YJR129C_p

Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR129C / YJR129C

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:3.56|P-value:7.15E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.42|P-value:1.15E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:6.46|P-value:2.70E-12 ID:SGTC_64|Compound:000l-0018|FD-Score:7.37|P-value:1.78E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:9.70|P-value:1.97E-25 ID:SGTC_103|Compound:0844-0104|FD-Score:5.37|P-value:5.00E-9 ID:SGTC_107|Compound:0358-0022|FD-Score:3.44|P-value:1.18E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:9.20|P-value:4.59E-23 ID:SGTC_142|Compound:0335-0849|FD-Score:10.10|P-value:1.73E-27 ID:SGTC_158|Compound:k038-0087|FD-Score:8.76|P-value:4.48E-21 ID:SGTC_163|Compound:1327-0036|FD-Score:3.11|P-value:4.55E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:2.90|P-value:9.71E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.84|P-value:1.20E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:3.90|P-value:1.57E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.13|P-value:4.12E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.07|P-value:5.25E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.29|P-value:2.17E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-4.28|P-value:2.48E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:12.20|P-value:7.07E-39 ID:SGTC_796|Compound:1234-0020|FD-Score:-5.17|P-value:1.78E-8 ID:SGTC_802|Compound:4112-3352|FD-Score:4.20|P-value:3.66E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.33|P-value:1.89E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.12|P-value:5.39E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.57|P-value:7.00E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.77|P-value:3.69E-10 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.54|P-value:7.88E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.62|P-value:2.05E-16 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.34|P-value:1.87E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.92|P-value:1.40E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.89|P-value:1.72E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:21.80|P-value:1.88E-120 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.17|P-value:3.54E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-2.92|P-value:9.32E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.07|P-value:6.83E-6 ID:SGTC_2103|Compound:5378138|FD-Score:3.76|P-value:2.92E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.08|P-value:5.01E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.11|P-value:4.40E-4 ID:SGTC_2245|Compound:6637752|FD-Score:4.32|P-value:1.95E-6 ID:SGTC_2305|Compound:7443522|FD-Score:4.46|P-value:9.74E-7 ID:SGTC_2315|Compound:7733312|FD-Score:-3.38|P-value:1.56E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.90|P-value:1.59E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.49|P-value:1.01E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.00|P-value:3.81E-14 ID:SGTC_2602|Compound:kawain|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.78|P-value:2.69E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.62|P-value:4.10E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.54|P-value:7.95E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.21|P-value:3.00E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.15|P-value:3.79E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.84|P-value:1.21E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.72|P-value:3.55E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.63|P-value:5.38E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-14.10|P-value:1.10E-51 ID:SGTC_3323|Compound:9138564|FD-Score:2.91|P-value:9.33E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.56|P-value:7.15E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.42|P-value:1.15E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:6.46|P-value:2.70E-12 ID:SGTC_64|Compound:000l-0018|FD-Score:7.37|P-value:1.78E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:9.70|P-value:1.97E-25 ID:SGTC_103|Compound:0844-0104|FD-Score:5.37|P-value:5.00E-9 ID:SGTC_107|Compound:0358-0022|FD-Score:3.44|P-value:1.18E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:9.20|P-value:4.59E-23 ID:SGTC_142|Compound:0335-0849|FD-Score:10.10|P-value:1.73E-27 ID:SGTC_158|Compound:k038-0087|FD-Score:8.76|P-value:4.48E-21 ID:SGTC_163|Compound:1327-0036|FD-Score:3.11|P-value:4.55E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:2.90|P-value:9.71E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.84|P-value:1.20E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:3.90|P-value:1.57E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.13|P-value:4.12E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.07|P-value:5.25E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.29|P-value:2.17E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-4.28|P-value:2.48E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:12.20|P-value:7.07E-39 ID:SGTC_796|Compound:1234-0020|FD-Score:-5.17|P-value:1.78E-8 ID:SGTC_802|Compound:4112-3352|FD-Score:4.20|P-value:3.66E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.33|P-value:1.89E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.12|P-value:5.39E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.57|P-value:7.00E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.77|P-value:3.69E-10 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.54|P-value:7.88E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.62|P-value:2.05E-16 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.34|P-value:1.87E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.92|P-value:1.40E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.89|P-value:1.72E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:21.80|P-value:1.88E-120 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.17|P-value:3.54E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-2.92|P-value:9.32E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.07|P-value:6.83E-6 ID:SGTC_2103|Compound:5378138|FD-Score:3.76|P-value:2.92E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.08|P-value:5.01E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.11|P-value:4.40E-4 ID:SGTC_2245|Compound:6637752|FD-Score:4.32|P-value:1.95E-6 ID:SGTC_2305|Compound:7443522|FD-Score:4.46|P-value:9.74E-7 ID:SGTC_2315|Compound:7733312|FD-Score:-3.38|P-value:1.56E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.90|P-value:1.59E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.49|P-value:1.01E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.00|P-value:3.81E-14 ID:SGTC_2602|Compound:kawain|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.78|P-value:2.69E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.62|P-value:4.10E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.54|P-value:7.95E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.21|P-value:3.00E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.15|P-value:3.79E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.84|P-value:1.21E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.72|P-value:3.55E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.63|P-value:5.38E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-14.10|P-value:1.10E-51 ID:SGTC_3323|Compound:9138564|FD-Score:2.91|P-value:9.33E-4

Top fitness defect scores for YJR129C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1294 1000-1494 21.80 117.0 µM 1.88E-120 3 4.94E-106
2 SGTC_794 k038-0031 12.20 316.0 µM 7.07E-39 ubiquinone biosynthesis & proteasome 9 2.27E-34
3 SGTC_142 0335-0849 10.10 62.7 µM 1.73E-27 ubiquinone biosynthesis & proteasome 28 2.31E-24
4 SGTC_86 0417-1630 9.70 471.9 µM 1.97E-25 ubiquinone biosynthesis & proteasome 41 1.49E-22
5 SGTC_137 0438-0332 9.20 85.4 µM 4.59E-23 ubiquinone biosynthesis & proteasome 27 1.79E-20
6 SGTC_158 k038-0087 8.76 26.4 µM 4.48E-21 ubiquinone biosynthesis & proteasome 39 1.01E-18
7 SGTC_1161 k007-0610 7.62 110.0 µM 2.05E-16 ERAD & cell cycle 27 1.26E-14
8 SGTC_64 000l-0018 7.37 272.1 µM 1.78E-15 ubiquinone biosynthesis & proteasome 54 8.44E-14
9 SGTC_2582 agaric acid 7.00 100.0 µM 3.81E-14 redox potentiating 128 1.25E-12
10 SGTC_58 0957-0393 6.46 9.0 µM 2.70E-12 cell wall 186 5.32E-11
11 SGTC_103 0844-0104 5.37 51.8 µM 5.00E-9 ERAD & cell cycle 93 4.00E-8
12 SGTC_340 k038-0059 4.84 454.0 µM 1.20E-7 ubiquinone biosynthesis & proteasome 32 6.58E-7
13 SGTC_3059 1327-0034 4.84 3.0 µM 1.21E-7 38 6.64E-7
14 SGTC_2754 granisetron 4.62 64.0 µM 4.10E-7 21 1.95E-6
15 SGTC_2305 7443522 4.46 69.2 µM 9.74E-7 9 4.17E-6
16 SGTC_36 0335-0881 4.42 14.2 µM 1.15E-6 ubiquinone biosynthesis & proteasome 103 4.85E-6
17 SGTC_2245 6637752 4.32 200.0 µM 1.95E-6 14 7.70E-6
18 SGTC_802 4112-3352 4.20 742.0 µM 3.66E-6 18 1.34E-5
19 SGTC_852 0418-0143 4.12 439.0 µM 5.39E-6 calcium & mitochondrial duress 61 1.89E-5
20 SGTC_1750 st081859 4.07 2.4 µM 6.83E-6 endomembrane recycling 177 2.33E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.718 0 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.700 0 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.676 0 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.633 0 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.622 0 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.611 0 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.577 3.88E-297 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.575 1.05E-294 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.450 9.55E-167 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.399 1.64E-128 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.391 4.09E-123 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.391 7.75E-123 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.383 1.99E-117 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.382 2.91E-117 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.381 4.23E-116 YNL136W EAF7 hom Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A