YJR124C_p

Putative protein of unknown function; expression induced under calcium shortage

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR124C / YJR124C

Click on Significant Values for Screen Details ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.59|P-value:4.92E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.91|P-value:8.31E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:2.98|P-value:4.92E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.31|P-value:1.30E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.06|P-value:3.80E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:3.82|P-value:1.27E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.47|P-value:6.42E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.35|P-value:1.10E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:2.97|P-value:5.12E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:2.88|P-value:7.28E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.78|P-value:1.51E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.77|P-value:1.63E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:2.80|P-value:9.87E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.04|P-value:4.20E-6 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.07|P-value:3.53E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.48|P-value:6.30E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.74|P-value:1.90E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.06|P-value:3.58E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.36|P-value:1.03E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.51|P-value:5.44E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.25|P-value:1.45E-6 ID:SGTC_2187|Compound:6125751|FD-Score:2.97|P-value:5.09E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.85|P-value:1.09E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.95|P-value:8.68E-6 ID:SGTC_2352|Compound:9027995|FD-Score:2.92|P-value:6.36E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.84|P-value:8.36E-4 ID:SGTC_2481|Compound:5478948|FD-Score:2.80|P-value:9.80E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.31|P-value:1.27E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.86|P-value:9.84E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:4.41|P-value:5.88E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.65|P-value:2.53E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.25|P-value:2.07E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.92|P-value:6.27E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.34|P-value:1.46E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.21|P-value:1.72E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.15|P-value:7.37E-9 ID:SGTC_2811|Compound:7967822|FD-Score:-4.51|P-value:4.62E-7 ID:SGTC_2935|Compound:9038016|FD-Score:4.60|P-value:2.06E-7 ID:SGTC_2939|Compound:9044578|FD-Score:5.98|P-value:2.42E-11 ID:SGTC_2940|Compound:9060638|FD-Score:3.10|P-value:3.12E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.55|P-value:4.42E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.16|P-value:3.04E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.59|P-value:4.92E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.91|P-value:8.31E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:2.98|P-value:4.92E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.31|P-value:1.30E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.06|P-value:3.80E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:3.82|P-value:1.27E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.47|P-value:6.42E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.35|P-value:1.10E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:2.97|P-value:5.12E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:2.88|P-value:7.28E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.78|P-value:1.51E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.77|P-value:1.63E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:2.80|P-value:9.87E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.04|P-value:4.20E-6 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.07|P-value:3.53E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.48|P-value:6.30E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.74|P-value:1.90E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.06|P-value:3.58E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.36|P-value:1.03E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.51|P-value:5.44E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.25|P-value:1.45E-6 ID:SGTC_2187|Compound:6125751|FD-Score:2.97|P-value:5.09E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.85|P-value:1.09E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.95|P-value:8.68E-6 ID:SGTC_2352|Compound:9027995|FD-Score:2.92|P-value:6.36E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.84|P-value:8.36E-4 ID:SGTC_2481|Compound:5478948|FD-Score:2.80|P-value:9.80E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.31|P-value:1.27E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.86|P-value:9.84E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:4.41|P-value:5.88E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.65|P-value:2.53E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.25|P-value:2.07E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.92|P-value:6.27E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.34|P-value:1.46E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.21|P-value:1.72E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.15|P-value:7.37E-9 ID:SGTC_2811|Compound:7967822|FD-Score:-4.51|P-value:4.62E-7 ID:SGTC_2935|Compound:9038016|FD-Score:4.60|P-value:2.06E-7 ID:SGTC_2939|Compound:9044578|FD-Score:5.98|P-value:2.42E-11 ID:SGTC_2940|Compound:9060638|FD-Score:3.10|P-value:3.12E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.55|P-value:4.42E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.16|P-value:3.04E-4

Top fitness defect scores for YJR124C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2939 9044578 5.98 71.4 µM 2.42E-11 15 1.11E-9
2 SGTC_2565 isoliquiritigenin 5.65 100.0 µM 2.53E-10 11 7.89E-9
3 SGTC_2810 7959871 5.15 45.5 µM 7.37E-9 copper-dependent oxidative stress 18 1.32E-7
4 SGTC_2935 9038016 4.60 30.0 µM 2.06E-7 8 2.13E-6
5 SGTC_2521 angolensin 4.41 13.4 µM 5.88E-7 7 5.11E-6
6 SGTC_2111 5486399 4.25 200.0 µM 1.45E-6 36 1.09E-5
7 SGTC_2633 5,7-dihydroxyisoflavone 4.21 100.0 µM 1.72E-6 26 1.25E-5
8 SGTC_577 r071-0003 4.06 38.6 µM 3.80E-6 fatty acid desaturase (OLE1) 48 2.44E-5
9 SGTC_1344 1488-0097 4.04 29.1 µM 4.20E-6 14 2.64E-5
10 SGTC_343 4130-2827 3.91 29.8 µM 8.31E-6 35 4.68E-5
11 SGTC_2240 6690706 3.85 185.9 µM 1.09E-5 19 5.87E-5
12 SGTC_616 4092-0450 3.82 108.0 µM 1.27E-5 17 6.68E-5
13 SGTC_1091 telmisartan 3.78 47.6 µM 1.51E-5 20 7.71E-5
14 SGTC_1146 3579-1023 3.77 7.0 µM 1.63E-5 18 8.23E-5
15 SGTC_1382 3002-2117 3.74 298.0 µM 1.90E-5 15 9.37E-5
16 SGTC_3150 9097574 3.55 49.5 µM 4.42E-5 15 1.90E-4
17 SGTC_2064 5220758 3.51 200.0 µM 5.44E-5 55 2.26E-4
18 SGTC_1364 1653-0028 3.48 37.6 µM 6.30E-5 40 2.55E-4
19 SGTC_803 4488-1585 3.47 147.0 µM 6.42E-5 24 2.59E-4
20 SGTC_1757 st041620 3.36 31.8 µM 1.03E-4 46 3.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.04E-10 YNL222W SSU72 het Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
0.105 9.72E-10 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.100 6.37E-9 YLR343W GAS2 hom 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
0.093 7.93E-8 YKL075C_p YKL075C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
0.088 3.30E-7 YMR261C TPS3 hom Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication
0.088 3.34E-7 YNL010W_p YNL010W_p hom Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
0.087 3.90E-7 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.087 5.04E-7 YDR503C LPP1 hom Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
0.086 5.20E-7 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.085 9.33E-7 YOL056W GPM3 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.079 5.17E-6 YHR184W SSP1 hom Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis
0.078 6.18E-6 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.072 2.82E-5 YDR233C RTN1 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication
0.072 3.22E-5 YNL142W MEP2 hom Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.071 3.69E-5 YIL016W SNL1 hom Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein