HIPHOP chemogenomics database
YKL005C / BYE1 
Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKL005C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.137 | 1.49E-15 | YPL217C | BMS1 | het | GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p |
| 0.136 | 2.33E-15 | YMR104C | YPK2 | hom | Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication |
| 0.136 | 2.61E-15 | YDR499W | LCD1 | het | Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress |
| 0.124 | 6.21E-13 | YER069W | ARG5,6 | hom | Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine |
| 0.123 | 1.06E-12 | YDR411C | DFM1 | hom | Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p |
| 0.118 | 7.97E-12 | YOR040W | GLO4 | hom | Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate |
| 0.102 | 3.13E-9 | YLR063W_p | YLR063W_p | hom | Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene |
| 0.098 | 1.14E-8 | YPL249C | GYP5 | hom | GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| 0.098 | 1.22E-8 | YGL059W | PKP2 | hom | Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress |
| 0.094 | 4.51E-8 | YIL046W-A_p | YIL046W-A_p | hom | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.093 | 5.95E-8 | YGR122C-A_d | YGR122C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W |
| 0.093 | 7.00E-8 | YOR100C | CRC1 | hom | Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
| 0.092 | 8.28E-8 | YNL067W-B_p | YNL067W-B_p | hom | Putative protein of unknown function |
| 0.092 | 8.62E-8 | YOL140W | ARG8 | hom | Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine |
| 0.092 | 8.95E-8 | YMR107W | SPG4 | hom | Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |