YJR134C / SGM1

Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR134C / SGM1

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.78|P-value:5.59E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.75|P-value:6.23E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.41|P-value:3.18E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.36|P-value:4.06E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:4.35|P-value:4.32E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.07|P-value:8.09E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.38|P-value:2.61E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.36|P-value:2.84E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.05|P-value:8.91E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.09|P-value:7.92E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.85|P-value:3.95E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.04|P-value:9.40E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.63|P-value:9.88E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.09|P-value:2.22E-10 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.52|P-value:1.57E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.64|P-value:1.04E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:3.14|P-value:6.49E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.68|P-value:8.23E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.78|P-value:5.55E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.17|P-value:5.88E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.13|P-value:6.87E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.43|P-value:2.28E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:5.70|P-value:2.61E-9 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.82|P-value:4.62E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.04|P-value:9.32E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.67|P-value:8.65E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.21|P-value:5.05E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.07|P-value:8.28E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.39|P-value:2.49E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.14|P-value:6.54E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.18|P-value:5.63E-4 ID:SGTC_1643|Compound:st009866|FD-Score:3.12|P-value:7.10E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.39|P-value:2.66E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.48|P-value:1.85E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.40|P-value:2.44E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-3.38|P-value:2.63E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.24|P-value:4.50E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.06|P-value:1.62E-5 ID:SGTC_2135|Compound:5326629|FD-Score:-3.98|P-value:2.20E-5 ID:SGTC_2145|Compound:5634607|FD-Score:-3.41|P-value:2.35E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.53|P-value:1.51E-4 ID:SGTC_2186|Compound:6124449|FD-Score:4.60|P-value:1.27E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.09|P-value:7.47E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.58|P-value:1.36E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-3.45|P-value:2.04E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.92|P-value:3.00E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.09|P-value:7.86E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.03|P-value:1.88E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.31|P-value:3.41E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.20|P-value:5.21E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.65|P-value:9.37E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.35|P-value:3.07E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.04|P-value:9.23E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.44|P-value:2.20E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.83|P-value:3.69E-7 ID:SGTC_2852|Compound:9023854|FD-Score:3.09|P-value:7.96E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.90|P-value:3.31E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.10|P-value:7.57E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.03|P-value:9.32E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.78|P-value:5.59E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.75|P-value:6.23E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.41|P-value:3.18E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.36|P-value:4.06E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:4.35|P-value:4.32E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.07|P-value:8.09E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.38|P-value:2.61E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.36|P-value:2.84E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.05|P-value:8.91E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.09|P-value:7.92E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.85|P-value:3.95E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.04|P-value:9.40E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.63|P-value:9.88E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.09|P-value:2.22E-10 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.52|P-value:1.57E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.64|P-value:1.04E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:3.14|P-value:6.49E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.68|P-value:8.23E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.78|P-value:5.55E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.17|P-value:5.88E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.13|P-value:6.87E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.43|P-value:2.28E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:5.70|P-value:2.61E-9 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.82|P-value:4.62E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.04|P-value:9.32E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.67|P-value:8.65E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.21|P-value:5.05E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.07|P-value:8.28E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.39|P-value:2.49E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.14|P-value:6.54E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.18|P-value:5.63E-4 ID:SGTC_1643|Compound:st009866|FD-Score:3.12|P-value:7.10E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.39|P-value:2.66E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.48|P-value:1.85E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.40|P-value:2.44E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-3.38|P-value:2.63E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.24|P-value:4.50E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.06|P-value:1.62E-5 ID:SGTC_2135|Compound:5326629|FD-Score:-3.98|P-value:2.20E-5 ID:SGTC_2145|Compound:5634607|FD-Score:-3.41|P-value:2.35E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.53|P-value:1.51E-4 ID:SGTC_2186|Compound:6124449|FD-Score:4.60|P-value:1.27E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.09|P-value:7.47E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.58|P-value:1.36E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-3.45|P-value:2.04E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.92|P-value:3.00E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.09|P-value:7.86E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.03|P-value:1.88E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.31|P-value:3.41E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.20|P-value:5.21E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.65|P-value:9.37E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.35|P-value:3.07E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.04|P-value:9.23E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.44|P-value:2.20E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.83|P-value:3.69E-7 ID:SGTC_2852|Compound:9023854|FD-Score:3.09|P-value:7.96E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.90|P-value:3.31E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.10|P-value:7.57E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.03|P-value:9.32E-4

Top fitness defect scores for YJR134C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 6.09 1.8 µM 2.22E-10 33 5.54E-10
2 SGTC_1288 0973-0013 5.70 65.5 µM 2.61E-9 3 5.83E-9
3 SGTC_1064 honokiol 4.64 6.8 µM 1.04E-6 15 1.78E-6
4 SGTC_2186 6124449 4.60 200.0 µM 1.27E-6 RSC complex & mRNA processing 12 2.15E-6
5 SGTC_2261 9010538 4.58 184.7 µM 1.36E-6 9 2.29E-6
6 SGTC_64 000l-0018 4.41 272.1 µM 3.18E-6 ubiquinone biosynthesis & proteasome 126 5.16E-6
7 SGTC_255 tunicamycin 4.36 200.5 nM 4.06E-6 unfolded protein response 57 6.51E-6
8 SGTC_375 3970-0961 4.35 9.3 µM 4.32E-6 tubulin folding & SWR complex 12 6.91E-6
9 SGTC_2133 5320837 4.06 200.0 µM 1.62E-5 ERG2 23 2.44E-5
10 SGTC_2368 9071271 4.03 200.0 µM 1.88E-5 30 2.81E-5
11 SGTC_2305 7443522 3.92 69.2 µM 3.00E-5 16 4.41E-5
12 SGTC_3081 9117243 3.90 49.5 µM 3.31E-5 fatty acid desaturase (OLE1) 21 4.84E-5
13 SGTC_1289 0976-0073 3.82 69.1 µM 4.62E-5 16 6.66E-5
14 SGTC_1132 3456-3614 3.78 2.5 µM 5.55E-5 tubulin folding & SWR complex 59 7.93E-5
15 SGTC_48 0382-0018 3.78 55.0 µM 5.59E-5 11 7.98E-5
16 SGTC_56 0957-0365 3.75 83.2 µM 6.23E-5 Golgi 57 8.85E-5
17 SGTC_1125 tnp00248 3.68 1.3 µM 8.23E-5 38 1.16E-4
18 SGTC_1330 1469-0054 3.67 61.8 µM 8.65E-5 iron homeostasis 23 1.21E-4
19 SGTC_2630 antimycin a 3.65 100.0 µM 9.37E-5 mitochondrial processes 49 1.31E-4
20 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.53 49.5 µM 1.51E-4 31 2.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 4.17E-39 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.183 1.42E-26 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.160 1.36E-20 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.159 1.54E-20 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.149 5.06E-18 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.144 5.66E-17 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.137 1.60E-15 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.132 1.56E-14 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.127 1.60E-13 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.122 1.46E-12 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.122 1.53E-12 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.117 8.79E-12 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.111 1.20E-10 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.109 2.52E-10 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.107 5.31E-10 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance