YJR130C / STR2

Cystathionine gamma-synthase, converts cysteine into cystathionine

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR130C / STR2

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:3.07|P-value:6.91E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.11|P-value:5.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.73|P-value:5.11E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.23|P-value:3.78E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.30|P-value:2.90E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.98|P-value:1.66E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.00|P-value:8.85E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.12|P-value:5.63E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.50|P-value:1.27E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.31|P-value:2.79E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.33|P-value:2.53E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.52|P-value:1.18E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.66|P-value:5.82E-7 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.29|P-value:3.01E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.19|P-value:4.45E-4 ID:SGTC_1630|Compound:st005209|FD-Score:2.99|P-value:9.12E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.12|P-value:5.67E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.86|P-value:2.85E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.08|P-value:6.73E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.04|P-value:7.56E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.93|P-value:2.09E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.07|P-value:6.93E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.40|P-value:1.98E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.38|P-value:2.43E-6 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.11|P-value:9.17E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.04|P-value:7.70E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.25|P-value:3.42E-4 ID:SGTC_2813|Compound:7971799|FD-Score:4.15|P-value:7.67E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-4.28|P-value:4.01E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.46|P-value:1.50E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.67|P-value:6.43E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.19|P-value:4.40E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.82|P-value:3.39E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.14|P-value:5.23E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.50|P-value:1.28E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.12|P-value:5.54E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.07|P-value:6.91E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.11|P-value:5.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.73|P-value:5.11E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.23|P-value:3.78E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.30|P-value:2.90E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.98|P-value:1.66E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.00|P-value:8.85E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.12|P-value:5.63E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.50|P-value:1.27E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.31|P-value:2.79E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.33|P-value:2.53E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.52|P-value:1.18E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.66|P-value:5.82E-7 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.29|P-value:3.01E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.19|P-value:4.45E-4 ID:SGTC_1630|Compound:st005209|FD-Score:2.99|P-value:9.12E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.12|P-value:5.67E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.86|P-value:2.85E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.08|P-value:6.73E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.04|P-value:7.56E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.93|P-value:2.09E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.07|P-value:6.93E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.40|P-value:1.98E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.38|P-value:2.43E-6 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.11|P-value:9.17E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.04|P-value:7.70E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.25|P-value:3.42E-4 ID:SGTC_2813|Compound:7971799|FD-Score:4.15|P-value:7.67E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-4.28|P-value:4.01E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.46|P-value:1.50E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.67|P-value:6.43E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.19|P-value:4.40E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.82|P-value:3.39E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.14|P-value:5.23E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.50|P-value:1.28E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.12|P-value:5.54E-4

Top fitness defect scores for YJR130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1330 1469-0054 4.66 61.8 µM 5.82E-7 iron homeostasis 10 1.56E-6
2 SGTC_2813 7971799 4.15 71.4 µM 7.67E-6 18 1.68E-5
3 SGTC_2684 capsaicin 4.11 100.0 µM 9.17E-6 16 1.99E-5
4 SGTC_1058 3448-5425 3.98 97.3 µM 1.66E-5 33 3.44E-5
5 SGTC_2978 9011784 3.82 43.0 µM 3.39E-5 33 6.64E-5
6 SGTC_514 4466-0038 3.73 2.6 nM 5.11E-5 cell wall 171 9.70E-5
7 SGTC_2844 9010103 3.67 26.0 µM 6.43E-5 40 1.20E-4
8 SGTC_2621 lithochol-11-enic acid 3.40 100.0 µM 1.98E-4 48 3.39E-4
9 SGTC_387 norethindrone acetate 3.35 66.7 µM 2.40E-4 34 4.05E-4
10 SGTC_1122 capsaicin 3.31 818.6 nM 2.79E-4 49 4.65E-4
11 SGTC_1333 1482-0047 3.29 286.0 µM 3.01E-4 35 4.99E-4
12 SGTC_2976 9009005 3.19 19.5 µM 4.40E-4 57 7.09E-4
13 SGTC_1395 3486-0190 3.19 4.3 µM 4.45E-4 45 7.16E-4
14 SGTC_1090 efavirenz 3.12 20.7 µM 5.63E-4 51 8.91E-4
15 SGTC_1779 st039427 3.12 55.0 µM 5.67E-4 64 8.96E-4
16 SGTC_2429 5902844 3.08 64.4 µM 6.73E-4 73 0.00105
17 SGTC_129 0088-0017 3.07 176.6 µM 6.91E-4 105 0.00108
18 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.07 100.0 µM 6.93E-4 58 0.00108
19 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.04 3.7 µM 7.56E-4 194 0.00117
20 SGTC_2754 granisetron 3.04 64.0 µM 7.70E-4 88 0.00119

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 8.69E-26 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.175 2.53E-24 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.155 2.12E-19 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.154 3.34E-19 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.154 4.03E-19 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.150 2.85E-18 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.146 1.71E-17 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.146 2.13E-17 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.142 1.83E-16 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140 4.31E-16 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.137 1.76E-15 YAL037C-A_p YAL037C-A_p hom Putative protein of unknown function
0.131 2.72E-14 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.129 5.85E-14 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.129 6.69E-14 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.127 1.51E-13 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport