 1486-1293 4.80 102.8 µM 7.25E-8 24 7.92E-7
3 SGTC_1206 3978-0017 4.29 132.0 µM 1.31E-6 ERG2 25 9.07E-6
4 SGTC_2101 5377231 4.15 179.2 µM 2.68E-6 6 1.65E-5
5 SGTC_64 000l-0018 4.11 272.1 µM 3.34E-6 ubiquinone biosynthesis & proteasome 140 1.99E-5
6 SGTC_1227 3909-8010 3.93 46.6 µM 8.11E-6 20 4.20E-5
7 SGTC_1288 0973-0013 3.67 65.5 µM 2.83E-5 24 1.21E-4
8 SGTC_3024 9090631 3.56 49.5 µM 4.72E-5 13 1.86E-4
9 SGTC_1231 0242-0792 3.51 125.0 µM 5.93E-5 28 2.25E-4
10 SGTC_2332 7982454 3.42 138.9 µM 8.68E-5 77 3.10E-4
11 SGTC_816 0325-0417 3.38 81.3 µM 1.04E-4 24 3.62E-4
12 SGTC_353 1988-1175 3.22 58.3 µM 2.04E-4 unfolded protein response 45 6.37E-4
13 SGTC_2243 6634756 3.11 200.0 µM 3.23E-4 43 9.41E-4
14 SGTC_3304 9125678 3.08 46.1 µM 3.60E-4 92 0.00103
15 SGTC_1996 st072960 3.07 66.8 µM 3.71E-4 49 0.00106
16 SGTC_1626 st003712 3.02 1.8 µM 4.56E-4 64 0.00126
17 SGTC_1002 4049-0206 3.02 172.0 µM 4.64E-4 90 0.00128
18 SGTC_194 1486-1323 3.00 56.9 µM 4.90E-4 45 0.00134
19 SGTC_362 0310-0100 2.98 9.0 µM 5.38E-4 RPP1 & pyrimidine depletion 85 0.00145
20 SGTC_619 1652-1634 2.95 108.0 µM 5.93E-4 PDR1 65 0.00157

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.40E-15 YOL058W ARG1 hom Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
0.130 4.14E-14 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.122 1.37E-12 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.122 1.49E-12 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.116 1.72E-11 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.113 5.28E-11 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.111 1.14E-10 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.109 2.48E-10 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.107 5.88E-10 YHR018C ARG4 hom Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
0.102 2.79E-9 YLR392C ART10 hom Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene
0.101 5.47E-9 YJR134C SGM1 hom Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
0.094 5.64E-8 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.092 9.05E-8 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.089 2.43E-7 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.089 2.79E-7 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene