YKL007W / CAP1

Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL007W / CAP1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:4.39|P-value:8.08E-6 ID:SGTC_109|Compound:0132-0036|FD-Score:3.85|P-value:7.81E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.97|P-value:4.82E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.66|P-value:1.35E-8 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:9.48|P-value:6.75E-21 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.24|P-value:1.58E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.50|P-value:4.92E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.35|P-value:7.39E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.59|P-value:3.25E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:4.42|P-value:6.97E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.80|P-value:1.23E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.29|P-value:6.06E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.36|P-value:4.84E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:4.73|P-value:1.72E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.09|P-value:3.23E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:3.86|P-value:7.28E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.95|P-value:5.13E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:4.00|P-value:4.29E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.35|P-value:5.46E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-4.55|P-value:4.38E-6 ID:SGTC_633|Compound:0437-0093|FD-Score:4.85|P-value:9.52E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:7.37|P-value:2.27E-13 ID:SGTC_652|Compound:0437-0092|FD-Score:6.09|P-value:1.11E-9 ID:SGTC_658|Compound:3253-0951|FD-Score:4.46|P-value:5.80E-6 ID:SGTC_694|Compound:1315-0438|FD-Score:3.80|P-value:9.29E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.53|P-value:2.58E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.32|P-value:5.51E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.63|P-value:1.79E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.28|P-value:6.88E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.87|P-value:8.75E-7 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.22|P-value:7.77E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.72|P-value:1.27E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.23|P-value:7.32E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.27|P-value:6.54E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.42|P-value:4.22E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.78|P-value:9.95E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.16|P-value:9.47E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.58|P-value:3.42E-6 ID:SGTC_1657|Compound:st012939|FD-Score:3.74|P-value:1.19E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.41|P-value:4.06E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.98|P-value:4.52E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.62|P-value:2.05E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.19|P-value:8.64E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.37|P-value:4.58E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.00|P-value:4.62E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.17|P-value:9.14E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.53|P-value:4.23E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.46|P-value:3.34E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.78|P-value:1.00E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.08|P-value:3.06E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.43|P-value:6.76E-6 ID:SGTC_2707|Compound:st078556|FD-Score:4.63|P-value:2.68E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-3.40|P-value:4.48E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.23|P-value:7.49E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.40|P-value:4.58E-4 ID:SGTC_2912|Compound:7964298|FD-Score:10.60|P-value:9.25E-26 ID:SGTC_2954|Compound:9074818|FD-Score:3.71|P-value:1.32E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.22|P-value:1.71E-5 ID:SGTC_2973|Compound:9094665|FD-Score:6.55|P-value:6.35E-11 ID:SGTC_3225|Compound:9130819|FD-Score:3.74|P-value:1.18E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.98|P-value:4.61E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.39|P-value:8.08E-6 ID:SGTC_109|Compound:0132-0036|FD-Score:3.85|P-value:7.81E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.97|P-value:4.82E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.66|P-value:1.35E-8 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:9.48|P-value:6.75E-21 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.24|P-value:1.58E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.50|P-value:4.92E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.35|P-value:7.39E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.59|P-value:3.25E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:4.42|P-value:6.97E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.80|P-value:1.23E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.29|P-value:6.06E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.36|P-value:4.84E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:4.73|P-value:1.72E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.09|P-value:3.23E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:3.86|P-value:7.28E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.95|P-value:5.13E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:4.00|P-value:4.29E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.35|P-value:5.46E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-4.55|P-value:4.38E-6 ID:SGTC_633|Compound:0437-0093|FD-Score:4.85|P-value:9.52E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:7.37|P-value:2.27E-13 ID:SGTC_652|Compound:0437-0092|FD-Score:6.09|P-value:1.11E-9 ID:SGTC_658|Compound:3253-0951|FD-Score:4.46|P-value:5.80E-6 ID:SGTC_694|Compound:1315-0438|FD-Score:3.80|P-value:9.29E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.53|P-value:2.58E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.32|P-value:5.51E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.63|P-value:1.79E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.28|P-value:6.88E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.87|P-value:8.75E-7 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.22|P-value:7.77E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.72|P-value:1.27E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.23|P-value:7.32E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.27|P-value:6.54E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.42|P-value:4.22E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.78|P-value:9.95E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.16|P-value:9.47E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.58|P-value:3.42E-6 ID:SGTC_1657|Compound:st012939|FD-Score:3.74|P-value:1.19E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.41|P-value:4.06E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.98|P-value:4.52E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.62|P-value:2.05E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.19|P-value:8.64E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.37|P-value:4.58E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.00|P-value:4.62E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.17|P-value:9.14E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.53|P-value:4.23E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.46|P-value:3.34E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.78|P-value:1.00E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.08|P-value:3.06E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.43|P-value:6.76E-6 ID:SGTC_2707|Compound:st078556|FD-Score:4.63|P-value:2.68E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-3.40|P-value:4.48E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.23|P-value:7.49E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.40|P-value:4.58E-4 ID:SGTC_2912|Compound:7964298|FD-Score:10.60|P-value:9.25E-26 ID:SGTC_2954|Compound:9074818|FD-Score:3.71|P-value:1.32E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.22|P-value:1.71E-5 ID:SGTC_2973|Compound:9094665|FD-Score:6.55|P-value:6.35E-11 ID:SGTC_3225|Compound:9130819|FD-Score:3.74|P-value:1.18E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.98|P-value:4.61E-5

Top fitness defect scores for YKL007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2912 7964298 10.60 10.9 µM 9.25E-26 cell wall 13 1.08E-26
2 SGTC_238 5hr heat shock (37°C) + nsc-638432 9.48 8.9 µM 6.75E-21 heat shock/prefoldin 6 1.23E-21
3 SGTC_637 1181-0519 7.37 7.3 µM 2.27E-13 fatty acid desaturase (OLE1) 36 8.22E-14
4 SGTC_2973 9094665 6.55 18.0 µM 6.35E-11 NEO1 3 2.86E-11
5 SGTC_652 0437-0092 6.09 114.0 µM 1.11E-9 1 5.56E-10
6 SGTC_138 0850-0259 5.66 40.9 µM 1.35E-8 cell wall 116 7.49E-9
7 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.35 4.6 µM 7.39E-8 heat shock/prefoldin 19 4.37E-8
8 SGTC_1009 4106-0057 4.87 9.9 µM 8.75E-7 6 5.68E-7
9 SGTC_633 0437-0093 4.85 97.7 µM 9.52E-7 DNA intercalators 5 6.20E-7
10 SGTC_360 0957-0399 4.80 1.0 µM 1.23E-6 cell wall 26 8.07E-7
11 SGTC_413 propylparaben 4.73 100.0 µM 1.72E-6 amide catabolism 10 1.14E-6
12 SGTC_2707 st078556 4.63 66.6 µM 2.68E-6 6 1.81E-6
13 SGTC_243 5hr heat shock (37°C) + splitomicin 4.59 1.0 µM 3.25E-6 heat shock/prefoldin 32 2.21E-6
14 SGTC_1597 7-benzyloxygramine 4.58 47.5 µM 3.42E-6 calcium & mitochondrial duress 82 2.34E-6
15 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 4.53 49.5 µM 4.23E-6 13 2.92E-6
16 SGTC_240 5hr heat shock (37°C) + Streptovitacin 4.50 300.0 µM 4.92E-6 heat shock/prefoldin 29 3.41E-6
17 SGTC_658 3253-0951 4.46 102.0 µM 5.80E-6 calcium & mitochondrial duress 42 4.04E-6
18 SGTC_2582 agaric acid 4.43 100.0 µM 6.76E-6 redox potentiating 267 4.74E-6
19 SGTC_354 2783-3500 4.42 4.9 µM 6.97E-6 cell wall 36 4.89E-6
20 SGTC_77 0828-0286 4.39 12.5 µM 8.08E-6 TSC3-RPN4 24 5.70E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 1.82E-49 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.212 2.92E-35 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.209 1.30E-34 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.200 1.31E-31 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.198 6.30E-31 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.186 1.81E-27 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.182 2.77E-26 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.181 5.12E-26 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.169 8.19E-23 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.167 1.71E-22 YNL098C RAS2 hom GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
0.154 2.54E-19 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.153 7.14E-19 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.151 1.82E-18 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.141 1.81E-16 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.141 2.30E-16 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p