YJR141W_p

Essential protein of unknown function

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR141W / YJR141W

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:2.95|P-value:3.30E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-2.66|P-value:9.61E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.52|P-value:2.32E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:2.98|P-value:2.80E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.71|P-value:8.82E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.19|P-value:1.11E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.21|P-value:1.02E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.29|P-value:7.08E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.49|P-value:2.63E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:-2.89|P-value:3.72E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.25|P-value:8.51E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.38|P-value:4.00E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.17|P-value:6.72E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:-4.01|P-value:1.48E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:4.54|P-value:7.46E-8 ID:SGTC_943|Compound:3253-1379|FD-Score:5.31|P-value:3.92E-10 ID:SGTC_947|Compound:3447-0010|FD-Score:-2.70|P-value:8.08E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.65|P-value:1.05E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.87|P-value:4.03E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.02|P-value:2.37E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.26|P-value:8.21E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.78|P-value:1.03E-11 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.01|P-value:2.19E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.03|P-value:2.26E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.01|P-value:2.54E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.96|P-value:2.28E-6 ID:SGTC_1523|Compound:st012844|FD-Score:2.68|P-value:9.74E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.79|P-value:5.55E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.01|P-value:2.26E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.13|P-value:1.30E-4 ID:SGTC_1793|Compound:st048256|FD-Score:2.86|P-value:4.74E-4 ID:SGTC_1901|Compound:st060216|FD-Score:2.75|P-value:7.33E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.40|P-value:4.11E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.40|P-value:4.15E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.15|P-value:1.20E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.58|P-value:1.69E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.36|P-value:5.10E-5 ID:SGTC_1968|Compound:st069590|FD-Score:7.57|P-value:8.30E-19 ID:SGTC_1970|Compound:st070122|FD-Score:3.35|P-value:5.28E-5 ID:SGTC_1971|Compound:st069429|FD-Score:3.23|P-value:9.15E-5 ID:SGTC_2044|Compound:5102272|FD-Score:2.86|P-value:4.65E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.08|P-value:1.84E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.00|P-value:1.80E-6 ID:SGTC_2073|Compound:5212005|FD-Score:3.81|P-value:5.12E-6 ID:SGTC_2150|Compound:5556613|FD-Score:2.78|P-value:6.63E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-2.81|P-value:5.11E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.14|P-value:1.39E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-2.83|P-value:4.84E-4 ID:SGTC_2217|Compound:6934799|FD-Score:-2.72|P-value:7.41E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-3.98|P-value:1.74E-6 ID:SGTC_2260|Compound:7964312|FD-Score:3.76|P-value:6.58E-6 ID:SGTC_2266|Compound:7929956|FD-Score:2.72|P-value:8.50E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.27|P-value:7.89E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.66|P-value:1.14E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-2.96|P-value:2.72E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.66|P-value:1.01E-5 ID:SGTC_2464|Compound:5717415|FD-Score:3.09|P-value:1.80E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.29|P-value:6.92E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.17|P-value:1.25E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.73|P-value:7.86E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.12|P-value:1.56E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:2.89|P-value:4.22E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.87|P-value:3.29E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.06|P-value:1.97E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-4.04|P-value:1.23E-6 ID:SGTC_2994|Compound:9053520|FD-Score:3.58|P-value:1.67E-5 ID:SGTC_2997|Compound:9067075|FD-Score:2.86|P-value:4.68E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:2.95|P-value:3.30E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-2.66|P-value:9.61E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.52|P-value:2.32E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:2.98|P-value:2.80E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.71|P-value:8.82E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.19|P-value:1.11E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.21|P-value:1.02E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.29|P-value:7.08E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.49|P-value:2.63E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:-2.89|P-value:3.72E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.25|P-value:8.51E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.38|P-value:4.00E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.17|P-value:6.72E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:-4.01|P-value:1.48E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:4.54|P-value:7.46E-8 ID:SGTC_943|Compound:3253-1379|FD-Score:5.31|P-value:3.92E-10 ID:SGTC_947|Compound:3447-0010|FD-Score:-2.70|P-value:8.08E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.65|P-value:1.05E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.87|P-value:4.03E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.02|P-value:2.37E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.26|P-value:8.21E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.78|P-value:1.03E-11 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.01|P-value:2.19E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.03|P-value:2.26E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.01|P-value:2.54E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.96|P-value:2.28E-6 ID:SGTC_1523|Compound:st012844|FD-Score:2.68|P-value:9.74E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.79|P-value:5.55E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.01|P-value:2.26E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.13|P-value:1.30E-4 ID:SGTC_1793|Compound:st048256|FD-Score:2.86|P-value:4.74E-4 ID:SGTC_1901|Compound:st060216|FD-Score:2.75|P-value:7.33E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.40|P-value:4.11E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.40|P-value:4.15E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.15|P-value:1.20E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.58|P-value:1.69E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.36|P-value:5.10E-5 ID:SGTC_1968|Compound:st069590|FD-Score:7.57|P-value:8.30E-19 ID:SGTC_1970|Compound:st070122|FD-Score:3.35|P-value:5.28E-5 ID:SGTC_1971|Compound:st069429|FD-Score:3.23|P-value:9.15E-5 ID:SGTC_2044|Compound:5102272|FD-Score:2.86|P-value:4.65E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.08|P-value:1.84E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.00|P-value:1.80E-6 ID:SGTC_2073|Compound:5212005|FD-Score:3.81|P-value:5.12E-6 ID:SGTC_2150|Compound:5556613|FD-Score:2.78|P-value:6.63E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-2.81|P-value:5.11E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.14|P-value:1.39E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-2.83|P-value:4.84E-4 ID:SGTC_2217|Compound:6934799|FD-Score:-2.72|P-value:7.41E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-3.98|P-value:1.74E-6 ID:SGTC_2260|Compound:7964312|FD-Score:3.76|P-value:6.58E-6 ID:SGTC_2266|Compound:7929956|FD-Score:2.72|P-value:8.50E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.27|P-value:7.89E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.66|P-value:1.14E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-2.96|P-value:2.72E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.66|P-value:1.01E-5 ID:SGTC_2464|Compound:5717415|FD-Score:3.09|P-value:1.80E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.29|P-value:6.92E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.17|P-value:1.25E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.73|P-value:7.86E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.12|P-value:1.56E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:2.89|P-value:4.22E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.87|P-value:3.29E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.06|P-value:1.97E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-4.04|P-value:1.23E-6 ID:SGTC_2994|Compound:9053520|FD-Score:3.58|P-value:1.67E-5 ID:SGTC_2997|Compound:9067075|FD-Score:2.86|P-value:4.68E-4

Top fitness defect scores for YJR141W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1968 st069590 7.57 43.6 µM 8.30E-19 7 1.86E-14 1.60
2 SGTC_1248 0469-0687 5.78 58.6 µM 1.03E-11 4 3.68E-9 0.82
3 SGTC_943 3253-1379 5.31 105.0 µM 3.92E-10 1 5.60E-8 0.66
4 SGTC_939 1165-0479 4.54 45.3 µM 7.46E-8 5 2.87E-6 0.18
5 SGTC_881 0833-0569 4.17 170.0 µM 6.72E-7 3 1.50E-5 0.28
6 SGTC_2065 5221596 4.00 34.3 µM 1.80E-6 7 3.15E-5 0.35
7 SGTC_1522 st012842 3.96 45.6 µM 2.28E-6 RNA pol III & RNase P/MRP 14 3.75E-5 0.28
8 SGTC_2073 5212005 3.81 126.0 µM 5.12E-6 5 6.91E-5 0.23
9 SGTC_2260 7964312 3.76 200.0 µM 6.58E-6 7 8.34E-5 0.08
10 SGTC_2328 6201408 3.66 200.0 µM 1.14E-5 13 1.26E-4 0.12
11 SGTC_2994 9053520 3.58 71.4 µM 1.67E-5 RPP1 & pyrimidine depletion 12 1.69E-4 0.02
12 SGTC_1946 st076057 3.58 65.1 µM 1.69E-5 2 1.70E-4 0.40
13 SGTC_175 3793-3120 3.52 23.7 µM 2.32E-5 12 2.16E-4 0.20
14 SGTC_666 0272-0154 3.49 136.0 µM 2.63E-5 cell wall 21 2.38E-4 0.04
15 SGTC_1929 genistein trimethyl ether 3.40 50.5 µM 4.11E-5 7 3.33E-4 0.05
16 SGTC_1935 st074532 3.40 41.6 µM 4.15E-5 11 3.35E-4 0.03
17 SGTC_1958 st076513 3.36 41.9 µM 5.10E-5 60S ribosome export 9 3.92E-4 0.13
18 SGTC_1970 st070122 3.35 35.8 µM 5.28E-5 TSC3-RPN4 16 4.02E-4 0.03
19 SGTC_2471 5466956 3.29 24.8 µM 6.92E-5 mitochondrial processes 24 4.93E-4 0.00
20 SGTC_662 k832-1615 3.29 104.0 µM 7.08E-5 9 5.02E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.29E-11 YPL074W YTA6 hom Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress
0.108 2.89E-10 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.103 2.12E-9 YDR169C-A_p YDR169C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.102 3.73E-9 YER047C SAP1 hom Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
0.097 1.53E-8 YNL118C DCP2 het Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
0.097 1.96E-8 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.094 5.35E-8 YKL174C TPO5 hom Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
0.093 6.00E-8 YDR526C_d YDR526C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 1.04E-7 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.091 1.12E-7 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.090 1.76E-7 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.089 2.63E-7 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.087 4.35E-7 YPL053C KTR6 hom Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication
0.086 5.79E-7 YHL021C AIM17 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.084 9.71E-7 YNL130C CPT1 hom Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication