YJR142W_p

Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR142W / YJR142W

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.55|P-value:1.30E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:15.90|P-value:5.95E-61 ID:SGTC_138|Compound:0850-0259|FD-Score:14.00|P-value:1.67E-47 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.51|P-value:1.50E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.15|P-value:9.21E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.09|P-value:7.03E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.03|P-value:1.02E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:4.13|P-value:1.01E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.16|P-value:5.39E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.65|P-value:7.86E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.13|P-value:6.10E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.10|P-value:1.17E-13 ID:SGTC_459|Compound:nigericin|FD-Score:4.84|P-value:2.87E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.86|P-value:3.29E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.64|P-value:2.82E-9 ID:SGTC_545|Compound:4218-0007|FD-Score:3.48|P-value:1.60E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.28|P-value:3.45E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.06|P-value:7.74E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.17|P-value:5.22E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.10|P-value:7.27E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.52|P-value:1.39E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:5.45|P-value:9.07E-9 ID:SGTC_951|Compound:1171-0579|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.59|P-value:1.05E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.09|P-value:1.28E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.90|P-value:3.01E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.66|P-value:7.63E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.68|P-value:7.26E-7 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.15|P-value:5.64E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.50|P-value:1.66E-6 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.21|P-value:4.62E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.32|P-value:3.00E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.17|P-value:5.26E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.90|P-value:2.15E-7 ID:SGTC_1665|Compound:st014639|FD-Score:4.00|P-value:1.81E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.23|P-value:4.19E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.17|P-value:8.20E-6 ID:SGTC_1740|Compound:st038286|FD-Score:3.45|P-value:1.86E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.13|P-value:9.80E-6 ID:SGTC_1839|Compound:st053978|FD-Score:-3.59|P-value:1.12E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.52|P-value:1.37E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.86|P-value:2.55E-7 ID:SGTC_1934|Compound:st074720|FD-Score:3.20|P-value:4.64E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.02|P-value:8.95E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.37|P-value:2.67E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.53|P-value:1.44E-6 ID:SGTC_1966|Compound:st070145|FD-Score:3.52|P-value:1.38E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.12|P-value:1.05E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-3.40|P-value:2.39E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.43|P-value:1.96E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.56|P-value:1.24E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.18|P-value:7.82E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.31|P-value:4.23E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:10.70|P-value:8.33E-29 ID:SGTC_2619|Compound:obliquin|FD-Score:3.73|P-value:5.76E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.23|P-value:4.21E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.50|P-value:1.71E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.04|P-value:8.94E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.88|P-value:3.04E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.22|P-value:4.45E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.31|P-value:2.11E-8 ID:SGTC_2825|Compound:7998094|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.29|P-value:3.40E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.30|P-value:3.23E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.89|P-value:2.96E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.13|P-value:6.09E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.09|P-value:7.45E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.66|P-value:7.72E-5 ID:SGTC_3266|Compound:9136860|FD-Score:5.24|P-value:3.22E-8 ID:SGTC_3311|Compound:9131146|FD-Score:10.60|P-value:2.34E-28 ID:SGTC_3321|Compound:9137793|FD-Score:4.69|P-value:6.49E-7 ID:SGTC_3350|Compound:9150499|FD-Score:3.96|P-value:2.15E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.55|P-value:1.30E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:15.90|P-value:5.95E-61 ID:SGTC_138|Compound:0850-0259|FD-Score:14.00|P-value:1.67E-47 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.51|P-value:1.50E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.15|P-value:9.21E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.09|P-value:7.03E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.03|P-value:1.02E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:4.13|P-value:1.01E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.16|P-value:5.39E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.65|P-value:7.86E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.13|P-value:6.10E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.10|P-value:1.17E-13 ID:SGTC_459|Compound:nigericin|FD-Score:4.84|P-value:2.87E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.86|P-value:3.29E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.64|P-value:2.82E-9 ID:SGTC_545|Compound:4218-0007|FD-Score:3.48|P-value:1.60E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.28|P-value:3.45E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.06|P-value:7.74E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.17|P-value:5.22E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.10|P-value:7.27E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.52|P-value:1.39E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:5.45|P-value:9.07E-9 ID:SGTC_951|Compound:1171-0579|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.59|P-value:1.05E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.09|P-value:1.28E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.90|P-value:3.01E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.66|P-value:7.63E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.68|P-value:7.26E-7 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.15|P-value:5.64E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.50|P-value:1.66E-6 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.21|P-value:4.62E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.32|P-value:3.00E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.17|P-value:5.26E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.90|P-value:2.15E-7 ID:SGTC_1665|Compound:st014639|FD-Score:4.00|P-value:1.81E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.23|P-value:4.19E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.17|P-value:8.20E-6 ID:SGTC_1740|Compound:st038286|FD-Score:3.45|P-value:1.86E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.13|P-value:9.80E-6 ID:SGTC_1839|Compound:st053978|FD-Score:-3.59|P-value:1.12E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.52|P-value:1.37E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.86|P-value:2.55E-7 ID:SGTC_1934|Compound:st074720|FD-Score:3.20|P-value:4.64E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.02|P-value:8.95E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.37|P-value:2.67E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.53|P-value:1.44E-6 ID:SGTC_1966|Compound:st070145|FD-Score:3.52|P-value:1.38E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.12|P-value:1.05E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-3.40|P-value:2.39E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.43|P-value:1.96E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.56|P-value:1.24E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.18|P-value:7.82E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.31|P-value:4.23E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:10.70|P-value:8.33E-29 ID:SGTC_2619|Compound:obliquin|FD-Score:3.73|P-value:5.76E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.23|P-value:4.21E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.50|P-value:1.71E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.04|P-value:8.94E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.88|P-value:3.04E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.22|P-value:4.45E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.31|P-value:2.11E-8 ID:SGTC_2825|Compound:7998094|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.29|P-value:3.40E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.30|P-value:3.23E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.89|P-value:2.96E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.13|P-value:6.09E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.09|P-value:7.45E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.66|P-value:7.72E-5 ID:SGTC_3266|Compound:9136860|FD-Score:5.24|P-value:3.22E-8 ID:SGTC_3311|Compound:9131146|FD-Score:10.60|P-value:2.34E-28 ID:SGTC_3321|Compound:9137793|FD-Score:4.69|P-value:6.49E-7 ID:SGTC_3350|Compound:9150499|FD-Score:3.96|P-value:2.15E-5

Top fitness defect scores for YJR142W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 15.90 9.0 µM 5.95E-61 cell wall 26 2.01E-57
2 SGTC_138 0850-0259 14.00 40.9 µM 1.67E-47 cell wall 19 9.01E-45
3 SGTC_2584 androsterone 10.70 48.7 µM 8.33E-29 cell wall 15 3.49E-27
4 SGTC_3311 9131146 10.60 2.9 µM 2.34E-28 cell wall 15 9.22E-27
5 SGTC_453 enantio-paf c16 7.10 10.0 µM 1.17E-13 23 6.19E-13
6 SGTC_514 4466-0038 5.64 2.6 nM 2.82E-9 cell wall 85 8.26E-9
7 SGTC_916 4466-0038 5.45 42.0 nM 9.07E-9 cell wall 31 2.48E-8
8 SGTC_2788 5282734 5.31 71.4 µM 2.11E-8 19 5.48E-8
9 SGTC_3266 9136860 5.24 49.5 µM 3.22E-8 cell wall 24 8.18E-8
10 SGTC_268 camptothecin 5.03 39.6 µM 1.02E-7 DNA damage response 47 2.42E-7
11 SGTC_1623 st003709 4.90 20.3 µM 2.15E-7 calcium & mitochondrial duress 35 4.88E-7
12 SGTC_1921 5740136 4.86 50.0 µM 2.55E-7 TRP & mitochondrial translation 35 5.74E-7
13 SGTC_459 nigericin 4.84 15.3 µM 2.87E-7 48 6.40E-7
14 SGTC_3321 9137793 4.69 26.8 µM 6.49E-7 cell wall 55 1.38E-6
15 SGTC_1245 0418-0076 4.66 17.2 µM 7.63E-7 ERG2 16 1.61E-6
16 SGTC_351 caspofungin 4.65 25.0 nM 7.86E-7 cell wall 66 1.66E-6
17 SGTC_1163 k060-0048 4.59 49.9 µM 1.05E-6 12 2.17E-6
18 SGTC_2488 5268135 4.56 45.7 µM 1.24E-6 33 2.55E-6
19 SGTC_39 0986-0283 4.55 58.4 µM 1.30E-6 calcium & mitochondrial duress 19 2.66E-6
20 SGTC_1959 st077091 4.53 55.8 µM 1.44E-6 RPP1 & pyrimidine depletion 30 2.93E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.522 7.55E-234 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.505 1.93E-216 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.478 2.04E-191 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.469 4.38E-183 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.454 4.69E-170 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.449 8.63E-166 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.448 2.06E-165 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.446 1.98E-163 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.440 1.09E-158 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.438 4.73E-157 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.432 1.68E-152 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.429 1.50E-150 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.417 5.51E-141 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.416 8.28E-141 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.413 3.32E-138 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2