YJR122W / IBA57

Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR122W / IBA57

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:5.97|P-value:3.81E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:3.78|P-value:8.91E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:4.83|P-value:3.23E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:7.63|P-value:1.28E-10 ID:SGTC_100|Compound:0086-0128|FD-Score:7.07|P-value:2.40E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:5.41|P-value:3.83E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:7.89|P-value:3.11E-11 ID:SGTC_134|Compound:0269-0018|FD-Score:7.01|P-value:3.28E-9 ID:SGTC_156|Compound:3474-0145|FD-Score:4.09|P-value:3.55E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.91|P-value:6.12E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:7.98|P-value:1.94E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:7.56|P-value:1.94E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:10.60|P-value:5.75E-19 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.70|P-value:1.07E-22 ID:SGTC_283|Compound:0987-0079|FD-Score:4.05|P-value:4.04E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.75|P-value:9.01E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.66|P-value:5.33E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:7.54|P-value:2.16E-10 ID:SGTC_462|Compound:ag-879|FD-Score:4.71|P-value:4.95E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:-3.79|P-value:8.12E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:6.68|P-value:1.57E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:3.77|P-value:9.21E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:5.63|P-value:1.60E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:4.29|P-value:1.95E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.89|P-value:2.57E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:4.02|P-value:4.43E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.28|P-value:6.30E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:3.81|P-value:8.09E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.85|P-value:7.18E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.06|P-value:3.61E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:6.08|P-value:2.44E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.44|P-value:1.20E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:5.79|P-value:8.19E-7 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.74|P-value:9.34E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:5.64|P-value:1.52E-6 ID:SGTC_1635|Compound:st007035|FD-Score:12.70|P-value:4.28E-26 ID:SGTC_1707|Compound:st032323|FD-Score:-3.98|P-value:4.59E-4 ID:SGTC_1709|Compound:st033179|FD-Score:4.34|P-value:1.66E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.88|P-value:6.60E-4 ID:SGTC_1750|Compound:st081859|FD-Score:11.20|P-value:6.21E-21 ID:SGTC_1825|Compound:st052143|FD-Score:3.87|P-value:6.83E-4 ID:SGTC_1837|Compound:st055472|FD-Score:6.89|P-value:5.90E-9 ID:SGTC_1841|Compound:st054148|FD-Score:4.31|P-value:1.82E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.20|P-value:2.54E-4 ID:SGTC_2022|Compound:5136654|FD-Score:6.18|P-value:1.58E-7 ID:SGTC_2062|Compound:5245942|FD-Score:-3.79|P-value:8.09E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.51|P-value:2.53E-6 ID:SGTC_2126|Compound:5251174|FD-Score:3.84|P-value:7.44E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.39|P-value:1.43E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.65|P-value:1.44E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.81|P-value:3.18E-5 ID:SGTC_2433|Compound:5607874|FD-Score:8.21|P-value:5.36E-12 ID:SGTC_2434|Compound:5670830|FD-Score:4.09|P-value:3.64E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.37|P-value:1.50E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.73|P-value:1.26E-8 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.91|P-value:2.45E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.67|P-value:5.68E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.04|P-value:4.19E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.18|P-value:2.71E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.38|P-value:3.88E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-4.13|P-value:2.91E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-6.17|P-value:1.47E-7 ID:SGTC_2701|Compound:st077767|FD-Score:4.85|P-value:3.04E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.20|P-value:2.58E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-4.02|P-value:4.16E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.76|P-value:9.32E-4 ID:SGTC_2926|Compound:9010726|FD-Score:8.02|P-value:1.58E-11 ID:SGTC_3062|Compound:9077494|FD-Score:4.10|P-value:3.47E-4 ID:SGTC_3090|Compound:9117696|FD-Score:4.86|P-value:2.94E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.91|P-value:6.17E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.83|P-value:7.21E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:5.97|P-value:3.81E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:3.78|P-value:8.91E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:4.83|P-value:3.23E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:7.63|P-value:1.28E-10 ID:SGTC_100|Compound:0086-0128|FD-Score:7.07|P-value:2.40E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:5.41|P-value:3.83E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:7.89|P-value:3.11E-11 ID:SGTC_134|Compound:0269-0018|FD-Score:7.01|P-value:3.28E-9 ID:SGTC_156|Compound:3474-0145|FD-Score:4.09|P-value:3.55E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.91|P-value:6.12E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:7.98|P-value:1.94E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:7.56|P-value:1.94E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:10.60|P-value:5.75E-19 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.70|P-value:1.07E-22 ID:SGTC_283|Compound:0987-0079|FD-Score:4.05|P-value:4.04E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.75|P-value:9.01E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.66|P-value:5.33E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:7.54|P-value:2.16E-10 ID:SGTC_462|Compound:ag-879|FD-Score:4.71|P-value:4.95E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:-3.79|P-value:8.12E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:6.68|P-value:1.57E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:3.77|P-value:9.21E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:5.63|P-value:1.60E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:4.29|P-value:1.95E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.89|P-value:2.57E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:4.02|P-value:4.43E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.28|P-value:6.30E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:3.81|P-value:8.09E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.85|P-value:7.18E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.06|P-value:3.61E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:6.08|P-value:2.44E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.44|P-value:1.20E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:5.79|P-value:8.19E-7 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.74|P-value:9.34E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:5.64|P-value:1.52E-6 ID:SGTC_1635|Compound:st007035|FD-Score:12.70|P-value:4.28E-26 ID:SGTC_1707|Compound:st032323|FD-Score:-3.98|P-value:4.59E-4 ID:SGTC_1709|Compound:st033179|FD-Score:4.34|P-value:1.66E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.88|P-value:6.60E-4 ID:SGTC_1750|Compound:st081859|FD-Score:11.20|P-value:6.21E-21 ID:SGTC_1825|Compound:st052143|FD-Score:3.87|P-value:6.83E-4 ID:SGTC_1837|Compound:st055472|FD-Score:6.89|P-value:5.90E-9 ID:SGTC_1841|Compound:st054148|FD-Score:4.31|P-value:1.82E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.20|P-value:2.54E-4 ID:SGTC_2022|Compound:5136654|FD-Score:6.18|P-value:1.58E-7 ID:SGTC_2062|Compound:5245942|FD-Score:-3.79|P-value:8.09E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.51|P-value:2.53E-6 ID:SGTC_2126|Compound:5251174|FD-Score:3.84|P-value:7.44E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.39|P-value:1.43E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.65|P-value:1.44E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.81|P-value:3.18E-5 ID:SGTC_2433|Compound:5607874|FD-Score:8.21|P-value:5.36E-12 ID:SGTC_2434|Compound:5670830|FD-Score:4.09|P-value:3.64E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.37|P-value:1.50E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.73|P-value:1.26E-8 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.91|P-value:2.45E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.67|P-value:5.68E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.04|P-value:4.19E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.18|P-value:2.71E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.38|P-value:3.88E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-4.13|P-value:2.91E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-6.17|P-value:1.47E-7 ID:SGTC_2701|Compound:st077767|FD-Score:4.85|P-value:3.04E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.20|P-value:2.58E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-4.02|P-value:4.16E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.76|P-value:9.32E-4 ID:SGTC_2926|Compound:9010726|FD-Score:8.02|P-value:1.58E-11 ID:SGTC_3062|Compound:9077494|FD-Score:4.10|P-value:3.47E-4 ID:SGTC_3090|Compound:9117696|FD-Score:4.86|P-value:2.94E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.91|P-value:6.17E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.83|P-value:7.21E-4

Top fitness defect scores for YJR122W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 12.70 42.4 µM 4.28E-26 53 4.23E-37
2 SGTC_275 trichlorophene 11.70 5.7 µM 1.07E-22 mitochondrial stress 23 3.58E-32
3 SGTC_1750 st081859 11.20 2.4 µM 6.21E-21 endomembrane recycling 33 1.30E-29
4 SGTC_236 1509-0011 10.60 5.3 µM 5.75E-19 183 9.23E-27
5 SGTC_2433 5607874 8.21 27.8 µM 5.36E-12 1 1.14E-16
6 SGTC_2926 9010726 8.02 65.2 µM 1.58E-11 4 5.45E-16
7 SGTC_195 4234-0266 7.98 16.6 µM 1.94E-11 4 7.38E-16
8 SGTC_117 lucigenin 7.89 22.1 µM 3.11E-11 redox potentiating 17 1.45E-15
9 SGTC_86 0417-1630 7.63 471.9 µM 1.28E-10 ubiquinone biosynthesis & proteasome 62 1.13E-14
10 SGTC_207 4185-0010 7.56 4.5 µM 1.94E-10 endomembrane recycling 30 2.05E-14
11 SGTC_386 1509-0011 7.54 3.1 µM 2.16E-10 71 2.39E-14
12 SGTC_100 0086-0128 7.07 49.6 µM 2.40E-9 copper-dependent oxidative stress 12 7.75E-13
13 SGTC_134 0269-0018 7.01 6.9 µM 3.28E-9 67 1.22E-12
14 SGTC_1837 st055472 6.89 66.5 µM 5.90E-9 2 2.85E-12
15 SGTC_2582 agaric acid 6.73 100.0 µM 1.26E-8 redox potentiating 139 8.52E-12
16 SGTC_516 3992-2719 6.68 87.3 µM 1.57E-8 3 1.17E-11
17 SGTC_2022 5136654 6.18 200.0 µM 1.58E-7 7 3.27E-10
18 SGTC_1260 0700-1617 6.08 7.8 µM 2.44E-7 calcium & mitochondrial duress 7 6.12E-10
19 SGTC_21 0849-0113 5.97 23.0 µM 3.81E-7 10 1.16E-9
20 SGTC_1557 sumaresinolic acid 5.79 42.3 µM 8.19E-7 1 3.49E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.399 1.98E-128 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.371 1.30E-109 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.350 3.63E-97 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.350 3.17E-97 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.346 5.48E-95 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.340 2.88E-91 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.335 1.11E-88 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.322 2.38E-81 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.318 1.25E-79 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.318 1.29E-79 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.314 1.63E-77 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.314 2.48E-77 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.312 2.09E-76 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.311 4.75E-76 YPR067W ISA2 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
0.311 5.47E-76 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p