YJR113C / RSM7

Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR113C / RSM7

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:4.12|P-value:1.86E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.69|P-value:7.12E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.45|P-value:6.12E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.05|P-value:6.91E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.96|P-value:9.53E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.28|P-value:1.11E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.50|P-value:4.30E-31 ID:SGTC_195|Compound:4234-0266|FD-Score:4.96|P-value:9.55E-6 ID:SGTC_204|Compound:1543-0184|FD-Score:3.85|P-value:4.37E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.73|P-value:2.30E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:11.10|P-value:9.59E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.79|P-value:1.15E-11 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.22|P-value:1.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.86|P-value:1.86E-9 ID:SGTC_386|Compound:1509-0011|FD-Score:4.35|P-value:8.81E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.39|P-value:1.09E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.63|P-value:8.41E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:5.62|P-value:6.47E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.86|P-value:5.87E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.13|P-value:1.84E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.26|P-value:1.17E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.27|P-value:2.84E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:4.96|P-value:9.59E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.20|P-value:2.04E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:5.06|P-value:6.45E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.18|P-value:2.14E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.89|P-value:1.27E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.09|P-value:5.72E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.12|P-value:1.89E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.66|P-value:7.77E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.97|P-value:4.14E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.43|P-value:6.71E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.83|P-value:6.45E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-4.35|P-value:1.25E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.61|P-value:3.52E-5 ID:SGTC_1623|Compound:st003709|FD-Score:5.16|P-value:4.42E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.99|P-value:2.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.56|P-value:8.61E-7 ID:SGTC_1762|Compound:st045503|FD-Score:4.18|P-value:1.55E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.00|P-value:3.82E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.62|P-value:8.77E-4 ID:SGTC_1975|Compound:st070967|FD-Score:5.16|P-value:4.40E-6 ID:SGTC_2144|Compound:5628481|FD-Score:3.61|P-value:8.97E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-4.87|P-value:2.00E-5 ID:SGTC_2178|Compound:5812956|FD-Score:4.39|P-value:7.53E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.30|P-value:2.53E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.00|P-value:8.37E-6 ID:SGTC_2303|Compound:7774051|FD-Score:4.32|P-value:9.49E-5 ID:SGTC_2326|Compound:6164455|FD-Score:4.79|P-value:1.83E-5 ID:SGTC_2339|Compound:9000433|FD-Score:4.50|P-value:5.25E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.65|P-value:3.06E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.74|P-value:6.06E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-4.20|P-value:2.05E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:5.38|P-value:1.83E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.09|P-value:2.89E-4 ID:SGTC_2808|Compound:7946468|FD-Score:6.11|P-value:7.52E-8 ID:SGTC_2815|Compound:7968870|FD-Score:-4.53|P-value:6.74E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-6.39|P-value:3.26E-8 ID:SGTC_2910|Compound:7948405|FD-Score:3.81|P-value:4.98E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.17|P-value:2.20E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.37|P-value:8.24E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.66|P-value:2.91E-5 ID:SGTC_3334|Compound:9142812|FD-Score:4.54|P-value:4.57E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:4.12|P-value:1.86E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.69|P-value:7.12E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.45|P-value:6.12E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.05|P-value:6.91E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.96|P-value:9.53E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.28|P-value:1.11E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.50|P-value:4.30E-31 ID:SGTC_195|Compound:4234-0266|FD-Score:4.96|P-value:9.55E-6 ID:SGTC_204|Compound:1543-0184|FD-Score:3.85|P-value:4.37E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.73|P-value:2.30E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:11.10|P-value:9.59E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.79|P-value:1.15E-11 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.22|P-value:1.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.86|P-value:1.86E-9 ID:SGTC_386|Compound:1509-0011|FD-Score:4.35|P-value:8.81E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.39|P-value:1.09E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.63|P-value:8.41E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:5.62|P-value:6.47E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.86|P-value:5.87E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.13|P-value:1.84E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.26|P-value:1.17E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.27|P-value:2.84E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:4.96|P-value:9.59E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.20|P-value:2.04E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:5.06|P-value:6.45E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.18|P-value:2.14E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.89|P-value:1.27E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.09|P-value:5.72E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.12|P-value:1.89E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.66|P-value:7.77E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.97|P-value:4.14E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.43|P-value:6.71E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.83|P-value:6.45E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-4.35|P-value:1.25E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.61|P-value:3.52E-5 ID:SGTC_1623|Compound:st003709|FD-Score:5.16|P-value:4.42E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.99|P-value:2.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.56|P-value:8.61E-7 ID:SGTC_1762|Compound:st045503|FD-Score:4.18|P-value:1.55E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.00|P-value:3.82E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.62|P-value:8.77E-4 ID:SGTC_1975|Compound:st070967|FD-Score:5.16|P-value:4.40E-6 ID:SGTC_2144|Compound:5628481|FD-Score:3.61|P-value:8.97E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-4.87|P-value:2.00E-5 ID:SGTC_2178|Compound:5812956|FD-Score:4.39|P-value:7.53E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.30|P-value:2.53E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.00|P-value:8.37E-6 ID:SGTC_2303|Compound:7774051|FD-Score:4.32|P-value:9.49E-5 ID:SGTC_2326|Compound:6164455|FD-Score:4.79|P-value:1.83E-5 ID:SGTC_2339|Compound:9000433|FD-Score:4.50|P-value:5.25E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.65|P-value:3.06E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.74|P-value:6.06E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-4.20|P-value:2.05E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:5.38|P-value:1.83E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.09|P-value:2.89E-4 ID:SGTC_2808|Compound:7946468|FD-Score:6.11|P-value:7.52E-8 ID:SGTC_2815|Compound:7968870|FD-Score:-4.53|P-value:6.74E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-6.39|P-value:3.26E-8 ID:SGTC_2910|Compound:7948405|FD-Score:3.81|P-value:4.98E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.17|P-value:2.20E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.37|P-value:8.24E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.66|P-value:2.91E-5 ID:SGTC_3334|Compound:9142812|FD-Score:4.54|P-value:4.57E-5

Top fitness defect scores for YJR113C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 13.50 2.7 µM 4.30E-31 mitochondrial stress 11 1.06E-41
2 SGTC_236 1509-0011 11.10 5.3 µM 9.59E-22 173 6.29E-29
3 SGTC_275 trichlorophene 7.79 5.7 µM 1.15E-11 mitochondrial stress 80 3.39E-15
4 SGTC_310 1273-0058 6.86 1.1 µM 1.86E-9 mitochondrial stress 121 3.39E-12
5 SGTC_2808 7946468 6.11 45.5 µM 7.52E-8 5 5.08E-10
6 SGTC_596 1155-0152 5.62 116.0 µM 6.47E-7 TRP & mitochondrial translation 10 9.30E-9
7 SGTC_1742 st038235 5.56 28.9 µM 8.61E-7 mitochondrial stress 58 1.37E-8
8 SGTC_2749 bexarotene 5.38 57.4 µM 1.83E-6 6 3.80E-8
9 SGTC_2183 6420625 5.30 130.5 µM 2.53E-6 mitochondrial processes 24 5.86E-8
10 SGTC_800 3448-7362 5.27 155.0 µM 2.84E-6 translation 78 6.83E-8
11 SGTC_1975 st070967 5.16 30.8 µM 4.40E-6 15 1.23E-7
12 SGTC_1623 st003709 5.16 20.3 µM 4.42E-6 calcium & mitochondrial duress 25 1.24E-7
13 SGTC_1247 0448-0043 5.09 5.8 µM 5.72E-6 ERG2 19 1.76E-7
14 SGTC_1056 3448-1962 5.06 115.0 µM 6.45E-6 amide catabolism 8 2.07E-7
15 SGTC_118 0083-0097 5.05 135.3 µM 6.91E-6 translation 55 2.26E-7
16 SGTC_2232 chlorophetanol 5.00 41.5 µM 8.37E-6 TRP & mitochondrial translation 78 2.93E-7
17 SGTC_119 0121-0043 4.96 24.8 µM 9.53E-6 mitochondrial stress 58 3.49E-7
18 SGTC_195 4234-0266 4.96 16.6 µM 9.55E-6 14 3.50E-7
19 SGTC_949 1165-0505 4.96 146.0 µM 9.59E-6 7 3.52E-7
20 SGTC_1188 1403-0014 4.89 4.6 µM 1.27E-5 mitochondrial stress 30 5.12E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.441 4.05E-159 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.426 5.20E-148 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.418 8.02E-142 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.417 6.46E-141 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.410 3.17E-135 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.407 5.62E-134 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.405 1.42E-132 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.404 8.39E-132 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.395 1.32E-125 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.394 4.41E-125 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.393 2.73E-124 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.392 1.15E-123 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.389 2.19E-121 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.389 2.29E-121 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.385 4.89E-119 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit