YJR154W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR154W / YJR154W

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.39|P-value:8.19E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.31|P-value:6.17E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:-2.74|P-value:9.21E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:2.92|P-value:7.97E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.28|P-value:1.85E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.45|P-value:8.84E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.02|P-value:2.07E-8 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.56|P-value:5.34E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:3.17|P-value:2.97E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.00|P-value:6.66E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.05|P-value:4.76E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.28|P-value:1.83E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.27|P-value:1.94E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.28|P-value:1.03E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.73|P-value:2.52E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.57|P-value:5.23E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.25|P-value:2.06E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.27|P-value:1.93E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.49|P-value:4.75E-7 ID:SGTC_1522|Compound:st012842|FD-Score:2.87|P-value:9.36E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-2.97|P-value:3.83E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.03|P-value:5.10E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-2.77|P-value:8.34E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-2.76|P-value:8.69E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.04|P-value:5.36E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.67|P-value:1.76E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.53|P-value:6.32E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.98|P-value:3.57E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.08|P-value:4.22E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.87|P-value:6.44E-6 ID:SGTC_2800|Compound:7887935|FD-Score:4.80|P-value:7.99E-8 ID:SGTC_2825|Compound:7998094|FD-Score:-3.62|P-value:2.18E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-2.84|P-value:6.46E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-2.88|P-value:5.52E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.83|P-value:6.66E-4 ID:SGTC_2981|Compound:9013952|FD-Score:2.97|P-value:6.60E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.83|P-value:1.51E-5 ID:SGTC_3075|Compound:9116269|FD-Score:-4.08|P-value:2.20E-6 ID:SGTC_3082|Compound:9117008|FD-Score:4.06|P-value:4.86E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-3.33|P-value:8.26E-5 ID:SGTC_3159|Compound:9100096|FD-Score:3.48|P-value:7.75E-5 ID:SGTC_3226|Compound:9131256|FD-Score:-3.02|P-value:3.10E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.01|P-value:5.56E-4 ID:SGTC_3323|Compound:9138564|FD-Score:-3.04|P-value:2.86E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.39|P-value:8.19E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.31|P-value:6.17E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:-2.74|P-value:9.21E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:2.92|P-value:7.97E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.28|P-value:1.85E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.45|P-value:8.84E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.02|P-value:2.07E-8 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.56|P-value:5.34E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:3.17|P-value:2.97E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.00|P-value:6.66E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.05|P-value:4.76E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.28|P-value:1.83E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.27|P-value:1.94E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.28|P-value:1.03E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.73|P-value:2.52E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.57|P-value:5.23E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.25|P-value:2.06E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.27|P-value:1.93E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.49|P-value:4.75E-7 ID:SGTC_1522|Compound:st012842|FD-Score:2.87|P-value:9.36E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-2.97|P-value:3.83E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.03|P-value:5.10E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-2.77|P-value:8.34E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-2.76|P-value:8.69E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.04|P-value:5.36E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.67|P-value:1.76E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.53|P-value:6.32E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.98|P-value:3.57E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.08|P-value:4.22E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.87|P-value:6.44E-6 ID:SGTC_2800|Compound:7887935|FD-Score:4.80|P-value:7.99E-8 ID:SGTC_2825|Compound:7998094|FD-Score:-3.62|P-value:2.18E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-2.84|P-value:6.46E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-2.88|P-value:5.52E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.83|P-value:6.66E-4 ID:SGTC_2981|Compound:9013952|FD-Score:2.97|P-value:6.60E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.83|P-value:1.51E-5 ID:SGTC_3075|Compound:9116269|FD-Score:-4.08|P-value:2.20E-6 ID:SGTC_3082|Compound:9117008|FD-Score:4.06|P-value:4.86E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-3.33|P-value:8.26E-5 ID:SGTC_3159|Compound:9100096|FD-Score:3.48|P-value:7.75E-5 ID:SGTC_3226|Compound:9131256|FD-Score:-3.02|P-value:3.10E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.01|P-value:5.56E-4 ID:SGTC_3323|Compound:9138564|FD-Score:-3.04|P-value:2.86E-4

Top fitness defect scores for YJR154W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_219 mitoxanthrone 5.02 164.4 µM 2.07E-8 DNA intercalators 26 2.63E-7
2 SGTC_2800 7887935 4.80 81.8 µM 7.99E-8 RPP1 & pyrimidine depletion 10 8.07E-7
3 SGTC_1350 1495-0454 4.49 146.0 µM 4.75E-7 13 3.55E-6
4 SGTC_46 0329-0187a 4.39 2.2 µM 8.19E-7 55 5.59E-6
5 SGTC_3082 9117008 4.06 49.5 µM 4.86E-6 14 2.47E-5
6 SGTC_2071 5230951 4.04 39.9 µM 5.36E-6 TSC3-RPN4 16 2.68E-5
7 SGTC_953 1188-0045 4.00 9.7 µM 6.66E-6 60S ribosome export 26 3.21E-5
8 SGTC_2993 9054257 3.83 71.4 µM 1.51E-5 fatty acid desaturase (OLE1) 49 6.35E-5
9 SGTC_1224 0823-0416 3.73 294.0 µM 2.52E-5 13 9.75E-5
10 SGTC_1248 0469-0687 3.57 58.6 µM 5.23E-5 40 1.80E-4
11 SGTC_407 eburnamonine 3.56 100.0 µM 5.34E-5 23 1.83E-4
12 SGTC_2407 paclitaxel 3.53 400.0 µM 6.32E-5 52 2.11E-4
13 SGTC_3159 9100096 3.48 49.5 µM 7.75E-5 35 2.50E-4
14 SGTC_214 4373-3496 3.45 70.0 µM 8.84E-5 92 2.79E-4
15 SGTC_1143 3454-2408 3.28 5.1 µM 1.83E-4 60S ribosome export 11 5.15E-4
16 SGTC_212 3807-4682 3.28 38.8 µM 1.85E-4 tubulin folding & SWR complex 108 5.19E-4
17 SGTC_1325 1431-0015 3.27 227.0 µM 1.93E-4 Golgi 40 5.37E-4
18 SGTC_1156 4092-0367 3.27 4.9 µM 1.94E-4 51 5.40E-4
19 SGTC_1312 1218-2183 3.25 165.0 µM 2.06E-4 18 5.68E-4
20 SGTC_508 roscovitine 3.17 141.0 µM 2.97E-4 19 7.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.26E-13 YGR287C IMA1 hom Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family
0.110 1.82E-10 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.110 1.94E-10 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.109 2.19E-10 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.107 4.33E-10 YDR164C SEC1 het Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
0.107 6.01E-10 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.102 3.56E-9 YDR249C_p YDR249C_p hom Putative protein of unknown function
0.100 5.65E-9 YGL128C CWC23 het Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p
0.100 6.77E-9 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.099 9.87E-9 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.096 2.21E-8 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.093 5.87E-8 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.091 1.10E-7 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.091 1.42E-7 YEL011W GLC3 hom Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.091 1.45E-7 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress