YJR111C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR111C / YJR111C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:7.07|P-value:5.71E-13 ID:SGTC_70|Compound:0141-0289|FD-Score:3.59|P-value:1.45E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.57|P-value:2.07E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:13.90|P-value:1.30E-44 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.31|P-value:5.77E-8 ID:SGTC_214|Compound:4373-3496|FD-Score:3.85|P-value:5.16E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.64|P-value:1.51E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:7.05|P-value:6.55E-13 ID:SGTC_309|Compound:k408-0051|FD-Score:3.21|P-value:5.90E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.94|P-value:3.58E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.06|P-value:2.17E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.16|P-value:1.41E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:6.85|P-value:2.86E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:4.63|P-value:1.54E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:4.55|P-value:2.31E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:3.34|P-value:3.72E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.11|P-value:8.49E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.26|P-value:5.88E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.09|P-value:1.92E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.11|P-value:8.38E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.09|P-value:9.12E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.31|P-value:4.24E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.78|P-value:7.41E-7 ID:SGTC_994|Compound:3910-0338|FD-Score:3.79|P-value:6.79E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.47|P-value:2.33E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.10|P-value:2.15E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.13|P-value:8.98E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.52|P-value:1.92E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.94|P-value:3.60E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.05|P-value:1.90E-7 ID:SGTC_1919|Compound:st067113|FD-Score:3.36|P-value:3.53E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.31|P-value:4.90E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-3.41|P-value:3.38E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.80|P-value:6.32E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.10|P-value:8.83E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.13|P-value:1.56E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.84|P-value:5.47E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.86|P-value:5.08E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.21|P-value:5.91E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.66|P-value:1.13E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.96|P-value:3.23E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.68|P-value:1.04E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.86|P-value:5.08E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.35|P-value:3.61E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.45|P-value:2.50E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.84|P-value:5.37E-5 ID:SGTC_2923|Compound:7992654|FD-Score:5.12|P-value:1.30E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.55|P-value:1.69E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.71|P-value:1.06E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.83|P-value:5.72E-5 ID:SGTC_3028|Compound:9087778|FD-Score:4.74|P-value:9.24E-7 ID:SGTC_3032|Compound:9089427|FD-Score:-3.58|P-value:1.80E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.54|P-value:1.76E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.88|P-value:4.62E-5 ID:SGTC_3173|Compound:9105693|FD-Score:3.70|P-value:9.49E-5 ID:SGTC_3265|Compound:9137266|FD-Score:-3.23|P-value:6.43E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.11|P-value:1.37E-7 ID:SGTC_3278|Compound:9139605|FD-Score:-4.21|P-value:1.35E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.42|P-value:4.17E-6 ID:SGTC_3351|Compound:9150312|FD-Score:3.35|P-value:3.66E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.25|P-value:6.00E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.07|P-value:5.71E-13 ID:SGTC_70|Compound:0141-0289|FD-Score:3.59|P-value:1.45E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.57|P-value:2.07E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:13.90|P-value:1.30E-44 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.31|P-value:5.77E-8 ID:SGTC_214|Compound:4373-3496|FD-Score:3.85|P-value:5.16E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.64|P-value:1.51E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:7.05|P-value:6.55E-13 ID:SGTC_309|Compound:k408-0051|FD-Score:3.21|P-value:5.90E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.94|P-value:3.58E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.06|P-value:2.17E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.16|P-value:1.41E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:6.85|P-value:2.86E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:4.63|P-value:1.54E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:4.55|P-value:2.31E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:3.34|P-value:3.72E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.11|P-value:8.49E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.26|P-value:5.88E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.09|P-value:1.92E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.11|P-value:8.38E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.09|P-value:9.12E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.31|P-value:4.24E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.78|P-value:7.41E-7 ID:SGTC_994|Compound:3910-0338|FD-Score:3.79|P-value:6.79E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.47|P-value:2.33E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.10|P-value:2.15E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.13|P-value:8.98E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.52|P-value:1.92E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.94|P-value:3.60E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.05|P-value:1.90E-7 ID:SGTC_1919|Compound:st067113|FD-Score:3.36|P-value:3.53E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.31|P-value:4.90E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-3.41|P-value:3.38E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.80|P-value:6.32E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.10|P-value:8.83E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.13|P-value:1.56E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.84|P-value:5.47E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.86|P-value:5.08E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.21|P-value:5.91E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.66|P-value:1.13E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.96|P-value:3.23E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.68|P-value:1.04E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.86|P-value:5.08E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.35|P-value:3.61E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.45|P-value:2.50E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.84|P-value:5.37E-5 ID:SGTC_2923|Compound:7992654|FD-Score:5.12|P-value:1.30E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.55|P-value:1.69E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.71|P-value:1.06E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.83|P-value:5.72E-5 ID:SGTC_3028|Compound:9087778|FD-Score:4.74|P-value:9.24E-7 ID:SGTC_3032|Compound:9089427|FD-Score:-3.58|P-value:1.80E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.54|P-value:1.76E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.88|P-value:4.62E-5 ID:SGTC_3173|Compound:9105693|FD-Score:3.70|P-value:9.49E-5 ID:SGTC_3265|Compound:9137266|FD-Score:-3.23|P-value:6.43E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.11|P-value:1.37E-7 ID:SGTC_3278|Compound:9139605|FD-Score:-4.21|P-value:1.35E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.42|P-value:4.17E-6 ID:SGTC_3351|Compound:9150312|FD-Score:3.35|P-value:3.66E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.25|P-value:6.00E-4

Top fitness defect scores for YJR111C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 13.90 40.9 µM 1.30E-44 cell wall 21 2.92E-44
2 SGTC_58 0957-0393 7.07 9.0 µM 5.71E-13 cell wall 161 7.60E-13
3 SGTC_304 1310-0298 7.05 97.0 µM 6.55E-13 cell wall 10 8.70E-13
4 SGTC_514 4466-0038 6.85 2.6 nM 2.86E-12 cell wall 56 3.75E-12
5 SGTC_2923 7992654 5.12 58.1 µM 1.30E-7 Golgi 10 1.56E-7
6 SGTC_3266 9136860 5.11 49.5 µM 1.37E-7 cell wall 26 1.64E-7
7 SGTC_1712 st032288 5.05 53.4 µM 1.90E-7 calcium & mitochondrial duress 115 2.27E-7
8 SGTC_951 1171-0579 4.78 82.7 µM 7.41E-7 cell wall 50 8.75E-7
9 SGTC_3028 9087778 4.74 49.5 µM 9.24E-7 5 1.09E-6
10 SGTC_219 mitoxanthrone 4.64 164.4 µM 1.51E-6 DNA intercalators 36 1.77E-6
11 SGTC_528 3492-0019 4.63 172.0 µM 1.54E-6 calcium & mitochondrial duress 175 1.81E-6
12 SGTC_114 0364-0001 4.57 490.3 µM 2.07E-6 26 2.42E-6
13 SGTC_582 0987-0078 4.55 156.0 µM 2.31E-6 calcium & mitochondrial duress 46 2.70E-6
14 SGTC_3311 9131146 4.42 2.9 µM 4.17E-6 cell wall 100 4.85E-6
15 SGTC_467 ro 31-8220 4.16 72.8 µM 1.41E-5 calcium & mitochondrial duress 68 1.62E-5
16 SGTC_2365 9042475 4.13 200.0 µM 1.56E-5 30 1.79E-5
17 SGTC_666 0272-0154 4.09 136.0 µM 1.92E-5 cell wall 52 2.20E-5
18 SGTC_453 enantio-paf c16 4.06 10.0 µM 2.17E-5 136 2.49E-5
19 SGTC_2657 nystatin 3.96 74.4 µM 3.23E-5 9 3.68E-5
20 SGTC_333 3486-0131 3.94 40.1 µM 3.58E-5 amide catabolism 11 4.08E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.380 7.47E-116 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.377 8.84E-114 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.377 1.72E-113 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.371 3.94E-110 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.367 2.28E-107 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.363 2.93E-105 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.359 1.12E-102 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.354 2.03E-99 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.350 1.94E-97 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.325 3.30E-83 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.324 1.25E-82 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.317 5.76E-79 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.314 8.51E-78 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.313 3.16E-77 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.313 3.73E-77 YOR258W HNT3 hom DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress