HIPHOP chemogenomics database

YJR121W / ATP2

Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated

Zygosity: Homozygous strain

fixedexpanded
Profile for YJR121W / ATP2

Click on Significant Values for Screen Details

Top fitness defect scores for YJR121W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2370	9071495	15.00	200.0 µM	4.02E-53	mitochondrial processes	1	7.12E-51
2	SGTC_2630	antimycin a	11.20	100.0 µM	1.08E-30	mitochondrial processes	3	1.99E-29
3	SGTC_236	1509-0011	10.70	5.3 µM	4.21E-28		181	5.99E-27
4	SGTC_1635	st007035	9.46	42.4 µM	1.98E-22		80	1.59E-21
5	SGTC_2591	skatole	9.05	100.0 µM	1.05E-20		1	7.13E-20
6	SGTC_2284	7945075	8.99	39.2 µM	1.93E-20	mitochondrial processes	1	1.27E-19
7	SGTC_2011	4012611	7.99	177.0 µM	1.49E-16	mitochondrial processes	3	6.67E-16
8	SGTC_2177	5811945	7.73	192.0 µM	1.28E-15		4	5.20E-15
9	SGTC_2176	5809774	7.51	34.0 µM	7.68E-15	mitochondrial processes	1	2.89E-14
10	SGTC_880	0833-0487	7.12	87.2 µM	1.60E-13	mitochondrial processes	2	5.27E-13
11	SGTC_1796	st049173	7.05	110.4 µM	2.79E-13		1	8.99E-13
12	SGTC_1145	3546-0597	6.22	10.2 µM	1.01E-10	mitochondrial processes	2	2.53E-10
13	SGTC_310	1273-0058	6.04	1.1 µM	3.15E-10	mitochondrial stress	143	7.48E-10
14	SGTC_2871	9038510	5.65	13.0 µM	3.83E-9		2	8.18E-9
15	SGTC_2586	curcumin	5.59	80.0 µM	5.28E-9	iron homeostasis	23	1.11E-8
16	SGTC_219	mitoxanthrone	5.53	164.4 µM	7.81E-9	DNA intercalators	21	1.62E-8
17	SGTC_744	1594-0068	5.27	283.0 µM	3.45E-8	amide catabolism	6	6.69E-8
18	SGTC_2310	7668677	5.24	200.0 µM	4.25E-8		11	8.18E-8
19	SGTC_607	4491-0986	4.97	66.8 µM	1.85E-7	heme requiring	9	3.34E-7
20	SGTC_1044	1222-0021	4.88	1.8 µM	3.07E-7	heme biosynthesis & mitochondrial translocase	24	5.44E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.473	1.09E-186	YNL315C	ATP11	hom	Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
0.425	2.38E-147	YJL180C	ATP12	hom	Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
0.304	1.49E-72	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.300	1.69E-70	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.285	1.10E-63	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.283	4.73E-63	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.281	6.24E-62	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.281	8.30E-62	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.280	2.13E-61	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.279	4.67E-61	YPL270W	MDL2	hom	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.273	1.48E-58	YGR183C	QCR9	hom	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.272	4.65E-58	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.271	1.23E-57	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.270	2.80E-57	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.267	6.25E-56	YJL022W_d	YJL022W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130