YKL011C / CCE1

Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL011C / CCE1

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:-3.88|P-value:9.02E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.54|P-value:3.23E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:4.33|P-value:1.54E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:4.43|P-value:9.93E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.61|P-value:2.45E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.30|P-value:7.40E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.37|P-value:5.73E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:4.85|P-value:1.50E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:4.11|P-value:3.75E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:4.32|P-value:1.62E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:4.49|P-value:7.58E-6 ID:SGTC_821|Compound:1114-0266|FD-Score:4.68|P-value:3.27E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.27|P-value:8.03E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.40|P-value:5.35E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.01|P-value:5.65E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.77|P-value:1.41E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.96|P-value:6.48E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.44|P-value:8.06E-8 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.21|P-value:9.96E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.33|P-value:1.53E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:5.83|P-value:9.56E-9 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.35|P-value:1.38E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.30|P-value:7.38E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.25|P-value:8.89E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.92|P-value:1.28E-11 ID:SGTC_1629|Compound:st005085|FD-Score:-3.57|P-value:2.85E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.57|P-value:5.27E-6 ID:SGTC_1810|Compound:st050138|FD-Score:3.77|P-value:1.41E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.28|P-value:1.84E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.64|P-value:2.31E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.46|P-value:4.29E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-6.53|P-value:1.43E-10 ID:SGTC_2310|Compound:7668677|FD-Score:-4.49|P-value:7.19E-6 ID:SGTC_2349|Compound:9023730|FD-Score:3.62|P-value:2.48E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.21|P-value:9.48E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.27|P-value:8.15E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.28|P-value:1.89E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.46|P-value:4.12E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-4.11|P-value:3.60E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-5.11|P-value:4.01E-7 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.15|P-value:3.24E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.24|P-value:9.21E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.61|P-value:2.52E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.59|P-value:2.67E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.27|P-value:7.80E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.32|P-value:6.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.55|P-value:3.13E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-6.05|P-value:2.58E-9 ID:SGTC_2791|Compound:5663188|FD-Score:3.79|P-value:1.31E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.62|P-value:2.43E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.44|P-value:4.71E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.51|P-value:3.48E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.79|P-value:1.94E-6 ID:SGTC_2960|Compound:9079389|FD-Score:5.49|P-value:6.04E-8 ID:SGTC_2976|Compound:9009005|FD-Score:3.36|P-value:6.06E-4 ID:SGTC_2980|Compound:9014342|FD-Score:5.08|P-value:4.89E-7 ID:SGTC_3044|Compound:9093193|FD-Score:4.91|P-value:1.13E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-3.44|P-value:4.45E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.89|P-value:8.85E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.88|P-value:9.02E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.54|P-value:3.23E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:4.33|P-value:1.54E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:4.43|P-value:9.93E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.61|P-value:2.45E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.30|P-value:7.40E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.37|P-value:5.73E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:4.85|P-value:1.50E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:4.11|P-value:3.75E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:4.32|P-value:1.62E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:4.49|P-value:7.58E-6 ID:SGTC_821|Compound:1114-0266|FD-Score:4.68|P-value:3.27E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.27|P-value:8.03E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.40|P-value:5.35E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.01|P-value:5.65E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.77|P-value:1.41E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.96|P-value:6.48E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.44|P-value:8.06E-8 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.21|P-value:9.96E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.33|P-value:1.53E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:5.83|P-value:9.56E-9 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.35|P-value:1.38E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.30|P-value:7.38E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.25|P-value:8.89E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.92|P-value:1.28E-11 ID:SGTC_1629|Compound:st005085|FD-Score:-3.57|P-value:2.85E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.57|P-value:5.27E-6 ID:SGTC_1810|Compound:st050138|FD-Score:3.77|P-value:1.41E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.28|P-value:1.84E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.64|P-value:2.31E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.46|P-value:4.29E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-6.53|P-value:1.43E-10 ID:SGTC_2310|Compound:7668677|FD-Score:-4.49|P-value:7.19E-6 ID:SGTC_2349|Compound:9023730|FD-Score:3.62|P-value:2.48E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.21|P-value:9.48E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.27|P-value:8.15E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.28|P-value:1.89E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.46|P-value:4.12E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-4.11|P-value:3.60E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-5.11|P-value:4.01E-7 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.15|P-value:3.24E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.24|P-value:9.21E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.61|P-value:2.52E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.59|P-value:2.67E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.27|P-value:7.80E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.32|P-value:6.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.55|P-value:3.13E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-6.05|P-value:2.58E-9 ID:SGTC_2791|Compound:5663188|FD-Score:3.79|P-value:1.31E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.62|P-value:2.43E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.44|P-value:4.71E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.51|P-value:3.48E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.79|P-value:1.94E-6 ID:SGTC_2960|Compound:9079389|FD-Score:5.49|P-value:6.04E-8 ID:SGTC_2976|Compound:9009005|FD-Score:3.36|P-value:6.06E-4 ID:SGTC_2980|Compound:9014342|FD-Score:5.08|P-value:4.89E-7 ID:SGTC_3044|Compound:9093193|FD-Score:4.91|P-value:1.13E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-3.44|P-value:4.45E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.89|P-value:8.85E-5

Top fitness defect scores for YKL011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1626 st003712 6.92 1.8 µM 1.28E-11 4 2.23E-12
2 SGTC_1136 pergolide 5.83 1.1 µM 9.56E-9 8 2.73E-9
3 SGTC_2960 9079389 5.49 6.0 µM 6.04E-8 9 1.97E-8
4 SGTC_1082 camptothecin 5.44 424.9 nM 8.06E-8 DNA damage response 24 2.69E-8
5 SGTC_2980 9014342 5.08 25.3 µM 4.89E-7 17 1.86E-7
6 SGTC_3044 9093193 4.91 49.5 µM 1.13E-6 12 4.60E-7
7 SGTC_647 0140-0236 4.85 81.0 µM 1.50E-6 5 6.21E-7
8 SGTC_2957 9076800 4.79 11.5 µM 1.94E-6 11 8.17E-7
9 SGTC_821 1114-0266 4.68 29.2 µM 3.27E-6 10 1.43E-6
10 SGTC_1633 st005664 4.57 67.9 µM 5.27E-6 18 2.39E-6
11 SGTC_817 1391-0715 4.49 46.0 µM 7.58E-6 10 3.53E-6
12 SGTC_326 k292-0812 4.43 17.5 µM 9.93E-6 3 4.72E-6
13 SGTC_1297 1068-0111 4.35 14.1 µM 1.38E-5 4 6.72E-6
14 SGTC_1135 dihydrocapsaicin 4.33 536.7 nM 1.53E-5 25 7.52E-6
15 SGTC_198 3454-2873 4.33 16.2 µM 1.54E-5 60S ribosome export 9 7.55E-6
16 SGTC_786 4544-0069 4.32 423.0 µM 1.62E-5 18 7.98E-6
17 SGTC_2104 5389443 4.28 200.0 µM 1.84E-5 7 9.15E-6
18 SGTC_2430 5571206 4.28 200.0 µM 1.89E-5 46 9.42E-6
19 SGTC_2502 avocadyne acetate 4.15 18.6 µM 3.24E-5 22 1.68E-5
20 SGTC_735 3076-0345 4.11 636.0 µM 3.75E-5 24 1.96E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.58E-8 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.087 4.76E-7 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.079 4.44E-6 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.078 6.16E-6 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.077 7.68E-6 YGL202W ARO8 hom Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
0.077 7.87E-6 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.076 1.07E-5 YER150W SPI1 hom GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
0.074 1.58E-5 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.073 2.25E-5 YML032C RAD52 hom Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
0.072 3.11E-5 YNR050C LYS9 hom Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
0.070 5.30E-5 YGR013W SNU71 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
0.067 9.43E-5 YEL046C GLY1 hom Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
0.067 9.57E-5 YLR178C TFS1 hom Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
0.067 1.15E-4 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.066 1.36E-4 YMR158W-B_d YMR158W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C