YKL006C-A / SFT1

Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL006C-A / SFT1

Click on Significant Values for Screen Details ID:SGTC_161|Compound:4065-0411|FD-Score:3.23|P-value:2.97E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.11|P-value:8.30E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:3.81|P-value:2.56E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:-3.05|P-value:7.06E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.50|P-value:9.91E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:5.34|P-value:7.47E-9 ID:SGTC_714|Compound:4296-0578|FD-Score:2.99|P-value:7.33E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.32|P-value:2.19E-6 ID:SGTC_798|Compound:1287-0182|FD-Score:3.15|P-value:3.99E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.47|P-value:1.11E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.15|P-value:4.03E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:2.98|P-value:7.44E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.17|P-value:3.71E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.10|P-value:4.83E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.07|P-value:7.80E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.87|P-value:1.55E-7 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.08|P-value:6.38E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.07|P-value:7.79E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.73|P-value:3.70E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.00|P-value:8.62E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.85|P-value:2.10E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.30|P-value:2.27E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.07|P-value:7.52E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:2.99|P-value:7.30E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.07|P-value:6.59E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.83|P-value:2.38E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.81|P-value:2.57E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-4.37|P-value:2.30E-6 ID:SGTC_1927|Compound:st060202|FD-Score:2.95|P-value:8.36E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.61|P-value:7.94E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.33|P-value:1.95E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.14|P-value:4.17E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.14|P-value:5.17E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.22|P-value:3.70E-6 ID:SGTC_2297|Compound:7971671|FD-Score:3.03|P-value:6.19E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.92|P-value:9.45E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.21|P-value:5.00E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.49|P-value:2.95E-9 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.13|P-value:5.82E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:3.30|P-value:2.21E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.23|P-value:2.91E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-4.24|P-value:4.28E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.45|P-value:1.24E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.75|P-value:4.27E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.00|P-value:8.52E-4 ID:SGTC_2836|Compound:9010338|FD-Score:2.91|P-value:9.54E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.93|P-value:1.87E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-3.80|P-value:3.35E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.72|P-value:3.76E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.14|P-value:5.17E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.32|P-value:2.59E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.70|P-value:4.18E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.23|P-value:2.97E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.11|P-value:8.30E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:3.81|P-value:2.56E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:-3.05|P-value:7.06E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.50|P-value:9.91E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:5.34|P-value:7.47E-9 ID:SGTC_714|Compound:4296-0578|FD-Score:2.99|P-value:7.33E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.32|P-value:2.19E-6 ID:SGTC_798|Compound:1287-0182|FD-Score:3.15|P-value:3.99E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.47|P-value:1.11E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.15|P-value:4.03E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:2.98|P-value:7.44E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.17|P-value:3.71E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.10|P-value:4.83E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.07|P-value:7.80E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.87|P-value:1.55E-7 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.08|P-value:6.38E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.07|P-value:7.79E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.73|P-value:3.70E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.00|P-value:8.62E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.85|P-value:2.10E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.30|P-value:2.27E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.07|P-value:7.52E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:2.99|P-value:7.30E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.07|P-value:6.59E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.83|P-value:2.38E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.81|P-value:2.57E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-4.37|P-value:2.30E-6 ID:SGTC_1927|Compound:st060202|FD-Score:2.95|P-value:8.36E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.61|P-value:7.94E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.33|P-value:1.95E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.14|P-value:4.17E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.14|P-value:5.17E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.22|P-value:3.70E-6 ID:SGTC_2297|Compound:7971671|FD-Score:3.03|P-value:6.19E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.92|P-value:9.45E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.21|P-value:5.00E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.49|P-value:2.95E-9 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.13|P-value:5.82E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:3.30|P-value:2.21E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.23|P-value:2.91E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-4.24|P-value:4.28E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.45|P-value:1.24E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.75|P-value:4.27E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.00|P-value:8.52E-4 ID:SGTC_2836|Compound:9010338|FD-Score:2.91|P-value:9.54E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.93|P-value:1.87E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-3.80|P-value:3.35E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.72|P-value:3.76E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.14|P-value:5.17E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.32|P-value:2.59E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.70|P-value:4.18E-5

Top fitness defect scores for YKL006C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2565 isoliquiritigenin 5.49 100.0 µM 2.95E-9 2 2.04E-8 0.66
2 SGTC_669 0108-0021 5.34 26.2 µM 7.47E-9 fatty acid desaturase (OLE1) 4 4.69E-8 0.49
3 SGTC_747 3448-8087 4.32 38.7 µM 2.19E-6 8 7.63E-6 0.68
4 SGTC_2147 5545932 4.22 89.7 µM 3.70E-6 ergosterol biosynthesis 11 1.22E-5 0.15
5 SGTC_2592 piperlongumine 4.13 83.3 µM 5.82E-6 TSC3-RPN4 4 1.84E-5 0.06
6 SGTC_1372 2752-0194 4.07 270.0 µM 7.52E-6 1 2.31E-5 0.49
7 SGTC_1113 artemisinin 4.07 1.2 µM 7.79E-6 heme biosynthesis & mitochondrial translocase 32 2.38E-5 0.09
8 SGTC_1098 clofazimine 4.07 15.1 µM 7.80E-6 heme biosynthesis & mitochondrial translocase 27 2.39E-5 0.23
9 SGTC_1234 0326-0494 3.85 15.5 µM 2.10E-5 4 5.81E-5 0.24
10 SGTC_1699 st031318 3.83 29.1 µM 2.38E-5 2 6.49E-5 0.38
11 SGTC_170 4197-0004 3.81 226.0 µM 2.56E-5 5 6.94E-5 0.06
12 SGTC_1851 st056236 3.81 18.9 µM 2.57E-5 4 6.95E-5 0.03
13 SGTC_1136 pergolide 3.73 1.1 µM 3.70E-5 23 9.64E-5 0.06
14 SGTC_2989 9073649 3.72 71.4 µM 3.76E-5 14 9.79E-5 0.02
15 SGTC_3314 9135860 3.70 59.4 µM 4.18E-5 3 1.08E-4 0.16
16 SGTC_549 1661-1316 3.50 519.0 µM 9.91E-5 10 2.33E-4 0.14
17 SGTC_802 4112-3352 3.47 742.0 µM 1.11E-4 8 2.59E-4 0.42
18 SGTC_2783 7738165 3.45 71.4 µM 1.24E-4 9 2.85E-4 0.03
19 SGTC_1979 st071809 3.33 45.3 µM 1.95E-4 RPP1 & pyrimidine depletion 10 4.28E-4 0.10
20 SGTC_2686 alizarin 3.30 95.4 µM 2.21E-4 RPP1 & pyrimidine depletion 13 4.80E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.88E-19 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.135 3.54E-15 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.134 5.55E-15 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.134 6.79E-15 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.130 5.09E-14 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.126 1.97E-13 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.126 2.06E-13 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.125 4.10E-13 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.123 7.37E-13 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.123 8.88E-13 YKR049C FMP46 hom Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.122 1.55E-12 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.119 3.96E-12 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.118 7.09E-12 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.117 9.05E-12 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.116 1.42E-11 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds