YJR150C / DAN1

Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR150C / DAN1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-4.58|P-value:9.22E-7 ID:SGTC_264|Compound:promethazine|FD-Score:-3.47|P-value:1.61E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.87|P-value:8.90E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:7.02|P-value:3.30E-14 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.27|P-value:3.54E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.04|P-value:7.20E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:4.48|P-value:7.76E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:2.88|P-value:9.31E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.47|P-value:1.63E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.09|P-value:4.25E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.72|P-value:3.15E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:3.24|P-value:2.36E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.95|P-value:1.07E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.19|P-value:2.88E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.25|P-value:2.30E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.21|P-value:2.62E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.25|P-value:2.53E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.86|P-value:9.85E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.78|P-value:1.53E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.11|P-value:3.92E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.32|P-value:1.75E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.09|P-value:7.04E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.87|P-value:9.62E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.03|P-value:8.52E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.82|P-value:1.98E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.43|P-value:1.90E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.46|P-value:9.61E-5 ID:SGTC_1854|Compound:st056233|FD-Score:2.98|P-value:6.42E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.60|P-value:5.30E-5 ID:SGTC_2013|Compound:4024628|FD-Score:5.80|P-value:2.77E-10 ID:SGTC_2026|Compound:5148700|FD-Score:-3.57|P-value:1.06E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.27|P-value:3.49E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.34|P-value:2.74E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:5.37|P-value:4.61E-9 ID:SGTC_2044|Compound:5102272|FD-Score:3.45|P-value:1.00E-4 ID:SGTC_2045|Compound:5106652|FD-Score:4.82|P-value:1.23E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.81|P-value:3.79E-5 ID:SGTC_2258|Compound:7960471|FD-Score:-3.53|P-value:1.28E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.03|P-value:5.35E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.15|P-value:5.49E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.80|P-value:3.96E-5 ID:SGTC_2324|Compound:6149169|FD-Score:6.89|P-value:9.32E-14 ID:SGTC_2397|Compound:5161689|FD-Score:3.14|P-value:3.44E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-3.01|P-value:9.39E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.31|P-value:2.99E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.42|P-value:1.95E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.07|P-value:4.55E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.94|P-value:2.15E-5 ID:SGTC_2887|Compound:9044784|FD-Score:-3.64|P-value:8.08E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.88|P-value:1.54E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.26|P-value:3.65E-4 ID:SGTC_2899|Compound:9053889|FD-Score:7.26|P-value:4.74E-15 ID:SGTC_3017|Compound:9080681|FD-Score:2.94|P-value:7.40E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.02|P-value:9.01E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.23|P-value:2.41E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.28|P-value:1.99E-4 ID:SGTC_3342|Compound:9147791|FD-Score:4.20|P-value:3.25E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.58|P-value:9.22E-7 ID:SGTC_264|Compound:promethazine|FD-Score:-3.47|P-value:1.61E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.87|P-value:8.90E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:7.02|P-value:3.30E-14 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.27|P-value:3.54E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.04|P-value:7.20E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:4.48|P-value:7.76E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:2.88|P-value:9.31E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.47|P-value:1.63E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.09|P-value:4.25E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.72|P-value:3.15E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:3.24|P-value:2.36E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.95|P-value:1.07E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.19|P-value:2.88E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.25|P-value:2.30E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.21|P-value:2.62E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.25|P-value:2.53E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.86|P-value:9.85E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.78|P-value:1.53E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.11|P-value:3.92E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.32|P-value:1.75E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.09|P-value:7.04E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.87|P-value:9.62E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.03|P-value:8.52E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.82|P-value:1.98E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.43|P-value:1.90E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.46|P-value:9.61E-5 ID:SGTC_1854|Compound:st056233|FD-Score:2.98|P-value:6.42E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.60|P-value:5.30E-5 ID:SGTC_2013|Compound:4024628|FD-Score:5.80|P-value:2.77E-10 ID:SGTC_2026|Compound:5148700|FD-Score:-3.57|P-value:1.06E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.27|P-value:3.49E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.34|P-value:2.74E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:5.37|P-value:4.61E-9 ID:SGTC_2044|Compound:5102272|FD-Score:3.45|P-value:1.00E-4 ID:SGTC_2045|Compound:5106652|FD-Score:4.82|P-value:1.23E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.81|P-value:3.79E-5 ID:SGTC_2258|Compound:7960471|FD-Score:-3.53|P-value:1.28E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.03|P-value:5.35E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.15|P-value:5.49E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.80|P-value:3.96E-5 ID:SGTC_2324|Compound:6149169|FD-Score:6.89|P-value:9.32E-14 ID:SGTC_2397|Compound:5161689|FD-Score:3.14|P-value:3.44E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-3.01|P-value:9.39E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.31|P-value:2.99E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.42|P-value:1.95E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.07|P-value:4.55E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.94|P-value:2.15E-5 ID:SGTC_2887|Compound:9044784|FD-Score:-3.64|P-value:8.08E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.88|P-value:1.54E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.26|P-value:3.65E-4 ID:SGTC_2899|Compound:9053889|FD-Score:7.26|P-value:4.74E-15 ID:SGTC_3017|Compound:9080681|FD-Score:2.94|P-value:7.40E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.02|P-value:9.01E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.23|P-value:2.41E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.28|P-value:1.99E-4 ID:SGTC_3342|Compound:9147791|FD-Score:4.20|P-value:3.25E-6

Top fitness defect scores for YJR150C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2899 9053889 7.26 58.4 µM 4.74E-15 1 1.93E-13
2 SGTC_270 tamoxifen 7.02 5.5 µM 3.30E-14 NEO1 4 1.08E-12
3 SGTC_2324 6149169 6.89 200.0 µM 9.32E-14 2 2.72E-12
4 SGTC_2013 4024628 5.80 200.0 µM 2.77E-10 17 3.29E-9
5 SGTC_2042 p-Dimethylaminoacetophenone 5.37 200.0 µM 4.61E-9 3 4.00E-8
6 SGTC_266 formosanin C 4.87 406.0 nM 8.90E-8 sphingolipid biosynthesis & PDR1 49 5.53E-7
7 SGTC_2045 5106652 4.82 78.0 µM 1.23E-7 4 7.35E-7
8 SGTC_1202 1988-0068 4.78 29.6 µM 1.53E-7 RNA processing & uracil transport 10 8.93E-7
9 SGTC_523 1934-0222 4.48 13.7 µM 7.76E-7 23 3.77E-6
10 SGTC_1045 1348-1485 4.25 165.0 µM 2.53E-6 23 1.08E-5
11 SGTC_3342 9147791 4.20 14.5 µM 3.25E-6 11 1.34E-5
12 SGTC_520 3584-0023 4.04 682.0 µM 7.20E-6 24 2.72E-5
13 SGTC_807 1315-0151 3.95 48.0 µM 1.07E-5 27 3.86E-5
14 SGTC_2891 9063876 3.88 19.5 µM 1.54E-5 8 5.32E-5
15 SGTC_1554 st069299 3.82 38.7 µM 1.98E-5 26 6.64E-5
16 SGTC_633 0437-0093 3.72 97.7 µM 3.15E-5 DNA intercalators 18 1.00E-4
17 SGTC_2004 4023728 3.60 41.9 µM 5.30E-5 36 1.59E-4
18 SGTC_1785 bathophenanthroline 3.46 24.0 µM 9.61E-5 heme requiring 72 2.70E-4
19 SGTC_2044 5102272 3.45 200.0 µM 1.00E-4 23 2.80E-4
20 SGTC_1227 3909-8010 3.32 46.6 µM 1.75E-4 41 4.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.91E-11 YOR041C_d YOR041C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance
0.115 2.00E-11 YIL051C MMF1 het Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
0.105 9.34E-10 YFR021W ATG18 hom Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
0.104 1.37E-9 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.091 1.45E-7 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.090 1.62E-7 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.085 8.84E-7 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.082 2.26E-6 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.081 2.86E-6 YPL273W SAM4 hom S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.079 4.47E-6 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.078 6.23E-6 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.077 8.70E-6 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.076 1.19E-5 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.076 1.16E-5 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.075 1.48E-5 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data