YJR144W / MGM101

Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR144W / MGM101

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.70|P-value:2.03E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:6.13|P-value:2.58E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:14.80|P-value:1.48E-39 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.19|P-value:1.97E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.15|P-value:1.15E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.21|P-value:1.48E-13 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.01|P-value:1.82E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.10|P-value:2.10E-31 ID:SGTC_182|Compound:3448-4371|FD-Score:3.54|P-value:8.32E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:16.90|P-value:4.63E-51 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.70|P-value:8.29E-26 ID:SGTC_310|Compound:1273-0058|FD-Score:5.22|P-value:1.78E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:-4.02|P-value:1.79E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.17|P-value:2.10E-8 ID:SGTC_462|Compound:ag-879|FD-Score:5.66|P-value:2.47E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-4.70|P-value:1.46E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:-4.06|P-value:1.56E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.78|P-value:1.43E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:9.23|P-value:1.16E-16 ID:SGTC_760|Compound:0568-0725|FD-Score:3.71|P-value:4.82E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.51|P-value:3.01E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.74|P-value:4.40E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.95|P-value:2.21E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.34|P-value:3.50E-11 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.75|P-value:4.35E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.67|P-value:5.57E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.56|P-value:2.52E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.44|P-value:4.01E-5 ID:SGTC_1635|Compound:st007035|FD-Score:13.70|P-value:3.46E-34 ID:SGTC_1729|Compound:st035615|FD-Score:5.09|P-value:3.09E-6 ID:SGTC_1737|Compound:st035557|FD-Score:4.35|P-value:5.47E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.82|P-value:6.75E-10 ID:SGTC_1791|Compound:st048313|FD-Score:4.25|P-value:8.02E-5 ID:SGTC_1796|Compound:st049173|FD-Score:3.86|P-value:2.97E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.21|P-value:1.85E-6 ID:SGTC_2195|Compound:6536160|FD-Score:3.56|P-value:7.86E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.11|P-value:2.81E-6 ID:SGTC_2264|Compound:7948757|FD-Score:4.82|P-value:9.32E-6 ID:SGTC_2266|Compound:7929956|FD-Score:6.71|P-value:1.27E-9 ID:SGTC_2272|Compound:7805186|FD-Score:-5.35|P-value:9.86E-7 ID:SGTC_2278|Compound:7948257|FD-Score:4.40|P-value:4.68E-5 ID:SGTC_2279|Compound:7948423|FD-Score:4.94|P-value:5.64E-6 ID:SGTC_2352|Compound:9027995|FD-Score:-4.28|P-value:7.23E-5 ID:SGTC_2361|Compound:9034121|FD-Score:3.92|P-value:2.45E-4 ID:SGTC_2363|Compound:9053361|FD-Score:-4.96|P-value:5.15E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.74|P-value:4.38E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.53|P-value:4.37E-7 ID:SGTC_2472|Compound:5377652|FD-Score:7.24|P-value:6.33E-11 ID:SGTC_2488|Compound:5268135|FD-Score:3.49|P-value:9.61E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.53|P-value:8.60E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.49|P-value:9.69E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.97|P-value:5.00E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-4.05|P-value:1.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.80|P-value:7.66E-10 ID:SGTC_2927|Compound:9011802|FD-Score:3.76|P-value:4.22E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.28|P-value:7.26E-5 ID:SGTC_3152|Compound:9099253|FD-Score:4.62|P-value:2.02E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.75|P-value:4.31E-4 ID:SGTC_3184|Compound:9108758|FD-Score:4.01|P-value:1.82E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.78|P-value:1.10E-5 ID:SGTC_3249|Compound:9135183|FD-Score:-4.58|P-value:2.33E-5 ID:SGTC_3255|Compound:9139072|FD-Score:-3.61|P-value:6.67E-4 ID:SGTC_3276|Compound:9139060|FD-Score:-3.79|P-value:3.83E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-4.29|P-value:6.83E-5 ID:SGTC_3299|Compound:9121982|FD-Score:3.97|P-value:2.09E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.81|P-value:3.59E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.70|P-value:2.03E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:6.13|P-value:2.58E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:14.80|P-value:1.48E-39 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.19|P-value:1.97E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.15|P-value:1.15E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.21|P-value:1.48E-13 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.01|P-value:1.82E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.10|P-value:2.10E-31 ID:SGTC_182|Compound:3448-4371|FD-Score:3.54|P-value:8.32E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:16.90|P-value:4.63E-51 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.70|P-value:8.29E-26 ID:SGTC_310|Compound:1273-0058|FD-Score:5.22|P-value:1.78E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:-4.02|P-value:1.79E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.17|P-value:2.10E-8 ID:SGTC_462|Compound:ag-879|FD-Score:5.66|P-value:2.47E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-4.70|P-value:1.46E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:-4.06|P-value:1.56E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.78|P-value:1.43E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:9.23|P-value:1.16E-16 ID:SGTC_760|Compound:0568-0725|FD-Score:3.71|P-value:4.82E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.51|P-value:3.01E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.74|P-value:4.40E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.95|P-value:2.21E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.34|P-value:3.50E-11 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.75|P-value:4.35E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.67|P-value:5.57E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.56|P-value:2.52E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.44|P-value:4.01E-5 ID:SGTC_1635|Compound:st007035|FD-Score:13.70|P-value:3.46E-34 ID:SGTC_1729|Compound:st035615|FD-Score:5.09|P-value:3.09E-6 ID:SGTC_1737|Compound:st035557|FD-Score:4.35|P-value:5.47E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.82|P-value:6.75E-10 ID:SGTC_1791|Compound:st048313|FD-Score:4.25|P-value:8.02E-5 ID:SGTC_1796|Compound:st049173|FD-Score:3.86|P-value:2.97E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.21|P-value:1.85E-6 ID:SGTC_2195|Compound:6536160|FD-Score:3.56|P-value:7.86E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.11|P-value:2.81E-6 ID:SGTC_2264|Compound:7948757|FD-Score:4.82|P-value:9.32E-6 ID:SGTC_2266|Compound:7929956|FD-Score:6.71|P-value:1.27E-9 ID:SGTC_2272|Compound:7805186|FD-Score:-5.35|P-value:9.86E-7 ID:SGTC_2278|Compound:7948257|FD-Score:4.40|P-value:4.68E-5 ID:SGTC_2279|Compound:7948423|FD-Score:4.94|P-value:5.64E-6 ID:SGTC_2352|Compound:9027995|FD-Score:-4.28|P-value:7.23E-5 ID:SGTC_2361|Compound:9034121|FD-Score:3.92|P-value:2.45E-4 ID:SGTC_2363|Compound:9053361|FD-Score:-4.96|P-value:5.15E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.74|P-value:4.38E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.53|P-value:4.37E-7 ID:SGTC_2472|Compound:5377652|FD-Score:7.24|P-value:6.33E-11 ID:SGTC_2488|Compound:5268135|FD-Score:3.49|P-value:9.61E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.53|P-value:8.60E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.49|P-value:9.69E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.97|P-value:5.00E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-4.05|P-value:1.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.80|P-value:7.66E-10 ID:SGTC_2927|Compound:9011802|FD-Score:3.76|P-value:4.22E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.28|P-value:7.26E-5 ID:SGTC_3152|Compound:9099253|FD-Score:4.62|P-value:2.02E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.75|P-value:4.31E-4 ID:SGTC_3184|Compound:9108758|FD-Score:4.01|P-value:1.82E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.78|P-value:1.10E-5 ID:SGTC_3249|Compound:9135183|FD-Score:-4.58|P-value:2.33E-5 ID:SGTC_3255|Compound:9139072|FD-Score:-3.61|P-value:6.67E-4 ID:SGTC_3276|Compound:9139060|FD-Score:-3.79|P-value:3.83E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-4.29|P-value:6.83E-5 ID:SGTC_3299|Compound:9121982|FD-Score:3.97|P-value:2.09E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.81|P-value:3.59E-4

Top fitness defect scores for YJR144W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 16.90 5.3 µM 4.63E-51 79 4.23E-64
2 SGTC_70 0141-0289 14.80 43.3 µM 1.48E-39 mitochondrial stress 9 1.51E-49
3 SGTC_1635 st007035 13.70 42.4 µM 3.46E-34 49 9.34E-43
4 SGTC_173 1273-0061 13.10 2.7 µM 2.10E-31 mitochondrial stress 17 3.10E-39
5 SGTC_275 trichlorophene 11.70 5.7 µM 8.29E-26 mitochondrial stress 24 3.68E-32
6 SGTC_520 3584-0023 9.23 682.0 µM 1.16E-16 1 1.32E-20
7 SGTC_134 0269-0018 8.21 6.9 µM 1.48E-13 60 1.10E-16
8 SGTC_1188 1403-0014 7.34 4.6 µM 3.50E-11 mitochondrial stress 8 1.09E-13
9 SGTC_2472 5377652 7.24 49.4 µM 6.33E-11 TRP & mitochondrial translation 14 2.29E-13
10 SGTC_2266 7929956 6.71 200.0 µM 1.27E-9 7 1.00E-11
11 SGTC_386 1509-0011 6.17 3.1 µM 2.10E-8 89 3.42E-10
12 SGTC_68 0986-0284 6.13 82.8 µM 2.58E-8 19 4.44E-10
13 SGTC_10 0279-0212 5.70 42.6 µM 2.03E-7 TRP & mitochondrial translation 34 5.96E-9
14 SGTC_462 ag-879 5.66 158.0 µM 2.47E-7 9 7.62E-9
15 SGTC_2454 5-benzylidenerhodanine 5.53 10.4 µM 4.37E-7 TRP & mitochondrial translation 16 1.56E-8
16 SGTC_310 1273-0058 5.22 1.1 µM 1.78E-6 mitochondrial stress 176 9.10E-8
17 SGTC_1921 5740136 5.21 50.0 µM 1.85E-6 TRP & mitochondrial translation 29 9.57E-8
18 SGTC_2232 chlorophetanol 5.11 41.5 µM 2.81E-6 TRP & mitochondrial translation 74 1.62E-7
19 SGTC_1729 st035615 5.09 46.0 µM 3.09E-6 16 1.83E-7
20 SGTC_2279 7948423 4.94 32.9 µM 5.64E-6 6 3.89E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.535 9.06E-248 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.511 1.20E-222 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.510 2.04E-221 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.494 2.37E-206 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.492 2.72E-204 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.492 2.22E-203 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.489 3.40E-201 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.488 2.39E-200 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.471 1.16E-184 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.471 1.19E-184 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.470 5.74E-184 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.469 8.62E-183 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.466 2.57E-180 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.461 2.56E-176 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.454 2.22E-170 YMR138W CIN4 hom GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog