YJR110W / YMR1

Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR110W / YMR1

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-3.19|P-value:7.19E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.20|P-value:6.91E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.11|P-value:9.37E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.53|P-value:2.08E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.65|P-value:1.35E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.12|P-value:9.00E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.14|P-value:8.74E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.10|P-value:9.82E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.78|P-value:8.22E-5 ID:SGTC_1531|Compound:st059297|FD-Score:-3.36|P-value:3.95E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.56|P-value:1.89E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.06|P-value:2.49E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.32|P-value:4.60E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.90|P-value:1.94E-9 ID:SGTC_1842|Compound:st055362|FD-Score:4.28|P-value:9.74E-6 ID:SGTC_1958|Compound:st076513|FD-Score:-4.38|P-value:6.10E-6 ID:SGTC_2005|Compound:4024620|FD-Score:3.26|P-value:5.53E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.13|P-value:8.95E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.13|P-value:8.83E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.33|P-value:4.43E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.40|P-value:3.38E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.14|P-value:8.46E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.31|P-value:4.69E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.11|P-value:9.59E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.76|P-value:8.77E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.11|P-value:9.56E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.32|P-value:4.64E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.40|P-value:5.52E-6 ID:SGTC_3299|Compound:9121982|FD-Score:-6.50|P-value:4.24E-11 ID:SGTC_3310|Compound:9130229|FD-Score:-3.21|P-value:6.88E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.19|P-value:7.19E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.20|P-value:6.91E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.11|P-value:9.37E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.53|P-value:2.08E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.65|P-value:1.35E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.12|P-value:9.00E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.14|P-value:8.74E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.10|P-value:9.82E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.78|P-value:8.22E-5 ID:SGTC_1531|Compound:st059297|FD-Score:-3.36|P-value:3.95E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.56|P-value:1.89E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.06|P-value:2.49E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.32|P-value:4.60E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.90|P-value:1.94E-9 ID:SGTC_1842|Compound:st055362|FD-Score:4.28|P-value:9.74E-6 ID:SGTC_1958|Compound:st076513|FD-Score:-4.38|P-value:6.10E-6 ID:SGTC_2005|Compound:4024620|FD-Score:3.26|P-value:5.53E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.13|P-value:8.95E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.13|P-value:8.83E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.33|P-value:4.43E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.40|P-value:3.38E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.14|P-value:8.46E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.31|P-value:4.69E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.11|P-value:9.59E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.76|P-value:8.77E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.11|P-value:9.56E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.32|P-value:4.64E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.40|P-value:5.52E-6 ID:SGTC_3299|Compound:9121982|FD-Score:-6.50|P-value:4.24E-11 ID:SGTC_3310|Compound:9130229|FD-Score:-3.21|P-value:6.88E-4

Top fitness defect scores for YJR110W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1826 st055655 5.90 41.6 µM 1.94E-9 ERG2 14 1.86E-9
2 SGTC_3192 9110362 4.40 49.5 µM 5.52E-6 mitochondrial processes 4 5.40E-6
3 SGTC_1842 st055362 4.28 61.2 µM 9.74E-6 8 9.55E-6
4 SGTC_949 1165-0505 3.65 146.0 µM 1.35E-4 27 1.33E-4
5 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.62 66.5 µM 1.47E-4 22 1.45E-4
6 SGTC_662 k832-1615 3.53 104.0 µM 2.08E-4 33 2.05E-4
7 SGTC_2377 9073351 3.40 62.6 µM 3.38E-4 ergosterol biosynthesis 38 3.34E-4
8 SGTC_2211 7117706 3.33 200.0 µM 4.43E-4 24 4.38E-4
9 SGTC_1800 st050079 3.32 29.1 µM 4.60E-4 NEO1-PIK1 180 4.55E-4
10 SGTC_2437 5741531 3.31 144.2 µM 4.69E-4 63 4.64E-4
11 SGTC_2005 4024620 3.26 188.0 µM 5.53E-4 48 5.48E-4
12 SGTC_96 0929-0093 3.20 37.3 µM 6.91E-4 calcium & mitochondrial duress 38 6.85E-4
13 SGTC_2388 9080168 3.14 200.0 µM 8.46E-4 24 8.38E-4
14 SGTC_2131 toluylene red 3.13 5.3 µM 8.95E-4 60S ribosome export 66 8.87E-4
15 SGTC_993 3909-8757 3.12 62.7 µM 9.00E-4 60 8.92E-4
16 SGTC_509 pifithrin 3.11 175.0 µM 9.37E-4 mitochondrial processes 21 9.29E-4
17 SGTC_2806 7952793 3.11 58.4 µM 9.56E-4 59 9.47E-4
18 SGTC_1419 3993-2473 3.10 62.6 µM 9.82E-4 46 9.74E-4
19 SGTC_1864 st057645 3.08 30.4 µM 0.00103 amide catabolism 33 0.00102
20 SGTC_393 acivicin 3.08 6.2 µM 0.00104 40 0.00103

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.70E-9 YIR006C PAN1 het Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease
0.094 4.98E-8 YOL098C_p YOL098C_p hom Putative metalloprotease
0.088 3.12E-7 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.081 2.47E-6 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.077 8.19E-6 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p
0.077 9.10E-6 YEL018W EAF5 hom Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
0.074 1.59E-5 YLR175W CBF5 het Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
0.074 2.02E-5 YBR086C IST2 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.071 4.08E-5 YML042W CAT2 hom Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
0.070 4.45E-5 YMR237W BCH1 hom Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication
0.068 8.16E-5 YNR009W NRM1 hom Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
0.066 1.32E-4 YGR018C_p YGR018C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W
0.066 1.34E-4 YGL184C STR3 hom Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.065 1.62E-4 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.064 1.96E-4 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis