YKL005C / BYE1

Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL005C / BYE1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-4.82|P-value:1.32E-7 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.46|P-value:1.19E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.98|P-value:7.82E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.48|P-value:1.01E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.07|P-value:5.07E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.80|P-value:2.71E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:2.99|P-value:7.56E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.40|P-value:1.50E-6 ID:SGTC_738|Compound:1315-0003|FD-Score:3.82|P-value:2.51E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.57|P-value:7.48E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.95|P-value:8.02E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-2.91|P-value:9.32E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:6.89|P-value:1.16E-13 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.55|P-value:8.30E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.26|P-value:2.49E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.19|P-value:3.57E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:6.85|P-value:1.66E-13 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.29|P-value:2.20E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.11|P-value:6.28E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.01|P-value:6.44E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.01|P-value:6.54E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.60|P-value:5.92E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.84|P-value:2.29E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-3.20|P-value:3.17E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.03|P-value:9.40E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.06|P-value:5.86E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.10|P-value:4.55E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.09|P-value:5.22E-4 ID:SGTC_2478|Compound:5763493|FD-Score:2.98|P-value:7.93E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.19|P-value:3.58E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.09|P-value:4.73E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.79|P-value:2.83E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.04|P-value:5.84E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:2.94|P-value:9.10E-4 ID:SGTC_2809|Compound:7964133|FD-Score:5.13|P-value:2.47E-8 ID:SGTC_2829|Compound:7992743|FD-Score:4.98|P-value:5.84E-8 ID:SGTC_2852|Compound:9023854|FD-Score:-3.10|P-value:4.65E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.68|P-value:3.26E-7 ID:SGTC_3215|Compound:9129942|FD-Score:3.09|P-value:5.25E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.02|P-value:6.80E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.25|P-value:2.84E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.12|P-value:4.67E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-4.82|P-value:1.32E-7 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.46|P-value:1.19E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.98|P-value:7.82E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.48|P-value:1.01E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.07|P-value:5.07E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.80|P-value:2.71E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:2.99|P-value:7.56E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.40|P-value:1.50E-6 ID:SGTC_738|Compound:1315-0003|FD-Score:3.82|P-value:2.51E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.57|P-value:7.48E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.95|P-value:8.02E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-2.91|P-value:9.32E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:6.89|P-value:1.16E-13 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.55|P-value:8.30E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.26|P-value:2.49E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.19|P-value:3.57E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:6.85|P-value:1.66E-13 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.29|P-value:2.20E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.11|P-value:6.28E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.01|P-value:6.44E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.01|P-value:6.54E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.60|P-value:5.92E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.84|P-value:2.29E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-3.20|P-value:3.17E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.03|P-value:9.40E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.06|P-value:5.86E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.10|P-value:4.55E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.09|P-value:5.22E-4 ID:SGTC_2478|Compound:5763493|FD-Score:2.98|P-value:7.93E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.19|P-value:3.58E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.09|P-value:4.73E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.79|P-value:2.83E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.04|P-value:5.84E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:2.94|P-value:9.10E-4 ID:SGTC_2809|Compound:7964133|FD-Score:5.13|P-value:2.47E-8 ID:SGTC_2829|Compound:7992743|FD-Score:4.98|P-value:5.84E-8 ID:SGTC_2852|Compound:9023854|FD-Score:-3.10|P-value:4.65E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.68|P-value:3.26E-7 ID:SGTC_3215|Compound:9129942|FD-Score:3.09|P-value:5.25E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.02|P-value:6.80E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.25|P-value:2.84E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.12|P-value:4.67E-4

Top fitness defect scores for YKL005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_802 4112-3352 6.89 742.0 µM 1.16E-13 2 2.78E-12
2 SGTC_1125 tnp00248 6.85 1.3 µM 1.66E-13 3 3.80E-12
3 SGTC_2809 7964133 5.13 13.0 µM 2.47E-8 60S ribosome export 13 1.45E-7
4 SGTC_2829 7992743 4.98 58.4 µM 5.84E-8 16 3.10E-7
5 SGTC_3211 9128781 4.68 49.5 µM 3.26E-7 42 1.43E-6
6 SGTC_653 0203-0016 4.40 55.2 µM 1.50E-6 6 5.52E-6
7 SGTC_1147 3809-1045 4.11 12.3 µM 6.28E-6 21 1.97E-5
8 SGTC_2062 5245942 4.03 200.0 µM 9.40E-6 16 2.82E-5
9 SGTC_1881 5652484 3.84 16.0 µM 2.29E-5 TRP & mitochondrial translation 31 6.21E-5
10 SGTC_738 1315-0003 3.82 72.4 µM 2.51E-5 25 6.74E-5
11 SGTC_421 streptovitacin 3.80 30.0 mM 2.71E-5 25 7.23E-5
12 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.79 100.0 µM 2.83E-5 25 7.52E-5
13 SGTC_762 1165-0429 3.57 115.0 µM 7.48E-5 TSC3-RPN4 29 1.78E-4
14 SGTC_1000 4048-0884 3.55 8.7 µM 8.30E-5 copper-dependent oxidative stress 42 1.96E-4
15 SGTC_254 nsc-64875 3.46 3.8 µM 1.19E-4 ergosterol depletion effects on membrane 44 2.70E-4
16 SGTC_381 3461-2219 3.46 42.7 µM 1.22E-4 copper-dependent oxidative stress 32 2.75E-4
17 SGTC_3276 9139060 3.25 49.5 µM 2.84E-4 60S ribosome export 18 5.85E-4
18 SGTC_1054 3429-0080 3.19 167.0 µM 3.57E-4 52 7.17E-4
19 SGTC_2480 5767542 3.19 37.2 µM 3.58E-4 36 7.19E-4
20 SGTC_3309 9129340 3.12 25.8 µM 4.67E-4 46 9.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.49E-15 YPL217C BMS1 het GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p
0.136 2.33E-15 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.136 2.61E-15 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.124 6.21E-13 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.123 1.06E-12 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.118 7.97E-12 YOR040W GLO4 hom Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.102 3.13E-9 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.098 1.14E-8 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.098 1.22E-8 YGL059W PKP2 hom Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.094 4.51E-8 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.093 5.95E-8 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.093 7.00E-8 YOR100C CRC1 hom Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
0.092 8.28E-8 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.092 8.62E-8 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.092 8.95E-8 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources