YKL012W / PRP40

U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL012W / PRP40

Click on Significant Values for Screen Details ID:SGTC_128|Compound:0906-2981|FD-Score:-4.08|P-value:2.16E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:3.07|P-value:2.64E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.16|P-value:1.82E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.78|P-value:9.70E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:4.64|P-value:7.95E-8 ID:SGTC_623|Compound:k072-0108|FD-Score:-2.92|P-value:5.03E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.82|P-value:7.40E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.55|P-value:3.05E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:2.77|P-value:8.80E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.72|P-value:1.32E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:2.92|P-value:4.85E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.84|P-value:6.71E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.33|P-value:8.95E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:4.29|P-value:6.50E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:3.38|P-value:6.63E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-2.82|P-value:7.45E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.70|P-value:1.49E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:-2.90|P-value:5.56E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.45|P-value:5.06E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.65|P-value:1.90E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.79|P-value:8.03E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-2.90|P-value:5.53E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.67|P-value:6.61E-8 ID:SGTC_1386|Compound:3228-0095|FD-Score:-2.82|P-value:7.55E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.04|P-value:3.00E-4 ID:SGTC_1695|Compound:st026914|FD-Score:2.84|P-value:6.67E-4 ID:SGTC_1801|Compound:st050089|FD-Score:2.78|P-value:8.42E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.90|P-value:5.34E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.98|P-value:3.74E-4 ID:SGTC_2033|Compound:5192550|FD-Score:2.92|P-value:4.91E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.00|P-value:3.22E-6 ID:SGTC_2123|Compound:5259487|FD-Score:2.99|P-value:3.65E-4 ID:SGTC_2143|Compound:5623677|FD-Score:2.78|P-value:8.33E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-4.61|P-value:1.02E-7 ID:SGTC_2434|Compound:5670830|FD-Score:-5.93|P-value:1.20E-11 ID:SGTC_2437|Compound:5741531|FD-Score:3.79|P-value:9.20E-6 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-6.22|P-value:1.21E-12 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.80|P-value:7.74E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.77|P-value:9.16E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-4.23|P-value:9.54E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:-2.92|P-value:5.04E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.98|P-value:7.48E-12 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.31|P-value:9.29E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.10|P-value:4.53E-9 ID:SGTC_3010|Compound:9080089|FD-Score:3.20|P-value:1.51E-4 ID:SGTC_3157|Compound:9099274|FD-Score:2.75|P-value:9.31E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.39|P-value:6.89E-5 ID:SGTC_3323|Compound:9138564|FD-Score:3.02|P-value:3.30E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.08|P-value:2.16E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:3.07|P-value:2.64E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.16|P-value:1.82E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.78|P-value:9.70E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:4.64|P-value:7.95E-8 ID:SGTC_623|Compound:k072-0108|FD-Score:-2.92|P-value:5.03E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.82|P-value:7.40E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.55|P-value:3.05E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:2.77|P-value:8.80E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.72|P-value:1.32E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:2.92|P-value:4.85E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.84|P-value:6.71E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.33|P-value:8.95E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:4.29|P-value:6.50E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:3.38|P-value:6.63E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-2.82|P-value:7.45E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.70|P-value:1.49E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:-2.90|P-value:5.56E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.45|P-value:5.06E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.65|P-value:1.90E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.79|P-value:8.03E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-2.90|P-value:5.53E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.67|P-value:6.61E-8 ID:SGTC_1386|Compound:3228-0095|FD-Score:-2.82|P-value:7.55E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.04|P-value:3.00E-4 ID:SGTC_1695|Compound:st026914|FD-Score:2.84|P-value:6.67E-4 ID:SGTC_1801|Compound:st050089|FD-Score:2.78|P-value:8.42E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.90|P-value:5.34E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.98|P-value:3.74E-4 ID:SGTC_2033|Compound:5192550|FD-Score:2.92|P-value:4.91E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.00|P-value:3.22E-6 ID:SGTC_2123|Compound:5259487|FD-Score:2.99|P-value:3.65E-4 ID:SGTC_2143|Compound:5623677|FD-Score:2.78|P-value:8.33E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-4.61|P-value:1.02E-7 ID:SGTC_2434|Compound:5670830|FD-Score:-5.93|P-value:1.20E-11 ID:SGTC_2437|Compound:5741531|FD-Score:3.79|P-value:9.20E-6 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-6.22|P-value:1.21E-12 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.80|P-value:7.74E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.77|P-value:9.16E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-4.23|P-value:9.54E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:-2.92|P-value:5.04E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.98|P-value:7.48E-12 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.31|P-value:9.29E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.10|P-value:4.53E-9 ID:SGTC_3010|Compound:9080089|FD-Score:3.20|P-value:1.51E-4 ID:SGTC_3157|Compound:9099274|FD-Score:2.75|P-value:9.31E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.39|P-value:6.89E-5 ID:SGTC_3323|Compound:9138564|FD-Score:3.02|P-value:3.30E-4

Top fitness defect scores for YKL012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2588 indole-3-carbinol 5.98 100.0 µM 7.48E-12 2 1.12E-9 1.38
2 SGTC_1339 1486-1321 4.67 22.7 µM 6.61E-8 ERG2 2 1.48E-6 0.03
3 SGTC_364 0083-0097 4.64 67.7 µM 7.95E-8 3 1.71E-6 0.04
4 SGTC_876 0720-0963 4.29 56.8 µM 6.50E-7 3 9.05E-6 0.16
5 SGTC_2085 5307070 4.00 144.1 µM 3.22E-6 superoxide 7 3.22E-5 0.04
6 SGTC_2437 5741531 3.79 144.2 µM 9.20E-6 7 7.42E-5 0.00
7 SGTC_303 1348-1668 3.78 34.2 µM 9.70E-6 4 7.73E-5 0.14
8 SGTC_774 k060-0086 3.72 136.0 µM 1.32E-5 6 9.88E-5 0.10
9 SGTC_1153 4055-0057 3.70 267.0 µM 1.49E-5 10 1.09E-4 0.12
10 SGTC_1258 0671-0043 3.65 57.1 µM 1.90E-5 6 1.32E-4 0.04
11 SGTC_736 0958-0254 3.55 92.6 µM 3.05E-5 Golgi 9 1.92E-4 0.05
12 SGTC_878 0828-0289 3.38 13.7 µM 6.63E-5 26 3.57E-4 0.05
13 SGTC_2663 amphotericin b 3.31 100.0 µM 9.29E-5 12 4.67E-4 0.03
14 SGTC_3010 9080089 3.20 71.4 µM 1.51E-4 3 6.87E-4 0.05
15 SGTC_298 1391-0729 3.16 10.0 µM 1.82E-4 calcium & mitochondrial duress 8 7.98E-4 0.08
16 SGTC_136 0097-0015 3.07 404.5 µM 2.64E-4 60S ribosome export 14 0.00107 0.05
17 SGTC_1456 k015-0012 3.04 13.0 µM 3.00E-4 24 0.00119 0.05
18 SGTC_3323 9138564 3.02 53.9 µM 3.30E-4 15 0.00128 0.01
19 SGTC_2123 5259487 2.99 200.0 µM 3.65E-4 10 0.00139 0.16
20 SGTC_1823 3-hydroxy-2-naphthoic acid 2.98 106.0 µM 3.74E-4 9 0.00142 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.61E-15 YBR259W YBR259W hom Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
0.127 1.26E-13 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.125 3.12E-13 YDL102W POL3 het Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
0.112 6.55E-11 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.111 9.88E-11 YML077W BET5 het Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
0.106 7.68E-10 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.100 5.55E-9 YGR018C_p YGR018C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W
0.092 9.71E-8 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.090 1.59E-7 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.090 2.03E-7 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.088 2.94E-7 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.087 4.03E-7 YJR036C HUL4 hom Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex
0.087 4.49E-7 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.085 7.56E-7 YLR286C CTS1 hom Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
0.085 8.27E-7 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus