YJR121W / ATP2

Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR121W / ATP2

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.13|P-value:6.83E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:-4.85|P-value:3.54E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:-3.51|P-value:1.66E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.62|P-value:1.07E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.29|P-value:3.83E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.65|P-value:1.02E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.53|P-value:7.81E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:10.70|P-value:4.21E-28 ID:SGTC_310|Compound:1273-0058|FD-Score:6.04|P-value:3.15E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:4.27|P-value:6.21E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:4.97|P-value:1.85E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:5.27|P-value:3.45E-8 ID:SGTC_778|Compound:3456-2434|FD-Score:3.40|P-value:2.50E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.90|P-value:3.32E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:3.43|P-value:2.29E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:7.12|P-value:1.60E-13 ID:SGTC_908|Compound:3448-7491|FD-Score:3.22|P-value:4.95E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.25|P-value:4.53E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.16|P-value:1.04E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.58|P-value:1.25E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.34|P-value:4.51E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.88|P-value:3.07E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.38|P-value:2.71E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:6.22|P-value:1.01E-10 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.22|P-value:4.90E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.06|P-value:8.74E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.03|P-value:9.63E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.24|P-value:4.64E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.18|P-value:5.77E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.46|P-value:1.98E-22 ID:SGTC_1641|Compound:st009299|FD-Score:3.92|P-value:3.05E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.49|P-value:1.82E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.24|P-value:4.70E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-4.62|P-value:1.13E-6 ID:SGTC_1775|Compound:st081588|FD-Score:4.64|P-value:1.04E-6 ID:SGTC_1791|Compound:st048313|FD-Score:4.12|P-value:1.27E-5 ID:SGTC_1796|Compound:st049173|FD-Score:7.05|P-value:2.79E-13 ID:SGTC_1914|Compound:st062367|FD-Score:-3.20|P-value:5.24E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-4.35|P-value:4.35E-6 ID:SGTC_2011|Compound:4012611|FD-Score:7.99|P-value:1.49E-16 ID:SGTC_2026|Compound:5148700|FD-Score:-3.19|P-value:5.60E-4 ID:SGTC_2176|Compound:5809774|FD-Score:7.51|P-value:7.68E-15 ID:SGTC_2177|Compound:5811945|FD-Score:7.73|P-value:1.28E-15 ID:SGTC_2284|Compound:7945075|FD-Score:8.99|P-value:1.93E-20 ID:SGTC_2310|Compound:7668677|FD-Score:5.24|P-value:4.25E-8 ID:SGTC_2349|Compound:9023730|FD-Score:4.20|P-value:8.77E-6 ID:SGTC_2370|Compound:9071495|FD-Score:15.00|P-value:4.02E-53 ID:SGTC_2372|Compound:9071633|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.94|P-value:2.76E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.60|P-value:1.16E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:5.59|P-value:5.28E-9 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.92|P-value:2.39E-7 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.99|P-value:2.29E-5 ID:SGTC_2591|Compound:skatole|FD-Score:9.05|P-value:1.05E-20 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.00|P-value:2.13E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:11.20|P-value:1.08E-30 ID:SGTC_2676|Compound:harmalol|FD-Score:3.14|P-value:6.63E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.04|P-value:1.80E-5 ID:SGTC_2715|Compound:st079500|FD-Score:3.36|P-value:2.96E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.11|P-value:7.43E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.64|P-value:1.03E-6 ID:SGTC_2791|Compound:5663188|FD-Score:3.13|P-value:6.77E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.94|P-value:2.74E-5 ID:SGTC_2845|Compound:9003024|FD-Score:4.35|P-value:4.22E-6 ID:SGTC_2855|Compound:9016525|FD-Score:3.03|P-value:9.79E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.65|P-value:3.83E-9 ID:SGTC_2877|Compound:9040724|FD-Score:3.02|P-value:9.92E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.08|P-value:8.20E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.07|P-value:8.57E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.28|P-value:3.97E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.01|P-value:2.04E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.62|P-value:1.05E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.35|P-value:3.03E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.13|P-value:6.83E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:-4.85|P-value:3.54E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:-3.51|P-value:1.66E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.62|P-value:1.07E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.29|P-value:3.83E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.65|P-value:1.02E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.53|P-value:7.81E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:10.70|P-value:4.21E-28 ID:SGTC_310|Compound:1273-0058|FD-Score:6.04|P-value:3.15E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:4.27|P-value:6.21E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:4.97|P-value:1.85E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:5.27|P-value:3.45E-8 ID:SGTC_778|Compound:3456-2434|FD-Score:3.40|P-value:2.50E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.90|P-value:3.32E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:3.43|P-value:2.29E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:7.12|P-value:1.60E-13 ID:SGTC_908|Compound:3448-7491|FD-Score:3.22|P-value:4.95E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.25|P-value:4.53E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.16|P-value:1.04E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.58|P-value:1.25E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.34|P-value:4.51E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.88|P-value:3.07E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.38|P-value:2.71E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:6.22|P-value:1.01E-10 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.22|P-value:4.90E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.06|P-value:8.74E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.03|P-value:9.63E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.24|P-value:4.64E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.18|P-value:5.77E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.46|P-value:1.98E-22 ID:SGTC_1641|Compound:st009299|FD-Score:3.92|P-value:3.05E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.49|P-value:1.82E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.24|P-value:4.70E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-4.62|P-value:1.13E-6 ID:SGTC_1775|Compound:st081588|FD-Score:4.64|P-value:1.04E-6 ID:SGTC_1791|Compound:st048313|FD-Score:4.12|P-value:1.27E-5 ID:SGTC_1796|Compound:st049173|FD-Score:7.05|P-value:2.79E-13 ID:SGTC_1914|Compound:st062367|FD-Score:-3.20|P-value:5.24E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-4.35|P-value:4.35E-6 ID:SGTC_2011|Compound:4012611|FD-Score:7.99|P-value:1.49E-16 ID:SGTC_2026|Compound:5148700|FD-Score:-3.19|P-value:5.60E-4 ID:SGTC_2176|Compound:5809774|FD-Score:7.51|P-value:7.68E-15 ID:SGTC_2177|Compound:5811945|FD-Score:7.73|P-value:1.28E-15 ID:SGTC_2284|Compound:7945075|FD-Score:8.99|P-value:1.93E-20 ID:SGTC_2310|Compound:7668677|FD-Score:5.24|P-value:4.25E-8 ID:SGTC_2349|Compound:9023730|FD-Score:4.20|P-value:8.77E-6 ID:SGTC_2370|Compound:9071495|FD-Score:15.00|P-value:4.02E-53 ID:SGTC_2372|Compound:9071633|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.94|P-value:2.76E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.60|P-value:1.16E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:5.59|P-value:5.28E-9 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.92|P-value:2.39E-7 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.99|P-value:2.29E-5 ID:SGTC_2591|Compound:skatole|FD-Score:9.05|P-value:1.05E-20 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.00|P-value:2.13E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:11.20|P-value:1.08E-30 ID:SGTC_2676|Compound:harmalol|FD-Score:3.14|P-value:6.63E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.04|P-value:1.80E-5 ID:SGTC_2715|Compound:st079500|FD-Score:3.36|P-value:2.96E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.11|P-value:7.43E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.64|P-value:1.03E-6 ID:SGTC_2791|Compound:5663188|FD-Score:3.13|P-value:6.77E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.94|P-value:2.74E-5 ID:SGTC_2845|Compound:9003024|FD-Score:4.35|P-value:4.22E-6 ID:SGTC_2855|Compound:9016525|FD-Score:3.03|P-value:9.79E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.65|P-value:3.83E-9 ID:SGTC_2877|Compound:9040724|FD-Score:3.02|P-value:9.92E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.08|P-value:8.20E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.07|P-value:8.57E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.28|P-value:3.97E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.01|P-value:2.04E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.62|P-value:1.05E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.35|P-value:3.03E-4

Top fitness defect scores for YJR121W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2370 9071495 15.00 200.0 µM 4.02E-53 mitochondrial processes 1 7.12E-51
2 SGTC_2630 antimycin a 11.20 100.0 µM 1.08E-30 mitochondrial processes 3 1.99E-29
3 SGTC_236 1509-0011 10.70 5.3 µM 4.21E-28 181 5.99E-27
4 SGTC_1635 st007035 9.46 42.4 µM 1.98E-22 80 1.59E-21
5 SGTC_2591 skatole 9.05 100.0 µM 1.05E-20 1 7.13E-20
6 SGTC_2284 7945075 8.99 39.2 µM 1.93E-20 mitochondrial processes 1 1.27E-19
7 SGTC_2011 4012611 7.99 177.0 µM 1.49E-16 mitochondrial processes 3 6.67E-16
8 SGTC_2177 5811945 7.73 192.0 µM 1.28E-15 4 5.20E-15
9 SGTC_2176 5809774 7.51 34.0 µM 7.68E-15 mitochondrial processes 1 2.89E-14
10 SGTC_880 0833-0487 7.12 87.2 µM 1.60E-13 mitochondrial processes 2 5.27E-13
11 SGTC_1796 st049173 7.05 110.4 µM 2.79E-13 1 8.99E-13
12 SGTC_1145 3546-0597 6.22 10.2 µM 1.01E-10 mitochondrial processes 2 2.53E-10
13 SGTC_310 1273-0058 6.04 1.1 µM 3.15E-10 mitochondrial stress 143 7.48E-10
14 SGTC_2871 9038510 5.65 13.0 µM 3.83E-9 2 8.18E-9
15 SGTC_2586 curcumin 5.59 80.0 µM 5.28E-9 iron homeostasis 23 1.11E-8
16 SGTC_219 mitoxanthrone 5.53 164.4 µM 7.81E-9 DNA intercalators 21 1.62E-8
17 SGTC_744 1594-0068 5.27 283.0 µM 3.45E-8 amide catabolism 6 6.69E-8
18 SGTC_2310 7668677 5.24 200.0 µM 4.25E-8 11 8.18E-8
19 SGTC_607 4491-0986 4.97 66.8 µM 1.85E-7 heme requiring 9 3.34E-7
20 SGTC_1044 1222-0021 4.88 1.8 µM 3.07E-7 heme biosynthesis & mitochondrial translocase 24 5.44E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.473 1.09E-186 YNL315C ATP11 hom Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
0.425 2.38E-147 YJL180C ATP12 hom Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
0.304 1.49E-72 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.300 1.69E-70 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.285 1.10E-63 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.283 4.73E-63 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.281 6.24E-62 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.281 8.30E-62 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.280 2.13E-61 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.279 4.67E-61 YPL270W MDL2 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.273 1.48E-58 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.272 4.65E-58 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.271 1.23E-57 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.270 2.80E-57 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.267 6.25E-56 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130