YJR118C / ILM1

Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR118C / ILM1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-3.91|P-value:5.02E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:10.40|P-value:1.18E-18 ID:SGTC_21|Compound:0849-0113|FD-Score:6.55|P-value:1.66E-8 ID:SGTC_23|Compound:0213-0011|FD-Score:3.94|P-value:4.41E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.70|P-value:9.27E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.30|P-value:1.41E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:5.18|P-value:6.20E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:4.77|P-value:2.78E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:4.70|P-value:3.61E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:6.87|P-value:3.43E-9 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.39|P-value:1.11E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:6.31|P-value:4.94E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:4.31|P-value:1.39E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.74|P-value:3.13E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.68|P-value:9.33E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:5.69|P-value:7.84E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:5.64|P-value:9.60E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:5.24|P-value:4.85E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:5.68|P-value:8.27E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:5.67|P-value:8.68E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.20|P-value:1.93E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.00|P-value:3.71E-4 ID:SGTC_269|Compound:exalamide|FD-Score:6.20|P-value:8.44E-8 ID:SGTC_274|Compound:sirtinol|FD-Score:5.59|P-value:1.20E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:4.97|P-value:1.36E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.42|P-value:9.37E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.46|P-value:8.41E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.43|P-value:9.06E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.73|P-value:8.26E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.95|P-value:4.47E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:6.05|P-value:1.65E-7 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.69|P-value:9.39E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:6.58|P-value:1.39E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:4.14|P-value:2.36E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.92|P-value:4.61E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.33|P-value:1.30E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.78|P-value:6.98E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.05|P-value:3.14E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:7.42|P-value:1.91E-10 ID:SGTC_964|Compound:1287-0107|FD-Score:4.52|P-value:6.89E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.67|P-value:9.74E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:4.62|P-value:4.87E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:6.06|P-value:1.57E-7 ID:SGTC_1261|Compound:0712-0010|FD-Score:-4.75|P-value:3.22E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.23|P-value:5.04E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.86|P-value:5.60E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.01|P-value:3.57E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:5.78|P-value:5.32E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:5.39|P-value:2.64E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-4.28|P-value:1.58E-4 ID:SGTC_1638|Compound:st008370|FD-Score:7.91|P-value:1.21E-11 ID:SGTC_1696|Compound:st025591|FD-Score:4.85|P-value:2.10E-5 ID:SGTC_1884|Compound:5633444|FD-Score:4.99|P-value:1.28E-5 ID:SGTC_1911|Compound:st060208|FD-Score:6.69|P-value:8.29E-9 ID:SGTC_2003|Compound:4023581|FD-Score:3.69|P-value:9.13E-4 ID:SGTC_2046|Compound:4110841|FD-Score:5.97|P-value:2.30E-7 ID:SGTC_2134|Compound:5324836|FD-Score:-3.68|P-value:9.63E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.21|P-value:1.89E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.32|P-value:1.33E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.72|P-value:8.49E-4 ID:SGTC_2201|Compound:6605497|FD-Score:4.52|P-value:6.81E-5 ID:SGTC_2289|Compound:7946404|FD-Score:7.52|P-value:1.09E-10 ID:SGTC_2315|Compound:7733312|FD-Score:3.98|P-value:3.83E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.74|P-value:3.09E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-4.18|P-value:2.18E-4 ID:SGTC_2377|Compound:9073351|FD-Score:5.24|P-value:4.92E-6 ID:SGTC_2414|Compound:st077232|FD-Score:5.61|P-value:1.07E-6 ID:SGTC_2462|Compound:5162487|FD-Score:5.83|P-value:4.23E-7 ID:SGTC_2467|Compound:5474540|FD-Score:6.60|P-value:1.31E-8 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.02|P-value:1.15E-5 ID:SGTC_2525|Compound:harmine|FD-Score:5.36|P-value:3.02E-6 ID:SGTC_2534|Compound:helenine|FD-Score:5.28|P-value:4.16E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.48|P-value:7.79E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:7.24|P-value:4.93E-10 ID:SGTC_2698|Compound:st077697|FD-Score:-3.94|P-value:4.49E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.85|P-value:5.98E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.58|P-value:5.55E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.93|P-value:4.56E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.88|P-value:5.26E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.77|P-value:2.78E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-4.38|P-value:1.15E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-4.16|P-value:2.31E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.74|P-value:7.94E-4 ID:SGTC_3152|Compound:9099253|FD-Score:8.21|P-value:2.14E-12 ID:SGTC_3154|Compound:9100113|FD-Score:9.94|P-value:2.57E-17 ID:SGTC_3197|Compound:9113331|FD-Score:3.76|P-value:7.54E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.95|P-value:1.49E-5 ID:SGTC_3265|Compound:9137266|FD-Score:4.29|P-value:1.47E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.77|P-value:7.31E-4 ID:SGTC_3331|Compound:9141060|FD-Score:5.53|P-value:1.50E-6 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.91|P-value:5.02E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:10.40|P-value:1.18E-18 ID:SGTC_21|Compound:0849-0113|FD-Score:6.55|P-value:1.66E-8 ID:SGTC_23|Compound:0213-0011|FD-Score:3.94|P-value:4.41E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.70|P-value:9.27E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.30|P-value:1.41E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:5.18|P-value:6.20E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:4.77|P-value:2.78E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:4.70|P-value:3.61E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:6.87|P-value:3.43E-9 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.39|P-value:1.11E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:6.31|P-value:4.94E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:4.31|P-value:1.39E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.74|P-value:3.13E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.68|P-value:9.33E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:5.69|P-value:7.84E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:5.64|P-value:9.60E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:5.24|P-value:4.85E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:5.68|P-value:8.27E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:5.67|P-value:8.68E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.20|P-value:1.93E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.00|P-value:3.71E-4 ID:SGTC_269|Compound:exalamide|FD-Score:6.20|P-value:8.44E-8 ID:SGTC_274|Compound:sirtinol|FD-Score:5.59|P-value:1.20E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:4.97|P-value:1.36E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.42|P-value:9.37E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.46|P-value:8.41E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.43|P-value:9.06E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.73|P-value:8.26E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.95|P-value:4.47E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:6.05|P-value:1.65E-7 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.69|P-value:9.39E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:6.58|P-value:1.39E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:4.14|P-value:2.36E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.92|P-value:4.61E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.33|P-value:1.30E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.78|P-value:6.98E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.05|P-value:3.14E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:7.42|P-value:1.91E-10 ID:SGTC_964|Compound:1287-0107|FD-Score:4.52|P-value:6.89E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.67|P-value:9.74E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:4.62|P-value:4.87E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:6.06|P-value:1.57E-7 ID:SGTC_1261|Compound:0712-0010|FD-Score:-4.75|P-value:3.22E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.23|P-value:5.04E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.86|P-value:5.60E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.01|P-value:3.57E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:5.78|P-value:5.32E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:5.39|P-value:2.64E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-4.28|P-value:1.58E-4 ID:SGTC_1638|Compound:st008370|FD-Score:7.91|P-value:1.21E-11 ID:SGTC_1696|Compound:st025591|FD-Score:4.85|P-value:2.10E-5 ID:SGTC_1884|Compound:5633444|FD-Score:4.99|P-value:1.28E-5 ID:SGTC_1911|Compound:st060208|FD-Score:6.69|P-value:8.29E-9 ID:SGTC_2003|Compound:4023581|FD-Score:3.69|P-value:9.13E-4 ID:SGTC_2046|Compound:4110841|FD-Score:5.97|P-value:2.30E-7 ID:SGTC_2134|Compound:5324836|FD-Score:-3.68|P-value:9.63E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.21|P-value:1.89E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.32|P-value:1.33E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.72|P-value:8.49E-4 ID:SGTC_2201|Compound:6605497|FD-Score:4.52|P-value:6.81E-5 ID:SGTC_2289|Compound:7946404|FD-Score:7.52|P-value:1.09E-10 ID:SGTC_2315|Compound:7733312|FD-Score:3.98|P-value:3.83E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.74|P-value:3.09E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-4.18|P-value:2.18E-4 ID:SGTC_2377|Compound:9073351|FD-Score:5.24|P-value:4.92E-6 ID:SGTC_2414|Compound:st077232|FD-Score:5.61|P-value:1.07E-6 ID:SGTC_2462|Compound:5162487|FD-Score:5.83|P-value:4.23E-7 ID:SGTC_2467|Compound:5474540|FD-Score:6.60|P-value:1.31E-8 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.02|P-value:1.15E-5 ID:SGTC_2525|Compound:harmine|FD-Score:5.36|P-value:3.02E-6 ID:SGTC_2534|Compound:helenine|FD-Score:5.28|P-value:4.16E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.48|P-value:7.79E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:7.24|P-value:4.93E-10 ID:SGTC_2698|Compound:st077697|FD-Score:-3.94|P-value:4.49E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.85|P-value:5.98E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.58|P-value:5.55E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.93|P-value:4.56E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.88|P-value:5.26E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.77|P-value:2.78E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-4.38|P-value:1.15E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-4.16|P-value:2.31E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.74|P-value:7.94E-4 ID:SGTC_3152|Compound:9099253|FD-Score:8.21|P-value:2.14E-12 ID:SGTC_3154|Compound:9100113|FD-Score:9.94|P-value:2.57E-17 ID:SGTC_3197|Compound:9113331|FD-Score:3.76|P-value:7.54E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.95|P-value:1.49E-5 ID:SGTC_3265|Compound:9137266|FD-Score:4.29|P-value:1.47E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.77|P-value:7.31E-4 ID:SGTC_3331|Compound:9141060|FD-Score:5.53|P-value:1.50E-6

Top fitness defect scores for YJR118C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_12 0849-0099 10.40 9.3 µM 1.18E-18 2 1.93E-25
2 SGTC_3154 9100113 9.94 49.5 µM 2.57E-17 2 1.43E-23
3 SGTC_3152 9099253 8.21 49.5 µM 2.14E-12 NEO1-PIK1 33 1.10E-16
4 SGTC_1638 st008370 7.91 60.6 µM 1.21E-11 ergosterol biosynthesis 4 1.24E-15
5 SGTC_2289 7946404 7.52 165.1 µM 1.09E-10 21 2.67E-14
6 SGTC_960 1222-0186 7.42 7.7 µM 1.91E-10 1 5.83E-14
7 SGTC_2659 sanguinarine 7.24 24.2 µM 4.93E-10 4 2.20E-13
8 SGTC_90 0870-0863 6.87 4.6 µM 3.43E-9 11 3.29E-12
9 SGTC_1911 st060208 6.69 74.3 µM 8.29E-9 3 1.13E-11
10 SGTC_2467 5474540 6.60 200.0 µM 1.31E-8 1 2.12E-11
11 SGTC_611 3453-1652 6.58 23.7 µM 1.39E-8 3 2.31E-11
12 SGTC_21 0849-0113 6.55 23.0 µM 1.66E-8 7 2.96E-11
13 SGTC_107 0358-0022 6.31 2.7 µM 4.94E-8 SWF1 & branched chain AA biosynthesis 14 1.36E-10
14 SGTC_269 exalamide 6.20 29.0 µM 8.44E-8 ergosterol biosynthesis 3 2.86E-10
15 SGTC_1253 0550-0034 6.06 176.0 µM 1.57E-7 5 6.80E-10
16 SGTC_576 1073-0113 6.05 22.7 µM 1.65E-7 redox potentiating 16 7.28E-10
17 SGTC_2046 4110841 5.97 106.0 µM 2.30E-7 iron homeostasis 7 1.16E-9
18 SGTC_2462 5162487 5.83 171.8 µM 4.23E-7 4 2.69E-9
19 SGTC_1579 chlormadinone acetate 5.78 49.4 µM 5.32E-7 1 3.71E-9
20 SGTC_123 0083-0120 5.69 66.7 µM 7.84E-7 23 6.35E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 4.48E-21 YJR073C OPI3 hom Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
0.135 5.19E-15 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.126 2.82E-13 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.118 7.01E-12 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.117 8.96E-12 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.115 2.66E-11 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.113 5.18E-11 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.113 6.06E-11 YGR229C SMI1 hom Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
0.112 7.26E-11 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.109 2.17E-10 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.107 5.13E-10 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.107 5.51E-10 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.107 5.77E-10 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.106 8.13E-10 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.104 1.30E-9 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication