YJR152W / DAL5

Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR152W / DAL5

Click on Significant Values for Screen Details ID:SGTC_791|Compound:1348-1292|FD-Score:-3.43|P-value:3.08E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:4.90|P-value:4.02E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.13|P-value:8.99E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.67|P-value:1.08E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.11|P-value:8.52E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.10|P-value:9.01E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.10|P-value:1.47E-7 ID:SGTC_1348|Compound:1493-0373|FD-Score:5.75|P-value:3.68E-9 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.64|P-value:1.24E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-5.24|P-value:7.78E-8 ID:SGTC_1741|Compound:st038134|FD-Score:4.33|P-value:6.58E-6 ID:SGTC_1842|Compound:st055362|FD-Score:3.19|P-value:6.49E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.13|P-value:8.84E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.77|P-value:7.44E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.51|P-value:2.04E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.57|P-value:2.08E-6 ID:SGTC_2317|Compound:5986382|FD-Score:4.27|P-value:8.69E-6 ID:SGTC_2326|Compound:6164455|FD-Score:4.58|P-value:2.03E-6 ID:SGTC_2337|Compound:9009472|FD-Score:3.20|P-value:6.41E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.17|P-value:6.98E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.14|P-value:7.84E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.15|P-value:7.42E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-4.71|P-value:1.26E-6 ID:SGTC_2942|Compound:9052777|FD-Score:3.72|P-value:9.16E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.96|P-value:3.70E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.80|P-value:7.24E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.48|P-value:2.51E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.43|P-value:3.08E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:4.90|P-value:4.02E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.13|P-value:8.99E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.67|P-value:1.08E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.11|P-value:8.52E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.10|P-value:9.01E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.10|P-value:1.47E-7 ID:SGTC_1348|Compound:1493-0373|FD-Score:5.75|P-value:3.68E-9 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.64|P-value:1.24E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-5.24|P-value:7.78E-8 ID:SGTC_1741|Compound:st038134|FD-Score:4.33|P-value:6.58E-6 ID:SGTC_1842|Compound:st055362|FD-Score:3.19|P-value:6.49E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.13|P-value:8.84E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.77|P-value:7.44E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.51|P-value:2.04E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.57|P-value:2.08E-6 ID:SGTC_2317|Compound:5986382|FD-Score:4.27|P-value:8.69E-6 ID:SGTC_2326|Compound:6164455|FD-Score:4.58|P-value:2.03E-6 ID:SGTC_2337|Compound:9009472|FD-Score:3.20|P-value:6.41E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.17|P-value:6.98E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.14|P-value:7.84E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.15|P-value:7.42E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-4.71|P-value:1.26E-6 ID:SGTC_2942|Compound:9052777|FD-Score:3.72|P-value:9.16E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.96|P-value:3.70E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.80|P-value:7.24E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.48|P-value:2.51E-4

Top fitness defect scores for YJR152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1348 1493-0373 5.75 93.8 µM 3.68E-9 4 4.46E-9
2 SGTC_1347 1493-0251 5.10 600.0 nM 1.47E-7 mitochondrial response to ROS 7 1.73E-7
3 SGTC_909 3448-9333 4.90 149.0 µM 4.02E-7 7 4.68E-7
4 SGTC_2326 6164455 4.58 177.6 µM 2.03E-6 mitochondrial processes 12 2.33E-6
5 SGTC_2316 5844804 4.57 197.4 µM 2.08E-6 10 2.39E-6
6 SGTC_1741 st038134 4.33 10.2 µM 6.58E-6 22 7.48E-6
7 SGTC_2317 5986382 4.27 200.0 µM 8.69E-6 10 9.85E-6
8 SGTC_1976 st070609 3.77 63.5 µM 7.44E-5 15 8.26E-5
9 SGTC_2942 9052777 3.72 62.2 µM 9.16E-5 43 1.02E-4
10 SGTC_1084 voriconazole 3.67 435.0 nM 1.08E-4 azole & statin 36 1.20E-4
11 SGTC_1350 1495-0454 3.64 146.0 µM 1.24E-4 43 1.37E-4
12 SGTC_2100 5377183 3.51 190.0 µM 2.04E-4 60S ribosome export 18 2.24E-4
13 SGTC_2337 9009472 3.20 200.0 µM 6.41E-4 64 6.98E-4
14 SGTC_1842 st055362 3.19 61.2 µM 6.49E-4 38 7.06E-4
15 SGTC_2516 gossypol 3.17 71.5 µM 6.98E-4 48 7.59E-4
16 SGTC_2857 9024691 3.15 58.4 µM 7.42E-4 57 8.06E-4
17 SGTC_2833 9001315 3.14 45.5 µM 7.84E-4 amide catabolism 92 8.52E-4
18 SGTC_1187 1391-0724 3.11 117.0 µM 8.52E-4 amide catabolism 51 9.24E-4
19 SGTC_1262 0737-0114 3.10 49.6 µM 9.01E-4 54 9.78E-4
20 SGTC_915 methyl methanesulfonate (MMS) 2.87 110.0 mM 0.00191 DNA damage response 96 0.00206

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 5.02E-20 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.150 3.23E-18 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.138 9.02E-16 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.136 2.86E-15 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.133 1.02E-14 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.130 4.79E-14 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.125 3.20E-13 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.121 2.17E-12 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.120 2.91E-12 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.120 3.68E-12 YJR037W_d YJR037W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces
0.119 4.70E-12 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.117 1.05E-11 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.114 3.36E-11 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.113 5.59E-11 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.110 1.61E-10 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm