YJR140C / HIR3

Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR140C / HIR3

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:4.20|P-value:2.93E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:4.19|P-value:2.99E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:5.16|P-value:4.00E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.75|P-value:2.06E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.29|P-value:7.99E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.66|P-value:2.29E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.85|P-value:1.42E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.51|P-value:4.73E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.57|P-value:3.09E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.20|P-value:4.42E-7 ID:SGTC_433|Compound:pimozide|FD-Score:-5.20|P-value:4.34E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.31|P-value:7.53E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.77|P-value:1.90E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.49|P-value:4.96E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.37|P-value:7.47E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-5.08|P-value:8.05E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:3.54|P-value:3.48E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.01|P-value:6.02E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.98|P-value:6.85E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.13|P-value:4.59E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.52|P-value:4.51E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.47|P-value:9.23E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.41|P-value:5.34E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.70|P-value:1.97E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.28|P-value:8.16E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.50|P-value:3.90E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.39|P-value:5.78E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.78|P-value:1.69E-8 ID:SGTC_1728|Compound:st035614|FD-Score:-6.94|P-value:2.48E-11 ID:SGTC_1733|Compound:st037357|FD-Score:3.73|P-value:1.77E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.46|P-value:5.63E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.58|P-value:3.05E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.26|P-value:8.94E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.37|P-value:6.19E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.34|P-value:8.22E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.36|P-value:7.73E-4 ID:SGTC_2463|Compound:5473429|FD-Score:4.48|P-value:9.06E-6 ID:SGTC_2556|Compound:citropten|FD-Score:3.53|P-value:3.54E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.50|P-value:4.86E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.33|P-value:8.51E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.19|P-value:3.52E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.06|P-value:6.61E-7 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.23|P-value:9.62E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_2792|Compound:7535235|FD-Score:3.52|P-value:3.75E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.23|P-value:9.60E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-6.12|P-value:3.56E-9 ID:SGTC_2957|Compound:9076800|FD-Score:4.75|P-value:2.72E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-3.61|P-value:3.34E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.81|P-value:1.32E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.27|P-value:8.64E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.36|P-value:7.60E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.40|P-value:5.47E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.41|P-value:5.28E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.20|P-value:2.93E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:4.19|P-value:2.99E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:5.16|P-value:4.00E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.75|P-value:2.06E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.29|P-value:7.99E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.66|P-value:2.29E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.85|P-value:1.42E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.51|P-value:4.73E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.57|P-value:3.09E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.20|P-value:4.42E-7 ID:SGTC_433|Compound:pimozide|FD-Score:-5.20|P-value:4.34E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.31|P-value:7.53E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.77|P-value:1.90E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.49|P-value:4.96E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.37|P-value:7.47E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-5.08|P-value:8.05E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:3.54|P-value:3.48E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.01|P-value:6.02E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.98|P-value:6.85E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.13|P-value:4.59E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.52|P-value:4.51E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.47|P-value:9.23E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.41|P-value:5.34E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.70|P-value:1.97E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.28|P-value:8.16E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.50|P-value:3.90E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.39|P-value:5.78E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.78|P-value:1.69E-8 ID:SGTC_1728|Compound:st035614|FD-Score:-6.94|P-value:2.48E-11 ID:SGTC_1733|Compound:st037357|FD-Score:3.73|P-value:1.77E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.46|P-value:5.63E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.58|P-value:3.05E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.26|P-value:8.94E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.37|P-value:6.19E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.34|P-value:8.22E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.36|P-value:7.73E-4 ID:SGTC_2463|Compound:5473429|FD-Score:4.48|P-value:9.06E-6 ID:SGTC_2556|Compound:citropten|FD-Score:3.53|P-value:3.54E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.50|P-value:4.86E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.33|P-value:8.51E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.19|P-value:3.52E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.06|P-value:6.61E-7 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.23|P-value:9.62E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_2792|Compound:7535235|FD-Score:3.52|P-value:3.75E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.23|P-value:9.60E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-6.12|P-value:3.56E-9 ID:SGTC_2957|Compound:9076800|FD-Score:4.75|P-value:2.72E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-3.61|P-value:3.34E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.81|P-value:1.32E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.27|P-value:8.64E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.36|P-value:7.60E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.40|P-value:5.47E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.41|P-value:5.28E-4

Top fitness defect scores for YJR140C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1727 st034309 5.78 9.9 µM 1.69E-8 9 3.80E-9
2 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 5.19 100.0 µM 3.52E-7 6 1.07E-7
3 SGTC_117 lucigenin 5.16 22.1 µM 4.00E-7 redox potentiating 56 1.23E-7
4 SGTC_1061 3448-9325 5.13 110.0 µM 4.59E-7 6 1.43E-7
5 SGTC_2640 pentamidine 5.06 10.4 µM 6.61E-7 mitochondrial processes 12 2.13E-7
6 SGTC_2957 9076800 4.75 11.5 µM 2.72E-6 13 1.00E-6
7 SGTC_2463 5473429 4.48 200.0 µM 9.06E-6 ERG2 9 3.75E-6
8 SGTC_1176 0848-0131 4.47 83.3 µM 9.23E-6 Golgi 14 3.82E-6
9 SGTC_2788 5282734 4.36 71.4 µM 1.52E-5 29 6.62E-6
10 SGTC_56 0957-0365 4.20 83.2 µM 2.93E-5 Golgi 40 1.35E-5
11 SGTC_61 0978-8327 4.19 98.6 µM 2.99E-5 ergosterol biosynthesis 25 1.39E-5
12 SGTC_967 1306-0166 4.01 352.0 µM 6.02E-5 31 2.98E-5
13 SGTC_1045 1348-1485 3.98 165.0 µM 6.85E-5 30 3.43E-5
14 SGTC_3007 9078383 3.81 71.4 µM 1.32E-4 18 7.01E-5
15 SGTC_1733 st037357 3.73 54.9 µM 1.77E-4 60S ribosome export 40 9.65E-5
16 SGTC_1565 sinapyl alcohol 3.70 95.1 µM 1.97E-4 38 1.09E-4
17 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.66 4.6 µM 2.29E-4 heat shock/prefoldin 46 1.28E-4
18 SGTC_1824 st053723 3.58 68.6 µM 3.05E-4 43 1.75E-4
19 SGTC_303 1348-1668 3.57 34.2 µM 3.09E-4 11 1.77E-4
20 SGTC_956 1185-0240 3.54 191.0 µM 3.48E-4 35 2.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.07E-11 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.112 8.30E-11 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.106 6.75E-10 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.102 3.10E-9 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.094 5.46E-8 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.093 7.53E-8 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.091 1.31E-7 YOL069W NUF2 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.086 5.40E-7 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.086 6.08E-7 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.086 6.13E-7 YDR460W TFB3 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.086 6.27E-7 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.084 9.65E-7 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.083 1.31E-6 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.082 1.98E-6 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.081 2.31E-6 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31