YJR126C / VPS70

Protein of unknown function involved in vacuolar protein sorting

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR126C / VPS70

Click on Significant Values for Screen Details ID:SGTC_198|Compound:3454-2873|FD-Score:-3.73|P-value:4.73E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.03|P-value:7.63E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.39|P-value:2.03E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.06|P-value:6.61E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.83|P-value:2.90E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.80|P-value:3.31E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:3.19|P-value:4.01E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.55|P-value:9.49E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:2.96|P-value:9.23E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.40|P-value:1.79E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.17|P-value:4.38E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.14|P-value:5.18E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.40|P-value:1.77E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.32|P-value:2.58E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.99|P-value:8.52E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.95|P-value:1.82E-5 ID:SGTC_1810|Compound:st050138|FD-Score:4.41|P-value:1.81E-6 ID:SGTC_1825|Compound:st052143|FD-Score:3.52|P-value:1.08E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-3.01|P-value:8.19E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.81|P-value:3.09E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-3.20|P-value:4.12E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.37|P-value:2.09E-4 ID:SGTC_2333|Compound:9017922|FD-Score:4.48|P-value:1.30E-6 ID:SGTC_2354|Compound:9060492|FD-Score:3.12|P-value:5.18E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.39|P-value:1.83E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.38|P-value:1.93E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.08|P-value:6.35E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.13|P-value:5.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.35|P-value:2.17E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.73|P-value:4.54E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.06|P-value:6.92E-4 ID:SGTC_2974|Compound:9094440|FD-Score:2.99|P-value:8.36E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.93|P-value:1.93E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.01|P-value:1.24E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.06|P-value:1.01E-5 ID:SGTC_3000|Compound:9075062|FD-Score:4.18|P-value:5.68E-6 ID:SGTC_3084|Compound:9116877|FD-Score:3.63|P-value:6.96E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.02|P-value:1.20E-5 ID:SGTC_3152|Compound:9099253|FD-Score:6.56|P-value:2.93E-12 ID:SGTC_3155|Compound:9099265|FD-Score:3.91|P-value:2.02E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.23|P-value:3.73E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.52|P-value:1.09E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.53|P-value:1.02E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.38|P-value:2.08E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-3.88|P-value:2.45E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.73|P-value:4.73E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.03|P-value:7.63E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.39|P-value:2.03E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.06|P-value:6.61E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.83|P-value:2.90E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.80|P-value:3.31E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:3.19|P-value:4.01E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.55|P-value:9.49E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:2.96|P-value:9.23E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.40|P-value:1.79E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.17|P-value:4.38E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.14|P-value:5.18E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.40|P-value:1.77E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.32|P-value:2.58E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.99|P-value:8.52E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.95|P-value:1.82E-5 ID:SGTC_1810|Compound:st050138|FD-Score:4.41|P-value:1.81E-6 ID:SGTC_1825|Compound:st052143|FD-Score:3.52|P-value:1.08E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-3.01|P-value:8.19E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.81|P-value:3.09E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-3.20|P-value:4.12E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.37|P-value:2.09E-4 ID:SGTC_2333|Compound:9017922|FD-Score:4.48|P-value:1.30E-6 ID:SGTC_2354|Compound:9060492|FD-Score:3.12|P-value:5.18E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.39|P-value:1.83E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.38|P-value:1.93E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.08|P-value:6.35E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.13|P-value:5.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.35|P-value:2.17E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.73|P-value:4.54E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.06|P-value:6.92E-4 ID:SGTC_2974|Compound:9094440|FD-Score:2.99|P-value:8.36E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.93|P-value:1.93E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.01|P-value:1.24E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.06|P-value:1.01E-5 ID:SGTC_3000|Compound:9075062|FD-Score:4.18|P-value:5.68E-6 ID:SGTC_3084|Compound:9116877|FD-Score:3.63|P-value:6.96E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.02|P-value:1.20E-5 ID:SGTC_3152|Compound:9099253|FD-Score:6.56|P-value:2.93E-12 ID:SGTC_3155|Compound:9099265|FD-Score:3.91|P-value:2.02E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.23|P-value:3.73E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.52|P-value:1.09E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.53|P-value:1.02E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.38|P-value:2.08E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-3.88|P-value:2.45E-5

Top fitness defect scores for YJR126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3152 9099253 6.56 49.5 µM 2.93E-12 NEO1-PIK1 47 2.73E-11
2 SGTC_2333 9017922 4.48 200.0 µM 1.30E-6 17 3.81E-6
3 SGTC_1810 st050138 4.41 53.0 µM 1.81E-6 PDR1 6 5.15E-6
4 SGTC_365 0121-0052 4.39 13.6 µM 2.03E-6 mitochondrial response to ROS 43 5.72E-6
5 SGTC_3000 9075062 4.18 71.4 µM 5.68E-6 11 1.46E-5
6 SGTC_2998 9066762 4.06 71.4 µM 1.01E-5 RPP1 & pyrimidine depletion 24 2.46E-5
7 SGTC_3145 9085516 4.02 49.5 µM 1.20E-5 fatty acid desaturase (OLE1) 28 2.90E-5
8 SGTC_2989 9073649 4.01 71.4 µM 1.24E-5 36 2.98E-5
9 SGTC_3155 9099265 3.91 49.5 µM 2.02E-5 23 4.65E-5
10 SGTC_456 gingerol 3.83 170.0 µM 2.90E-5 23 6.47E-5
11 SGTC_2208 7283366 3.81 200.0 µM 3.09E-5 11 6.85E-5
12 SGTC_536 3852-0578 3.80 10.6 µM 3.31E-5 28 7.30E-5
13 SGTC_2825 7998094 3.73 58.4 µM 4.54E-5 fatty acid desaturase (OLE1) 39 9.74E-5
14 SGTC_3084 9116877 3.63 49.5 µM 6.96E-5 11 1.44E-4
15 SGTC_1058 3448-5425 3.55 97.3 µM 9.49E-5 41 1.91E-4
16 SGTC_3257 9139206 3.53 33.0 µM 1.02E-4 9 2.05E-4
17 SGTC_1825 st052143 3.52 62.6 µM 1.08E-4 24 2.15E-4
18 SGTC_3251 9135047 3.52 49.5 µM 1.09E-4 60S ribosome export 14 2.17E-4
19 SGTC_1714 st033236 3.40 13.6 µM 1.77E-4 45 3.37E-4
20 SGTC_1552 6-methylflavone 3.40 10.6 µM 1.79E-4 superoxide 27 3.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.12E-16 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.122 1.13E-12 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.119 4.28E-12 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.115 2.73E-11 YCL054W SPB1 het AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
0.113 6.14E-11 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.111 1.00E-10 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.111 9.76E-11 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.103 1.86E-9 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.101 5.11E-9 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.100 6.91E-9 YOL108C INO4 hom Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
0.097 1.76E-8 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.093 7.11E-8 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.090 1.55E-7 YLR255C_d YLR255C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.30E-7 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.084 1.17E-6 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication