YJR146W_p

Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR146W / YJR146W

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-2.91|P-value:7.97E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:2.96|P-value:7.28E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.39|P-value:1.17E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.19|P-value:2.98E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.82|P-value:1.97E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.21|P-value:2.51E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-2.91|P-value:7.98E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.86|P-value:9.50E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.67|P-value:3.95E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.60|P-value:5.31E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.76|P-value:2.31E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-4.58|P-value:3.37E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.94|P-value:7.87E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.22|P-value:7.94E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.30|P-value:4.73E-9 ID:SGTC_1637|Compound:st007924|FD-Score:-3.08|P-value:4.21E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.48|P-value:7.88E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.21|P-value:2.72E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.01|P-value:5.99E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.50|P-value:8.19E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.93|P-value:5.52E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.94|P-value:5.19E-8 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.38|P-value:1.36E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.47|P-value:6.30E-7 ID:SGTC_2817|Compound:7995342|FD-Score:-2.87|P-value:9.17E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.67|P-value:3.36E-5 ID:SGTC_3104|Compound:9120930|FD-Score:2.93|P-value:8.14E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-2.88|P-value:8.70E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.91|P-value:7.97E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:2.96|P-value:7.28E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.39|P-value:1.17E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.19|P-value:2.98E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.82|P-value:1.97E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.21|P-value:2.51E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-2.91|P-value:7.98E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.86|P-value:9.50E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.67|P-value:3.95E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.60|P-value:5.31E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.76|P-value:2.31E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-4.58|P-value:3.37E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.94|P-value:7.87E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.22|P-value:7.94E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.30|P-value:4.73E-9 ID:SGTC_1637|Compound:st007924|FD-Score:-3.08|P-value:4.21E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.48|P-value:7.88E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.21|P-value:2.72E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.01|P-value:5.99E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.50|P-value:8.19E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.93|P-value:5.52E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.94|P-value:5.19E-8 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.38|P-value:1.36E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.47|P-value:6.30E-7 ID:SGTC_2817|Compound:7995342|FD-Score:-2.87|P-value:9.17E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.67|P-value:3.36E-5 ID:SGTC_3104|Compound:9120930|FD-Score:2.93|P-value:8.14E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-2.88|P-value:8.70E-4

Top fitness defect scores for YJR146W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2616 abietic acid 4.94 100.0 µM 5.19E-8 19 3.98E-7
2 SGTC_2568 diosmetin 4.93 100.0 µM 5.52E-8 9 4.20E-7
3 SGTC_603 3794-0023 3.82 45.9 µM 1.97E-5 13 6.74E-5
4 SGTC_1208 2323-2347 3.67 50.3 µM 3.95E-5 11 1.23E-4
5 SGTC_1211 1056-0033 3.60 32.3 µM 5.31E-5 14 1.59E-4
6 SGTC_2419 paclitaxel 3.50 166.5 µM 8.19E-5 67 2.31E-4
7 SGTC_2644 guaiazulene 3.38 100.0 µM 1.36E-4 11 3.59E-4
8 SGTC_2014 4013930 3.21 200.0 µM 2.72E-4 75 6.55E-4
9 SGTC_597 k018-0003 3.19 82.8 µM 2.98E-4 RNA pol III & RNase P/MRP 32 7.10E-4
10 SGTC_2316 5844804 3.01 197.4 µM 5.99E-4 91 0.00130
11 SGTC_437 s-farnesyl-l-cysteine methyl ester 2.96 6.7 µM 7.28E-4 54 0.00154
12 SGTC_1311 1190-0148 2.94 100.0 µM 7.87E-4 azole & statin 75 0.00165
13 SGTC_3104 9120930 2.93 49.5 µM 8.14E-4 49 0.00170
14 SGTC_2404 5161160 2.84 200.0 µM 0.00113 82 0.00225
15 SGTC_2978 9011784 2.83 43.0 µM 0.00116 102 0.00231
16 SGTC_1245 0418-0076 2.82 17.2 µM 0.00121 ERG2 84 0.00240
17 SGTC_453 enantio-paf c16 2.81 10.0 µM 0.00127 276 0.00250
18 SGTC_2641 levomentholum 2.77 100.0 µM 0.00146 31 0.00283
19 SGTC_367 0335-0881 2.77 7.1 µM 0.00147 ubiquinone biosynthesis & proteasome 165 0.00284
20 SGTC_1134 3477-0009 2.67 42.5 µM 0.00205 133 0.00380

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.375 2.94E-112 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.336 5.00E-89 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.334 4.78E-88 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.327 3.42E-84 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.322 1.14E-81 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.307 4.00E-74 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.304 1.10E-72 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.297 3.05E-69 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.295 4.05E-68 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.291 2.68E-66 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.276 8.78E-60 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.270 3.78E-57 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.269 1.46E-56 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.263 4.73E-54 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.255 1.01E-50 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene